Decidual vascularization during organogenesis after perigestational alcohol ingestion

Autores
Ventureira, Martín Ricardo; Sobarzo, Cristian Marcelo; Argandoña, Felipe; Palomino, Wilder A.; Barbeito, Claudio Gustavo; Cebral, Elisa
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Perigestational alcohol consumption up to early organogenesis can produce abnormal maternal vascularization via altered decidual VEGF/receptor expression. CF-1 female mice were administered with 10% ethanol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received water without ethanol. Treated females had reduced frequency of implantation sites with expanded vascular lumen (P<0.05), a-SMA-immunoreactive spiral arteries in proximal mesometrial decidua, reduced PCNApositive endothelial cells (P<0.01) and diminished uterine NK cell numbers (P<0.05) in proximal decidua compared to controls. The VEGF expression (laser capture microscopy, RT-PCR, western blot and immunohistochemistry) was reduced in decidual tissue after perigestational alcohol consumption (P<0.05). The uNK-DBA+ cells of treated females had reduced VEGF immunoexpression compared to controls (P<0.01). Very low decidual and endothelial cell KDR immunoreactivity and reduced decidual gene and protein KDR expression was found in treated females compared to controls (P<0.001). Instead, strong FLT-1 immunoexpression was detected in decidual and uNK cells (P<0.05) in the proximal decidua from treated females compared to controls. In conclusion, perigestational alcohol ingestion induces the reduction of lumen expansion of spiral arteries, concomitant with reduced endothelial cell proliferation and uNK cell population, and uncompleted remodeling of the artery smooth muscle. These effects were supported by low decidual VEGF and KDR gene and protein expression and increased FLT-1 expression, suggesting that VEGF and KDR reduction may contribute, in part, to mechanisms involved in deficient decidual angiogenesis after perigestational alcohol consumption in mouse.
Fil: Ventureira, Martín Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Sobarzo, Cristian Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Argandoña, Felipe. Universidad de Chile; Chile
Fil: Palomino, Wilder A.. Universidad de Chile; Chile
Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Cebral, Elisa. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Materia
angiogenesis
decidua
uterine NK
alcohol
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96221

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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Decidual vascularization during organogenesis after perigestational alcohol ingestionVentureira, Martín RicardoSobarzo, Cristian MarceloArgandoña, FelipePalomino, Wilder A.Barbeito, Claudio GustavoCebral, Elisaangiogenesisdeciduauterine NKalcoholhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Perigestational alcohol consumption up to early organogenesis can produce abnormal maternal vascularization via altered decidual VEGF/receptor expression. CF-1 female mice were administered with 10% ethanol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received water without ethanol. Treated females had reduced frequency of implantation sites with expanded vascular lumen (P<0.05), a-SMA-immunoreactive spiral arteries in proximal mesometrial decidua, reduced PCNApositive endothelial cells (P<0.01) and diminished uterine NK cell numbers (P<0.05) in proximal decidua compared to controls. The VEGF expression (laser capture microscopy, RT-PCR, western blot and immunohistochemistry) was reduced in decidual tissue after perigestational alcohol consumption (P<0.05). The uNK-DBA+ cells of treated females had reduced VEGF immunoexpression compared to controls (P<0.01). Very low decidual and endothelial cell KDR immunoreactivity and reduced decidual gene and protein KDR expression was found in treated females compared to controls (P<0.001). Instead, strong FLT-1 immunoexpression was detected in decidual and uNK cells (P<0.05) in the proximal decidua from treated females compared to controls. In conclusion, perigestational alcohol ingestion induces the reduction of lumen expansion of spiral arteries, concomitant with reduced endothelial cell proliferation and uNK cell population, and uncompleted remodeling of the artery smooth muscle. These effects were supported by low decidual VEGF and KDR gene and protein expression and increased FLT-1 expression, suggesting that VEGF and KDR reduction may contribute, in part, to mechanisms involved in deficient decidual angiogenesis after perigestational alcohol consumption in mouse.Fil: Ventureira, Martín Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Sobarzo, Cristian Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Argandoña, Felipe. Universidad de Chile; ChileFil: Palomino, Wilder A.. Universidad de Chile; ChileFil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Cebral, Elisa. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaBioScientifica2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96221Ventureira, Martín Ricardo; Sobarzo, Cristian Marcelo; Argandoña, Felipe; Palomino, Wilder A.; Barbeito, Claudio Gustavo; et al.; Decidual vascularization during organogenesis after perigestational alcohol ingestion; BioScientifica; Reproduction; 158; 1; 12-2018; 109-1221470-1626CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1530/REP-18-0230info:eu-repo/semantics/altIdentifier/url/rep.bioscientifica.com/view/journals/rep/158/1/REP-18-0230.xmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:35Zoai:ri.conicet.gov.ar:11336/96221instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:35.672CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Decidual vascularization during organogenesis after perigestational alcohol ingestion
title Decidual vascularization during organogenesis after perigestational alcohol ingestion
spellingShingle Decidual vascularization during organogenesis after perigestational alcohol ingestion
Ventureira, Martín Ricardo
angiogenesis
decidua
uterine NK
alcohol
title_short Decidual vascularization during organogenesis after perigestational alcohol ingestion
title_full Decidual vascularization during organogenesis after perigestational alcohol ingestion
title_fullStr Decidual vascularization during organogenesis after perigestational alcohol ingestion
title_full_unstemmed Decidual vascularization during organogenesis after perigestational alcohol ingestion
title_sort Decidual vascularization during organogenesis after perigestational alcohol ingestion
dc.creator.none.fl_str_mv Ventureira, Martín Ricardo
Sobarzo, Cristian Marcelo
Argandoña, Felipe
Palomino, Wilder A.
Barbeito, Claudio Gustavo
Cebral, Elisa
author Ventureira, Martín Ricardo
author_facet Ventureira, Martín Ricardo
Sobarzo, Cristian Marcelo
Argandoña, Felipe
Palomino, Wilder A.
Barbeito, Claudio Gustavo
Cebral, Elisa
author_role author
author2 Sobarzo, Cristian Marcelo
Argandoña, Felipe
Palomino, Wilder A.
Barbeito, Claudio Gustavo
Cebral, Elisa
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv angiogenesis
decidua
uterine NK
alcohol
topic angiogenesis
decidua
uterine NK
alcohol
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Perigestational alcohol consumption up to early organogenesis can produce abnormal maternal vascularization via altered decidual VEGF/receptor expression. CF-1 female mice were administered with 10% ethanol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received water without ethanol. Treated females had reduced frequency of implantation sites with expanded vascular lumen (P<0.05), a-SMA-immunoreactive spiral arteries in proximal mesometrial decidua, reduced PCNApositive endothelial cells (P<0.01) and diminished uterine NK cell numbers (P<0.05) in proximal decidua compared to controls. The VEGF expression (laser capture microscopy, RT-PCR, western blot and immunohistochemistry) was reduced in decidual tissue after perigestational alcohol consumption (P<0.05). The uNK-DBA+ cells of treated females had reduced VEGF immunoexpression compared to controls (P<0.01). Very low decidual and endothelial cell KDR immunoreactivity and reduced decidual gene and protein KDR expression was found in treated females compared to controls (P<0.001). Instead, strong FLT-1 immunoexpression was detected in decidual and uNK cells (P<0.05) in the proximal decidua from treated females compared to controls. In conclusion, perigestational alcohol ingestion induces the reduction of lumen expansion of spiral arteries, concomitant with reduced endothelial cell proliferation and uNK cell population, and uncompleted remodeling of the artery smooth muscle. These effects were supported by low decidual VEGF and KDR gene and protein expression and increased FLT-1 expression, suggesting that VEGF and KDR reduction may contribute, in part, to mechanisms involved in deficient decidual angiogenesis after perigestational alcohol consumption in mouse.
Fil: Ventureira, Martín Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Sobarzo, Cristian Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Argandoña, Felipe. Universidad de Chile; Chile
Fil: Palomino, Wilder A.. Universidad de Chile; Chile
Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Cebral, Elisa. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
description Perigestational alcohol consumption up to early organogenesis can produce abnormal maternal vascularization via altered decidual VEGF/receptor expression. CF-1 female mice were administered with 10% ethanol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received water without ethanol. Treated females had reduced frequency of implantation sites with expanded vascular lumen (P<0.05), a-SMA-immunoreactive spiral arteries in proximal mesometrial decidua, reduced PCNApositive endothelial cells (P<0.01) and diminished uterine NK cell numbers (P<0.05) in proximal decidua compared to controls. The VEGF expression (laser capture microscopy, RT-PCR, western blot and immunohistochemistry) was reduced in decidual tissue after perigestational alcohol consumption (P<0.05). The uNK-DBA+ cells of treated females had reduced VEGF immunoexpression compared to controls (P<0.01). Very low decidual and endothelial cell KDR immunoreactivity and reduced decidual gene and protein KDR expression was found in treated females compared to controls (P<0.001). Instead, strong FLT-1 immunoexpression was detected in decidual and uNK cells (P<0.05) in the proximal decidua from treated females compared to controls. In conclusion, perigestational alcohol ingestion induces the reduction of lumen expansion of spiral arteries, concomitant with reduced endothelial cell proliferation and uNK cell population, and uncompleted remodeling of the artery smooth muscle. These effects were supported by low decidual VEGF and KDR gene and protein expression and increased FLT-1 expression, suggesting that VEGF and KDR reduction may contribute, in part, to mechanisms involved in deficient decidual angiogenesis after perigestational alcohol consumption in mouse.
publishDate 2018
dc.date.none.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96221
Ventureira, Martín Ricardo; Sobarzo, Cristian Marcelo; Argandoña, Felipe; Palomino, Wilder A.; Barbeito, Claudio Gustavo; et al.; Decidual vascularization during organogenesis after perigestational alcohol ingestion; BioScientifica; Reproduction; 158; 1; 12-2018; 109-122
1470-1626
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96221
identifier_str_mv Ventureira, Martín Ricardo; Sobarzo, Cristian Marcelo; Argandoña, Felipe; Palomino, Wilder A.; Barbeito, Claudio Gustavo; et al.; Decidual vascularization during organogenesis after perigestational alcohol ingestion; BioScientifica; Reproduction; 158; 1; 12-2018; 109-122
1470-1626
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioScientifica
publisher.none.fl_str_mv BioScientifica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
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