The induction and function of the anti-inflammatory fate of TH17 cells

Autores
Xu, Hao; Agalioti, Theodora; Zhao, Jun; Steglich, Babett; Wahib, Ramez; Amezcua Vesely, Maria Carolina; Bielecki, Piotr; Bailis, Will; Jackson, Ruaidhri; Perez, Daniel; Izbicki, Jakob; Licona-Limón, Paula; Kaartinen, Vesa; Geginat, Jens; Esplugues, Enric; Tolosa, Eva; Huber, Samuel; Flavell, Richard A.; Gagliani, Nicola
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.
Fil: Xu, Hao. University of Yale. School of Medicine; Estados Unidos
Fil: Agalioti, Theodora. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Zhao, Jun. University of Yale. School of Medicine; Estados Unidos
Fil: Steglich, Babett. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Wahib, Ramez. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Amezcua Vesely, Maria Carolina. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Bielecki, Piotr. University of Yale. School of Medicine; Estados Unidos
Fil: Bailis, Will. University of Yale. School of Medicine; Estados Unidos
Fil: Jackson, Ruaidhri. University of Yale. School of Medicine; Estados Unidos
Fil: Perez, Daniel. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Izbicki, Jakob. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Licona-Limón, Paula. University of Yale. School of Medicine; Estados Unidos
Fil: Kaartinen, Vesa. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Geginat, Jens. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Esplugues, Enric. University of Yale. School of Medicine; Estados Unidos
Fil: Tolosa, Eva. University of Yale. School of Medicine; Estados Unidos
Fil: Huber, Samuel. University of Yale. School of Medicine; Estados Unidos
Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos
Fil: Gagliani, Nicola. University Medical Center Hamburg-Eppendorf; Alemania
Materia
TGFb
Th17
Smad
Plasticity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/146971
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/146971
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The induction and function of the anti-inflammatory fate of TH17 cellsXu, HaoAgalioti, TheodoraZhao, JunSteglich, BabettWahib, RamezAmezcua Vesely, Maria CarolinaBielecki, PiotrBailis, WillJackson, RuaidhriPerez, DanielIzbicki, JakobLicona-Limón, PaulaKaartinen, VesaGeginat, JensEsplugues, EnricTolosa, EvaHuber, SamuelFlavell, Richard A.Gagliani, NicolaTGFbTh17SmadPlasticityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.Fil: Xu, Hao. University of Yale. School of Medicine; Estados UnidosFil: Agalioti, Theodora. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Zhao, Jun. University of Yale. School of Medicine; Estados UnidosFil: Steglich, Babett. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Wahib, Ramez. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Amezcua Vesely, Maria Carolina. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Bielecki, Piotr. University of Yale. School of Medicine; Estados UnidosFil: Bailis, Will. University of Yale. School of Medicine; Estados UnidosFil: Jackson, Ruaidhri. University of Yale. School of Medicine; Estados UnidosFil: Perez, Daniel. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Izbicki, Jakob. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Licona-Limón, Paula. University of Yale. School of Medicine; Estados UnidosFil: Kaartinen, Vesa. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Geginat, Jens. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Esplugues, Enric. University of Yale. School of Medicine; Estados UnidosFil: Tolosa, Eva. University of Yale. School of Medicine; Estados UnidosFil: Huber, Samuel. University of Yale. School of Medicine; Estados UnidosFil: Flavell, Richard A.. University of Yale. School of Medicine; Estados UnidosFil: Gagliani, Nicola. University Medical Center Hamburg-Eppendorf; AlemaniaNature2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/146971Xu, Hao; Agalioti, Theodora; Zhao, Jun; Steglich, Babett; Wahib, Ramez; et al.; The induction and function of the anti-inflammatory fate of TH17 cells; Nature; Nature Communications; 11; 1; 12-2020; 1-132041-1723CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41467-020-17097-5info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-020-17097-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:17Zoai:ri.conicet.gov.ar:11336/146971instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:17.828CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The induction and function of the anti-inflammatory fate of TH17 cells
title The induction and function of the anti-inflammatory fate of TH17 cells
spellingShingle The induction and function of the anti-inflammatory fate of TH17 cells
Xu, Hao
TGFb
Th17
Smad
Plasticity
title_short The induction and function of the anti-inflammatory fate of TH17 cells
title_full The induction and function of the anti-inflammatory fate of TH17 cells
title_fullStr The induction and function of the anti-inflammatory fate of TH17 cells
title_full_unstemmed The induction and function of the anti-inflammatory fate of TH17 cells
title_sort The induction and function of the anti-inflammatory fate of TH17 cells
dc.creator.none.fl_str_mv Xu, Hao
Agalioti, Theodora
Zhao, Jun
Steglich, Babett
Wahib, Ramez
Amezcua Vesely, Maria Carolina
Bielecki, Piotr
Bailis, Will
Jackson, Ruaidhri
Perez, Daniel
Izbicki, Jakob
Licona-Limón, Paula
Kaartinen, Vesa
Geginat, Jens
Esplugues, Enric
Tolosa, Eva
Huber, Samuel
Flavell, Richard A.
Gagliani, Nicola
author Xu, Hao
author_facet Xu, Hao
Agalioti, Theodora
Zhao, Jun
Steglich, Babett
Wahib, Ramez
Amezcua Vesely, Maria Carolina
Bielecki, Piotr
Bailis, Will
Jackson, Ruaidhri
Perez, Daniel
Izbicki, Jakob
Licona-Limón, Paula
Kaartinen, Vesa
Geginat, Jens
Esplugues, Enric
Tolosa, Eva
Huber, Samuel
Flavell, Richard A.
Gagliani, Nicola
author_role author
author2 Agalioti, Theodora
Zhao, Jun
Steglich, Babett
Wahib, Ramez
Amezcua Vesely, Maria Carolina
Bielecki, Piotr
Bailis, Will
Jackson, Ruaidhri
Perez, Daniel
Izbicki, Jakob
Licona-Limón, Paula
Kaartinen, Vesa
Geginat, Jens
Esplugues, Enric
Tolosa, Eva
Huber, Samuel
Flavell, Richard A.
Gagliani, Nicola
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TGFb
Th17
Smad
Plasticity
topic TGFb
Th17
Smad
Plasticity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.
Fil: Xu, Hao. University of Yale. School of Medicine; Estados Unidos
Fil: Agalioti, Theodora. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Zhao, Jun. University of Yale. School of Medicine; Estados Unidos
Fil: Steglich, Babett. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Wahib, Ramez. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Amezcua Vesely, Maria Carolina. University of Yale. School of Medicine; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Bielecki, Piotr. University of Yale. School of Medicine; Estados Unidos
Fil: Bailis, Will. University of Yale. School of Medicine; Estados Unidos
Fil: Jackson, Ruaidhri. University of Yale. School of Medicine; Estados Unidos
Fil: Perez, Daniel. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Izbicki, Jakob. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Licona-Limón, Paula. University of Yale. School of Medicine; Estados Unidos
Fil: Kaartinen, Vesa. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Geginat, Jens. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Esplugues, Enric. University of Yale. School of Medicine; Estados Unidos
Fil: Tolosa, Eva. University of Yale. School of Medicine; Estados Unidos
Fil: Huber, Samuel. University of Yale. School of Medicine; Estados Unidos
Fil: Flavell, Richard A.. University of Yale. School of Medicine; Estados Unidos
Fil: Gagliani, Nicola. University Medical Center Hamburg-Eppendorf; Alemania
description TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance, yet it impairs immune protection against S. aureus. Additionally, we find that TGF-β signalling via Smad3/Smad4 is sufficient for the expression of the anti-inflammatory cytokine, IL-10, in TH17 cells. Our data thus indicate a key function of TH17 cell plasticity in maintaining immune homeostasis, and dissect the molecular mechanisms explaining the functional flexibility of TH17 cells with regard to environmental changes.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/146971
Xu, Hao; Agalioti, Theodora; Zhao, Jun; Steglich, Babett; Wahib, Ramez; et al.; The induction and function of the anti-inflammatory fate of TH17 cells; Nature; Nature Communications; 11; 1; 12-2020; 1-13
2041-1723
CONICET Digital
CONICET
url http://hdl.handle.net/11336/146971
identifier_str_mv Xu, Hao; Agalioti, Theodora; Zhao, Jun; Steglich, Babett; Wahib, Ramez; et al.; The induction and function of the anti-inflammatory fate of TH17 cells; Nature; Nature Communications; 11; 1; 12-2020; 1-13
2041-1723
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41467-020-17097-5
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-020-17097-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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