Intersection between metabolic dysfunction, high fat diet consumption, and brain aging

Autores
Uranga, Romina Maria; Bruce Keller, Annadora J.; Morrison, Christopher D.; Fernandez Kim, Sun Ok; Ebenezer, Philip J.; Zhang, Le; Dasuri, Kalavathi; Keller, Jeffrey N.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these aspects are altered in aging individuals, remains to be elucidated. An increasing number of individuals regularly consume a diet high in fat, with high‐fat diet consumption known to be sufficient to promote metabolic dysfunction, although the links between high‐fat diet consumption and aging are only now beginning to be elucidated. In this review we discuss the potential role for age‐related metabolic disturbances serving as an important basis for deleterious perturbations in the aging brain. These data not only have important implications for understanding the basis of brain aging, but also may be important to the development of therapeutic interventions which promote successful brain aging.
Fil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Bruce Keller, Annadora J.. State University of Louisiana; Estados Unidos
Fil: Morrison, Christopher D.. State University of Louisiana; Estados Unidos
Fil: Fernandez Kim, Sun Ok. State University of Louisiana; Estados Unidos
Fil: Ebenezer, Philip J.. State University of Louisiana; Estados Unidos
Fil: Zhang, Le. State University of Louisiana; Estados Unidos
Fil: Dasuri, Kalavathi. State University of Louisiana; Estados Unidos
Fil: Keller, Jeffrey N.. State University of Louisiana; Estados Unidos
Materia
AGING
BRAIN
DIABETES
INSULINE RESISTANCE
METABOLISM
NEURODEGENERATION
OBESITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42241
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Intersection between metabolic dysfunction, high fat diet consumption, and brain agingUranga, Romina MariaBruce Keller, Annadora J.Morrison, Christopher D.Fernandez Kim, Sun OkEbenezer, Philip J.Zhang, LeDasuri, KalavathiKeller, Jeffrey N.AGINGBRAINDIABETESINSULINE RESISTANCEMETABOLISMNEURODEGENERATIONOBESITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these aspects are altered in aging individuals, remains to be elucidated. An increasing number of individuals regularly consume a diet high in fat, with high‐fat diet consumption known to be sufficient to promote metabolic dysfunction, although the links between high‐fat diet consumption and aging are only now beginning to be elucidated. In this review we discuss the potential role for age‐related metabolic disturbances serving as an important basis for deleterious perturbations in the aging brain. These data not only have important implications for understanding the basis of brain aging, but also may be important to the development of therapeutic interventions which promote successful brain aging.Fil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Bruce Keller, Annadora J.. State University of Louisiana; Estados UnidosFil: Morrison, Christopher D.. State University of Louisiana; Estados UnidosFil: Fernandez Kim, Sun Ok. State University of Louisiana; Estados UnidosFil: Ebenezer, Philip J.. State University of Louisiana; Estados UnidosFil: Zhang, Le. State University of Louisiana; Estados UnidosFil: Dasuri, Kalavathi. State University of Louisiana; Estados UnidosFil: Keller, Jeffrey N.. State University of Louisiana; Estados UnidosWiley Blackwell Publishing, Inc2010-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42241Uranga, Romina Maria; Bruce Keller, Annadora J.; Morrison, Christopher D.; Fernandez Kim, Sun Ok; Ebenezer, Philip J.; et al.; Intersection between metabolic dysfunction, high fat diet consumption, and brain aging; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 114; 2; 7-2010; 344-3610022-3042CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1471-4159.2010.06803.xinfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2010.06803.xinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910139/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:05Zoai:ri.conicet.gov.ar:11336/42241instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:06.048CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
title Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
spellingShingle Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
Uranga, Romina Maria
AGING
BRAIN
DIABETES
INSULINE RESISTANCE
METABOLISM
NEURODEGENERATION
OBESITY
title_short Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
title_full Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
title_fullStr Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
title_full_unstemmed Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
title_sort Intersection between metabolic dysfunction, high fat diet consumption, and brain aging
dc.creator.none.fl_str_mv Uranga, Romina Maria
Bruce Keller, Annadora J.
Morrison, Christopher D.
Fernandez Kim, Sun Ok
Ebenezer, Philip J.
Zhang, Le
Dasuri, Kalavathi
Keller, Jeffrey N.
author Uranga, Romina Maria
author_facet Uranga, Romina Maria
Bruce Keller, Annadora J.
Morrison, Christopher D.
Fernandez Kim, Sun Ok
Ebenezer, Philip J.
Zhang, Le
Dasuri, Kalavathi
Keller, Jeffrey N.
author_role author
author2 Bruce Keller, Annadora J.
Morrison, Christopher D.
Fernandez Kim, Sun Ok
Ebenezer, Philip J.
Zhang, Le
Dasuri, Kalavathi
Keller, Jeffrey N.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AGING
BRAIN
DIABETES
INSULINE RESISTANCE
METABOLISM
NEURODEGENERATION
OBESITY
topic AGING
BRAIN
DIABETES
INSULINE RESISTANCE
METABOLISM
NEURODEGENERATION
OBESITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these aspects are altered in aging individuals, remains to be elucidated. An increasing number of individuals regularly consume a diet high in fat, with high‐fat diet consumption known to be sufficient to promote metabolic dysfunction, although the links between high‐fat diet consumption and aging are only now beginning to be elucidated. In this review we discuss the potential role for age‐related metabolic disturbances serving as an important basis for deleterious perturbations in the aging brain. These data not only have important implications for understanding the basis of brain aging, but also may be important to the development of therapeutic interventions which promote successful brain aging.
Fil: Uranga, Romina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Bruce Keller, Annadora J.. State University of Louisiana; Estados Unidos
Fil: Morrison, Christopher D.. State University of Louisiana; Estados Unidos
Fil: Fernandez Kim, Sun Ok. State University of Louisiana; Estados Unidos
Fil: Ebenezer, Philip J.. State University of Louisiana; Estados Unidos
Fil: Zhang, Le. State University of Louisiana; Estados Unidos
Fil: Dasuri, Kalavathi. State University of Louisiana; Estados Unidos
Fil: Keller, Jeffrey N.. State University of Louisiana; Estados Unidos
description Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these aspects are altered in aging individuals, remains to be elucidated. An increasing number of individuals regularly consume a diet high in fat, with high‐fat diet consumption known to be sufficient to promote metabolic dysfunction, although the links between high‐fat diet consumption and aging are only now beginning to be elucidated. In this review we discuss the potential role for age‐related metabolic disturbances serving as an important basis for deleterious perturbations in the aging brain. These data not only have important implications for understanding the basis of brain aging, but also may be important to the development of therapeutic interventions which promote successful brain aging.
publishDate 2010
dc.date.none.fl_str_mv 2010-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42241
Uranga, Romina Maria; Bruce Keller, Annadora J.; Morrison, Christopher D.; Fernandez Kim, Sun Ok; Ebenezer, Philip J.; et al.; Intersection between metabolic dysfunction, high fat diet consumption, and brain aging; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 114; 2; 7-2010; 344-361
0022-3042
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42241
identifier_str_mv Uranga, Romina Maria; Bruce Keller, Annadora J.; Morrison, Christopher D.; Fernandez Kim, Sun Ok; Ebenezer, Philip J.; et al.; Intersection between metabolic dysfunction, high fat diet consumption, and brain aging; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 114; 2; 7-2010; 344-361
0022-3042
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1471-4159.2010.06803.x
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2010.06803.x
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910139/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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