Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina

Autores
Marcone, Débora Natalia; Durand, Lizette O.; Azziz Baumgartner, Eduardo; Vidaurreta, Santiago Manuel; Ekstrom, Jorge; Carballal, Guadalupe; Echavarría, Marcela Silvia
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries. Methods: During 2008-2010, we conducted a prospective cohort study and followed ~1,800 Argentinian children aged ≤5years to identify those children who were hospitalized or who sought care at an emergency room with any acute respiratory infection sign or symptom (e.g., rhinorrhea, cough, wheezing, tachypnea, retractions, or cyanosis). Respiratory samples were obtained for respiratory syncytial virus, influenza, parainfluenza, adenovirus, and metapneumovirus testing by immunofluorescence and for rhinovirus by real-time reverse transcription polymerase chain reaction. Results: The incidence of respiratory syncytial virus (24/1000 children-years), human metapneumovirus (8/1000 children-years), and influenza (8/1000 children-years) illnesses was highest among hospitalized children aged <6months and decreased among older children. In contrast, the incidence of rhinovirus was highest (12/1000 children-years) among those aged 6-23 months. In the emergency room, the incidence of rhinovirus was 459; respiratory syncytial virus 352; influenza 185; parainfluenza 177; metapneumovirus 130; and adenovirus 73/1,000 children-years. The total cost of hospitalization was a median of US$529 (Interquartile range, US$362-789). Conclusions: Our findings indicate that respiratory viruses, in particular rhinovirus, respiratory syncytial virus, metapneumovirus, and influenza may be associated with severe illness causing substantial economic burden.
Fil: Marcone, Débora Natalia. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Durand, Lizette O.. Centers for Disease Control and Prevention; Estados Unidos
Fil: Azziz Baumgartner, Eduardo. Centers for Disease Control and Prevention; Estados Unidos
Fil: Vidaurreta, Santiago Manuel. Centro de Educaciones Médicas e Investigación Clínica ; Argentina
Fil: Ekstrom, Jorge. Centro de Educaciones Médicas e Investigación Clínica ; Argentina
Fil: Carballal, Guadalupe. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Echavarría, Marcela Silvia. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CHARGES
CHILDREN
HOSPITALIZED AND OUTPATIENTS
INCIDENCE
INFLUENZA
RESPIRATORY SYNCYTIAL VIRUS
RHINOVIRUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42055
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/42055
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, ArgentinaMarcone, Débora NataliaDurand, Lizette O.Azziz Baumgartner, EduardoVidaurreta, Santiago ManuelEkstrom, JorgeCarballal, GuadalupeEchavarría, Marcela SilviaCHARGESCHILDRENHOSPITALIZED AND OUTPATIENTSINCIDENCEINFLUENZARESPIRATORY SYNCYTIAL VIRUSRHINOVIRUShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries. Methods: During 2008-2010, we conducted a prospective cohort study and followed ~1,800 Argentinian children aged ≤5years to identify those children who were hospitalized or who sought care at an emergency room with any acute respiratory infection sign or symptom (e.g., rhinorrhea, cough, wheezing, tachypnea, retractions, or cyanosis). Respiratory samples were obtained for respiratory syncytial virus, influenza, parainfluenza, adenovirus, and metapneumovirus testing by immunofluorescence and for rhinovirus by real-time reverse transcription polymerase chain reaction. Results: The incidence of respiratory syncytial virus (24/1000 children-years), human metapneumovirus (8/1000 children-years), and influenza (8/1000 children-years) illnesses was highest among hospitalized children aged <6months and decreased among older children. In contrast, the incidence of rhinovirus was highest (12/1000 children-years) among those aged 6-23 months. In the emergency room, the incidence of rhinovirus was 459; respiratory syncytial virus 352; influenza 185; parainfluenza 177; metapneumovirus 130; and adenovirus 73/1,000 children-years. The total cost of hospitalization was a median of US$529 (Interquartile range, US$362-789). Conclusions: Our findings indicate that respiratory viruses, in particular rhinovirus, respiratory syncytial virus, metapneumovirus, and influenza may be associated with severe illness causing substantial economic burden.Fil: Marcone, Débora Natalia. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Durand, Lizette O.. Centers for Disease Control and Prevention; Estados UnidosFil: Azziz Baumgartner, Eduardo. Centers for Disease Control and Prevention; Estados UnidosFil: Vidaurreta, Santiago Manuel. Centro de Educaciones Médicas e Investigación Clínica ; ArgentinaFil: Ekstrom, Jorge. Centro de Educaciones Médicas e Investigación Clínica ; ArgentinaFil: Carballal, Guadalupe. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Echavarría, Marcela Silvia. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaBioMed Central2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42055Marcone, Débora Natalia; Durand, Lizette O.; Azziz Baumgartner, Eduardo; Vidaurreta, Santiago Manuel; Ekstrom, Jorge; et al.; Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina; BioMed Central; BMC Infectious Diseases; 15; 1; 10-2015; 1-91471-2334CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s12879-015-1213-4info:eu-repo/semantics/altIdentifier/url/https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-1213-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:33Zoai:ri.conicet.gov.ar:11336/42055instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:34.086CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina
title Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina
spellingShingle Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina
Marcone, Débora Natalia
CHARGES
CHILDREN
HOSPITALIZED AND OUTPATIENTS
INCIDENCE
INFLUENZA
RESPIRATORY SYNCYTIAL VIRUS
RHINOVIRUS
title_short Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina
title_full Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina
title_fullStr Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina
title_full_unstemmed Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina
title_sort Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina
dc.creator.none.fl_str_mv Marcone, Débora Natalia
Durand, Lizette O.
Azziz Baumgartner, Eduardo
Vidaurreta, Santiago Manuel
Ekstrom, Jorge
Carballal, Guadalupe
Echavarría, Marcela Silvia
author Marcone, Débora Natalia
author_facet Marcone, Débora Natalia
Durand, Lizette O.
Azziz Baumgartner, Eduardo
Vidaurreta, Santiago Manuel
Ekstrom, Jorge
Carballal, Guadalupe
Echavarría, Marcela Silvia
author_role author
author2 Durand, Lizette O.
Azziz Baumgartner, Eduardo
Vidaurreta, Santiago Manuel
Ekstrom, Jorge
Carballal, Guadalupe
Echavarría, Marcela Silvia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CHARGES
CHILDREN
HOSPITALIZED AND OUTPATIENTS
INCIDENCE
INFLUENZA
RESPIRATORY SYNCYTIAL VIRUS
RHINOVIRUS
topic CHARGES
CHILDREN
HOSPITALIZED AND OUTPATIENTS
INCIDENCE
INFLUENZA
RESPIRATORY SYNCYTIAL VIRUS
RHINOVIRUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries. Methods: During 2008-2010, we conducted a prospective cohort study and followed ~1,800 Argentinian children aged ≤5years to identify those children who were hospitalized or who sought care at an emergency room with any acute respiratory infection sign or symptom (e.g., rhinorrhea, cough, wheezing, tachypnea, retractions, or cyanosis). Respiratory samples were obtained for respiratory syncytial virus, influenza, parainfluenza, adenovirus, and metapneumovirus testing by immunofluorescence and for rhinovirus by real-time reverse transcription polymerase chain reaction. Results: The incidence of respiratory syncytial virus (24/1000 children-years), human metapneumovirus (8/1000 children-years), and influenza (8/1000 children-years) illnesses was highest among hospitalized children aged <6months and decreased among older children. In contrast, the incidence of rhinovirus was highest (12/1000 children-years) among those aged 6-23 months. In the emergency room, the incidence of rhinovirus was 459; respiratory syncytial virus 352; influenza 185; parainfluenza 177; metapneumovirus 130; and adenovirus 73/1,000 children-years. The total cost of hospitalization was a median of US$529 (Interquartile range, US$362-789). Conclusions: Our findings indicate that respiratory viruses, in particular rhinovirus, respiratory syncytial virus, metapneumovirus, and influenza may be associated with severe illness causing substantial economic burden.
Fil: Marcone, Débora Natalia. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Durand, Lizette O.. Centers for Disease Control and Prevention; Estados Unidos
Fil: Azziz Baumgartner, Eduardo. Centers for Disease Control and Prevention; Estados Unidos
Fil: Vidaurreta, Santiago Manuel. Centro de Educaciones Médicas e Investigación Clínica ; Argentina
Fil: Ekstrom, Jorge. Centro de Educaciones Médicas e Investigación Clínica ; Argentina
Fil: Carballal, Guadalupe. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Echavarría, Marcela Silvia. Centro de Educaciones Médicas e Investigación Clínica ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries. Methods: During 2008-2010, we conducted a prospective cohort study and followed ~1,800 Argentinian children aged ≤5years to identify those children who were hospitalized or who sought care at an emergency room with any acute respiratory infection sign or symptom (e.g., rhinorrhea, cough, wheezing, tachypnea, retractions, or cyanosis). Respiratory samples were obtained for respiratory syncytial virus, influenza, parainfluenza, adenovirus, and metapneumovirus testing by immunofluorescence and for rhinovirus by real-time reverse transcription polymerase chain reaction. Results: The incidence of respiratory syncytial virus (24/1000 children-years), human metapneumovirus (8/1000 children-years), and influenza (8/1000 children-years) illnesses was highest among hospitalized children aged <6months and decreased among older children. In contrast, the incidence of rhinovirus was highest (12/1000 children-years) among those aged 6-23 months. In the emergency room, the incidence of rhinovirus was 459; respiratory syncytial virus 352; influenza 185; parainfluenza 177; metapneumovirus 130; and adenovirus 73/1,000 children-years. The total cost of hospitalization was a median of US$529 (Interquartile range, US$362-789). Conclusions: Our findings indicate that respiratory viruses, in particular rhinovirus, respiratory syncytial virus, metapneumovirus, and influenza may be associated with severe illness causing substantial economic burden.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42055
Marcone, Débora Natalia; Durand, Lizette O.; Azziz Baumgartner, Eduardo; Vidaurreta, Santiago Manuel; Ekstrom, Jorge; et al.; Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina; BioMed Central; BMC Infectious Diseases; 15; 1; 10-2015; 1-9
1471-2334
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42055
identifier_str_mv Marcone, Débora Natalia; Durand, Lizette O.; Azziz Baumgartner, Eduardo; Vidaurreta, Santiago Manuel; Ekstrom, Jorge; et al.; Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina; BioMed Central; BMC Infectious Diseases; 15; 1; 10-2015; 1-9
1471-2334
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s12879-015-1213-4
info:eu-repo/semantics/altIdentifier/url/https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-1213-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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