Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction

Autores
Hagen, Martine Kienzle; Lehenbauer Lüdke, Ana Raquel; Paludo, Ana Carolina; Schenkel, Paulo; Gonçalves, Lessane; Fernandes, Tânia Gatelli; Caron, Rafaela; Llesuy, Susana Francisca; Mill, José Geraldo; Belló Klein, Adriane
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We investigated the effects of an isolated soy protein (ISP) diet offered over a 9-week period to rats in whom myocardial infarction (MI) had been induced, and a casein diet given as a control. Male Wistar rats were assigned to six groups after infarct size determination (n Z 8/group): Sham Casein (SC); Infarct Casein < 25% (IC < 25%); Infarct Casein > 25% (IC > 25%); Sham Soy (SS); Infarct Soy < 25% (IS < 25%); and Infarct Soy > 25% (IS > 25%). MI surgery was performed at the fifth week, and one month later, the animals were hemodynamically assessed to evaluate left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), contractility and relaxation indexes (dP/dt). Lung and liver specimens were also collected for the estimation of organ congestion. Oxidative stress was evaluated in heart homogenates through chemiluminescence (CL), carbonyl groups, and antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Infarcted groups treated with casein showed cardiac hypertrophy, lung and liver congestion, increased LVEDP and decreased LVSP and dP/dt, all typical signals of heart failure. Ventricular dysfunction was correlated with increased myocardial oxidative damage as seen by CL and carbonyl groups data in the groups IC < 25% and IC > 25% (3 and 10-fold increase, respectively). The ISP diet was able to improve ventricular systolic and diastolic function in the groups IS < 25% and IS > 25% (LVEDP was reduced by 44% and 24%, respectively) and to decrease myocardial oxidative stress. The overall results confirm the preventive role of soy-derived products in terms of post-MI myocardial dysfunction probably by an antioxidant action.
Fil: Hagen, Martine Kienzle. Universidade Federal do Rio Grande do Sul; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; Brasil
Fil: Lehenbauer Lüdke, Ana Raquel. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Paludo, Ana Carolina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Schenkel, Paulo. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gonçalves, Lessane. Universidade Federal do Rio Grande do Sul; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; Brasil
Fil: Fernandes, Tânia Gatelli. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Caron, Rafaela. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Mill, José Geraldo. Universidade Federal do Espírito Santo; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
Materia
ISOFLAVONES
LIPID PEROXIDATION
ANTIOXIDANT ENZYMES
HEART FAILURE
HEMODYNAMIC ASSESSMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/102474
Acceder
id CONICETDig_4a5cb3712cf2a3c9e6ae80b20b339d7f
oai_identifier_str oai:ri.conicet.gov.ar:11336/102474
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarctionHagen, Martine KienzleLehenbauer Lüdke, Ana RaquelPaludo, Ana CarolinaSchenkel, PauloGonçalves, LessaneFernandes, Tânia GatelliCaron, RafaelaLlesuy, Susana FranciscaMill, José GeraldoBelló Klein, AdrianeISOFLAVONESLIPID PEROXIDATIONANTIOXIDANT ENZYMESHEART FAILUREHEMODYNAMIC ASSESSMENThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We investigated the effects of an isolated soy protein (ISP) diet offered over a 9-week period to rats in whom myocardial infarction (MI) had been induced, and a casein diet given as a control. Male Wistar rats were assigned to six groups after infarct size determination (n Z 8/group): Sham Casein (SC); Infarct Casein < 25% (IC < 25%); Infarct Casein > 25% (IC > 25%); Sham Soy (SS); Infarct Soy < 25% (IS < 25%); and Infarct Soy > 25% (IS > 25%). MI surgery was performed at the fifth week, and one month later, the animals were hemodynamically assessed to evaluate left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), contractility and relaxation indexes (dP/dt). Lung and liver specimens were also collected for the estimation of organ congestion. Oxidative stress was evaluated in heart homogenates through chemiluminescence (CL), carbonyl groups, and antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Infarcted groups treated with casein showed cardiac hypertrophy, lung and liver congestion, increased LVEDP and decreased LVSP and dP/dt, all typical signals of heart failure. Ventricular dysfunction was correlated with increased myocardial oxidative damage as seen by CL and carbonyl groups data in the groups IC < 25% and IC > 25% (3 and 10-fold increase, respectively). The ISP diet was able to improve ventricular systolic and diastolic function in the groups IS < 25% and IS > 25% (LVEDP was reduced by 44% and 24%, respectively) and to decrease myocardial oxidative stress. The overall results confirm the preventive role of soy-derived products in terms of post-MI myocardial dysfunction probably by an antioxidant action.Fil: Hagen, Martine Kienzle. Universidade Federal do Rio Grande do Sul; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; BrasilFil: Lehenbauer Lüdke, Ana Raquel. Universidade Federal do Rio Grande do Sul; BrasilFil: Paludo, Ana Carolina. Universidade Federal do Rio Grande do Sul; BrasilFil: Schenkel, Paulo. Universidade Federal do Rio Grande do Sul; BrasilFil: Gonçalves, Lessane. Universidade Federal do Rio Grande do Sul; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; BrasilFil: Fernandes, Tânia Gatelli. Universidade Federal do Rio Grande do Sul; BrasilFil: Caron, Rafaela. Universidade Federal do Rio Grande do Sul; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal do Rio Grande do Sul; BrasilFil: Mill, José Geraldo. Universidade Federal do Espírito Santo; BrasilFil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; BrasilElsevier2009-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/102474Hagen, Martine Kienzle; Lehenbauer Lüdke, Ana Raquel; Paludo, Ana Carolina; Schenkel, Paulo; Gonçalves, Lessane; et al.; Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction; Elsevier; Nutrition, Metabolism and Cardiovascular Diseases; 19; 2; 2-2009; 91-970939-4753CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.numecd.2008.03.001info:eu-repo/semantics/altIdentifier/url/https://www.nmcd-journal.com/article/S0939-4753(08)00059-8/fulltextinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0939475308000598info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:46Zoai:ri.conicet.gov.ar:11336/102474instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:46.373CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction
title Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction
spellingShingle Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction
Hagen, Martine Kienzle
ISOFLAVONES
LIPID PEROXIDATION
ANTIOXIDANT ENZYMES
HEART FAILURE
HEMODYNAMIC ASSESSMENT
title_short Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction
title_full Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction
title_fullStr Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction
title_full_unstemmed Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction
title_sort Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction
dc.creator.none.fl_str_mv Hagen, Martine Kienzle
Lehenbauer Lüdke, Ana Raquel
Paludo, Ana Carolina
Schenkel, Paulo
Gonçalves, Lessane
Fernandes, Tânia Gatelli
Caron, Rafaela
Llesuy, Susana Francisca
Mill, José Geraldo
Belló Klein, Adriane
author Hagen, Martine Kienzle
author_facet Hagen, Martine Kienzle
Lehenbauer Lüdke, Ana Raquel
Paludo, Ana Carolina
Schenkel, Paulo
Gonçalves, Lessane
Fernandes, Tânia Gatelli
Caron, Rafaela
Llesuy, Susana Francisca
Mill, José Geraldo
Belló Klein, Adriane
author_role author
author2 Lehenbauer Lüdke, Ana Raquel
Paludo, Ana Carolina
Schenkel, Paulo
Gonçalves, Lessane
Fernandes, Tânia Gatelli
Caron, Rafaela
Llesuy, Susana Francisca
Mill, José Geraldo
Belló Klein, Adriane
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ISOFLAVONES
LIPID PEROXIDATION
ANTIOXIDANT ENZYMES
HEART FAILURE
HEMODYNAMIC ASSESSMENT
topic ISOFLAVONES
LIPID PEROXIDATION
ANTIOXIDANT ENZYMES
HEART FAILURE
HEMODYNAMIC ASSESSMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We investigated the effects of an isolated soy protein (ISP) diet offered over a 9-week period to rats in whom myocardial infarction (MI) had been induced, and a casein diet given as a control. Male Wistar rats were assigned to six groups after infarct size determination (n Z 8/group): Sham Casein (SC); Infarct Casein < 25% (IC < 25%); Infarct Casein > 25% (IC > 25%); Sham Soy (SS); Infarct Soy < 25% (IS < 25%); and Infarct Soy > 25% (IS > 25%). MI surgery was performed at the fifth week, and one month later, the animals were hemodynamically assessed to evaluate left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), contractility and relaxation indexes (dP/dt). Lung and liver specimens were also collected for the estimation of organ congestion. Oxidative stress was evaluated in heart homogenates through chemiluminescence (CL), carbonyl groups, and antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Infarcted groups treated with casein showed cardiac hypertrophy, lung and liver congestion, increased LVEDP and decreased LVSP and dP/dt, all typical signals of heart failure. Ventricular dysfunction was correlated with increased myocardial oxidative damage as seen by CL and carbonyl groups data in the groups IC < 25% and IC > 25% (3 and 10-fold increase, respectively). The ISP diet was able to improve ventricular systolic and diastolic function in the groups IS < 25% and IS > 25% (LVEDP was reduced by 44% and 24%, respectively) and to decrease myocardial oxidative stress. The overall results confirm the preventive role of soy-derived products in terms of post-MI myocardial dysfunction probably by an antioxidant action.
Fil: Hagen, Martine Kienzle. Universidade Federal do Rio Grande do Sul; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; Brasil
Fil: Lehenbauer Lüdke, Ana Raquel. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Paludo, Ana Carolina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Schenkel, Paulo. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Gonçalves, Lessane. Universidade Federal do Rio Grande do Sul; Brasil. Pontificia Universidade Católica do Rio Grande do Sul; Brasil
Fil: Fernandes, Tânia Gatelli. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Caron, Rafaela. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Mill, José Geraldo. Universidade Federal do Espírito Santo; Brasil
Fil: Belló Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
description We investigated the effects of an isolated soy protein (ISP) diet offered over a 9-week period to rats in whom myocardial infarction (MI) had been induced, and a casein diet given as a control. Male Wistar rats were assigned to six groups after infarct size determination (n Z 8/group): Sham Casein (SC); Infarct Casein < 25% (IC < 25%); Infarct Casein > 25% (IC > 25%); Sham Soy (SS); Infarct Soy < 25% (IS < 25%); and Infarct Soy > 25% (IS > 25%). MI surgery was performed at the fifth week, and one month later, the animals were hemodynamically assessed to evaluate left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), contractility and relaxation indexes (dP/dt). Lung and liver specimens were also collected for the estimation of organ congestion. Oxidative stress was evaluated in heart homogenates through chemiluminescence (CL), carbonyl groups, and antioxidant enzyme activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Infarcted groups treated with casein showed cardiac hypertrophy, lung and liver congestion, increased LVEDP and decreased LVSP and dP/dt, all typical signals of heart failure. Ventricular dysfunction was correlated with increased myocardial oxidative damage as seen by CL and carbonyl groups data in the groups IC < 25% and IC > 25% (3 and 10-fold increase, respectively). The ISP diet was able to improve ventricular systolic and diastolic function in the groups IS < 25% and IS > 25% (LVEDP was reduced by 44% and 24%, respectively) and to decrease myocardial oxidative stress. The overall results confirm the preventive role of soy-derived products in terms of post-MI myocardial dysfunction probably by an antioxidant action.
publishDate 2009
dc.date.none.fl_str_mv 2009-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/102474
Hagen, Martine Kienzle; Lehenbauer Lüdke, Ana Raquel; Paludo, Ana Carolina; Schenkel, Paulo; Gonçalves, Lessane; et al.; Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction; Elsevier; Nutrition, Metabolism and Cardiovascular Diseases; 19; 2; 2-2009; 91-97
0939-4753
CONICET Digital
CONICET
url http://hdl.handle.net/11336/102474
identifier_str_mv Hagen, Martine Kienzle; Lehenbauer Lüdke, Ana Raquel; Paludo, Ana Carolina; Schenkel, Paulo; Gonçalves, Lessane; et al.; Diet with isolated soy protein reduces oxidative stress and preserves ventricular function in rats with myocardial infarction; Elsevier; Nutrition, Metabolism and Cardiovascular Diseases; 19; 2; 2-2009; 91-97
0939-4753
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.numecd.2008.03.001
info:eu-repo/semantics/altIdentifier/url/https://www.nmcd-journal.com/article/S0939-4753(08)00059-8/fulltext
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0939475308000598
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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