IL-22BP controls the progression of liver metastasis in colorectal cancer
- Autores
- Giannou, Anastasios D.; Kempski, Jan; Zhang, Tao; Lücke, Jöran; Shiri, Ahmad Mustafa; Zazara, Dimitra E.; Belios, Ioannis; Machicote, Andres; Seeger, Philipp; Agalioti, Theodora; Tintelnot, Joseph; Sagebiel, Adrian; Tomczak, Miriam; Bauditz, Lennart; Bedke, Tanja; Kocheise, Lorenz; Mercanoglu, Baris; Fard Aghaie, Mohammad; Giorgakis, Emmanouil; Lykoudis, Panagis M.; Pikouli, Anastasia; Grass, Julia Kristin; Wahib, Ramez; Bardenhagen, Jan; Gentilini, Maria Virginia; Mann, Oliver; Izbicki, Jakob R.; Gagliani, Nicola; Maroulis, Ioannis C.; Huber, Samuel
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: The immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). However, the role of IL-22BP in the process of metastasis formation remains unknown. Methods: We used two different murine in vivo metastasis models using the MC38 and LLC cancer cell lines and studied lung and liver metastasis formation after intracaecal or intrasplenic injection of cancer cells. Furthermore, IL22BP expression was measured in a clinical cohort of CRC patients and correlated with metastatic tumor stages. Results: Our data indicate that low levels of IL-22BP are associated with advanced (metastatic) tumor stages in colorectal cancer. Using two different murine in vivo models we show that IL-22BP indeed controls the progression of liver but not lung metastasis in mice. Conclusions: We here demonstrate a crucial role of IL-22BP in controlling metastasis progression. Thus, IL-22 might represent a future therapeutic target against the progression of metastatic CRC.
Fil: Giannou, Anastasios D.. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Kempski, Jan. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Zhang, Tao. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Lücke, Jöran. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Shiri, Ahmad Mustafa. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Zazara, Dimitra E.. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Belios, Ioannis. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Machicote, Andres. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Seeger, Philipp. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Agalioti, Theodora. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Tintelnot, Joseph. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Sagebiel, Adrian. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Tomczak, Miriam. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Bauditz, Lennart. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Bedke, Tanja. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Kocheise, Lorenz. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Mercanoglu, Baris. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Fard Aghaie, Mohammad. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Giorgakis, Emmanouil. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Lykoudis, Panagis M.. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Pikouli, Anastasia. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Grass, Julia Kristin. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Wahib, Ramez. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Bardenhagen, Jan. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Gentilini, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
Fil: Mann, Oliver. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Izbicki, Jakob R.. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Gagliani, Nicola. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Maroulis, Ioannis C.. University Medical Center Hamburg-Eppendorf; Alemania
Fil: Huber, Samuel. University Medical Center Hamburg-Eppendorf; Alemania - Materia
-
IL-22
IL-22BP
ONCOLOGY
LIVER - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/272332
Ver los metadatos del registro completo
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IL-22BP controls the progression of liver metastasis in colorectal cancerGiannou, Anastasios D.Kempski, JanZhang, TaoLücke, JöranShiri, Ahmad MustafaZazara, Dimitra E.Belios, IoannisMachicote, AndresSeeger, PhilippAgalioti, TheodoraTintelnot, JosephSagebiel, AdrianTomczak, MiriamBauditz, LennartBedke, TanjaKocheise, LorenzMercanoglu, BarisFard Aghaie, MohammadGiorgakis, EmmanouilLykoudis, Panagis M.Pikouli, AnastasiaGrass, Julia KristinWahib, RamezBardenhagen, JanGentilini, Maria VirginiaMann, OliverIzbicki, Jakob R.Gagliani, NicolaMaroulis, Ioannis C.Huber, SamuelIL-22IL-22BPONCOLOGYLIVERhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: The immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). However, the role of IL-22BP in the process of metastasis formation remains unknown. Methods: We used two different murine in vivo metastasis models using the MC38 and LLC cancer cell lines and studied lung and liver metastasis formation after intracaecal or intrasplenic injection of cancer cells. Furthermore, IL22BP expression was measured in a clinical cohort of CRC patients and correlated with metastatic tumor stages. Results: Our data indicate that low levels of IL-22BP are associated with advanced (metastatic) tumor stages in colorectal cancer. Using two different murine in vivo models we show that IL-22BP indeed controls the progression of liver but not lung metastasis in mice. Conclusions: We here demonstrate a crucial role of IL-22BP in controlling metastasis progression. Thus, IL-22 might represent a future therapeutic target against the progression of metastatic CRC.Fil: Giannou, Anastasios D.. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Kempski, Jan. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Zhang, Tao. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Lücke, Jöran. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Shiri, Ahmad Mustafa. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Zazara, Dimitra E.. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Belios, Ioannis. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Machicote, Andres. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Seeger, Philipp. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Agalioti, Theodora. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Tintelnot, Joseph. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Sagebiel, Adrian. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Tomczak, Miriam. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Bauditz, Lennart. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Bedke, Tanja. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Kocheise, Lorenz. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Mercanoglu, Baris. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Fard Aghaie, Mohammad. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Giorgakis, Emmanouil. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Lykoudis, Panagis M.. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Pikouli, Anastasia. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Grass, Julia Kristin. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Wahib, Ramez. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Bardenhagen, Jan. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Gentilini, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; ArgentinaFil: Mann, Oliver. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Izbicki, Jakob R.. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Gagliani, Nicola. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Maroulis, Ioannis C.. University Medical Center Hamburg-Eppendorf; AlemaniaFil: Huber, Samuel. University Medical Center Hamburg-Eppendorf; AlemaniaFrontiers Media2023-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/272332Giannou, Anastasios D.; Kempski, Jan; Zhang, Tao; Lücke, Jöran; Shiri, Ahmad Mustafa; et al.; IL-22BP controls the progression of liver metastasis in colorectal cancer; Frontiers Media; Frontiers in Oncology; 13; 1170502; 5-2023; 1-102234-943XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2023.1170502info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:48:02Zoai:ri.conicet.gov.ar:11336/272332instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:48:02.587CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
IL-22BP controls the progression of liver metastasis in colorectal cancer |
| title |
IL-22BP controls the progression of liver metastasis in colorectal cancer |
| spellingShingle |
IL-22BP controls the progression of liver metastasis in colorectal cancer Giannou, Anastasios D. IL-22 IL-22BP ONCOLOGY LIVER |
| title_short |
IL-22BP controls the progression of liver metastasis in colorectal cancer |
| title_full |
IL-22BP controls the progression of liver metastasis in colorectal cancer |
| title_fullStr |
IL-22BP controls the progression of liver metastasis in colorectal cancer |
| title_full_unstemmed |
IL-22BP controls the progression of liver metastasis in colorectal cancer |
| title_sort |
IL-22BP controls the progression of liver metastasis in colorectal cancer |
| dc.creator.none.fl_str_mv |
Giannou, Anastasios D. Kempski, Jan Zhang, Tao Lücke, Jöran Shiri, Ahmad Mustafa Zazara, Dimitra E. Belios, Ioannis Machicote, Andres Seeger, Philipp Agalioti, Theodora Tintelnot, Joseph Sagebiel, Adrian Tomczak, Miriam Bauditz, Lennart Bedke, Tanja Kocheise, Lorenz Mercanoglu, Baris Fard Aghaie, Mohammad Giorgakis, Emmanouil Lykoudis, Panagis M. Pikouli, Anastasia Grass, Julia Kristin Wahib, Ramez Bardenhagen, Jan Gentilini, Maria Virginia Mann, Oliver Izbicki, Jakob R. Gagliani, Nicola Maroulis, Ioannis C. Huber, Samuel |
| author |
Giannou, Anastasios D. |
| author_facet |
Giannou, Anastasios D. Kempski, Jan Zhang, Tao Lücke, Jöran Shiri, Ahmad Mustafa Zazara, Dimitra E. Belios, Ioannis Machicote, Andres Seeger, Philipp Agalioti, Theodora Tintelnot, Joseph Sagebiel, Adrian Tomczak, Miriam Bauditz, Lennart Bedke, Tanja Kocheise, Lorenz Mercanoglu, Baris Fard Aghaie, Mohammad Giorgakis, Emmanouil Lykoudis, Panagis M. Pikouli, Anastasia Grass, Julia Kristin Wahib, Ramez Bardenhagen, Jan Gentilini, Maria Virginia Mann, Oliver Izbicki, Jakob R. Gagliani, Nicola Maroulis, Ioannis C. Huber, Samuel |
| author_role |
author |
| author2 |
Kempski, Jan Zhang, Tao Lücke, Jöran Shiri, Ahmad Mustafa Zazara, Dimitra E. Belios, Ioannis Machicote, Andres Seeger, Philipp Agalioti, Theodora Tintelnot, Joseph Sagebiel, Adrian Tomczak, Miriam Bauditz, Lennart Bedke, Tanja Kocheise, Lorenz Mercanoglu, Baris Fard Aghaie, Mohammad Giorgakis, Emmanouil Lykoudis, Panagis M. Pikouli, Anastasia Grass, Julia Kristin Wahib, Ramez Bardenhagen, Jan Gentilini, Maria Virginia Mann, Oliver Izbicki, Jakob R. Gagliani, Nicola Maroulis, Ioannis C. Huber, Samuel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
IL-22 IL-22BP ONCOLOGY LIVER |
| topic |
IL-22 IL-22BP ONCOLOGY LIVER |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Background: The immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). However, the role of IL-22BP in the process of metastasis formation remains unknown. Methods: We used two different murine in vivo metastasis models using the MC38 and LLC cancer cell lines and studied lung and liver metastasis formation after intracaecal or intrasplenic injection of cancer cells. Furthermore, IL22BP expression was measured in a clinical cohort of CRC patients and correlated with metastatic tumor stages. Results: Our data indicate that low levels of IL-22BP are associated with advanced (metastatic) tumor stages in colorectal cancer. Using two different murine in vivo models we show that IL-22BP indeed controls the progression of liver but not lung metastasis in mice. Conclusions: We here demonstrate a crucial role of IL-22BP in controlling metastasis progression. Thus, IL-22 might represent a future therapeutic target against the progression of metastatic CRC. Fil: Giannou, Anastasios D.. University Medical Center Hamburg-Eppendorf; Alemania Fil: Kempski, Jan. University Medical Center Hamburg-Eppendorf; Alemania Fil: Zhang, Tao. University Medical Center Hamburg-Eppendorf; Alemania Fil: Lücke, Jöran. University Medical Center Hamburg-Eppendorf; Alemania Fil: Shiri, Ahmad Mustafa. University Medical Center Hamburg-Eppendorf; Alemania Fil: Zazara, Dimitra E.. University Medical Center Hamburg-Eppendorf; Alemania Fil: Belios, Ioannis. University Medical Center Hamburg-Eppendorf; Alemania Fil: Machicote, Andres. University Medical Center Hamburg-Eppendorf; Alemania Fil: Seeger, Philipp. University Medical Center Hamburg-Eppendorf; Alemania Fil: Agalioti, Theodora. University Medical Center Hamburg-Eppendorf; Alemania Fil: Tintelnot, Joseph. University Medical Center Hamburg-Eppendorf; Alemania Fil: Sagebiel, Adrian. University Medical Center Hamburg-Eppendorf; Alemania Fil: Tomczak, Miriam. University Medical Center Hamburg-Eppendorf; Alemania Fil: Bauditz, Lennart. University Medical Center Hamburg-Eppendorf; Alemania Fil: Bedke, Tanja. University Medical Center Hamburg-Eppendorf; Alemania Fil: Kocheise, Lorenz. University Medical Center Hamburg-Eppendorf; Alemania Fil: Mercanoglu, Baris. University Medical Center Hamburg-Eppendorf; Alemania Fil: Fard Aghaie, Mohammad. University Medical Center Hamburg-Eppendorf; Alemania Fil: Giorgakis, Emmanouil. University Medical Center Hamburg-Eppendorf; Alemania Fil: Lykoudis, Panagis M.. University Medical Center Hamburg-Eppendorf; Alemania Fil: Pikouli, Anastasia. University Medical Center Hamburg-Eppendorf; Alemania Fil: Grass, Julia Kristin. University Medical Center Hamburg-Eppendorf; Alemania Fil: Wahib, Ramez. University Medical Center Hamburg-Eppendorf; Alemania Fil: Bardenhagen, Jan. University Medical Center Hamburg-Eppendorf; Alemania Fil: Gentilini, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina Fil: Mann, Oliver. University Medical Center Hamburg-Eppendorf; Alemania Fil: Izbicki, Jakob R.. University Medical Center Hamburg-Eppendorf; Alemania Fil: Gagliani, Nicola. University Medical Center Hamburg-Eppendorf; Alemania Fil: Maroulis, Ioannis C.. University Medical Center Hamburg-Eppendorf; Alemania Fil: Huber, Samuel. University Medical Center Hamburg-Eppendorf; Alemania |
| description |
Background: The immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). However, the role of IL-22BP in the process of metastasis formation remains unknown. Methods: We used two different murine in vivo metastasis models using the MC38 and LLC cancer cell lines and studied lung and liver metastasis formation after intracaecal or intrasplenic injection of cancer cells. Furthermore, IL22BP expression was measured in a clinical cohort of CRC patients and correlated with metastatic tumor stages. Results: Our data indicate that low levels of IL-22BP are associated with advanced (metastatic) tumor stages in colorectal cancer. Using two different murine in vivo models we show that IL-22BP indeed controls the progression of liver but not lung metastasis in mice. Conclusions: We here demonstrate a crucial role of IL-22BP in controlling metastasis progression. Thus, IL-22 might represent a future therapeutic target against the progression of metastatic CRC. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-05 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/272332 Giannou, Anastasios D.; Kempski, Jan; Zhang, Tao; Lücke, Jöran; Shiri, Ahmad Mustafa; et al.; IL-22BP controls the progression of liver metastasis in colorectal cancer; Frontiers Media; Frontiers in Oncology; 13; 1170502; 5-2023; 1-10 2234-943X CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/272332 |
| identifier_str_mv |
Giannou, Anastasios D.; Kempski, Jan; Zhang, Tao; Lücke, Jöran; Shiri, Ahmad Mustafa; et al.; IL-22BP controls the progression of liver metastasis in colorectal cancer; Frontiers Media; Frontiers in Oncology; 13; 1170502; 5-2023; 1-10 2234-943X CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
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info:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2023.1170502 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf |
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Frontiers Media |
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Frontiers Media |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.22299 |