Lignans and gut microbiota: An interplay revealing potential health implications

Autores
Senizza, Alice; Rocchetti, Gabriele; Mosse, Juana Inés; Patrone, Vania; Callegari, Maria Luisa; Morelli, Lorenzo; Lucini, Luigi
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Plant polyphenols are a broad group of bioactive compounds characterized by different chemical and structural properties, low bioavailability, and several in vitro biological activities. Among these compounds, lignans (a non-flavonoid polyphenolic class found in plant foods for human nutrition) have been recently studied as potential modulators of the gut–brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic effects. However, variation in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of lignans through the entire gastrointestinal tract. Therefore, in this review, we summarized the most important dietary source of lignans, exploring the interesting interplay between gut metabolites, gut microbiota, and the so-called gut–brain axis.
Fil: Senizza, Alice. Catholic University Of The Sacred Heart, Piacenza, ; Italia
Fil: Rocchetti, Gabriele. Catholic University Of The Sacred Heart, Piacenza, ; Italia
Fil: Mosse, Juana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Patrone, Vania. Catholic University Of The Sacred Heart, Piacenza; Italia
Fil: Callegari, Maria Luisa. Catholic University Of The Sacred Heart, Piacenza, ; Italia
Fil: Morelli, Lorenzo. Catholic University Of The Sacred Heart, Piacenza, ; Italia
Fil: Lucini, Luigi. Catholic University Of The Sacred Heart, Piacenza, ; Italia
Materia
BIOACCESSIBILITY
ENTEROLIGNANS
GUT MICROBIOTA
GUT–BRAIN AXIS
PHENOLIC COMPOUNDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/139312
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Lignans and gut microbiota: An interplay revealing potential health implicationsSenizza, AliceRocchetti, GabrieleMosse, Juana InésPatrone, VaniaCallegari, Maria LuisaMorelli, LorenzoLucini, LuigiBIOACCESSIBILITYENTEROLIGNANSGUT MICROBIOTAGUT–BRAIN AXISPHENOLIC COMPOUNDShttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Plant polyphenols are a broad group of bioactive compounds characterized by different chemical and structural properties, low bioavailability, and several in vitro biological activities. Among these compounds, lignans (a non-flavonoid polyphenolic class found in plant foods for human nutrition) have been recently studied as potential modulators of the gut–brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic effects. However, variation in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of lignans through the entire gastrointestinal tract. Therefore, in this review, we summarized the most important dietary source of lignans, exploring the interesting interplay between gut metabolites, gut microbiota, and the so-called gut–brain axis.Fil: Senizza, Alice. Catholic University Of The Sacred Heart, Piacenza, ; ItaliaFil: Rocchetti, Gabriele. Catholic University Of The Sacred Heart, Piacenza, ; ItaliaFil: Mosse, Juana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Patrone, Vania. Catholic University Of The Sacred Heart, Piacenza; ItaliaFil: Callegari, Maria Luisa. Catholic University Of The Sacred Heart, Piacenza, ; ItaliaFil: Morelli, Lorenzo. Catholic University Of The Sacred Heart, Piacenza, ; ItaliaFil: Lucini, Luigi. Catholic University Of The Sacred Heart, Piacenza, ; ItaliaMolecular Diversity Preservation International2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/139312Senizza, Alice; Rocchetti, Gabriele; Mosse, Juana Inés; Patrone, Vania; Callegari, Maria Luisa; et al.; Lignans and gut microbiota: An interplay revealing potential health implications; Molecular Diversity Preservation International; Molecules; 25; 23; 12-2020; 1-171420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/molecules25235709info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/25/23/5709info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:02:00Zoai:ri.conicet.gov.ar:11336/139312instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:02:00.768CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Lignans and gut microbiota: An interplay revealing potential health implications
title Lignans and gut microbiota: An interplay revealing potential health implications
spellingShingle Lignans and gut microbiota: An interplay revealing potential health implications
Senizza, Alice
BIOACCESSIBILITY
ENTEROLIGNANS
GUT MICROBIOTA
GUT–BRAIN AXIS
PHENOLIC COMPOUNDS
title_short Lignans and gut microbiota: An interplay revealing potential health implications
title_full Lignans and gut microbiota: An interplay revealing potential health implications
title_fullStr Lignans and gut microbiota: An interplay revealing potential health implications
title_full_unstemmed Lignans and gut microbiota: An interplay revealing potential health implications
title_sort Lignans and gut microbiota: An interplay revealing potential health implications
dc.creator.none.fl_str_mv Senizza, Alice
Rocchetti, Gabriele
Mosse, Juana Inés
Patrone, Vania
Callegari, Maria Luisa
Morelli, Lorenzo
Lucini, Luigi
author Senizza, Alice
author_facet Senizza, Alice
Rocchetti, Gabriele
Mosse, Juana Inés
Patrone, Vania
Callegari, Maria Luisa
Morelli, Lorenzo
Lucini, Luigi
author_role author
author2 Rocchetti, Gabriele
Mosse, Juana Inés
Patrone, Vania
Callegari, Maria Luisa
Morelli, Lorenzo
Lucini, Luigi
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOACCESSIBILITY
ENTEROLIGNANS
GUT MICROBIOTA
GUT–BRAIN AXIS
PHENOLIC COMPOUNDS
topic BIOACCESSIBILITY
ENTEROLIGNANS
GUT MICROBIOTA
GUT–BRAIN AXIS
PHENOLIC COMPOUNDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Plant polyphenols are a broad group of bioactive compounds characterized by different chemical and structural properties, low bioavailability, and several in vitro biological activities. Among these compounds, lignans (a non-flavonoid polyphenolic class found in plant foods for human nutrition) have been recently studied as potential modulators of the gut–brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic effects. However, variation in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of lignans through the entire gastrointestinal tract. Therefore, in this review, we summarized the most important dietary source of lignans, exploring the interesting interplay between gut metabolites, gut microbiota, and the so-called gut–brain axis.
Fil: Senizza, Alice. Catholic University Of The Sacred Heart, Piacenza, ; Italia
Fil: Rocchetti, Gabriele. Catholic University Of The Sacred Heart, Piacenza, ; Italia
Fil: Mosse, Juana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Patrone, Vania. Catholic University Of The Sacred Heart, Piacenza; Italia
Fil: Callegari, Maria Luisa. Catholic University Of The Sacred Heart, Piacenza, ; Italia
Fil: Morelli, Lorenzo. Catholic University Of The Sacred Heart, Piacenza, ; Italia
Fil: Lucini, Luigi. Catholic University Of The Sacred Heart, Piacenza, ; Italia
description Plant polyphenols are a broad group of bioactive compounds characterized by different chemical and structural properties, low bioavailability, and several in vitro biological activities. Among these compounds, lignans (a non-flavonoid polyphenolic class found in plant foods for human nutrition) have been recently studied as potential modulators of the gut–brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic effects. However, variation in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of lignans through the entire gastrointestinal tract. Therefore, in this review, we summarized the most important dietary source of lignans, exploring the interesting interplay between gut metabolites, gut microbiota, and the so-called gut–brain axis.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/139312
Senizza, Alice; Rocchetti, Gabriele; Mosse, Juana Inés; Patrone, Vania; Callegari, Maria Luisa; et al.; Lignans and gut microbiota: An interplay revealing potential health implications; Molecular Diversity Preservation International; Molecules; 25; 23; 12-2020; 1-17
1420-3049
CONICET Digital
CONICET
url http://hdl.handle.net/11336/139312
identifier_str_mv Senizza, Alice; Rocchetti, Gabriele; Mosse, Juana Inés; Patrone, Vania; Callegari, Maria Luisa; et al.; Lignans and gut microbiota: An interplay revealing potential health implications; Molecular Diversity Preservation International; Molecules; 25; 23; 12-2020; 1-17
1420-3049
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules25235709
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/25/23/5709
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.004268

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