Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage

Autores
Brosens, Jan J.; Bennett, Phillip R.; Abrahams, Vikki M.; Ramhorst, Rosanna Elizabeth; Coomarasamy, Arri; Quenby, Siobhan; Lucas, Emma S.; McCoy, Rajiv C.
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Compared to most mammals, human pregnancy is unusual in that it involves chromosomally diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate integration of fetal and maternal cells at the uteroplacental interface. Not surprisingly, pregnancy often falters in early gestation. Whether these losses result in clinical miscarriages depends on the origins and impacts of chromosomal errors on fetal development and the ability of the decidualizing endometrium to engage in embryo biosensing and selection. Aneuploidy originating in oocytes during meiosis drives the age-related risk of miscarriage. By contrast, the frequency of endometrial cycles with an impaired decidual response may account for the stepwise increase in miscarriage rates with each pregnancy loss independently of maternal age. Additional physiological mechanisms operate in early gestation to ensure that most failing pregnancies are lost before vascular maternal-fetal connections are established by the end of the first trimester. Here, we summarise how investigations into the mechanisms that cause miscarriage led to new insights into the processes that govern maternal selection of human embryos in early gestation.
Fil: Brosens, Jan J.. University Hospital Coventry; Reino Unido. University of Warwick; Reino Unido
Fil: Bennett, Phillip R.. Imperial College London; Reino Unido
Fil: Abrahams, Vikki M.. University of Yale; Estados Unidos
Fil: Ramhorst, Rosanna Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Coomarasamy, Arri. The University Of Birmingham (tub);
Fil: Quenby, Siobhan. University of Warwick; Reino Unido. University Hospital Coventry; Reino Unido
Fil: Lucas, Emma S.. University of Warwick; Reino Unido
Fil: McCoy, Rajiv C.. University Johns Hopkins; Estados Unidos
Materia
ANEUPLOIDY
DECIDUALIZATION
EMBRYO
ENDOMETRIUM
MISCARRIAGE
PLACENTA
SELECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/212494
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/212494
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Maternal selection of human embryos in early gestation: Insights from recurrent miscarriageBrosens, Jan J.Bennett, Phillip R.Abrahams, Vikki M.Ramhorst, Rosanna ElizabethCoomarasamy, ArriQuenby, SiobhanLucas, Emma S.McCoy, Rajiv C.ANEUPLOIDYDECIDUALIZATIONEMBRYOENDOMETRIUMMISCARRIAGEPLACENTASELECTIONhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Compared to most mammals, human pregnancy is unusual in that it involves chromosomally diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate integration of fetal and maternal cells at the uteroplacental interface. Not surprisingly, pregnancy often falters in early gestation. Whether these losses result in clinical miscarriages depends on the origins and impacts of chromosomal errors on fetal development and the ability of the decidualizing endometrium to engage in embryo biosensing and selection. Aneuploidy originating in oocytes during meiosis drives the age-related risk of miscarriage. By contrast, the frequency of endometrial cycles with an impaired decidual response may account for the stepwise increase in miscarriage rates with each pregnancy loss independently of maternal age. Additional physiological mechanisms operate in early gestation to ensure that most failing pregnancies are lost before vascular maternal-fetal connections are established by the end of the first trimester. Here, we summarise how investigations into the mechanisms that cause miscarriage led to new insights into the processes that govern maternal selection of human embryos in early gestation.Fil: Brosens, Jan J.. University Hospital Coventry; Reino Unido. University of Warwick; Reino UnidoFil: Bennett, Phillip R.. Imperial College London; Reino UnidoFil: Abrahams, Vikki M.. University of Yale; Estados UnidosFil: Ramhorst, Rosanna Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Coomarasamy, Arri. The University Of Birmingham (tub);Fil: Quenby, Siobhan. University of Warwick; Reino Unido. University Hospital Coventry; Reino UnidoFil: Lucas, Emma S.. University of Warwick; Reino UnidoFil: McCoy, Rajiv C.. University Johns Hopkins; Estados UnidosAcademic Press Ltd - Elsevier Science Ltd2022-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/212494Brosens, Jan J.; Bennett, Phillip R.; Abrahams, Vikki M.; Ramhorst, Rosanna Elizabeth; Coomarasamy, Arri; et al.; Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage; Academic Press Ltd - Elsevier Science Ltd; Seminars In Cell & Developmental Biology; 131; 11-2022; 14-241084-9521CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1084952122000155info:eu-repo/semantics/altIdentifier/doi/10.1016/j.semcdb.2022.01.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:27Zoai:ri.conicet.gov.ar:11336/212494instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:27.527CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage
title Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage
spellingShingle Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage
Brosens, Jan J.
ANEUPLOIDY
DECIDUALIZATION
EMBRYO
ENDOMETRIUM
MISCARRIAGE
PLACENTA
SELECTION
title_short Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage
title_full Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage
title_fullStr Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage
title_full_unstemmed Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage
title_sort Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage
dc.creator.none.fl_str_mv Brosens, Jan J.
Bennett, Phillip R.
Abrahams, Vikki M.
Ramhorst, Rosanna Elizabeth
Coomarasamy, Arri
Quenby, Siobhan
Lucas, Emma S.
McCoy, Rajiv C.
author Brosens, Jan J.
author_facet Brosens, Jan J.
Bennett, Phillip R.
Abrahams, Vikki M.
Ramhorst, Rosanna Elizabeth
Coomarasamy, Arri
Quenby, Siobhan
Lucas, Emma S.
McCoy, Rajiv C.
author_role author
author2 Bennett, Phillip R.
Abrahams, Vikki M.
Ramhorst, Rosanna Elizabeth
Coomarasamy, Arri
Quenby, Siobhan
Lucas, Emma S.
McCoy, Rajiv C.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANEUPLOIDY
DECIDUALIZATION
EMBRYO
ENDOMETRIUM
MISCARRIAGE
PLACENTA
SELECTION
topic ANEUPLOIDY
DECIDUALIZATION
EMBRYO
ENDOMETRIUM
MISCARRIAGE
PLACENTA
SELECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Compared to most mammals, human pregnancy is unusual in that it involves chromosomally diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate integration of fetal and maternal cells at the uteroplacental interface. Not surprisingly, pregnancy often falters in early gestation. Whether these losses result in clinical miscarriages depends on the origins and impacts of chromosomal errors on fetal development and the ability of the decidualizing endometrium to engage in embryo biosensing and selection. Aneuploidy originating in oocytes during meiosis drives the age-related risk of miscarriage. By contrast, the frequency of endometrial cycles with an impaired decidual response may account for the stepwise increase in miscarriage rates with each pregnancy loss independently of maternal age. Additional physiological mechanisms operate in early gestation to ensure that most failing pregnancies are lost before vascular maternal-fetal connections are established by the end of the first trimester. Here, we summarise how investigations into the mechanisms that cause miscarriage led to new insights into the processes that govern maternal selection of human embryos in early gestation.
Fil: Brosens, Jan J.. University Hospital Coventry; Reino Unido. University of Warwick; Reino Unido
Fil: Bennett, Phillip R.. Imperial College London; Reino Unido
Fil: Abrahams, Vikki M.. University of Yale; Estados Unidos
Fil: Ramhorst, Rosanna Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Coomarasamy, Arri. The University Of Birmingham (tub);
Fil: Quenby, Siobhan. University of Warwick; Reino Unido. University Hospital Coventry; Reino Unido
Fil: Lucas, Emma S.. University of Warwick; Reino Unido
Fil: McCoy, Rajiv C.. University Johns Hopkins; Estados Unidos
description Compared to most mammals, human pregnancy is unusual in that it involves chromosomally diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate integration of fetal and maternal cells at the uteroplacental interface. Not surprisingly, pregnancy often falters in early gestation. Whether these losses result in clinical miscarriages depends on the origins and impacts of chromosomal errors on fetal development and the ability of the decidualizing endometrium to engage in embryo biosensing and selection. Aneuploidy originating in oocytes during meiosis drives the age-related risk of miscarriage. By contrast, the frequency of endometrial cycles with an impaired decidual response may account for the stepwise increase in miscarriage rates with each pregnancy loss independently of maternal age. Additional physiological mechanisms operate in early gestation to ensure that most failing pregnancies are lost before vascular maternal-fetal connections are established by the end of the first trimester. Here, we summarise how investigations into the mechanisms that cause miscarriage led to new insights into the processes that govern maternal selection of human embryos in early gestation.
publishDate 2022
dc.date.none.fl_str_mv 2022-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/212494
Brosens, Jan J.; Bennett, Phillip R.; Abrahams, Vikki M.; Ramhorst, Rosanna Elizabeth; Coomarasamy, Arri; et al.; Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage; Academic Press Ltd - Elsevier Science Ltd; Seminars In Cell & Developmental Biology; 131; 11-2022; 14-24
1084-9521
CONICET Digital
CONICET
url http://hdl.handle.net/11336/212494
identifier_str_mv Brosens, Jan J.; Bennett, Phillip R.; Abrahams, Vikki M.; Ramhorst, Rosanna Elizabeth; Coomarasamy, Arri; et al.; Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage; Academic Press Ltd - Elsevier Science Ltd; Seminars In Cell & Developmental Biology; 131; 11-2022; 14-24
1084-9521
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1084952122000155
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.semcdb.2022.01.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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