Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina

Autores
Marcone, Débora Natalia; Ellis, Alejandro; Videla, Cristina Mónica; Ekstrom, Jorge; Ricarte, Carmen; Carballal, Guadalupe; Vidaurreta, Santiago Manuel; Echavarría, Marcela Silvia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
OBJECTIVES: To determine and compare the viral frequency, seasonality and clinical-demographic features in 2 groups of children (hospitalized versus outpatients) with acute respiratory infections. MATERIAL AND METHODS: A cross-sectional, descriptive study was performed from 2008 to 2010 in 620 children <6 years of age with acute respiratory infection. Respiratory samples were studied for classical respiratory viruses by immunofluorescence and for human rhinoviruses (HRV) by real-time reverse transcription polymerase chain reaction. Clinical and demographic data were recorded. RESULTS: Viral detection by immunofluorescence was 48% in 434 inpatients and 37% in 186 outpatients. Viral diagnosis increased to 83% and 62%, respectively, when testing for HRV. HRV (41%) and respiratory syncytial virus (RSV) (27%) were most common viruses identified, followed by metapneumovirus (9%), influenza A and parainfluenza (3%), adenovirus and influenza B (2%). HRV frequency was significantly higher in hospitalized patients (47%) than in outpatients (27%) (P < 0.001). Coinfection was detected in 12% of hospitalized and 4% of outpatients (P < 0.031). HRV and adenovirus circulated throughout the entire year. RSV, influenza A and B predominated in winter, whereas metapneumovirus and parainfluenza predominated in spring. Of 362 patients with bronchiolitis, 84% had a virus identified; HRV (42%) and RSV (38%) were predominant. Of 77 patients with pneumonia, 84% had a virus detected with HRV (43%) and RSV (29%) predominating. CONCLUSIONS: HRV were significant pathogens associated with bronchiolitis and pneumonia, especially in hospitalized patients. Both, HRV and coinfections, were risk factors for hospitalization. These findings support the importance of including HRV detection in children with acute respiratory infection.
Fil: Marcone, Débora Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Ellis, Alejandro. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Mater Dei Hospital; Argentina
Fil: Videla, Cristina Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Ekstrom, Jorge. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Mater Dei Hospital; Argentina
Fil: Ricarte, Carmen. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Carballal, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Vidaurreta, Santiago Manuel. Mater Dei Hospital; Argentina
Fil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Materia
Respiratory Viruses
Rhinoviruses
Aacute Respiratory Infections
Real-Time Rt-Pcr
Coinfection
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23968
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/23968
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, ArgentinaMarcone, Débora NataliaEllis, AlejandroVidela, Cristina MónicaEkstrom, JorgeRicarte, CarmenCarballal, GuadalupeVidaurreta, Santiago ManuelEchavarría, Marcela SilviaRespiratory VirusesRhinovirusesAacute Respiratory InfectionsReal-Time Rt-PcrCoinfectionhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3OBJECTIVES: To determine and compare the viral frequency, seasonality and clinical-demographic features in 2 groups of children (hospitalized versus outpatients) with acute respiratory infections. MATERIAL AND METHODS: A cross-sectional, descriptive study was performed from 2008 to 2010 in 620 children <6 years of age with acute respiratory infection. Respiratory samples were studied for classical respiratory viruses by immunofluorescence and for human rhinoviruses (HRV) by real-time reverse transcription polymerase chain reaction. Clinical and demographic data were recorded. RESULTS: Viral detection by immunofluorescence was 48% in 434 inpatients and 37% in 186 outpatients. Viral diagnosis increased to 83% and 62%, respectively, when testing for HRV. HRV (41%) and respiratory syncytial virus (RSV) (27%) were most common viruses identified, followed by metapneumovirus (9%), influenza A and parainfluenza (3%), adenovirus and influenza B (2%). HRV frequency was significantly higher in hospitalized patients (47%) than in outpatients (27%) (P < 0.001). Coinfection was detected in 12% of hospitalized and 4% of outpatients (P < 0.031). HRV and adenovirus circulated throughout the entire year. RSV, influenza A and B predominated in winter, whereas metapneumovirus and parainfluenza predominated in spring. Of 362 patients with bronchiolitis, 84% had a virus identified; HRV (42%) and RSV (38%) were predominant. Of 77 patients with pneumonia, 84% had a virus detected with HRV (43%) and RSV (29%) predominating. CONCLUSIONS: HRV were significant pathogens associated with bronchiolitis and pneumonia, especially in hospitalized patients. Both, HRV and coinfections, were risk factors for hospitalization. These findings support the importance of including HRV detection in children with acute respiratory infection.Fil: Marcone, Débora Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; ArgentinaFil: Ellis, Alejandro. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Mater Dei Hospital; ArgentinaFil: Videla, Cristina Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; ArgentinaFil: Ekstrom, Jorge. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Mater Dei Hospital; ArgentinaFil: Ricarte, Carmen. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; ArgentinaFil: Carballal, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; ArgentinaFil: Vidaurreta, Santiago Manuel. Mater Dei Hospital; ArgentinaFil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; ArgentinaLippincott Williams2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23968Marcone, Débora Natalia; Ellis, Alejandro; Videla, Cristina Mónica; Ekstrom, Jorge; Ricarte, Carmen; et al.; Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina; Lippincott Williams; Pediatric Infectious Disease Journal; 32; 3; 3-2013; 105-1100891-3668CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/pidj/Abstract/2013/03000/Viral_Etiology_of_Acute_Respiratory_Infections_in.35.aspxinfo:eu-repo/semantics/altIdentifier/doi/10.1097/INF.0b013e31827cd06finfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:11:53Zoai:ri.conicet.gov.ar:11336/23968instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:11:53.364CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina
title Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina
spellingShingle Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina
Marcone, Débora Natalia
Respiratory Viruses
Rhinoviruses
Aacute Respiratory Infections
Real-Time Rt-Pcr
Coinfection
title_short Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina
title_full Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina
title_fullStr Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina
title_full_unstemmed Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina
title_sort Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina
dc.creator.none.fl_str_mv Marcone, Débora Natalia
Ellis, Alejandro
Videla, Cristina Mónica
Ekstrom, Jorge
Ricarte, Carmen
Carballal, Guadalupe
Vidaurreta, Santiago Manuel
Echavarría, Marcela Silvia
author Marcone, Débora Natalia
author_facet Marcone, Débora Natalia
Ellis, Alejandro
Videla, Cristina Mónica
Ekstrom, Jorge
Ricarte, Carmen
Carballal, Guadalupe
Vidaurreta, Santiago Manuel
Echavarría, Marcela Silvia
author_role author
author2 Ellis, Alejandro
Videla, Cristina Mónica
Ekstrom, Jorge
Ricarte, Carmen
Carballal, Guadalupe
Vidaurreta, Santiago Manuel
Echavarría, Marcela Silvia
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Respiratory Viruses
Rhinoviruses
Aacute Respiratory Infections
Real-Time Rt-Pcr
Coinfection
topic Respiratory Viruses
Rhinoviruses
Aacute Respiratory Infections
Real-Time Rt-Pcr
Coinfection
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv OBJECTIVES: To determine and compare the viral frequency, seasonality and clinical-demographic features in 2 groups of children (hospitalized versus outpatients) with acute respiratory infections. MATERIAL AND METHODS: A cross-sectional, descriptive study was performed from 2008 to 2010 in 620 children <6 years of age with acute respiratory infection. Respiratory samples were studied for classical respiratory viruses by immunofluorescence and for human rhinoviruses (HRV) by real-time reverse transcription polymerase chain reaction. Clinical and demographic data were recorded. RESULTS: Viral detection by immunofluorescence was 48% in 434 inpatients and 37% in 186 outpatients. Viral diagnosis increased to 83% and 62%, respectively, when testing for HRV. HRV (41%) and respiratory syncytial virus (RSV) (27%) were most common viruses identified, followed by metapneumovirus (9%), influenza A and parainfluenza (3%), adenovirus and influenza B (2%). HRV frequency was significantly higher in hospitalized patients (47%) than in outpatients (27%) (P < 0.001). Coinfection was detected in 12% of hospitalized and 4% of outpatients (P < 0.031). HRV and adenovirus circulated throughout the entire year. RSV, influenza A and B predominated in winter, whereas metapneumovirus and parainfluenza predominated in spring. Of 362 patients with bronchiolitis, 84% had a virus identified; HRV (42%) and RSV (38%) were predominant. Of 77 patients with pneumonia, 84% had a virus detected with HRV (43%) and RSV (29%) predominating. CONCLUSIONS: HRV were significant pathogens associated with bronchiolitis and pneumonia, especially in hospitalized patients. Both, HRV and coinfections, were risk factors for hospitalization. These findings support the importance of including HRV detection in children with acute respiratory infection.
Fil: Marcone, Débora Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Ellis, Alejandro. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Mater Dei Hospital; Argentina
Fil: Videla, Cristina Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Ekstrom, Jorge. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina. Mater Dei Hospital; Argentina
Fil: Ricarte, Carmen. Centro de Educación Médica e Investigaciones Clínicas “Norberto Quirno”; Argentina
Fil: Carballal, Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
Fil: Vidaurreta, Santiago Manuel. Mater Dei Hospital; Argentina
Fil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
description OBJECTIVES: To determine and compare the viral frequency, seasonality and clinical-demographic features in 2 groups of children (hospitalized versus outpatients) with acute respiratory infections. MATERIAL AND METHODS: A cross-sectional, descriptive study was performed from 2008 to 2010 in 620 children <6 years of age with acute respiratory infection. Respiratory samples were studied for classical respiratory viruses by immunofluorescence and for human rhinoviruses (HRV) by real-time reverse transcription polymerase chain reaction. Clinical and demographic data were recorded. RESULTS: Viral detection by immunofluorescence was 48% in 434 inpatients and 37% in 186 outpatients. Viral diagnosis increased to 83% and 62%, respectively, when testing for HRV. HRV (41%) and respiratory syncytial virus (RSV) (27%) were most common viruses identified, followed by metapneumovirus (9%), influenza A and parainfluenza (3%), adenovirus and influenza B (2%). HRV frequency was significantly higher in hospitalized patients (47%) than in outpatients (27%) (P < 0.001). Coinfection was detected in 12% of hospitalized and 4% of outpatients (P < 0.031). HRV and adenovirus circulated throughout the entire year. RSV, influenza A and B predominated in winter, whereas metapneumovirus and parainfluenza predominated in spring. Of 362 patients with bronchiolitis, 84% had a virus identified; HRV (42%) and RSV (38%) were predominant. Of 77 patients with pneumonia, 84% had a virus detected with HRV (43%) and RSV (29%) predominating. CONCLUSIONS: HRV were significant pathogens associated with bronchiolitis and pneumonia, especially in hospitalized patients. Both, HRV and coinfections, were risk factors for hospitalization. These findings support the importance of including HRV detection in children with acute respiratory infection.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23968
Marcone, Débora Natalia; Ellis, Alejandro; Videla, Cristina Mónica; Ekstrom, Jorge; Ricarte, Carmen; et al.; Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina; Lippincott Williams; Pediatric Infectious Disease Journal; 32; 3; 3-2013; 105-110
0891-3668
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23968
identifier_str_mv Marcone, Débora Natalia; Ellis, Alejandro; Videla, Cristina Mónica; Ekstrom, Jorge; Ricarte, Carmen; et al.; Viral etiology of acute respiratory infection in hospitalized and outpatient children from Buenos Aires, Argentina; Lippincott Williams; Pediatric Infectious Disease Journal; 32; 3; 3-2013; 105-110
0891-3668
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.lww.com/pidj/Abstract/2013/03000/Viral_Etiology_of_Acute_Respiratory_Infections_in.35.aspx
info:eu-repo/semantics/altIdentifier/doi/10.1097/INF.0b013e31827cd06f
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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