Association between a Maternal History of Miscarriages and Birth Defects
- Autores
- Campaña, Hebe Edith; Rittler, Mónica; Gili, Juan A.; Poletta, Fernando A.; Pawluk, Mariela S.; Giménez, Lucas G.; Cosentino, Viviana R.; Castilla, Eduardo E.; López Camelo, Jorge Santiago
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión enviada
- Descripción
- Some studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular it examined whether the risk depended on the number of losses, and it did suggest the existence of specific factors for each BD/miscarriage association observed. Methods: The study relied on the Latin American Collaborative Study on Congenital Malformations (ECLAMC) database registries including 26,906 live and stillborn infants with one out of 19 selected isolated BDs and 93,853 normal controls. Infants born to primigravid mothers were excluded from the present study. Demographic and reproductive variables were compared between control mothers With and Without previous miscarriages. The number, frequency, and distribution of miscarriages were observed for each BD and controls. A conditional logistic regression was computed to evaluate the miscarriage risk for each BD. Results: Control mothers with previous miscarriages were older, had had more pregnancies, and were less educated. Three risk patterns of miscarriages were observed: a very high risk of miscarriages associated with gastroschisis, omphalocele, and talipes; only one miscarriage associated with spina bifida, and two or more miscarriages associated with hypospadias. Conclusion: These three patterns suggest that different factors underly each BD/miscarriage association: infertility for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the much debated trophoblastic cell residue theory could not be discarded.
- Materia
-
Biología Celular, Microbiología
miscarriage
spina bifida
talipes
club foot
Hipospadias
Hernia Umbilical
Gastrosquisis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-nd/4.0/
- Repositorio
- Institución
- Comisión de Investigaciones Científicas de la Provincia de Buenos Aires
- OAI Identificador
- oai:digital.cic.gba.gob.ar:11746/5783
Ver los metadatos del registro completo
id |
CICBA_6d90b0acd01a79f15414b030ff911dec |
---|---|
oai_identifier_str |
oai:digital.cic.gba.gob.ar:11746/5783 |
network_acronym_str |
CICBA |
repository_id_str |
9441 |
network_name_str |
CIC Digital (CICBA) |
spelling |
Association between a Maternal History of Miscarriages and Birth DefectsCampaña, Hebe EdithRittler, MónicaGili, Juan A.Poletta, Fernando A.Pawluk, Mariela S.Giménez, Lucas G.Cosentino, Viviana R.Castilla, Eduardo E.López Camelo, Jorge SantiagoBiología Celular, Microbiologíamiscarriagespina bifidatalipesclub footHipospadiasHernia UmbilicalGastrosquisisSome studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular it examined whether the risk depended on the number of losses, and it did suggest the existence of specific factors for each BD/miscarriage association observed. Methods: The study relied on the Latin American Collaborative Study on Congenital Malformations (ECLAMC) database registries including 26,906 live and stillborn infants with one out of 19 selected isolated BDs and 93,853 normal controls. Infants born to primigravid mothers were excluded from the present study. Demographic and reproductive variables were compared between control mothers With and Without previous miscarriages. The number, frequency, and distribution of miscarriages were observed for each BD and controls. A conditional logistic regression was computed to evaluate the miscarriage risk for each BD. Results: Control mothers with previous miscarriages were older, had had more pregnancies, and were less educated. Three risk patterns of miscarriages were observed: a very high risk of miscarriages associated with gastroschisis, omphalocele, and talipes; only one miscarriage associated with spina bifida, and two or more miscarriages associated with hypospadias. Conclusion: These three patterns suggest that different factors underly each BD/miscarriage association: infertility for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the much debated trophoblastic cell residue theory could not be discarded.John Wiley & Sons2017-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttps://digital.cic.gba.gob.ar/handle/11746/5783enginfo:eu-repo/semantics/altIdentifier/doi/10.1002/bdra.23563info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/reponame:CIC Digital (CICBA)instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Airesinstacron:CICBA2025-09-29T13:40:05Zoai:digital.cic.gba.gob.ar:11746/5783Institucionalhttp://digital.cic.gba.gob.arOrganismo científico-tecnológicoNo correspondehttp://digital.cic.gba.gob.ar/oai/snrdmarisa.degiusti@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:94412025-09-29 13:40:05.326CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Airesfalse |
dc.title.none.fl_str_mv |
Association between a Maternal History of Miscarriages and Birth Defects |
title |
Association between a Maternal History of Miscarriages and Birth Defects |
spellingShingle |
Association between a Maternal History of Miscarriages and Birth Defects Campaña, Hebe Edith Biología Celular, Microbiología miscarriage spina bifida talipes club foot Hipospadias Hernia Umbilical Gastrosquisis |
title_short |
Association between a Maternal History of Miscarriages and Birth Defects |
title_full |
Association between a Maternal History of Miscarriages and Birth Defects |
title_fullStr |
Association between a Maternal History of Miscarriages and Birth Defects |
title_full_unstemmed |
Association between a Maternal History of Miscarriages and Birth Defects |
title_sort |
Association between a Maternal History of Miscarriages and Birth Defects |
dc.creator.none.fl_str_mv |
Campaña, Hebe Edith Rittler, Mónica Gili, Juan A. Poletta, Fernando A. Pawluk, Mariela S. Giménez, Lucas G. Cosentino, Viviana R. Castilla, Eduardo E. López Camelo, Jorge Santiago |
author |
Campaña, Hebe Edith |
author_facet |
Campaña, Hebe Edith Rittler, Mónica Gili, Juan A. Poletta, Fernando A. Pawluk, Mariela S. Giménez, Lucas G. Cosentino, Viviana R. Castilla, Eduardo E. López Camelo, Jorge Santiago |
author_role |
author |
author2 |
Rittler, Mónica Gili, Juan A. Poletta, Fernando A. Pawluk, Mariela S. Giménez, Lucas G. Cosentino, Viviana R. Castilla, Eduardo E. López Camelo, Jorge Santiago |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Biología Celular, Microbiología miscarriage spina bifida talipes club foot Hipospadias Hernia Umbilical Gastrosquisis |
topic |
Biología Celular, Microbiología miscarriage spina bifida talipes club foot Hipospadias Hernia Umbilical Gastrosquisis |
dc.description.none.fl_txt_mv |
Some studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular it examined whether the risk depended on the number of losses, and it did suggest the existence of specific factors for each BD/miscarriage association observed. Methods: The study relied on the Latin American Collaborative Study on Congenital Malformations (ECLAMC) database registries including 26,906 live and stillborn infants with one out of 19 selected isolated BDs and 93,853 normal controls. Infants born to primigravid mothers were excluded from the present study. Demographic and reproductive variables were compared between control mothers With and Without previous miscarriages. The number, frequency, and distribution of miscarriages were observed for each BD and controls. A conditional logistic regression was computed to evaluate the miscarriage risk for each BD. Results: Control mothers with previous miscarriages were older, had had more pregnancies, and were less educated. Three risk patterns of miscarriages were observed: a very high risk of miscarriages associated with gastroschisis, omphalocele, and talipes; only one miscarriage associated with spina bifida, and two or more miscarriages associated with hypospadias. Conclusion: These three patterns suggest that different factors underly each BD/miscarriage association: infertility for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the much debated trophoblastic cell residue theory could not be discarded. |
description |
Some studies, mainly in the older literature, observed a significant association between miscarriages and birth defects (BDs) occurring in the same sibship. However, few studies examined the BD/miscarriage relationship in depth. In addition nothing has been added to the underlying mechanisms possibly linking both events. The purpose of this work was to identify specific BDs associated with maternal miscarriages. In particular it examined whether the risk depended on the number of losses, and it did suggest the existence of specific factors for each BD/miscarriage association observed. Methods: The study relied on the Latin American Collaborative Study on Congenital Malformations (ECLAMC) database registries including 26,906 live and stillborn infants with one out of 19 selected isolated BDs and 93,853 normal controls. Infants born to primigravid mothers were excluded from the present study. Demographic and reproductive variables were compared between control mothers With and Without previous miscarriages. The number, frequency, and distribution of miscarriages were observed for each BD and controls. A conditional logistic regression was computed to evaluate the miscarriage risk for each BD. Results: Control mothers with previous miscarriages were older, had had more pregnancies, and were less educated. Three risk patterns of miscarriages were observed: a very high risk of miscarriages associated with gastroschisis, omphalocele, and talipes; only one miscarriage associated with spina bifida, and two or more miscarriages associated with hypospadias. Conclusion: These three patterns suggest that different factors underly each BD/miscarriage association: infertility for hypospadias, vascular disruption for gastroschisis and talipes, while for spina bifida, the much debated trophoblastic cell residue theory could not be discarded. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/submittedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
submittedVersion |
dc.identifier.none.fl_str_mv |
https://digital.cic.gba.gob.ar/handle/11746/5783 |
url |
https://digital.cic.gba.gob.ar/handle/11746/5783 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1002/bdra.23563 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons |
publisher.none.fl_str_mv |
John Wiley & Sons |
dc.source.none.fl_str_mv |
reponame:CIC Digital (CICBA) instname:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires instacron:CICBA |
reponame_str |
CIC Digital (CICBA) |
collection |
CIC Digital (CICBA) |
instname_str |
Comisión de Investigaciones Científicas de la Provincia de Buenos Aires |
instacron_str |
CICBA |
institution |
CICBA |
repository.name.fl_str_mv |
CIC Digital (CICBA) - Comisión de Investigaciones Científicas de la Provincia de Buenos Aires |
repository.mail.fl_str_mv |
marisa.degiusti@sedici.unlp.edu.ar |
_version_ |
1844618598809600000 |
score |
13.070432 |