Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period

Autores
Ratti, Silvia Gabriela; Alvarez Toro, Edgardo Orozimbo
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Trace elements are an omnipresent group of chemical elements that are present practically in all types of environments sustaining life. Previous evidence from our laboratory has shown that chronic administration of ZnTe to pregnant rats affected several behavioural parameters related to motivated, lateralized exploration, and defensive behaviour in litter rats. In the present work, the possible effect of trace elements administration in a time period before fertilization to parent rats was investigated in its litter rats. Three experimental groups were formed: parent rats receiving water, as control; parent rats receiving ZnTe (0.3 g/L, “ZnTe Pre”) during a short period before mating, and parent rats receiving receiving ZnTe (0.3 g/L) after mating in the same schedule than previous research (“ZnTe Post”). Results showed that in group “ZnTe Pre,” trace elements treatment increased significantly some parameters of motor activity in litter rats, and a similar finding also was observed in motivated exploration. In lateralized exploration as measured in the Lateral Double Hole-board Labyrinth, both “ZnTe Pre” and “ZnTe Post” groups showed absence of the natural left-biased exploration of litter rats, decreasing the proportion of animals exploring the left side of the labyrinth. Defensive behaviour was affected in minor degree in the “ZnTe Pre” group and was significantly different both from Control and “ZnTe Post” group. Other behaviours, such as social interaction was not affected in the “ZnTe Pre” group, while as found previously social parameters were significantly altered in the “ZnTe Post” group. Present data are in agreement with previous results, and support the concept that trace elements can act on epigenetic mechanism regulation occurring prior to the ontogenetic development.
Fil: Ratti, Silvia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Alvarez Toro, Edgardo Orozimbo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Materia
Defensive Behaviour
Lateralization
Trace Elements
Znte
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32025
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/32025
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal periodRatti, Silvia GabrielaAlvarez Toro, Edgardo OrozimboDefensive BehaviourLateralizationTrace ElementsZntehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Trace elements are an omnipresent group of chemical elements that are present practically in all types of environments sustaining life. Previous evidence from our laboratory has shown that chronic administration of ZnTe to pregnant rats affected several behavioural parameters related to motivated, lateralized exploration, and defensive behaviour in litter rats. In the present work, the possible effect of trace elements administration in a time period before fertilization to parent rats was investigated in its litter rats. Three experimental groups were formed: parent rats receiving water, as control; parent rats receiving ZnTe (0.3 g/L, “ZnTe Pre”) during a short period before mating, and parent rats receiving receiving ZnTe (0.3 g/L) after mating in the same schedule than previous research (“ZnTe Post”). Results showed that in group “ZnTe Pre,” trace elements treatment increased significantly some parameters of motor activity in litter rats, and a similar finding also was observed in motivated exploration. In lateralized exploration as measured in the Lateral Double Hole-board Labyrinth, both “ZnTe Pre” and “ZnTe Post” groups showed absence of the natural left-biased exploration of litter rats, decreasing the proportion of animals exploring the left side of the labyrinth. Defensive behaviour was affected in minor degree in the “ZnTe Pre” group and was significantly different both from Control and “ZnTe Post” group. Other behaviours, such as social interaction was not affected in the “ZnTe Pre” group, while as found previously social parameters were significantly altered in the “ZnTe Post” group. Present data are in agreement with previous results, and support the concept that trace elements can act on epigenetic mechanism regulation occurring prior to the ontogenetic development.Fil: Ratti, Silvia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Alvarez Toro, Edgardo Orozimbo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaAmerican Scientific Publishers2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32025Alvarez Toro, Edgardo Orozimbo; Ratti, Silvia Gabriela; Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period; American Scientific Publishers; American Journal of Neuroprotection and Neuroregeneration; 6; 1; 10-2014; 54-611947-29511947-296XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1166/ajnn.2014.1081info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/asp/ajnn/2014/00000006/00000001/art00009info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:19:20Zoai:ri.conicet.gov.ar:11336/32025instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:19:21.125CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period
title Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period
spellingShingle Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period
Ratti, Silvia Gabriela
Defensive Behaviour
Lateralization
Trace Elements
Znte
title_short Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period
title_full Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period
title_fullStr Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period
title_full_unstemmed Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period
title_sort Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period
dc.creator.none.fl_str_mv Ratti, Silvia Gabriela
Alvarez Toro, Edgardo Orozimbo
author Ratti, Silvia Gabriela
author_facet Ratti, Silvia Gabriela
Alvarez Toro, Edgardo Orozimbo
author_role author
author2 Alvarez Toro, Edgardo Orozimbo
author2_role author
dc.subject.none.fl_str_mv Defensive Behaviour
Lateralization
Trace Elements
Znte
topic Defensive Behaviour
Lateralization
Trace Elements
Znte
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Trace elements are an omnipresent group of chemical elements that are present practically in all types of environments sustaining life. Previous evidence from our laboratory has shown that chronic administration of ZnTe to pregnant rats affected several behavioural parameters related to motivated, lateralized exploration, and defensive behaviour in litter rats. In the present work, the possible effect of trace elements administration in a time period before fertilization to parent rats was investigated in its litter rats. Three experimental groups were formed: parent rats receiving water, as control; parent rats receiving ZnTe (0.3 g/L, “ZnTe Pre”) during a short period before mating, and parent rats receiving receiving ZnTe (0.3 g/L) after mating in the same schedule than previous research (“ZnTe Post”). Results showed that in group “ZnTe Pre,” trace elements treatment increased significantly some parameters of motor activity in litter rats, and a similar finding also was observed in motivated exploration. In lateralized exploration as measured in the Lateral Double Hole-board Labyrinth, both “ZnTe Pre” and “ZnTe Post” groups showed absence of the natural left-biased exploration of litter rats, decreasing the proportion of animals exploring the left side of the labyrinth. Defensive behaviour was affected in minor degree in the “ZnTe Pre” group and was significantly different both from Control and “ZnTe Post” group. Other behaviours, such as social interaction was not affected in the “ZnTe Pre” group, while as found previously social parameters were significantly altered in the “ZnTe Post” group. Present data are in agreement with previous results, and support the concept that trace elements can act on epigenetic mechanism regulation occurring prior to the ontogenetic development.
Fil: Ratti, Silvia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Alvarez Toro, Edgardo Orozimbo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
description Trace elements are an omnipresent group of chemical elements that are present practically in all types of environments sustaining life. Previous evidence from our laboratory has shown that chronic administration of ZnTe to pregnant rats affected several behavioural parameters related to motivated, lateralized exploration, and defensive behaviour in litter rats. In the present work, the possible effect of trace elements administration in a time period before fertilization to parent rats was investigated in its litter rats. Three experimental groups were formed: parent rats receiving water, as control; parent rats receiving ZnTe (0.3 g/L, “ZnTe Pre”) during a short period before mating, and parent rats receiving receiving ZnTe (0.3 g/L) after mating in the same schedule than previous research (“ZnTe Post”). Results showed that in group “ZnTe Pre,” trace elements treatment increased significantly some parameters of motor activity in litter rats, and a similar finding also was observed in motivated exploration. In lateralized exploration as measured in the Lateral Double Hole-board Labyrinth, both “ZnTe Pre” and “ZnTe Post” groups showed absence of the natural left-biased exploration of litter rats, decreasing the proportion of animals exploring the left side of the labyrinth. Defensive behaviour was affected in minor degree in the “ZnTe Pre” group and was significantly different both from Control and “ZnTe Post” group. Other behaviours, such as social interaction was not affected in the “ZnTe Pre” group, while as found previously social parameters were significantly altered in the “ZnTe Post” group. Present data are in agreement with previous results, and support the concept that trace elements can act on epigenetic mechanism regulation occurring prior to the ontogenetic development.
publishDate 2014
dc.date.none.fl_str_mv 2014-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32025
Alvarez Toro, Edgardo Orozimbo; Ratti, Silvia Gabriela; Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period; American Scientific Publishers; American Journal of Neuroprotection and Neuroregeneration; 6; 1; 10-2014; 54-61
1947-2951
1947-296X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32025
identifier_str_mv Alvarez Toro, Edgardo Orozimbo; Ratti, Silvia Gabriela; Short administration of ZnTe to male and female rats previous to mating and fertilization affects behavioural responses of litters during the prepuberal period; American Scientific Publishers; American Journal of Neuroprotection and Neuroregeneration; 6; 1; 10-2014; 54-61
1947-2951
1947-296X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1166/ajnn.2014.1081
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/asp/ajnn/2014/00000006/00000001/art00009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Scientific Publishers
publisher.none.fl_str_mv American Scientific Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.48226

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