Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?

Autores
Zerboni, S.; Chevel, J.; Torres, D.; Rearte, A. N.; Bonvehi, Pablo; Temporiti, E.; Querci, Marcia; Videla, C.; Romano, Vanesa; Echavarría, Marcela Silvia; Marcone, Débora Natalia; Herrera, F.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Background: Influenza A and B (Flu A/B), parainfluenza (PIV) and respiratory syncytial virus (RSV) cause lower and upper respiratory tract disease (LRD-URD) with significant clinical impact on patients with hematological malignancies (HM) or hematopoietic stem cell transplantation (HSCT). Rhinoviruses (HRV) are being increasingly detected in these infections, although their clinical impact remains a matter of debate. Our objective was to describe and compare clinical characteristics and outcomes of patients with HM and HSCT with LRD-URD caused by HRV versus non-HRV: Flu A/B, PIV and RSV. Methods & Materials: Prospective observational study. We compared HRV (G1) vs. Flu A/B, PIV and RSV (G2) respiratory infections in patients with HM and HSCT between January 2013 and September 2017. Chi-square analysis and Kruskal-Wallis test were used for categorical and continuous variables, respectively. Results: We enrolled 114 episodes: 45 in G1, 69 in G2. Both groups had patients with similar hematological diseases and stages, being lymphoma and acute leukemia the most frequent. Steroid therapy (20% vs 50.7%, p = 0.001) was significantly higher in G2, while use of biologic agents (40% vs 17.4%, p = 0.007), lymphopenia (33% vs 16.2% p = 0.034) and clinical presentation during preengraftment (20% vs 5.8%, p = 0.032) was higher in G1. Rhinorrhea was the most common symptom in G1 (71.1% vs 46.4%, p = 0.009). Other symptoms had similar frequencies in both groups. Over 50% of all infections presented as LRD (52% vs 50.7%, p = 0.968). Hypoxemia presented in similar rates (28.9% vs 27.5%, p = 0.875). The most common tomographic infiltrates were alveolar pattern and bilateral extension. In G1, co-pathogens in respiratory specimens were isolated in three patients (6.7% vs 0% p = 0.053) and other three had detectable plasma CMV viral load (6.7% vs 0% p = 0.012). Hospitalization was required in 58.8% of cases, with no significant difference between both groups. The 30-day overall mortality rate due to G1 and G2 infections were 6.7% and 7.2%, respectively (p = 1). Conclusion: Patients with HM or HSCT and HRV infections had similar clinical picture and outcome to common respiratory viruses, with significant morbidity. Therefore, active diagnostic approaches are required, especially in patients with lymphopenia or use of biologic agents.
Fil: Zerboni, S.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Chevel, J.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Torres, D.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Rearte, A. N.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Bonvehi, Pablo. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Temporiti, E.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Querci, Marcia. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Videla, C.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Romano, Vanesa. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Marcone, Débora Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Herrera, F.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
18th International Congress on Infectious Diseases
Argentina
International Society for Infectious Diseases
Materia
Rhinovirus
Transplant
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/276373
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/276373
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?Zerboni, S.Chevel, J.Torres, D.Rearte, A. N.Bonvehi, PabloTemporiti, E.Querci, MarciaVidela, C.Romano, VanesaEchavarría, Marcela SilviaMarcone, Débora NataliaHerrera, F.RhinovirusTransplanthttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Influenza A and B (Flu A/B), parainfluenza (PIV) and respiratory syncytial virus (RSV) cause lower and upper respiratory tract disease (LRD-URD) with significant clinical impact on patients with hematological malignancies (HM) or hematopoietic stem cell transplantation (HSCT). Rhinoviruses (HRV) are being increasingly detected in these infections, although their clinical impact remains a matter of debate. Our objective was to describe and compare clinical characteristics and outcomes of patients with HM and HSCT with LRD-URD caused by HRV versus non-HRV: Flu A/B, PIV and RSV. Methods & Materials: Prospective observational study. We compared HRV (G1) vs. Flu A/B, PIV and RSV (G2) respiratory infections in patients with HM and HSCT between January 2013 and September 2017. Chi-square analysis and Kruskal-Wallis test were used for categorical and continuous variables, respectively. Results: We enrolled 114 episodes: 45 in G1, 69 in G2. Both groups had patients with similar hematological diseases and stages, being lymphoma and acute leukemia the most frequent. Steroid therapy (20% vs 50.7%, p = 0.001) was significantly higher in G2, while use of biologic agents (40% vs 17.4%, p = 0.007), lymphopenia (33% vs 16.2% p = 0.034) and clinical presentation during preengraftment (20% vs 5.8%, p = 0.032) was higher in G1. Rhinorrhea was the most common symptom in G1 (71.1% vs 46.4%, p = 0.009). Other symptoms had similar frequencies in both groups. Over 50% of all infections presented as LRD (52% vs 50.7%, p = 0.968). Hypoxemia presented in similar rates (28.9% vs 27.5%, p = 0.875). The most common tomographic infiltrates were alveolar pattern and bilateral extension. In G1, co-pathogens in respiratory specimens were isolated in three patients (6.7% vs 0% p = 0.053) and other three had detectable plasma CMV viral load (6.7% vs 0% p = 0.012). Hospitalization was required in 58.8% of cases, with no significant difference between both groups. The 30-day overall mortality rate due to G1 and G2 infections were 6.7% and 7.2%, respectively (p = 1). Conclusion: Patients with HM or HSCT and HRV infections had similar clinical picture and outcome to common respiratory viruses, with significant morbidity. Therefore, active diagnostic approaches are required, especially in patients with lymphopenia or use of biologic agents.Fil: Zerboni, S.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Chevel, J.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Torres, D.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Rearte, A. N.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Bonvehi, Pablo. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Temporiti, E.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Querci, Marcia. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Videla, C.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Romano, Vanesa. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Marcone, Débora Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Herrera, F.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina18th International Congress on Infectious DiseasesArgentinaInternational Society for Infectious DiseasesElsevier2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/276373Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?; 18th International Congress on Infectious Diseases; Argentina; 2018; 1-1CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1201971218337305info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijid.2018.04.3646Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-03T08:52:49Zoai:ri.conicet.gov.ar:11336/276373instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-03 08:52:50.1CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?
title Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?
spellingShingle Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?
Zerboni, S.
Rhinovirus
Transplant
title_short Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?
title_full Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?
title_fullStr Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?
title_full_unstemmed Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?
title_sort Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?
dc.creator.none.fl_str_mv Zerboni, S.
Chevel, J.
Torres, D.
Rearte, A. N.
Bonvehi, Pablo
Temporiti, E.
Querci, Marcia
Videla, C.
Romano, Vanesa
Echavarría, Marcela Silvia
Marcone, Débora Natalia
Herrera, F.
author Zerboni, S.
author_facet Zerboni, S.
Chevel, J.
Torres, D.
Rearte, A. N.
Bonvehi, Pablo
Temporiti, E.
Querci, Marcia
Videla, C.
Romano, Vanesa
Echavarría, Marcela Silvia
Marcone, Débora Natalia
Herrera, F.
author_role author
author2 Chevel, J.
Torres, D.
Rearte, A. N.
Bonvehi, Pablo
Temporiti, E.
Querci, Marcia
Videla, C.
Romano, Vanesa
Echavarría, Marcela Silvia
Marcone, Débora Natalia
Herrera, F.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Rhinovirus
Transplant
topic Rhinovirus
Transplant
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Influenza A and B (Flu A/B), parainfluenza (PIV) and respiratory syncytial virus (RSV) cause lower and upper respiratory tract disease (LRD-URD) with significant clinical impact on patients with hematological malignancies (HM) or hematopoietic stem cell transplantation (HSCT). Rhinoviruses (HRV) are being increasingly detected in these infections, although their clinical impact remains a matter of debate. Our objective was to describe and compare clinical characteristics and outcomes of patients with HM and HSCT with LRD-URD caused by HRV versus non-HRV: Flu A/B, PIV and RSV. Methods & Materials: Prospective observational study. We compared HRV (G1) vs. Flu A/B, PIV and RSV (G2) respiratory infections in patients with HM and HSCT between January 2013 and September 2017. Chi-square analysis and Kruskal-Wallis test were used for categorical and continuous variables, respectively. Results: We enrolled 114 episodes: 45 in G1, 69 in G2. Both groups had patients with similar hematological diseases and stages, being lymphoma and acute leukemia the most frequent. Steroid therapy (20% vs 50.7%, p = 0.001) was significantly higher in G2, while use of biologic agents (40% vs 17.4%, p = 0.007), lymphopenia (33% vs 16.2% p = 0.034) and clinical presentation during preengraftment (20% vs 5.8%, p = 0.032) was higher in G1. Rhinorrhea was the most common symptom in G1 (71.1% vs 46.4%, p = 0.009). Other symptoms had similar frequencies in both groups. Over 50% of all infections presented as LRD (52% vs 50.7%, p = 0.968). Hypoxemia presented in similar rates (28.9% vs 27.5%, p = 0.875). The most common tomographic infiltrates were alveolar pattern and bilateral extension. In G1, co-pathogens in respiratory specimens were isolated in three patients (6.7% vs 0% p = 0.053) and other three had detectable plasma CMV viral load (6.7% vs 0% p = 0.012). Hospitalization was required in 58.8% of cases, with no significant difference between both groups. The 30-day overall mortality rate due to G1 and G2 infections were 6.7% and 7.2%, respectively (p = 1). Conclusion: Patients with HM or HSCT and HRV infections had similar clinical picture and outcome to common respiratory viruses, with significant morbidity. Therefore, active diagnostic approaches are required, especially in patients with lymphopenia or use of biologic agents.
Fil: Zerboni, S.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Chevel, J.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Torres, D.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Rearte, A. N.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Bonvehi, Pablo. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Temporiti, E.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Querci, Marcia. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Videla, C.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Romano, Vanesa. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Marcone, Débora Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Herrera, F.. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
18th International Congress on Infectious Diseases
Argentina
International Society for Infectious Diseases
description Background: Influenza A and B (Flu A/B), parainfluenza (PIV) and respiratory syncytial virus (RSV) cause lower and upper respiratory tract disease (LRD-URD) with significant clinical impact on patients with hematological malignancies (HM) or hematopoietic stem cell transplantation (HSCT). Rhinoviruses (HRV) are being increasingly detected in these infections, although their clinical impact remains a matter of debate. Our objective was to describe and compare clinical characteristics and outcomes of patients with HM and HSCT with LRD-URD caused by HRV versus non-HRV: Flu A/B, PIV and RSV. Methods & Materials: Prospective observational study. We compared HRV (G1) vs. Flu A/B, PIV and RSV (G2) respiratory infections in patients with HM and HSCT between January 2013 and September 2017. Chi-square analysis and Kruskal-Wallis test were used for categorical and continuous variables, respectively. Results: We enrolled 114 episodes: 45 in G1, 69 in G2. Both groups had patients with similar hematological diseases and stages, being lymphoma and acute leukemia the most frequent. Steroid therapy (20% vs 50.7%, p = 0.001) was significantly higher in G2, while use of biologic agents (40% vs 17.4%, p = 0.007), lymphopenia (33% vs 16.2% p = 0.034) and clinical presentation during preengraftment (20% vs 5.8%, p = 0.032) was higher in G1. Rhinorrhea was the most common symptom in G1 (71.1% vs 46.4%, p = 0.009). Other symptoms had similar frequencies in both groups. Over 50% of all infections presented as LRD (52% vs 50.7%, p = 0.968). Hypoxemia presented in similar rates (28.9% vs 27.5%, p = 0.875). The most common tomographic infiltrates were alveolar pattern and bilateral extension. In G1, co-pathogens in respiratory specimens were isolated in three patients (6.7% vs 0% p = 0.053) and other three had detectable plasma CMV viral load (6.7% vs 0% p = 0.012). Hospitalization was required in 58.8% of cases, with no significant difference between both groups. The 30-day overall mortality rate due to G1 and G2 infections were 6.7% and 7.2%, respectively (p = 1). Conclusion: Patients with HM or HSCT and HRV infections had similar clinical picture and outcome to common respiratory viruses, with significant morbidity. Therefore, active diagnostic approaches are required, especially in patients with lymphopenia or use of biologic agents.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/276373
Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?; 18th International Congress on Infectious Diseases; Argentina; 2018; 1-1
CONICET Digital
CONICET
url http://hdl.handle.net/11336/276373
identifier_str_mv Respiratory infections by human Rhinoviruses in oncohematological and stem cell transplant patients: do they have the same clinical impact as other respiratory viruses?; 18th International Congress on Infectious Diseases; Argentina; 2018; 1-1
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1201971218337305
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijid.2018.04.3646
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Elsevier
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