Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice

Autores
del Coco, Valeria Fernanda; Maria Alejandra, Córdoba; Sidoti, Alicia; Santín, Mónica; Drut, Ricardo; Basualdo Farjat, Juan Angel
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cryptosporidium parvum subtype IIaA21G1R1 oocysts were used to infect dexamethasone immunosuppressed N: NIH Swiss mice. This is the first Cryptosporidium mouse model in which the relationship between infection and apoptosis has been histologically studied at each portion of the gut in order to observe this dynamic in chronic cryptosporidiosis. Histology showed developmental stages in the duodenum, proximal and distal jejunum, ileum, cecum and colon, with the small intestine remaining infected until day 35 post infection. At proximal jejunum an inverse correlation between infection and apoptosis was observed at days 28 and 35 p.i. Data suggests that jejunum could be an interesting place to carry out further studies on the dynamics of Cryptosporidium infection and apoptosis. Based on these findings, this mouse model was useful to evaluate clinical, parasitological and histological aspects of C. parvum subtype IIaA21G1R1 infection, and it will be an appropriate tool to investigate different aspects of Cryptosporidium infection.
Fil: del Coco, Valeria Fernanda. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas. Cátedra de Microbiología y Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Maria Alejandra, Córdoba. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas. Cátedra de Microbiología y Parasitología; Argentina
Fil: Sidoti, Alicia. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Santín, Mónica. United States Department of Agriculture. Agriculture Research Service; Estados Unidos
Fil: Drut, Ricardo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Basualdo Farjat, Juan Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas. Cátedra de Microbiología y Parasitología; Argentina
Materia
APOPTOSIS
CRYPTOSPORIDIUM PARVUM
IMMUNOSUPPRESSION
MURINE MODEL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/195896
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed micedel Coco, Valeria FernandaMaria Alejandra, CórdobaSidoti, AliciaSantín, MónicaDrut, RicardoBasualdo Farjat, Juan AngelAPOPTOSISCRYPTOSPORIDIUM PARVUMIMMUNOSUPPRESSIONMURINE MODELhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cryptosporidium parvum subtype IIaA21G1R1 oocysts were used to infect dexamethasone immunosuppressed N: NIH Swiss mice. This is the first Cryptosporidium mouse model in which the relationship between infection and apoptosis has been histologically studied at each portion of the gut in order to observe this dynamic in chronic cryptosporidiosis. Histology showed developmental stages in the duodenum, proximal and distal jejunum, ileum, cecum and colon, with the small intestine remaining infected until day 35 post infection. At proximal jejunum an inverse correlation between infection and apoptosis was observed at days 28 and 35 p.i. Data suggests that jejunum could be an interesting place to carry out further studies on the dynamics of Cryptosporidium infection and apoptosis. Based on these findings, this mouse model was useful to evaluate clinical, parasitological and histological aspects of C. parvum subtype IIaA21G1R1 infection, and it will be an appropriate tool to investigate different aspects of Cryptosporidium infection.Fil: del Coco, Valeria Fernanda. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas. Cátedra de Microbiología y Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Maria Alejandra, Córdoba. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas. Cátedra de Microbiología y Parasitología; ArgentinaFil: Sidoti, Alicia. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Santín, Mónica. United States Department of Agriculture. Agriculture Research Service; Estados UnidosFil: Drut, Ricardo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Basualdo Farjat, Juan Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas. Cátedra de Microbiología y Parasitología; ArgentinaElsevier Science2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/195896del Coco, Valeria Fernanda; Maria Alejandra, Córdoba; Sidoti, Alicia; Santín, Mónica; Drut, Ricardo; et al.; Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice; Elsevier Science; Veterinary Parasitology; 190; 3-4; 7-2012; 411-4170304-4017CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304401712003470info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2012.06.033info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:54:27Zoai:ri.conicet.gov.ar:11336/195896instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:54:27.567CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice
title Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice
spellingShingle Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice
del Coco, Valeria Fernanda
APOPTOSIS
CRYPTOSPORIDIUM PARVUM
IMMUNOSUPPRESSION
MURINE MODEL
title_short Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice
title_full Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice
title_fullStr Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice
title_full_unstemmed Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice
title_sort Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice
dc.creator.none.fl_str_mv del Coco, Valeria Fernanda
Maria Alejandra, Córdoba
Sidoti, Alicia
Santín, Mónica
Drut, Ricardo
Basualdo Farjat, Juan Angel
author del Coco, Valeria Fernanda
author_facet del Coco, Valeria Fernanda
Maria Alejandra, Córdoba
Sidoti, Alicia
Santín, Mónica
Drut, Ricardo
Basualdo Farjat, Juan Angel
author_role author
author2 Maria Alejandra, Córdoba
Sidoti, Alicia
Santín, Mónica
Drut, Ricardo
Basualdo Farjat, Juan Angel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv APOPTOSIS
CRYPTOSPORIDIUM PARVUM
IMMUNOSUPPRESSION
MURINE MODEL
topic APOPTOSIS
CRYPTOSPORIDIUM PARVUM
IMMUNOSUPPRESSION
MURINE MODEL
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cryptosporidium parvum subtype IIaA21G1R1 oocysts were used to infect dexamethasone immunosuppressed N: NIH Swiss mice. This is the first Cryptosporidium mouse model in which the relationship between infection and apoptosis has been histologically studied at each portion of the gut in order to observe this dynamic in chronic cryptosporidiosis. Histology showed developmental stages in the duodenum, proximal and distal jejunum, ileum, cecum and colon, with the small intestine remaining infected until day 35 post infection. At proximal jejunum an inverse correlation between infection and apoptosis was observed at days 28 and 35 p.i. Data suggests that jejunum could be an interesting place to carry out further studies on the dynamics of Cryptosporidium infection and apoptosis. Based on these findings, this mouse model was useful to evaluate clinical, parasitological and histological aspects of C. parvum subtype IIaA21G1R1 infection, and it will be an appropriate tool to investigate different aspects of Cryptosporidium infection.
Fil: del Coco, Valeria Fernanda. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas. Cátedra de Microbiología y Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Maria Alejandra, Córdoba. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas. Cátedra de Microbiología y Parasitología; Argentina
Fil: Sidoti, Alicia. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Santín, Mónica. United States Department of Agriculture. Agriculture Research Service; Estados Unidos
Fil: Drut, Ricardo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Basualdo Farjat, Juan Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Departamento de Articulación de Ciencias Básicas y Clínicas. Cátedra de Microbiología y Parasitología; Argentina
description Cryptosporidium parvum subtype IIaA21G1R1 oocysts were used to infect dexamethasone immunosuppressed N: NIH Swiss mice. This is the first Cryptosporidium mouse model in which the relationship between infection and apoptosis has been histologically studied at each portion of the gut in order to observe this dynamic in chronic cryptosporidiosis. Histology showed developmental stages in the duodenum, proximal and distal jejunum, ileum, cecum and colon, with the small intestine remaining infected until day 35 post infection. At proximal jejunum an inverse correlation between infection and apoptosis was observed at days 28 and 35 p.i. Data suggests that jejunum could be an interesting place to carry out further studies on the dynamics of Cryptosporidium infection and apoptosis. Based on these findings, this mouse model was useful to evaluate clinical, parasitological and histological aspects of C. parvum subtype IIaA21G1R1 infection, and it will be an appropriate tool to investigate different aspects of Cryptosporidium infection.
publishDate 2012
dc.date.none.fl_str_mv 2012-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/195896
del Coco, Valeria Fernanda; Maria Alejandra, Córdoba; Sidoti, Alicia; Santín, Mónica; Drut, Ricardo; et al.; Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice; Elsevier Science; Veterinary Parasitology; 190; 3-4; 7-2012; 411-417
0304-4017
CONICET Digital
CONICET
url http://hdl.handle.net/11336/195896
identifier_str_mv del Coco, Valeria Fernanda; Maria Alejandra, Córdoba; Sidoti, Alicia; Santín, Mónica; Drut, Ricardo; et al.; Experimental infection with Cryptosporidium parvum IIaA21G1R1 subtype in immunosuppressed mice; Elsevier Science; Veterinary Parasitology; 190; 3-4; 7-2012; 411-417
0304-4017
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304401712003470
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetpar.2012.06.033
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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