Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental...

Autores
Roberti, Sabrina Lorena; Gatti, Cintia Romina; Leonardi, Maria Laura; Higa, Romina Daniela; Jawerbaum, Alicia Sandra
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Maternal diabetes induces alterations in decidualization, which may impact on decidual histotrophic function that include key roles of the uterine glands (UG) and the glycogenic area (GA). uNK cells, in- volved in angiogenesis and vessels remodeling, are needed for an adequate decidualization and feto-placental development. We pre- viously found that maternal diets enriched in polyunsaturated fatty acids (PUFAs) prevent increased resorption rates in diabetic preg- nancies. Aim: To evaluate the effect of diets enriched in sunflower and chia oil (rich in n-6 and n-3 PUFAs respectively) administrated during early postimplantation to diabetic rats on PAS staining of the GA and UG and on the number of uNK cells at day 9 of pregnancy and on decidual, fetal and placental growth at day 14 of pregnan- cy. Methods: Pregestational diabetes was induced in Wistar rats by streptozotocin (50 mg/kg). On days 7 to 9 of pregnancy diabetic rats received a standard diet or diets enriched in 6% of sunflower or chia oil. On day 9 of pregnancy GA, UG and uNK cells in the de- cidua were evaluated by PAS staining. On day 14 of pregnancy the fetal cephalic length was measured and the decidua and placenta were weighted. Results: At day 9 of pregnancy PAS staining of GA (p<0.001;74%) and UG (p<0.05;64%) and the number of uNK cells (p<0.001;62%) were reduced in diabetic rats, alterations prevented by the PUFAs enriched diets. At day 14 of pregnancy a decreased fetal cephalic length in diabetic rats (7.5%; p<0.05) was prevented by the sunflower oil supplementation. Both decidual (18.3%;p<0.05) and placental (12.4%;p<0.05) weights were decreased in the diabet- ic group. The diet enriched in sunflower oil prevented the reduced decidual weight while the diet enriched in chia oil prevented the re- duced placental weight. Conclusion: The early postimplantation is a key period for decidual and feto-placental development, affected by maternal diabetes, and in which dietary treatments can exert ben- eficial effects.
Fil: Roberti, Sabrina Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Gatti, Cintia Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Leonardi, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Higa, Romina Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas
Argentina
Sociedad Argentina de Investigacion Clinica
Sociedad Argentina de Inmunología
Asociación Argentina de Farmacología Experimental;
Asociación Argentina de Nanomedicinas;
Materia
DIABETES MATERNA
DECIDUA
NUTRICIÓN HISTOTRÓFICA
PUFAS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184190
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/184190
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growthRoberti, Sabrina LorenaGatti, Cintia RominaLeonardi, Maria LauraHiga, Romina DanielaJawerbaum, Alicia SandraDIABETES MATERNADECIDUANUTRICIÓN HISTOTRÓFICAPUFAShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Maternal diabetes induces alterations in decidualization, which may impact on decidual histotrophic function that include key roles of the uterine glands (UG) and the glycogenic area (GA). uNK cells, in- volved in angiogenesis and vessels remodeling, are needed for an adequate decidualization and feto-placental development. We pre- viously found that maternal diets enriched in polyunsaturated fatty acids (PUFAs) prevent increased resorption rates in diabetic preg- nancies. Aim: To evaluate the effect of diets enriched in sunflower and chia oil (rich in n-6 and n-3 PUFAs respectively) administrated during early postimplantation to diabetic rats on PAS staining of the GA and UG and on the number of uNK cells at day 9 of pregnancy and on decidual, fetal and placental growth at day 14 of pregnan- cy. Methods: Pregestational diabetes was induced in Wistar rats by streptozotocin (50 mg/kg). On days 7 to 9 of pregnancy diabetic rats received a standard diet or diets enriched in 6% of sunflower or chia oil. On day 9 of pregnancy GA, UG and uNK cells in the de- cidua were evaluated by PAS staining. On day 14 of pregnancy the fetal cephalic length was measured and the decidua and placenta were weighted. Results: At day 9 of pregnancy PAS staining of GA (p<0.001;74%) and UG (p<0.05;64%) and the number of uNK cells (p<0.001;62%) were reduced in diabetic rats, alterations prevented by the PUFAs enriched diets. At day 14 of pregnancy a decreased fetal cephalic length in diabetic rats (7.5%; p<0.05) was prevented by the sunflower oil supplementation. Both decidual (18.3%;p<0.05) and placental (12.4%;p<0.05) weights were decreased in the diabet- ic group. The diet enriched in sunflower oil prevented the reduced decidual weight while the diet enriched in chia oil prevented the re- duced placental weight. Conclusion: The early postimplantation is a key period for decidual and feto-placental development, affected by maternal diabetes, and in which dietary treatments can exert ben- eficial effects.Fil: Roberti, Sabrina Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Gatti, Cintia Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Leonardi, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Higa, Romina Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaLXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de NanomedicinasArgentinaSociedad Argentina de Investigacion ClinicaSociedad Argentina de InmunologíaAsociación Argentina de Farmacología Experimental;Asociación Argentina de Nanomedicinas;Fundación Revista Medicina2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184190Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth; LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas; Argentina; 2021; 1-2CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.saic.org.ar/reunion-anualNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:02:41Zoai:ri.conicet.gov.ar:11336/184190instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:02:42.166CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth
title Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth
spellingShingle Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth
Roberti, Sabrina Lorena
DIABETES MATERNA
DECIDUA
NUTRICIÓN HISTOTRÓFICA
PUFAS
title_short Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth
title_full Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth
title_fullStr Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth
title_full_unstemmed Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth
title_sort Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth
dc.creator.none.fl_str_mv Roberti, Sabrina Lorena
Gatti, Cintia Romina
Leonardi, Maria Laura
Higa, Romina Daniela
Jawerbaum, Alicia Sandra
author Roberti, Sabrina Lorena
author_facet Roberti, Sabrina Lorena
Gatti, Cintia Romina
Leonardi, Maria Laura
Higa, Romina Daniela
Jawerbaum, Alicia Sandra
author_role author
author2 Gatti, Cintia Romina
Leonardi, Maria Laura
Higa, Romina Daniela
Jawerbaum, Alicia Sandra
author2_role author
author
author
author
dc.subject.none.fl_str_mv DIABETES MATERNA
DECIDUA
NUTRICIÓN HISTOTRÓFICA
PUFAS
topic DIABETES MATERNA
DECIDUA
NUTRICIÓN HISTOTRÓFICA
PUFAS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Maternal diabetes induces alterations in decidualization, which may impact on decidual histotrophic function that include key roles of the uterine glands (UG) and the glycogenic area (GA). uNK cells, in- volved in angiogenesis and vessels remodeling, are needed for an adequate decidualization and feto-placental development. We pre- viously found that maternal diets enriched in polyunsaturated fatty acids (PUFAs) prevent increased resorption rates in diabetic preg- nancies. Aim: To evaluate the effect of diets enriched in sunflower and chia oil (rich in n-6 and n-3 PUFAs respectively) administrated during early postimplantation to diabetic rats on PAS staining of the GA and UG and on the number of uNK cells at day 9 of pregnancy and on decidual, fetal and placental growth at day 14 of pregnan- cy. Methods: Pregestational diabetes was induced in Wistar rats by streptozotocin (50 mg/kg). On days 7 to 9 of pregnancy diabetic rats received a standard diet or diets enriched in 6% of sunflower or chia oil. On day 9 of pregnancy GA, UG and uNK cells in the de- cidua were evaluated by PAS staining. On day 14 of pregnancy the fetal cephalic length was measured and the decidua and placenta were weighted. Results: At day 9 of pregnancy PAS staining of GA (p<0.001;74%) and UG (p<0.05;64%) and the number of uNK cells (p<0.001;62%) were reduced in diabetic rats, alterations prevented by the PUFAs enriched diets. At day 14 of pregnancy a decreased fetal cephalic length in diabetic rats (7.5%; p<0.05) was prevented by the sunflower oil supplementation. Both decidual (18.3%;p<0.05) and placental (12.4%;p<0.05) weights were decreased in the diabet- ic group. The diet enriched in sunflower oil prevented the reduced decidual weight while the diet enriched in chia oil prevented the re- duced placental weight. Conclusion: The early postimplantation is a key period for decidual and feto-placental development, affected by maternal diabetes, and in which dietary treatments can exert ben- eficial effects.
Fil: Roberti, Sabrina Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Gatti, Cintia Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Leonardi, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Higa, Romina Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas
Argentina
Sociedad Argentina de Investigacion Clinica
Sociedad Argentina de Inmunología
Asociación Argentina de Farmacología Experimental;
Asociación Argentina de Nanomedicinas;
description Maternal diabetes induces alterations in decidualization, which may impact on decidual histotrophic function that include key roles of the uterine glands (UG) and the glycogenic area (GA). uNK cells, in- volved in angiogenesis and vessels remodeling, are needed for an adequate decidualization and feto-placental development. We pre- viously found that maternal diets enriched in polyunsaturated fatty acids (PUFAs) prevent increased resorption rates in diabetic preg- nancies. Aim: To evaluate the effect of diets enriched in sunflower and chia oil (rich in n-6 and n-3 PUFAs respectively) administrated during early postimplantation to diabetic rats on PAS staining of the GA and UG and on the number of uNK cells at day 9 of pregnancy and on decidual, fetal and placental growth at day 14 of pregnan- cy. Methods: Pregestational diabetes was induced in Wistar rats by streptozotocin (50 mg/kg). On days 7 to 9 of pregnancy diabetic rats received a standard diet or diets enriched in 6% of sunflower or chia oil. On day 9 of pregnancy GA, UG and uNK cells in the de- cidua were evaluated by PAS staining. On day 14 of pregnancy the fetal cephalic length was measured and the decidua and placenta were weighted. Results: At day 9 of pregnancy PAS staining of GA (p<0.001;74%) and UG (p<0.05;64%) and the number of uNK cells (p<0.001;62%) were reduced in diabetic rats, alterations prevented by the PUFAs enriched diets. At day 14 of pregnancy a decreased fetal cephalic length in diabetic rats (7.5%; p<0.05) was prevented by the sunflower oil supplementation. Both decidual (18.3%;p<0.05) and placental (12.4%;p<0.05) weights were decreased in the diabet- ic group. The diet enriched in sunflower oil prevented the reduced decidual weight while the diet enriched in chia oil prevented the re- duced placental weight. Conclusion: The early postimplantation is a key period for decidual and feto-placental development, affected by maternal diabetes, and in which dietary treatments can exert ben- eficial effects.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184190
Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth; LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas; Argentina; 2021; 1-2
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184190
identifier_str_mv Effect of maternal diets enriched in PUFAs administrated to diabetic rats during early postimplantation on structures involved in decidual histotrophic function and feto placental growth; LXVI Reunión anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunión Anual de la Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas; Argentina; 2021; 1-2
CONICET Digital
CONICET
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language eng
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Fundación Revista Medicina
publisher.none.fl_str_mv Fundación Revista Medicina
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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