Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species

Autores
Quiroga, Emma Nelly; Sampietro, Diego Alejandro; Sgariglia, Melina Araceli; Soberon, Jose Rodolfo; Vattuone, Marta Amelia
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The antifungal activity of the ethanolic extract (EE), (3R)-5,7,2′,3′-tetrahydroxy-4′-methoxy-5′-prenylisoflavanone (1) and (3R)-7-2′-3′-trihydroxy-4′-methoxy-5′-prenylisoflavanone (2) isolated from Geoffroea decorticans was evaluated against four different species of Aspergillus. Their effect was compared with that displayed by synthetic products. The antifungal activity was assayed by bioautography, hyphal radial growth, hyphal extent and microdilution in liquid medium. The percentage of hyphal radial growth inhibition produced by EE varied between 18.4 ± 0.1 and 39.6 ± 0.2 for Aspergillus nomius VSC23 and Aspergillus nomius 13137, respectively; and the same value for 1 and 2 were between 31.2 ± 0.1–60.8 ± 1.5 and 28.9 ± 0.7–57.2 ±0.6 for Aspergillus flavus (IEV 018) and Aspergillus nomius 13137, respectively. The values of MIC/MFC determined for EE, 1 and 2 were compared with the actions of ascorbic and sorbic acids, and clotrimazole. The sequence of antifungal potency was clotrimazole > 1 > 2 > ascorbic acid > sorbic acid > EE. Consequently, EE as well as the purified substances from Geoffroea decorticans would be used as biopesticides against Aspergillus species. The cytotoxicity was evaluated.
Fil: Quiroga, Emma Nelly. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentina
Fil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Sgariglia, Melina Araceli. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Soberon, Jose Rodolfo. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Materia
Antifungal Activity
Bioassays
Geoffroea Decorticans
Biopesticide
5´-Prenylisoflavanones
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/80459
Acceder
id CONICETDig_4ade273deccd6bfd86baae328d9ab6d8
oai_identifier_str oai:ri.conicet.gov.ar:11336/80459
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus speciesQuiroga, Emma NellySampietro, Diego AlejandroSgariglia, Melina AraceliSoberon, Jose RodolfoVattuone, Marta AmeliaAntifungal ActivityBioassaysGeoffroea DecorticansBiopesticide5´-Prenylisoflavanoneshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The antifungal activity of the ethanolic extract (EE), (3R)-5,7,2′,3′-tetrahydroxy-4′-methoxy-5′-prenylisoflavanone (1) and (3R)-7-2′-3′-trihydroxy-4′-methoxy-5′-prenylisoflavanone (2) isolated from Geoffroea decorticans was evaluated against four different species of Aspergillus. Their effect was compared with that displayed by synthetic products. The antifungal activity was assayed by bioautography, hyphal radial growth, hyphal extent and microdilution in liquid medium. The percentage of hyphal radial growth inhibition produced by EE varied between 18.4 ± 0.1 and 39.6 ± 0.2 for Aspergillus nomius VSC23 and Aspergillus nomius 13137, respectively; and the same value for 1 and 2 were between 31.2 ± 0.1–60.8 ± 1.5 and 28.9 ± 0.7–57.2 ±0.6 for Aspergillus flavus (IEV 018) and Aspergillus nomius 13137, respectively. The values of MIC/MFC determined for EE, 1 and 2 were compared with the actions of ascorbic and sorbic acids, and clotrimazole. The sequence of antifungal potency was clotrimazole > 1 > 2 > ascorbic acid > sorbic acid > EE. Consequently, EE as well as the purified substances from Geoffroea decorticans would be used as biopesticides against Aspergillus species. The cytotoxicity was evaluated.Fil: Quiroga, Emma Nelly. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; ArgentinaFil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Sgariglia, Melina Araceli. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Soberon, Jose Rodolfo. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaFil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; ArgentinaElsevier Science2009-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80459Quiroga, Emma Nelly; Sampietro, Diego Alejandro; Sgariglia, Melina Araceli; Soberon, Jose Rodolfo; Vattuone, Marta Amelia; Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species; Elsevier Science; International Journal of Food Microbiology; 132; 1; 3-2009; 42-460168-1605CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168160509001639?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijfoodmicro.2009.03.013info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:32Zoai:ri.conicet.gov.ar:11336/80459instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:33.082CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species
title Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species
spellingShingle Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species
Quiroga, Emma Nelly
Antifungal Activity
Bioassays
Geoffroea Decorticans
Biopesticide
5´-Prenylisoflavanones
title_short Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species
title_full Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species
title_fullStr Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species
title_full_unstemmed Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species
title_sort Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species
dc.creator.none.fl_str_mv Quiroga, Emma Nelly
Sampietro, Diego Alejandro
Sgariglia, Melina Araceli
Soberon, Jose Rodolfo
Vattuone, Marta Amelia
author Quiroga, Emma Nelly
author_facet Quiroga, Emma Nelly
Sampietro, Diego Alejandro
Sgariglia, Melina Araceli
Soberon, Jose Rodolfo
Vattuone, Marta Amelia
author_role author
author2 Sampietro, Diego Alejandro
Sgariglia, Melina Araceli
Soberon, Jose Rodolfo
Vattuone, Marta Amelia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Antifungal Activity
Bioassays
Geoffroea Decorticans
Biopesticide
5´-Prenylisoflavanones
topic Antifungal Activity
Bioassays
Geoffroea Decorticans
Biopesticide
5´-Prenylisoflavanones
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The antifungal activity of the ethanolic extract (EE), (3R)-5,7,2′,3′-tetrahydroxy-4′-methoxy-5′-prenylisoflavanone (1) and (3R)-7-2′-3′-trihydroxy-4′-methoxy-5′-prenylisoflavanone (2) isolated from Geoffroea decorticans was evaluated against four different species of Aspergillus. Their effect was compared with that displayed by synthetic products. The antifungal activity was assayed by bioautography, hyphal radial growth, hyphal extent and microdilution in liquid medium. The percentage of hyphal radial growth inhibition produced by EE varied between 18.4 ± 0.1 and 39.6 ± 0.2 for Aspergillus nomius VSC23 and Aspergillus nomius 13137, respectively; and the same value for 1 and 2 were between 31.2 ± 0.1–60.8 ± 1.5 and 28.9 ± 0.7–57.2 ±0.6 for Aspergillus flavus (IEV 018) and Aspergillus nomius 13137, respectively. The values of MIC/MFC determined for EE, 1 and 2 were compared with the actions of ascorbic and sorbic acids, and clotrimazole. The sequence of antifungal potency was clotrimazole > 1 > 2 > ascorbic acid > sorbic acid > EE. Consequently, EE as well as the purified substances from Geoffroea decorticans would be used as biopesticides against Aspergillus species. The cytotoxicity was evaluated.
Fil: Quiroga, Emma Nelly. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentina
Fil: Sampietro, Diego Alejandro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Sgariglia, Melina Araceli. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Soberon, Jose Rodolfo. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Estudios Vegetales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
Fil: Vattuone, Marta Amelia. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
description The antifungal activity of the ethanolic extract (EE), (3R)-5,7,2′,3′-tetrahydroxy-4′-methoxy-5′-prenylisoflavanone (1) and (3R)-7-2′-3′-trihydroxy-4′-methoxy-5′-prenylisoflavanone (2) isolated from Geoffroea decorticans was evaluated against four different species of Aspergillus. Their effect was compared with that displayed by synthetic products. The antifungal activity was assayed by bioautography, hyphal radial growth, hyphal extent and microdilution in liquid medium. The percentage of hyphal radial growth inhibition produced by EE varied between 18.4 ± 0.1 and 39.6 ± 0.2 for Aspergillus nomius VSC23 and Aspergillus nomius 13137, respectively; and the same value for 1 and 2 were between 31.2 ± 0.1–60.8 ± 1.5 and 28.9 ± 0.7–57.2 ±0.6 for Aspergillus flavus (IEV 018) and Aspergillus nomius 13137, respectively. The values of MIC/MFC determined for EE, 1 and 2 were compared with the actions of ascorbic and sorbic acids, and clotrimazole. The sequence of antifungal potency was clotrimazole > 1 > 2 > ascorbic acid > sorbic acid > EE. Consequently, EE as well as the purified substances from Geoffroea decorticans would be used as biopesticides against Aspergillus species. The cytotoxicity was evaluated.
publishDate 2009
dc.date.none.fl_str_mv 2009-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/80459
Quiroga, Emma Nelly; Sampietro, Diego Alejandro; Sgariglia, Melina Araceli; Soberon, Jose Rodolfo; Vattuone, Marta Amelia; Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species; Elsevier Science; International Journal of Food Microbiology; 132; 1; 3-2009; 42-46
0168-1605
CONICET Digital
CONICET
url http://hdl.handle.net/11336/80459
identifier_str_mv Quiroga, Emma Nelly; Sampietro, Diego Alejandro; Sgariglia, Melina Araceli; Soberon, Jose Rodolfo; Vattuone, Marta Amelia; Antimicotic activity of 5´-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species; Elsevier Science; International Journal of Food Microbiology; 132; 1; 3-2009; 42-46
0168-1605
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168160509001639?via%3Dihub
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijfoodmicro.2009.03.013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268738940829696
score 13.13397

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