TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
- Autores
- Perez, Laura Garcia; Kempski, Jan; McGee, Heather M.; Pelzcar, Penelope; Agalioti, Theodora; Giannou, Anastasios; Konczalla, Leonie; Brockmann, Leonie; Wahib, Ramez; Xu, Hao; Amezcua Vesely, Maria Carolina; Soukou, Shiwa; Steglich, Babett; Bedke, Tanja; Manthey, Carolin; Seiz, Oliver; Diercks, Björn-Philipp; Gnafakis, Stylianos; Guse, Andreas H.; Perez, Daniel; Izbicki, Jakob R.; Gagliani, Nicola; Flavell, Richard A.; Huber, Samuel
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cancer compared to normal adjacent tissue, whereas the frequency of IL-22 single producing cells is not changed. Accordingly, TGF-β signaling in CD4+ T cells (specifically Th17 cells) promotes the emergence of IL-22-producing Th17 cells and thereby tumorigenesis in mice. IL-22 single producing T cells, however, are not dependent on TGF-β signaling. We show that TGF-β, via AhR induction, and PI3K signaling promotes IL-22 production in Th17 cells.
Fil: Perez, Laura Garcia. Department Of Medicine, University Medical Center Hamb; Alemania
Fil: Kempski, Jan. Universitat Hamburg; Alemania
Fil: McGee, Heather M.. Universitat Hamburg; Alemania
Fil: Pelzcar, Penelope. Universitat Hamburg; Alemania
Fil: Agalioti, Theodora. Universitat Hamburg; Alemania
Fil: Giannou, Anastasios. Universitat Hamburg; Alemania
Fil: Konczalla, Leonie. Universitat Hamburg; Alemania
Fil: Brockmann, Leonie. Universitat Hamburg; Alemania
Fil: Wahib, Ramez. Universitat Hamburg; Alemania
Fil: Xu, Hao. University of Yale. School of Medicine; Estados Unidos
Fil: Amezcua Vesely, Maria Carolina. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Soukou, Shiwa. Universitat Hamburg; Alemania
Fil: Steglich, Babett. Universitat Hamburg; Alemania
Fil: Bedke, Tanja. Universitat Hamburg; Alemania
Fil: Manthey, Carolin. Universitat Hamburg; Alemania
Fil: Seiz, Oliver. Universitat Hamburg; Alemania
Fil: Diercks, Björn-Philipp. Universitat Hamburg; Alemania
Fil: Gnafakis, Stylianos. Universitat Hamburg; Alemania
Fil: Guse, Andreas H.. Universitat Hamburg; Alemania
Fil: Perez, Daniel. Universitat Hamburg; Alemania
Fil: Izbicki, Jakob R.. Universitat Hamburg; Alemania
Fil: Gagliani, Nicola. Universitat Hamburg; Alemania
Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos
Fil: Huber, Samuel. Universitat Hamburg; Alemania - Materia
-
TGFb
IL-22
Th17
AhR - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/159230
Ver los metadatos del registro completo
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TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancerPerez, Laura GarciaKempski, JanMcGee, Heather M.Pelzcar, PenelopeAgalioti, TheodoraGiannou, AnastasiosKonczalla, LeonieBrockmann, LeonieWahib, RamezXu, HaoAmezcua Vesely, Maria CarolinaSoukou, ShiwaSteglich, BabettBedke, TanjaManthey, CarolinSeiz, OliverDiercks, Björn-PhilippGnafakis, StylianosGuse, Andreas H.Perez, DanielIzbicki, Jakob R.Gagliani, NicolaFlavell, Richard A.Huber, SamuelTGFbIL-22Th17AhRhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cancer compared to normal adjacent tissue, whereas the frequency of IL-22 single producing cells is not changed. Accordingly, TGF-β signaling in CD4+ T cells (specifically Th17 cells) promotes the emergence of IL-22-producing Th17 cells and thereby tumorigenesis in mice. IL-22 single producing T cells, however, are not dependent on TGF-β signaling. We show that TGF-β, via AhR induction, and PI3K signaling promotes IL-22 production in Th17 cells.Fil: Perez, Laura Garcia. Department Of Medicine, University Medical Center Hamb; AlemaniaFil: Kempski, Jan. Universitat Hamburg; AlemaniaFil: McGee, Heather M.. Universitat Hamburg; AlemaniaFil: Pelzcar, Penelope. Universitat Hamburg; AlemaniaFil: Agalioti, Theodora. Universitat Hamburg; AlemaniaFil: Giannou, Anastasios. Universitat Hamburg; AlemaniaFil: Konczalla, Leonie. Universitat Hamburg; AlemaniaFil: Brockmann, Leonie. Universitat Hamburg; AlemaniaFil: Wahib, Ramez. Universitat Hamburg; AlemaniaFil: Xu, Hao. University of Yale. School of Medicine; Estados UnidosFil: Amezcua Vesely, Maria Carolina. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Soukou, Shiwa. Universitat Hamburg; AlemaniaFil: Steglich, Babett. Universitat Hamburg; AlemaniaFil: Bedke, Tanja. Universitat Hamburg; AlemaniaFil: Manthey, Carolin. Universitat Hamburg; AlemaniaFil: Seiz, Oliver. Universitat Hamburg; AlemaniaFil: Diercks, Björn-Philipp. Universitat Hamburg; AlemaniaFil: Gnafakis, Stylianos. Universitat Hamburg; AlemaniaFil: Guse, Andreas H.. Universitat Hamburg; AlemaniaFil: Perez, Daniel. Universitat Hamburg; AlemaniaFil: Izbicki, Jakob R.. Universitat Hamburg; AlemaniaFil: Gagliani, Nicola. Universitat Hamburg; AlemaniaFil: Flavell, Richard A.. University of Yale. School of Medicine; Estados UnidosFil: Huber, Samuel. Universitat Hamburg; AlemaniaNature Research2020-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/159230Perez, Laura Garcia; Kempski, Jan; McGee, Heather M.; Pelzcar, Penelope; Agalioti, Theodora; et al.; TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer; Nature Research; Nature Communications; 11; 1; 5-2020; 1-142041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41467-020-16363-winfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-020-16363-winfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:47:55Zoai:ri.conicet.gov.ar:11336/159230instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:47:55.72CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title |
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| spellingShingle |
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer Perez, Laura Garcia TGFb IL-22 Th17 AhR |
| title_short |
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title_full |
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title_fullStr |
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title_full_unstemmed |
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| title_sort |
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer |
| dc.creator.none.fl_str_mv |
Perez, Laura Garcia Kempski, Jan McGee, Heather M. Pelzcar, Penelope Agalioti, Theodora Giannou, Anastasios Konczalla, Leonie Brockmann, Leonie Wahib, Ramez Xu, Hao Amezcua Vesely, Maria Carolina Soukou, Shiwa Steglich, Babett Bedke, Tanja Manthey, Carolin Seiz, Oliver Diercks, Björn-Philipp Gnafakis, Stylianos Guse, Andreas H. Perez, Daniel Izbicki, Jakob R. Gagliani, Nicola Flavell, Richard A. Huber, Samuel |
| author |
Perez, Laura Garcia |
| author_facet |
Perez, Laura Garcia Kempski, Jan McGee, Heather M. Pelzcar, Penelope Agalioti, Theodora Giannou, Anastasios Konczalla, Leonie Brockmann, Leonie Wahib, Ramez Xu, Hao Amezcua Vesely, Maria Carolina Soukou, Shiwa Steglich, Babett Bedke, Tanja Manthey, Carolin Seiz, Oliver Diercks, Björn-Philipp Gnafakis, Stylianos Guse, Andreas H. Perez, Daniel Izbicki, Jakob R. Gagliani, Nicola Flavell, Richard A. Huber, Samuel |
| author_role |
author |
| author2 |
Kempski, Jan McGee, Heather M. Pelzcar, Penelope Agalioti, Theodora Giannou, Anastasios Konczalla, Leonie Brockmann, Leonie Wahib, Ramez Xu, Hao Amezcua Vesely, Maria Carolina Soukou, Shiwa Steglich, Babett Bedke, Tanja Manthey, Carolin Seiz, Oliver Diercks, Björn-Philipp Gnafakis, Stylianos Guse, Andreas H. Perez, Daniel Izbicki, Jakob R. Gagliani, Nicola Flavell, Richard A. Huber, Samuel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
TGFb IL-22 Th17 AhR |
| topic |
TGFb IL-22 Th17 AhR |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cancer compared to normal adjacent tissue, whereas the frequency of IL-22 single producing cells is not changed. Accordingly, TGF-β signaling in CD4+ T cells (specifically Th17 cells) promotes the emergence of IL-22-producing Th17 cells and thereby tumorigenesis in mice. IL-22 single producing T cells, however, are not dependent on TGF-β signaling. We show that TGF-β, via AhR induction, and PI3K signaling promotes IL-22 production in Th17 cells. Fil: Perez, Laura Garcia. Department Of Medicine, University Medical Center Hamb; Alemania Fil: Kempski, Jan. Universitat Hamburg; Alemania Fil: McGee, Heather M.. Universitat Hamburg; Alemania Fil: Pelzcar, Penelope. Universitat Hamburg; Alemania Fil: Agalioti, Theodora. Universitat Hamburg; Alemania Fil: Giannou, Anastasios. Universitat Hamburg; Alemania Fil: Konczalla, Leonie. Universitat Hamburg; Alemania Fil: Brockmann, Leonie. Universitat Hamburg; Alemania Fil: Wahib, Ramez. Universitat Hamburg; Alemania Fil: Xu, Hao. University of Yale. School of Medicine; Estados Unidos Fil: Amezcua Vesely, Maria Carolina. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Soukou, Shiwa. Universitat Hamburg; Alemania Fil: Steglich, Babett. Universitat Hamburg; Alemania Fil: Bedke, Tanja. Universitat Hamburg; Alemania Fil: Manthey, Carolin. Universitat Hamburg; Alemania Fil: Seiz, Oliver. Universitat Hamburg; Alemania Fil: Diercks, Björn-Philipp. Universitat Hamburg; Alemania Fil: Gnafakis, Stylianos. Universitat Hamburg; Alemania Fil: Guse, Andreas H.. Universitat Hamburg; Alemania Fil: Perez, Daniel. Universitat Hamburg; Alemania Fil: Izbicki, Jakob R.. Universitat Hamburg; Alemania Fil: Gagliani, Nicola. Universitat Hamburg; Alemania Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos Fil: Huber, Samuel. Universitat Hamburg; Alemania |
| description |
IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight regulation of IL-22 is essential. TGF-β1 promotes the differentiation of Th17 cells, which are known to be a major source of IL-22, but the effect of TGF-β signaling on the production of IL-22 in CD4+ T cells is controversial. Here we show an increased presence of IL-17+IL-22+ cells and TGF-β1 in colorectal cancer compared to normal adjacent tissue, whereas the frequency of IL-22 single producing cells is not changed. Accordingly, TGF-β signaling in CD4+ T cells (specifically Th17 cells) promotes the emergence of IL-22-producing Th17 cells and thereby tumorigenesis in mice. IL-22 single producing T cells, however, are not dependent on TGF-β signaling. We show that TGF-β, via AhR induction, and PI3K signaling promotes IL-22 production in Th17 cells. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-05 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/159230 Perez, Laura Garcia; Kempski, Jan; McGee, Heather M.; Pelzcar, Penelope; Agalioti, Theodora; et al.; TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer; Nature Research; Nature Communications; 11; 1; 5-2020; 1-14 2041-1723 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/159230 |
| identifier_str_mv |
Perez, Laura Garcia; Kempski, Jan; McGee, Heather M.; Pelzcar, Penelope; Agalioti, Theodora; et al.; TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer; Nature Research; Nature Communications; 11; 1; 5-2020; 1-14 2041-1723 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
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info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41467-020-16363-w info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-020-16363-w |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf |
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Nature Research |
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Nature Research |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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