Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis

Autores
Uranga, Romina Maria; Keller, Jeffrey N.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis. An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia. Additionally, modern societies are becoming increasingly aged, causing a collision between increased hypercholesterolemia and increased aging, which will likely lead to the development of increased pathological conditions due to hypercholesterolemia, thereby promoting deleterious neurochemical and behavioral changes in the brain. Lastly, while beneficial in controlling cholesterol levels, the long-term use of statins itself may potentially promote adverse effects on brain homeostasis, although specifics on this remain largely unknown. This review will focus on linking the current understanding of diet-induced hypercholesterolemia (as well as statin use) to the development of oxidative stress, neurochemical alterations, and cognitive disturbances in the aging brain.
Fil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Keller, Jeffrey N.. State University of Louisiana; Estados Unidos
Materia
AGING
NEURODEGENERATION
DIETS
BRAIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42242
Acceder
id CONICETDig_150d9f5815e3ecefe8d7011caddb0950
oai_identifier_str oai:ri.conicet.gov.ar:11336/42242
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diet and Age Interactions with Regards to Cholesterol Regulation and Brain PathogenesisUranga, Romina MariaKeller, Jeffrey N.AGINGNEURODEGENERATIONDIETSBRAINhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis. An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia. Additionally, modern societies are becoming increasingly aged, causing a collision between increased hypercholesterolemia and increased aging, which will likely lead to the development of increased pathological conditions due to hypercholesterolemia, thereby promoting deleterious neurochemical and behavioral changes in the brain. Lastly, while beneficial in controlling cholesterol levels, the long-term use of statins itself may potentially promote adverse effects on brain homeostasis, although specifics on this remain largely unknown. This review will focus on linking the current understanding of diet-induced hypercholesterolemia (as well as statin use) to the development of oxidative stress, neurochemical alterations, and cognitive disturbances in the aging brain.Fil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Keller, Jeffrey N.. State University of Louisiana; Estados UnidosHindawi Publishing Corporation2010-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42242Uranga, Romina Maria; Keller, Jeffrey N.; Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis; Hindawi Publishing Corporation; Current Gerontology and Geriatrics Research; 2010; 2-2010; 1-141687-7063 / 1687-70711687-7071CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852598/info:eu-repo/semantics/altIdentifier/doi/10.1155/2010/219683info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/cggr/2010/219683/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:18:57Zoai:ri.conicet.gov.ar:11336/42242instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:18:58.317CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
title Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
spellingShingle Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
Uranga, Romina Maria
AGING
NEURODEGENERATION
DIETS
BRAIN
title_short Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
title_full Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
title_fullStr Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
title_full_unstemmed Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
title_sort Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
dc.creator.none.fl_str_mv Uranga, Romina Maria
Keller, Jeffrey N.
author Uranga, Romina Maria
author_facet Uranga, Romina Maria
Keller, Jeffrey N.
author_role author
author2 Keller, Jeffrey N.
author2_role author
dc.subject.none.fl_str_mv AGING
NEURODEGENERATION
DIETS
BRAIN
topic AGING
NEURODEGENERATION
DIETS
BRAIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis. An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia. Additionally, modern societies are becoming increasingly aged, causing a collision between increased hypercholesterolemia and increased aging, which will likely lead to the development of increased pathological conditions due to hypercholesterolemia, thereby promoting deleterious neurochemical and behavioral changes in the brain. Lastly, while beneficial in controlling cholesterol levels, the long-term use of statins itself may potentially promote adverse effects on brain homeostasis, although specifics on this remain largely unknown. This review will focus on linking the current understanding of diet-induced hypercholesterolemia (as well as statin use) to the development of oxidative stress, neurochemical alterations, and cognitive disturbances in the aging brain.
Fil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Keller, Jeffrey N.. State University of Louisiana; Estados Unidos
description Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis. An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia. Additionally, modern societies are becoming increasingly aged, causing a collision between increased hypercholesterolemia and increased aging, which will likely lead to the development of increased pathological conditions due to hypercholesterolemia, thereby promoting deleterious neurochemical and behavioral changes in the brain. Lastly, while beneficial in controlling cholesterol levels, the long-term use of statins itself may potentially promote adverse effects on brain homeostasis, although specifics on this remain largely unknown. This review will focus on linking the current understanding of diet-induced hypercholesterolemia (as well as statin use) to the development of oxidative stress, neurochemical alterations, and cognitive disturbances in the aging brain.
publishDate 2010
dc.date.none.fl_str_mv 2010-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42242
Uranga, Romina Maria; Keller, Jeffrey N.; Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis; Hindawi Publishing Corporation; Current Gerontology and Geriatrics Research; 2010; 2-2010; 1-14
1687-7063 / 1687-7071
1687-7071
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42242
identifier_str_mv Uranga, Romina Maria; Keller, Jeffrey N.; Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis; Hindawi Publishing Corporation; Current Gerontology and Geriatrics Research; 2010; 2-2010; 1-14
1687-7063 / 1687-7071
1687-7071
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852598/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2010/219683
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/cggr/2010/219683/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981031994458112
score 12.48226

Publicaciones similares