A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease

Autores
Bonfili, Laura; Grasselli, Francesco Maria; Cucciolonii, Massimiliano; Cecarini, Valentina; Lufrano, Daniela; Vittadini, Elena; Galosi, Livio; Sonsini, Gregorio; Ubaldi, Massimo; Turck, Jonathan Louis; da Costa Medina, Luis Fernando; Suchodolski, Jan; Eleuteri, Anna Maria
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gut microbiota preservation or rational manipulation is a key condition for healthy longevity and a promising strategy to prevent neurodegenerations exploiting the gut-brain axis, with a key role of prebiotics and probiotics. Whether their combination in a functional food can provide a synergistic effect to the host remains controversial. To fill this gap, we supplemented the diet of 3xTg-AD Alzheimer’s disease mice with a red lentils (prebiotic)-based cookie enriched with neuroprotective probiotics and we performed behavioural, biochemical and molecular tests. Chronic consumption of this synbiotic preparation (functional cookie) preserved cognition, reduced amyloid load, improved glucose and lipid homeostasis and diminished oxidation and inflammation related damages compared to animals receiving a classic cookie (standard recipe). The synergistic effect was indicated by significantly higher glucose insulinotropic polypeptide concentrations in the functional cookie group compared to probiotic group. Moreover, Ruminoclostridium sp KB18 and Ruminicoccus decreased in the gut of mice supplemented with the functional cookie, partially explaining the improved short-term memory upon treatments and substantiating the combined use over individual components. This synbiotic innovative snack represents a prototype of a simple and affordable dietary approach to promote healthy aging and prevent or delay the onset of neurodegenerations.
Fil: Bonfili, Laura. Universita Degli Di Camerino; Italia
Fil: Grasselli, Francesco Maria. Universita Degli Di Camerino; Italia
Fil: Cucciolonii, Massimiliano. Universita Degli Di Camerino; Italia
Fil: Cecarini, Valentina. Universita Degli Di Camerino; Italia
Fil: Lufrano, Daniela. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Vittadini, Elena. Universita Degli Di Camerino; Italia
Fil: Galosi, Livio. Universita Degli Di Camerino; Italia
Fil: Sonsini, Gregorio. Universita Degli Di Camerino; Italia
Fil: Ubaldi, Massimo. Universita Degli Di Camerino; Italia
Fil: Turck, Jonathan Louis. Texas A&M University; Estados Unidos
Fil: da Costa Medina, Luis Fernando. Texas A&M University; Estados Unidos
Fil: Suchodolski, Jan. Texas A&M University; Estados Unidos
Fil: Eleuteri, Anna Maria. Universita Degli Di Camerino; Italia
Materia
FUNCTIONAL COOKIE
SYNBIOTIC
NEURODEGENERATION
HEALTHY AGING
GUT-BRAIN AXIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/281797
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/281797
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's diseaseBonfili, LauraGrasselli, Francesco MariaCucciolonii, MassimilianoCecarini, ValentinaLufrano, DanielaVittadini, ElenaGalosi, LivioSonsini, GregorioUbaldi, MassimoTurck, Jonathan Louisda Costa Medina, Luis FernandoSuchodolski, JanEleuteri, Anna MariaFUNCTIONAL COOKIESYNBIOTICNEURODEGENERATIONHEALTHY AGINGGUT-BRAIN AXIShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Gut microbiota preservation or rational manipulation is a key condition for healthy longevity and a promising strategy to prevent neurodegenerations exploiting the gut-brain axis, with a key role of prebiotics and probiotics. Whether their combination in a functional food can provide a synergistic effect to the host remains controversial. To fill this gap, we supplemented the diet of 3xTg-AD Alzheimer’s disease mice with a red lentils (prebiotic)-based cookie enriched with neuroprotective probiotics and we performed behavioural, biochemical and molecular tests. Chronic consumption of this synbiotic preparation (functional cookie) preserved cognition, reduced amyloid load, improved glucose and lipid homeostasis and diminished oxidation and inflammation related damages compared to animals receiving a classic cookie (standard recipe). The synergistic effect was indicated by significantly higher glucose insulinotropic polypeptide concentrations in the functional cookie group compared to probiotic group. Moreover, Ruminoclostridium sp KB18 and Ruminicoccus decreased in the gut of mice supplemented with the functional cookie, partially explaining the improved short-term memory upon treatments and substantiating the combined use over individual components. This synbiotic innovative snack represents a prototype of a simple and affordable dietary approach to promote healthy aging and prevent or delay the onset of neurodegenerations.Fil: Bonfili, Laura. Universita Degli Di Camerino; ItaliaFil: Grasselli, Francesco Maria. Universita Degli Di Camerino; ItaliaFil: Cucciolonii, Massimiliano. Universita Degli Di Camerino; ItaliaFil: Cecarini, Valentina. Universita Degli Di Camerino; ItaliaFil: Lufrano, Daniela. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Vittadini, Elena. Universita Degli Di Camerino; ItaliaFil: Galosi, Livio. Universita Degli Di Camerino; ItaliaFil: Sonsini, Gregorio. Universita Degli Di Camerino; ItaliaFil: Ubaldi, Massimo. Universita Degli Di Camerino; ItaliaFil: Turck, Jonathan Louis. Texas A&M University; Estados UnidosFil: da Costa Medina, Luis Fernando. Texas A&M University; Estados UnidosFil: Suchodolski, Jan. Texas A&M University; Estados UnidosFil: Eleuteri, Anna Maria. Universita Degli Di Camerino; ItaliaElsevier Science Inc.2025-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/281797Bonfili, Laura; Grasselli, Francesco Maria; Cucciolonii, Massimiliano; Cecarini, Valentina; Lufrano, Daniela; et al.; A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease; Elsevier Science Inc.; Journal of Nutritional Biochemistry; 141; 7-2025; 1-120955-2863CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jnutbio.2025.109904info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0955286325000671?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-05-06T16:58:39Zoai:ri.conicet.gov.ar:11336/281797instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-05-06 16:58:39.764CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease
title A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease
spellingShingle A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease
Bonfili, Laura
FUNCTIONAL COOKIE
SYNBIOTIC
NEURODEGENERATION
HEALTHY AGING
GUT-BRAIN AXIS
title_short A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease
title_full A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease
title_fullStr A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease
title_full_unstemmed A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease
title_sort A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease
dc.creator.none.fl_str_mv Bonfili, Laura
Grasselli, Francesco Maria
Cucciolonii, Massimiliano
Cecarini, Valentina
Lufrano, Daniela
Vittadini, Elena
Galosi, Livio
Sonsini, Gregorio
Ubaldi, Massimo
Turck, Jonathan Louis
da Costa Medina, Luis Fernando
Suchodolski, Jan
Eleuteri, Anna Maria
author Bonfili, Laura
author_facet Bonfili, Laura
Grasselli, Francesco Maria
Cucciolonii, Massimiliano
Cecarini, Valentina
Lufrano, Daniela
Vittadini, Elena
Galosi, Livio
Sonsini, Gregorio
Ubaldi, Massimo
Turck, Jonathan Louis
da Costa Medina, Luis Fernando
Suchodolski, Jan
Eleuteri, Anna Maria
author_role author
author2 Grasselli, Francesco Maria
Cucciolonii, Massimiliano
Cecarini, Valentina
Lufrano, Daniela
Vittadini, Elena
Galosi, Livio
Sonsini, Gregorio
Ubaldi, Massimo
Turck, Jonathan Louis
da Costa Medina, Luis Fernando
Suchodolski, Jan
Eleuteri, Anna Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FUNCTIONAL COOKIE
SYNBIOTIC
NEURODEGENERATION
HEALTHY AGING
GUT-BRAIN AXIS
topic FUNCTIONAL COOKIE
SYNBIOTIC
NEURODEGENERATION
HEALTHY AGING
GUT-BRAIN AXIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Gut microbiota preservation or rational manipulation is a key condition for healthy longevity and a promising strategy to prevent neurodegenerations exploiting the gut-brain axis, with a key role of prebiotics and probiotics. Whether their combination in a functional food can provide a synergistic effect to the host remains controversial. To fill this gap, we supplemented the diet of 3xTg-AD Alzheimer’s disease mice with a red lentils (prebiotic)-based cookie enriched with neuroprotective probiotics and we performed behavioural, biochemical and molecular tests. Chronic consumption of this synbiotic preparation (functional cookie) preserved cognition, reduced amyloid load, improved glucose and lipid homeostasis and diminished oxidation and inflammation related damages compared to animals receiving a classic cookie (standard recipe). The synergistic effect was indicated by significantly higher glucose insulinotropic polypeptide concentrations in the functional cookie group compared to probiotic group. Moreover, Ruminoclostridium sp KB18 and Ruminicoccus decreased in the gut of mice supplemented with the functional cookie, partially explaining the improved short-term memory upon treatments and substantiating the combined use over individual components. This synbiotic innovative snack represents a prototype of a simple and affordable dietary approach to promote healthy aging and prevent or delay the onset of neurodegenerations.
Fil: Bonfili, Laura. Universita Degli Di Camerino; Italia
Fil: Grasselli, Francesco Maria. Universita Degli Di Camerino; Italia
Fil: Cucciolonii, Massimiliano. Universita Degli Di Camerino; Italia
Fil: Cecarini, Valentina. Universita Degli Di Camerino; Italia
Fil: Lufrano, Daniela. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación de Proteínas Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Vittadini, Elena. Universita Degli Di Camerino; Italia
Fil: Galosi, Livio. Universita Degli Di Camerino; Italia
Fil: Sonsini, Gregorio. Universita Degli Di Camerino; Italia
Fil: Ubaldi, Massimo. Universita Degli Di Camerino; Italia
Fil: Turck, Jonathan Louis. Texas A&M University; Estados Unidos
Fil: da Costa Medina, Luis Fernando. Texas A&M University; Estados Unidos
Fil: Suchodolski, Jan. Texas A&M University; Estados Unidos
Fil: Eleuteri, Anna Maria. Universita Degli Di Camerino; Italia
description Gut microbiota preservation or rational manipulation is a key condition for healthy longevity and a promising strategy to prevent neurodegenerations exploiting the gut-brain axis, with a key role of prebiotics and probiotics. Whether their combination in a functional food can provide a synergistic effect to the host remains controversial. To fill this gap, we supplemented the diet of 3xTg-AD Alzheimer’s disease mice with a red lentils (prebiotic)-based cookie enriched with neuroprotective probiotics and we performed behavioural, biochemical and molecular tests. Chronic consumption of this synbiotic preparation (functional cookie) preserved cognition, reduced amyloid load, improved glucose and lipid homeostasis and diminished oxidation and inflammation related damages compared to animals receiving a classic cookie (standard recipe). The synergistic effect was indicated by significantly higher glucose insulinotropic polypeptide concentrations in the functional cookie group compared to probiotic group. Moreover, Ruminoclostridium sp KB18 and Ruminicoccus decreased in the gut of mice supplemented with the functional cookie, partially explaining the improved short-term memory upon treatments and substantiating the combined use over individual components. This synbiotic innovative snack represents a prototype of a simple and affordable dietary approach to promote healthy aging and prevent or delay the onset of neurodegenerations.
publishDate 2025
dc.date.none.fl_str_mv 2025-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/281797
Bonfili, Laura; Grasselli, Francesco Maria; Cucciolonii, Massimiliano; Cecarini, Valentina; Lufrano, Daniela; et al.; A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease; Elsevier Science Inc.; Journal of Nutritional Biochemistry; 141; 7-2025; 1-12
0955-2863
CONICET Digital
CONICET
url http://hdl.handle.net/11336/281797
identifier_str_mv Bonfili, Laura; Grasselli, Francesco Maria; Cucciolonii, Massimiliano; Cecarini, Valentina; Lufrano, Daniela; et al.; A red lentils-based synbiotic cookie exerts neuroprotective effects in a mouse model of Alzheimer's disease; Elsevier Science Inc.; Journal of Nutritional Biochemistry; 141; 7-2025; 1-12
0955-2863
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jnutbio.2025.109904
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0955286325000671?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.1485815

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