Decidual vascularization during organogenesis after perigestational alcohol ingestion
- Autores
- Ventureira, Martín Ricardo; Sobarzo, Cristian Marcelo; Argandoña, Felipe; Palomino, Wilder A.; Barbeito, Claudio Gustavo; Cebral, Elisa
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Perigestational alcohol consumption up to early organogenesis can produce abnormal maternal vascularization via altered decidual VEGF/receptor expression. CF-1 female mice were administered with 10% ethanol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received water without ethanol. Treated females had reduced frequency of implantation sites with expanded vascular lumen (P<0.05), a-SMA-immunoreactive spiral arteries in proximal mesometrial decidua, reduced PCNApositive endothelial cells (P<0.01) and diminished uterine NK cell numbers (P<0.05) in proximal decidua compared to controls. The VEGF expression (laser capture microscopy, RT-PCR, western blot and immunohistochemistry) was reduced in decidual tissue after perigestational alcohol consumption (P<0.05). The uNK-DBA+ cells of treated females had reduced VEGF immunoexpression compared to controls (P<0.01). Very low decidual and endothelial cell KDR immunoreactivity and reduced decidual gene and protein KDR expression was found in treated females compared to controls (P<0.001). Instead, strong FLT-1 immunoexpression was detected in decidual and uNK cells (P<0.05) in the proximal decidua from treated females compared to controls. In conclusion, perigestational alcohol ingestion induces the reduction of lumen expansion of spiral arteries, concomitant with reduced endothelial cell proliferation and uNK cell population, and uncompleted remodeling of the artery smooth muscle. These effects were supported by low decidual VEGF and KDR gene and protein expression and increased FLT-1 expression, suggesting that VEGF and KDR reduction may contribute, in part, to mechanisms involved in deficient decidual angiogenesis after perigestational alcohol consumption in mouse.
Fil: Ventureira, Martín Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
Fil: Sobarzo, Cristian Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
Fil: Argandoña, Felipe. Universidad de Chile; Chile
Fil: Palomino, Wilder A.. Universidad de Chile; Chile
Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Cebral, Elisa. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina - Materia
-
angiogenesis
decidua
uterine NK
alcohol - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/96221
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Decidual vascularization during organogenesis after perigestational alcohol ingestionVentureira, Martín RicardoSobarzo, Cristian MarceloArgandoña, FelipePalomino, Wilder A.Barbeito, Claudio GustavoCebral, Elisaangiogenesisdeciduauterine NKalcoholhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Perigestational alcohol consumption up to early organogenesis can produce abnormal maternal vascularization via altered decidual VEGF/receptor expression. CF-1 female mice were administered with 10% ethanol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received water without ethanol. Treated females had reduced frequency of implantation sites with expanded vascular lumen (P<0.05), a-SMA-immunoreactive spiral arteries in proximal mesometrial decidua, reduced PCNApositive endothelial cells (P<0.01) and diminished uterine NK cell numbers (P<0.05) in proximal decidua compared to controls. The VEGF expression (laser capture microscopy, RT-PCR, western blot and immunohistochemistry) was reduced in decidual tissue after perigestational alcohol consumption (P<0.05). The uNK-DBA+ cells of treated females had reduced VEGF immunoexpression compared to controls (P<0.01). Very low decidual and endothelial cell KDR immunoreactivity and reduced decidual gene and protein KDR expression was found in treated females compared to controls (P<0.001). Instead, strong FLT-1 immunoexpression was detected in decidual and uNK cells (P<0.05) in the proximal decidua from treated females compared to controls. In conclusion, perigestational alcohol ingestion induces the reduction of lumen expansion of spiral arteries, concomitant with reduced endothelial cell proliferation and uNK cell population, and uncompleted remodeling of the artery smooth muscle. These effects were supported by low decidual VEGF and KDR gene and protein expression and increased FLT-1 expression, suggesting that VEGF and KDR reduction may contribute, in part, to mechanisms involved in deficient decidual angiogenesis after perigestational alcohol consumption in mouse.Fil: Ventureira, Martín Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaFil: Sobarzo, Cristian Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Argandoña, Felipe. Universidad de Chile; ChileFil: Palomino, Wilder A.. Universidad de Chile; ChileFil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Cebral, Elisa. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; ArgentinaBioScientifica2018-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96221Ventureira, Martín Ricardo; Sobarzo, Cristian Marcelo; Argandoña, Felipe; Palomino, Wilder A.; Barbeito, Claudio Gustavo; et al.; Decidual vascularization during organogenesis after perigestational alcohol ingestion; BioScientifica; Reproduction; 158; 1; 12-2018; 109-1221470-1626CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1530/REP-18-0230info:eu-repo/semantics/altIdentifier/url/rep.bioscientifica.com/view/journals/rep/158/1/REP-18-0230.xmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:35Zoai:ri.conicet.gov.ar:11336/96221instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:35.672CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Decidual vascularization during organogenesis after perigestational alcohol ingestion |
title |
Decidual vascularization during organogenesis after perigestational alcohol ingestion |
spellingShingle |
Decidual vascularization during organogenesis after perigestational alcohol ingestion Ventureira, Martín Ricardo angiogenesis decidua uterine NK alcohol |
title_short |
Decidual vascularization during organogenesis after perigestational alcohol ingestion |
title_full |
Decidual vascularization during organogenesis after perigestational alcohol ingestion |
title_fullStr |
Decidual vascularization during organogenesis after perigestational alcohol ingestion |
title_full_unstemmed |
Decidual vascularization during organogenesis after perigestational alcohol ingestion |
title_sort |
Decidual vascularization during organogenesis after perigestational alcohol ingestion |
dc.creator.none.fl_str_mv |
Ventureira, Martín Ricardo Sobarzo, Cristian Marcelo Argandoña, Felipe Palomino, Wilder A. Barbeito, Claudio Gustavo Cebral, Elisa |
author |
Ventureira, Martín Ricardo |
author_facet |
Ventureira, Martín Ricardo Sobarzo, Cristian Marcelo Argandoña, Felipe Palomino, Wilder A. Barbeito, Claudio Gustavo Cebral, Elisa |
author_role |
author |
author2 |
Sobarzo, Cristian Marcelo Argandoña, Felipe Palomino, Wilder A. Barbeito, Claudio Gustavo Cebral, Elisa |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
angiogenesis decidua uterine NK alcohol |
topic |
angiogenesis decidua uterine NK alcohol |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Perigestational alcohol consumption up to early organogenesis can produce abnormal maternal vascularization via altered decidual VEGF/receptor expression. CF-1 female mice were administered with 10% ethanol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received water without ethanol. Treated females had reduced frequency of implantation sites with expanded vascular lumen (P<0.05), a-SMA-immunoreactive spiral arteries in proximal mesometrial decidua, reduced PCNApositive endothelial cells (P<0.01) and diminished uterine NK cell numbers (P<0.05) in proximal decidua compared to controls. The VEGF expression (laser capture microscopy, RT-PCR, western blot and immunohistochemistry) was reduced in decidual tissue after perigestational alcohol consumption (P<0.05). The uNK-DBA+ cells of treated females had reduced VEGF immunoexpression compared to controls (P<0.01). Very low decidual and endothelial cell KDR immunoreactivity and reduced decidual gene and protein KDR expression was found in treated females compared to controls (P<0.001). Instead, strong FLT-1 immunoexpression was detected in decidual and uNK cells (P<0.05) in the proximal decidua from treated females compared to controls. In conclusion, perigestational alcohol ingestion induces the reduction of lumen expansion of spiral arteries, concomitant with reduced endothelial cell proliferation and uNK cell population, and uncompleted remodeling of the artery smooth muscle. These effects were supported by low decidual VEGF and KDR gene and protein expression and increased FLT-1 expression, suggesting that VEGF and KDR reduction may contribute, in part, to mechanisms involved in deficient decidual angiogenesis after perigestational alcohol consumption in mouse. Fil: Ventureira, Martín Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina Fil: Sobarzo, Cristian Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina Fil: Argandoña, Felipe. Universidad de Chile; Chile Fil: Palomino, Wilder A.. Universidad de Chile; Chile Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Cebral, Elisa. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina |
description |
Perigestational alcohol consumption up to early organogenesis can produce abnormal maternal vascularization via altered decidual VEGF/receptor expression. CF-1 female mice were administered with 10% ethanol in drinking water for 17 days prior to and up to day 10 of gestation. Control females received water without ethanol. Treated females had reduced frequency of implantation sites with expanded vascular lumen (P<0.05), a-SMA-immunoreactive spiral arteries in proximal mesometrial decidua, reduced PCNApositive endothelial cells (P<0.01) and diminished uterine NK cell numbers (P<0.05) in proximal decidua compared to controls. The VEGF expression (laser capture microscopy, RT-PCR, western blot and immunohistochemistry) was reduced in decidual tissue after perigestational alcohol consumption (P<0.05). The uNK-DBA+ cells of treated females had reduced VEGF immunoexpression compared to controls (P<0.01). Very low decidual and endothelial cell KDR immunoreactivity and reduced decidual gene and protein KDR expression was found in treated females compared to controls (P<0.001). Instead, strong FLT-1 immunoexpression was detected in decidual and uNK cells (P<0.05) in the proximal decidua from treated females compared to controls. In conclusion, perigestational alcohol ingestion induces the reduction of lumen expansion of spiral arteries, concomitant with reduced endothelial cell proliferation and uNK cell population, and uncompleted remodeling of the artery smooth muscle. These effects were supported by low decidual VEGF and KDR gene and protein expression and increased FLT-1 expression, suggesting that VEGF and KDR reduction may contribute, in part, to mechanisms involved in deficient decidual angiogenesis after perigestational alcohol consumption in mouse. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/96221 Ventureira, Martín Ricardo; Sobarzo, Cristian Marcelo; Argandoña, Felipe; Palomino, Wilder A.; Barbeito, Claudio Gustavo; et al.; Decidual vascularization during organogenesis after perigestational alcohol ingestion; BioScientifica; Reproduction; 158; 1; 12-2018; 109-122 1470-1626 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/96221 |
identifier_str_mv |
Ventureira, Martín Ricardo; Sobarzo, Cristian Marcelo; Argandoña, Felipe; Palomino, Wilder A.; Barbeito, Claudio Gustavo; et al.; Decidual vascularization during organogenesis after perigestational alcohol ingestion; BioScientifica; Reproduction; 158; 1; 12-2018; 109-122 1470-1626 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1530/REP-18-0230 info:eu-repo/semantics/altIdentifier/url/rep.bioscientifica.com/view/journals/rep/158/1/REP-18-0230.xml |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
BioScientifica |
publisher.none.fl_str_mv |
BioScientifica |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613341221224448 |
score |
13.070432 |