Association between a Maternal History of Miscarriages and Birth Defects

Autores
Campaña, Hebe Edith; Rittler, Mónica; Gili, Juan A.; Poletta, Fernando A.; Pawluk, Mariela S.; Giménez, Lucas G.; Cosentino, Viviana R.; Castilla, Eduardo E.; López Camelo, Jorge Santiago
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión enviada
Descripción
Some studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular it examined whether the risk depended on the number of losses, and it did suggest the existence of specific factors for each BD/miscarriage association observed. Methods: The study relied on the Latin American Collaborative Study on Congenital Malformations (ECLAMC) database registries including 26,906 live and stillborn infants with one out of 19 selected isolated BDs and 93,853 normal controls. Infants born to primigravid mothers were excluded from the present study. Demographic and reproductive variables were compared between control mothers With and Without previous miscarriages. The number, frequency, and distribution of miscarriages were observed for each BD and controls. A conditional logistic regression was computed to evaluate the miscarriage risk for each BD. Results: Control mothers with previous miscarriages were older, had had more pregnancies, and were less educated. Three risk patterns of miscarriages were observed: a very high risk of miscarriages associated with gastroschisis, omphalocele, and talipes; only one miscarriage associated with spina bifida, and two or more miscarriages associated with hypospadias. Conclusion: These three patterns suggest that different factors underly each BD/miscarriage association: infertility for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the much debated trophoblastic cell residue theory could not be discarded.
Materia
Biología Celular, Microbiología
miscarriage
spina bifida
talipes
club foot
Hipospadias
Hernia Umbilical
Gastrosquisis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-nd/4.0/
Repositorio
CIC Digital (CICBA)
Institución
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
OAI Identificador
oai:digital.cic.gba.gob.ar:11746/5783

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oai_identifier_str oai:digital.cic.gba.gob.ar:11746/5783
network_acronym_str CICBA
repository_id_str 9441
network_name_str CIC Digital (CICBA)
spelling Association between a Maternal History of Miscarriages and Birth DefectsCampaña, Hebe EdithRittler, MónicaGili, Juan A.Poletta, Fernando A.Pawluk, Mariela S.Giménez, Lucas G.Cosentino, Viviana R.Castilla, Eduardo E.López Camelo, Jorge SantiagoBiología Celular, Microbiologíamiscarriagespina bifidatalipesclub footHipospadiasHernia UmbilicalGastrosquisisSome studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular it examined whether the risk depended on the number of losses, and it did suggest the existence of specific factors for each BD/miscarriage association observed. Methods: The study relied on the Latin American Collaborative Study on Congenital Malformations (ECLAMC) database registries including 26,906 live and stillborn infants with one out of 19 selected isolated BDs and 93,853 normal controls. Infants born to primigravid mothers were excluded from the present study. Demographic and reproductive variables were compared between control mothers With and Without previous miscarriages. The number, frequency, and distribution of miscarriages were observed for each BD and controls. A conditional logistic regression was computed to evaluate the miscarriage risk for each BD. Results: Control mothers with previous miscarriages were older, had had more pregnancies, and were less educated. Three risk patterns of miscarriages were observed: a very high risk of miscarriages associated with gastroschisis, omphalocele, and talipes; only one miscarriage associated with spina bifida, and two or more miscarriages associated with hypospadias. Conclusion: These three patterns suggest that different factors underly each BD/miscarriage association: infertility for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the much debated trophoblastic cell residue theory could not be discarded.John Wiley & Sons2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/5783enginfo:eu-repo/semantics/altIdentifier/doi/10.1002/bdra.23563info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-09-29T13:40:05Zoai:digital.cic.gba.gob.ar:11746/5783Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-09-29 13:40:05.326CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse
dc.title.none.fl_str_mv Association between a Maternal History of Miscarriages and Birth Defects
title Association between a Maternal History of Miscarriages and Birth Defects
spellingShingle Association between a Maternal History of Miscarriages and Birth Defects
Campaña, Hebe Edith
Biología Celular, Microbiología
miscarriage
spina bifida
talipes
club foot
Hipospadias
Hernia Umbilical
Gastrosquisis
title_short Association between a Maternal History of Miscarriages and Birth Defects
title_full Association between a Maternal History of Miscarriages and Birth Defects
title_fullStr Association between a Maternal History of Miscarriages and Birth Defects
title_full_unstemmed Association between a Maternal History of Miscarriages and Birth Defects
title_sort Association between a Maternal History of Miscarriages and Birth Defects
dc.creator.none.fl_str_mv Campaña, Hebe Edith
Rittler, Mónica
Gili, Juan A.
Poletta, Fernando A.
Pawluk, Mariela S.
Giménez, Lucas G.
Cosentino, Viviana R.
Castilla, Eduardo E.
López Camelo, Jorge Santiago
author Campaña, Hebe Edith
author_facet Campaña, Hebe Edith
Rittler, Mónica
Gili, Juan A.
Poletta, Fernando A.
Pawluk, Mariela S.
Giménez, Lucas G.
Cosentino, Viviana R.
Castilla, Eduardo E.
López Camelo, Jorge Santiago
author_role author
author2 Rittler, Mónica
Gili, Juan A.
Poletta, Fernando A.
Pawluk, Mariela S.
Giménez, Lucas G.
Cosentino, Viviana R.
Castilla, Eduardo E.
López Camelo, Jorge Santiago
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biología Celular, Microbiología
miscarriage
spina bifida
talipes
club foot
Hipospadias
Hernia Umbilical
Gastrosquisis
topic Biología Celular, Microbiología
miscarriage
spina bifida
talipes
club foot
Hipospadias
Hernia Umbilical
Gastrosquisis
dc.description.none.fl_txt_mv Some studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular it examined whether the risk depended on the number of losses, and it did suggest the existence of specific factors for each BD/miscarriage association observed. Methods: The study relied on the Latin American Collaborative Study on Congenital Malformations (ECLAMC) database registries including 26,906 live and stillborn infants with one out of 19 selected isolated BDs and 93,853 normal controls. Infants born to primigravid mothers were excluded from the present study. Demographic and reproductive variables were compared between control mothers With and Without previous miscarriages. The number, frequency, and distribution of miscarriages were observed for each BD and controls. A conditional logistic regression was computed to evaluate the miscarriage risk for each BD. Results: Control mothers with previous miscarriages were older, had had more pregnancies, and were less educated. Three risk patterns of miscarriages were observed: a very high risk of miscarriages associated with gastroschisis, omphalocele, and talipes; only one miscarriage associated with spina bifida, and two or more miscarriages associated with hypospadias. Conclusion: These three patterns suggest that different factors underly each BD/miscarriage association: infertility for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the much debated trophoblastic cell residue theory could not be discarded.
description Some studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular it examined whether the risk depended on the number of losses, and it did suggest the existence of specific factors for each BD/miscarriage association observed. Methods: The study relied on the Latin American Collaborative Study on Congenital Malformations (ECLAMC) database registries including 26,906 live and stillborn infants with one out of 19 selected isolated BDs and 93,853 normal controls. Infants born to primigravid mothers were excluded from the present study. Demographic and reproductive variables were compared between control mothers With and Without previous miscarriages. The number, frequency, and distribution of miscarriages were observed for each BD and controls. A conditional logistic regression was computed to evaluate the miscarriage risk for each BD. Results: Control mothers with previous miscarriages were older, had had more pregnancies, and were less educated. Three risk patterns of miscarriages were observed: a very high risk of miscarriages associated with gastroschisis, omphalocele, and talipes; only one miscarriage associated with spina bifida, and two or more miscarriages associated with hypospadias. Conclusion: These three patterns suggest that different factors underly each BD/miscarriage association: infertility for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the much debated trophoblastic cell residue theory could not be discarded.
publishDate 2017
dc.date.none.fl_str_mv 2017-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://digital.cic.gba.gob.ar/handle/11746/5783
url https://digital.cic.gba.gob.ar/handle/11746/5783
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/bdra.23563
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:CIC Digital (CICBA)
instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
instacron:CICBA
reponame_str CIC Digital (CICBA)
collection CIC Digital (CICBA)
instname_str Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
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institution CICBA
repository.name.fl_str_mv CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
repository.mail.fl_str_mv marisa.degiusti@sedici.unlp.edu.ar
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