CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis
- Autores
- Zhang, Tao; Wahib, Ramez; Zazara, Dimitra E.; Lücke, Jöran; Shiri, Ahmad Mustafa; Kempski, Jan; Zhao, Lilan; Agalioti, Theodora; Machicote, Andrés Pablo; Giannou, Olympia; Belios, Ioannis; Jia, Rongrong; Zhang, Siwen; Tintelnot, Joseph; Seese, Hannes; Grass, Julia Kristin; Mercanoglu, Baris; Stern, Louisa; Scognamiglio, Pasquale; Fard Aghaie, Mohammad; Seeger, Philipp; Wakker, Jonas; Kemper, Marius; Brunswig, Benjamin; Duprée, Anna; Lykoudis, Panagis M.; Pikouli, Anastasia; Giorgakis, Emmanouil; Stringa, Pablo Luis; Lausada, Natalia Raquel; Gentilini, Maria Virginia; Gondolesi, Gabriel Eduardo; Bachmann, Kai; Busch, Philipp; Grotelüschen, Rainer; Maroulis, Ioannis C.; Arck, Petra Clara; Nakano, Ryosuke; Thomson, Angus W.; Ghadban, Tarik; Tachezy, Michael; Melling, Nathaniel; Achilles, Eike Gert; Puelles, Victor G.; Nickel, Felix; Hackert, Thilo; Mann, Oliver; Izbicki, Jakob R.; Li, Jun; Gagliani, Nicola; Huber, Samuel; Giannou, Anastasios D.
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis.
Fil: Zhang, Tao. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Wahib, Ramez. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Zazara, Dimitra E.. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Lücke, Jöran. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Shiri, Ahmad Mustafa. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Kempski, Jan. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Zhao, Lilan. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Agalioti, Theodora. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Machicote, Andrés Pablo. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Giannou, Olympia. University of Patras; Grecia
Fil: Belios, Ioannis. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Jia, Rongrong. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Zhang, Siwen. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Tintelnot, Joseph. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Seese, Hannes. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Grass, Julia Kristin. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Mercanoglu, Baris. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Stern, Louisa. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Scognamiglio, Pasquale. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Fard Aghaie, Mohammad. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Seeger, Philipp. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Wakker, Jonas. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Kemper, Marius. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Brunswig, Benjamin. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Duprée, Anna. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Lykoudis, Panagis M.. Colegio Universitario de Londres; Reino Unido. National And Kapodistrian University of Athens; Grecia
Fil: Pikouli, Anastasia. National And Kapodistrian University of Athens; Grecia
Fil: Giorgakis, Emmanouil. Winthrop P. Rockefeller Cancer Institute; Estados Unidos. University of Arkansas for Medical Sciences; Estados Unidos
Fil: Stringa, Pablo Luis. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: Lausada, Natalia Raquel. Fundación Favaloro; Argentina
Fil: Gentilini, Maria Virginia. Universidad Favaloro; Argentina
Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina
Fil: Bachmann, Kai. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Busch, Philipp. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Grotelüschen, Rainer. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Maroulis, Ioannis C.. School of Medicine of Patras University; Grecia
Fil: Arck, Petra Clara. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Nakano, Ryosuke. Univeristy of Pittsburgh. School of Medicine; Estados Unidos
Fil: Thomson, Angus W.. Univeristy of Pittsburgh. School of Medicine; Estados Unidos
Fil: Ghadban, Tarik. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Tachezy, Michael. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Melling, Nathaniel. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Achilles, Eike Gert. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Puelles, Victor G.. University Aarhus; Dinamarca. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Nickel, Felix. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Hackert, Thilo. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Mann, Oliver. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Izbicki, Jakob R.. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Li, Jun. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Gagliani, Nicola. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Huber, Samuel. Universitätsklinikum Hamburg-Eppendorf; Alemania
Fil: Giannou, Anastasios D.. Universitätsklinikum Hamburg-Eppendorf; Alemania - Materia
-
IL-22
LIVER METASTASIS
TH22 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/253820
Ver los metadatos del registro completo
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CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesisZhang, TaoWahib, RamezZazara, Dimitra E.Lücke, JöranShiri, Ahmad MustafaKempski, JanZhao, LilanAgalioti, TheodoraMachicote, Andrés PabloGiannou, OlympiaBelios, IoannisJia, RongrongZhang, SiwenTintelnot, JosephSeese, HannesGrass, Julia KristinMercanoglu, BarisStern, LouisaScognamiglio, PasqualeFard Aghaie, MohammadSeeger, PhilippWakker, JonasKemper, MariusBrunswig, BenjaminDuprée, AnnaLykoudis, Panagis M.Pikouli, AnastasiaGiorgakis, EmmanouilStringa, Pablo LuisLausada, Natalia RaquelGentilini, Maria VirginiaGondolesi, Gabriel EduardoBachmann, KaiBusch, PhilippGrotelüschen, RainerMaroulis, Ioannis C.Arck, Petra ClaraNakano, RyosukeThomson, Angus W.Ghadban, TarikTachezy, MichaelMelling, NathanielAchilles, Eike GertPuelles, Victor G.Nickel, FelixHackert, ThiloMann, OliverIzbicki, Jakob R.Li, JunGagliani, NicolaHuber, SamuelGiannou, Anastasios D.IL-22LIVER METASTASISTH22https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis.Fil: Zhang, Tao. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Wahib, Ramez. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Zazara, Dimitra E.. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Lücke, Jöran. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Shiri, Ahmad Mustafa. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Kempski, Jan. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Zhao, Lilan. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Agalioti, Theodora. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Machicote, Andrés Pablo. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Giannou, Olympia. University of Patras; GreciaFil: Belios, Ioannis. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Jia, Rongrong. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Zhang, Siwen. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Tintelnot, Joseph. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Seese, Hannes. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Grass, Julia Kristin. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Mercanoglu, Baris. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Stern, Louisa. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Scognamiglio, Pasquale. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Fard Aghaie, Mohammad. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Seeger, Philipp. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Wakker, Jonas. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Kemper, Marius. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Brunswig, Benjamin. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Duprée, Anna. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Lykoudis, Panagis M.. Colegio Universitario de Londres; Reino Unido. National And Kapodistrian University of Athens; GreciaFil: Pikouli, Anastasia. National And Kapodistrian University of Athens; GreciaFil: Giorgakis, Emmanouil. Winthrop P. Rockefeller Cancer Institute; Estados Unidos. University of Arkansas for Medical Sciences; Estados UnidosFil: Stringa, Pablo Luis. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Lausada, Natalia Raquel. Fundación Favaloro; ArgentinaFil: Gentilini, Maria Virginia. Universidad Favaloro; ArgentinaFil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; ArgentinaFil: Bachmann, Kai. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Busch, Philipp. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Grotelüschen, Rainer. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Maroulis, Ioannis C.. School of Medicine of Patras University; GreciaFil: Arck, Petra Clara. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Nakano, Ryosuke. Univeristy of Pittsburgh. School of Medicine; Estados UnidosFil: Thomson, Angus W.. Univeristy of Pittsburgh. School of Medicine; Estados UnidosFil: Ghadban, Tarik. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Tachezy, Michael. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Melling, Nathaniel. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Achilles, Eike Gert. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Puelles, Victor G.. University Aarhus; Dinamarca. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Nickel, Felix. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Hackert, Thilo. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Mann, Oliver. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Izbicki, Jakob R.. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Li, Jun. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Gagliani, Nicola. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Huber, Samuel. Universitätsklinikum Hamburg-Eppendorf; AlemaniaFil: Giannou, Anastasios D.. Universitätsklinikum Hamburg-Eppendorf; AlemaniaTaylor & Francis2023-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/253820Zhang, Tao; Wahib, Ramez; Zazara, Dimitra E.; Lücke, Jöran; Shiri, Ahmad Mustafa; et al.; CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis; Taylor & Francis; OncoImmunology; 12; 1; 10-2023; 1-122162-40112162-402XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/2162402X.2023.2269634info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/2162402X.2023.2269634info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:18:14Zoai:ri.conicet.gov.ar:11336/253820instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:18:14.66CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| title |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| spellingShingle |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis Zhang, Tao IL-22 LIVER METASTASIS TH22 |
| title_short |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| title_full |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| title_fullStr |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| title_full_unstemmed |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| title_sort |
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis |
| dc.creator.none.fl_str_mv |
Zhang, Tao Wahib, Ramez Zazara, Dimitra E. Lücke, Jöran Shiri, Ahmad Mustafa Kempski, Jan Zhao, Lilan Agalioti, Theodora Machicote, Andrés Pablo Giannou, Olympia Belios, Ioannis Jia, Rongrong Zhang, Siwen Tintelnot, Joseph Seese, Hannes Grass, Julia Kristin Mercanoglu, Baris Stern, Louisa Scognamiglio, Pasquale Fard Aghaie, Mohammad Seeger, Philipp Wakker, Jonas Kemper, Marius Brunswig, Benjamin Duprée, Anna Lykoudis, Panagis M. Pikouli, Anastasia Giorgakis, Emmanouil Stringa, Pablo Luis Lausada, Natalia Raquel Gentilini, Maria Virginia Gondolesi, Gabriel Eduardo Bachmann, Kai Busch, Philipp Grotelüschen, Rainer Maroulis, Ioannis C. Arck, Petra Clara Nakano, Ryosuke Thomson, Angus W. Ghadban, Tarik Tachezy, Michael Melling, Nathaniel Achilles, Eike Gert Puelles, Victor G. Nickel, Felix Hackert, Thilo Mann, Oliver Izbicki, Jakob R. Li, Jun Gagliani, Nicola Huber, Samuel Giannou, Anastasios D. |
| author |
Zhang, Tao |
| author_facet |
Zhang, Tao Wahib, Ramez Zazara, Dimitra E. Lücke, Jöran Shiri, Ahmad Mustafa Kempski, Jan Zhao, Lilan Agalioti, Theodora Machicote, Andrés Pablo Giannou, Olympia Belios, Ioannis Jia, Rongrong Zhang, Siwen Tintelnot, Joseph Seese, Hannes Grass, Julia Kristin Mercanoglu, Baris Stern, Louisa Scognamiglio, Pasquale Fard Aghaie, Mohammad Seeger, Philipp Wakker, Jonas Kemper, Marius Brunswig, Benjamin Duprée, Anna Lykoudis, Panagis M. Pikouli, Anastasia Giorgakis, Emmanouil Stringa, Pablo Luis Lausada, Natalia Raquel Gentilini, Maria Virginia Gondolesi, Gabriel Eduardo Bachmann, Kai Busch, Philipp Grotelüschen, Rainer Maroulis, Ioannis C. Arck, Petra Clara Nakano, Ryosuke Thomson, Angus W. Ghadban, Tarik Tachezy, Michael Melling, Nathaniel Achilles, Eike Gert Puelles, Victor G. Nickel, Felix Hackert, Thilo Mann, Oliver Izbicki, Jakob R. Li, Jun Gagliani, Nicola Huber, Samuel Giannou, Anastasios D. |
| author_role |
author |
| author2 |
Wahib, Ramez Zazara, Dimitra E. Lücke, Jöran Shiri, Ahmad Mustafa Kempski, Jan Zhao, Lilan Agalioti, Theodora Machicote, Andrés Pablo Giannou, Olympia Belios, Ioannis Jia, Rongrong Zhang, Siwen Tintelnot, Joseph Seese, Hannes Grass, Julia Kristin Mercanoglu, Baris Stern, Louisa Scognamiglio, Pasquale Fard Aghaie, Mohammad Seeger, Philipp Wakker, Jonas Kemper, Marius Brunswig, Benjamin Duprée, Anna Lykoudis, Panagis M. Pikouli, Anastasia Giorgakis, Emmanouil Stringa, Pablo Luis Lausada, Natalia Raquel Gentilini, Maria Virginia Gondolesi, Gabriel Eduardo Bachmann, Kai Busch, Philipp Grotelüschen, Rainer Maroulis, Ioannis C. Arck, Petra Clara Nakano, Ryosuke Thomson, Angus W. Ghadban, Tarik Tachezy, Michael Melling, Nathaniel Achilles, Eike Gert Puelles, Victor G. Nickel, Felix Hackert, Thilo Mann, Oliver Izbicki, Jakob R. Li, Jun Gagliani, Nicola Huber, Samuel Giannou, Anastasios D. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
IL-22 LIVER METASTASIS TH22 |
| topic |
IL-22 LIVER METASTASIS TH22 |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. Fil: Zhang, Tao. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Wahib, Ramez. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Zazara, Dimitra E.. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Lücke, Jöran. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Shiri, Ahmad Mustafa. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Kempski, Jan. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Zhao, Lilan. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Agalioti, Theodora. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Machicote, Andrés Pablo. University Medical Center Hamburg-Eppendorf; Alemania Fil: Giannou, Olympia. University of Patras; Grecia Fil: Belios, Ioannis. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Jia, Rongrong. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Zhang, Siwen. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Tintelnot, Joseph. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Seese, Hannes. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Grass, Julia Kristin. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Mercanoglu, Baris. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Stern, Louisa. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Scognamiglio, Pasquale. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Fard Aghaie, Mohammad. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Seeger, Philipp. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Wakker, Jonas. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Kemper, Marius. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Brunswig, Benjamin. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Duprée, Anna. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Lykoudis, Panagis M.. Colegio Universitario de Londres; Reino Unido. National And Kapodistrian University of Athens; Grecia Fil: Pikouli, Anastasia. National And Kapodistrian University of Athens; Grecia Fil: Giorgakis, Emmanouil. Winthrop P. Rockefeller Cancer Institute; Estados Unidos. University of Arkansas for Medical Sciences; Estados Unidos Fil: Stringa, Pablo Luis. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina Fil: Lausada, Natalia Raquel. Fundación Favaloro; Argentina Fil: Gentilini, Maria Virginia. Universidad Favaloro; Argentina Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina Fil: Bachmann, Kai. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Busch, Philipp. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Grotelüschen, Rainer. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Maroulis, Ioannis C.. School of Medicine of Patras University; Grecia Fil: Arck, Petra Clara. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Nakano, Ryosuke. Univeristy of Pittsburgh. School of Medicine; Estados Unidos Fil: Thomson, Angus W.. Univeristy of Pittsburgh. School of Medicine; Estados Unidos Fil: Ghadban, Tarik. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Tachezy, Michael. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Melling, Nathaniel. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Achilles, Eike Gert. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Puelles, Victor G.. University Aarhus; Dinamarca. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Nickel, Felix. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Hackert, Thilo. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Mann, Oliver. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Izbicki, Jakob R.. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Li, Jun. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Gagliani, Nicola. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Huber, Samuel. Universitätsklinikum Hamburg-Eppendorf; Alemania Fil: Giannou, Anastasios D.. Universitätsklinikum Hamburg-Eppendorf; Alemania |
| description |
Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-10 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/253820 Zhang, Tao; Wahib, Ramez; Zazara, Dimitra E.; Lücke, Jöran; Shiri, Ahmad Mustafa; et al.; CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis; Taylor & Francis; OncoImmunology; 12; 1; 10-2023; 1-12 2162-4011 2162-402X CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/253820 |
| identifier_str_mv |
Zhang, Tao; Wahib, Ramez; Zazara, Dimitra E.; Lücke, Jöran; Shiri, Ahmad Mustafa; et al.; CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis; Taylor & Francis; OncoImmunology; 12; 1; 10-2023; 1-12 2162-4011 2162-402X CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1080/2162402X.2023.2269634 info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/2162402X.2023.2269634 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Taylor & Francis |
| publisher.none.fl_str_mv |
Taylor & Francis |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1842980997771034624 |
| score |
12.993085 |