Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina

Autores
Costamagna, D.; Gaggiotti, M.; Signorini Porchietto, Marcelo Lisandro
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A quantitative risk assessment for exposure to aflatoxin M1 (AFM1) related to the consumption of milk and traditional dairy products of Argentina was developed. The frequency and concentration of AFM1 was modelled at various stages through the milk processes, considering Argentinean practices. Concentration of AFM1 (0.046 μg/l, 95%CI = 0.002?0.264 μg/l) in raw milk was estimated. The AFM1 concentration in milk was sensitive to the carry-over rate (r = 0.80), and milk yield in the first third of lactation during the spring?summer season (r = 0.11). AFB1 levels in silage (r = 0.22), pasture during the spring?summer season (r = 0.11), concentrate (r = 0.08), and cotton seed (r = 0.05) were the factors most correlated with AFM1 concentrations. Although the results showed that MoE values for the mean and median exposure to AFM1 were < 10,000 in infants, toddlers, and other children, the additional cancer risk due to exposure to AFM1 in infants, toddlers, and other children was 0.007, 0.005, and 0.0009 additional cases per year per 100,000 individuals, respectively, which indicates no health concern. In addition, the percentages of the population exceeding HI values (HI > 1) for exposure to AFM1 for infants, toddlers, and other children were 45%, 49.1%, and 40.6%, respectively. Under this scenario, the most susceptible population at risk was children < 10 years old; therefore, it is necessary to establish measures to prevent contamination of AFM1 in milk and milk products.
Fil: Costamagna, D.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
Fil: Gaggiotti, M.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
Fil: Signorini Porchietto, Marcelo Lisandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
Materia
AFLATOXIN M1
EXPOSURE ASSESSMENT
MILK AND DAIRY PRODUCTS
RISK CHARACTERIZATION; MARGIN OF EXPOSURE (MOE)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/184515
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/184515
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in ArgentinaCostamagna, D.Gaggiotti, M.Signorini Porchietto, Marcelo LisandroAFLATOXIN M1EXPOSURE ASSESSMENTMILK AND DAIRY PRODUCTSRISK CHARACTERIZATION; MARGIN OF EXPOSURE (MOE)https://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4A quantitative risk assessment for exposure to aflatoxin M1 (AFM1) related to the consumption of milk and traditional dairy products of Argentina was developed. The frequency and concentration of AFM1 was modelled at various stages through the milk processes, considering Argentinean practices. Concentration of AFM1 (0.046 μg/l, 95%CI = 0.002?0.264 μg/l) in raw milk was estimated. The AFM1 concentration in milk was sensitive to the carry-over rate (r = 0.80), and milk yield in the first third of lactation during the spring?summer season (r = 0.11). AFB1 levels in silage (r = 0.22), pasture during the spring?summer season (r = 0.11), concentrate (r = 0.08), and cotton seed (r = 0.05) were the factors most correlated with AFM1 concentrations. Although the results showed that MoE values for the mean and median exposure to AFM1 were < 10,000 in infants, toddlers, and other children, the additional cancer risk due to exposure to AFM1 in infants, toddlers, and other children was 0.007, 0.005, and 0.0009 additional cases per year per 100,000 individuals, respectively, which indicates no health concern. In addition, the percentages of the population exceeding HI values (HI > 1) for exposure to AFM1 for infants, toddlers, and other children were 45%, 49.1%, and 40.6%, respectively. Under this scenario, the most susceptible population at risk was children < 10 years old; therefore, it is necessary to establish measures to prevent contamination of AFM1 in milk and milk products.Fil: Costamagna, D.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; ArgentinaFil: Gaggiotti, M.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; ArgentinaFil: Signorini Porchietto, Marcelo Lisandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; ArgentinaSpringer2021-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/184515Costamagna, D.; Gaggiotti, M.; Signorini Porchietto, Marcelo Lisandro; Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina; Springer; Mycotoxin Research; 37; 4; 11-2021; 315-3250178-78881867-1632CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s12550-021-00444-winfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s12550-021-00444-winfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:28Zoai:ri.conicet.gov.ar:11336/184515instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:28.87CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina
title Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina
spellingShingle Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina
Costamagna, D.
AFLATOXIN M1
EXPOSURE ASSESSMENT
MILK AND DAIRY PRODUCTS
RISK CHARACTERIZATION; MARGIN OF EXPOSURE (MOE)
title_short Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina
title_full Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina
title_fullStr Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina
title_full_unstemmed Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina
title_sort Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina
dc.creator.none.fl_str_mv Costamagna, D.
Gaggiotti, M.
Signorini Porchietto, Marcelo Lisandro
author Costamagna, D.
author_facet Costamagna, D.
Gaggiotti, M.
Signorini Porchietto, Marcelo Lisandro
author_role author
author2 Gaggiotti, M.
Signorini Porchietto, Marcelo Lisandro
author2_role author
author
dc.subject.none.fl_str_mv AFLATOXIN M1
EXPOSURE ASSESSMENT
MILK AND DAIRY PRODUCTS
RISK CHARACTERIZATION; MARGIN OF EXPOSURE (MOE)
topic AFLATOXIN M1
EXPOSURE ASSESSMENT
MILK AND DAIRY PRODUCTS
RISK CHARACTERIZATION; MARGIN OF EXPOSURE (MOE)
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv A quantitative risk assessment for exposure to aflatoxin M1 (AFM1) related to the consumption of milk and traditional dairy products of Argentina was developed. The frequency and concentration of AFM1 was modelled at various stages through the milk processes, considering Argentinean practices. Concentration of AFM1 (0.046 μg/l, 95%CI = 0.002?0.264 μg/l) in raw milk was estimated. The AFM1 concentration in milk was sensitive to the carry-over rate (r = 0.80), and milk yield in the first third of lactation during the spring?summer season (r = 0.11). AFB1 levels in silage (r = 0.22), pasture during the spring?summer season (r = 0.11), concentrate (r = 0.08), and cotton seed (r = 0.05) were the factors most correlated with AFM1 concentrations. Although the results showed that MoE values for the mean and median exposure to AFM1 were < 10,000 in infants, toddlers, and other children, the additional cancer risk due to exposure to AFM1 in infants, toddlers, and other children was 0.007, 0.005, and 0.0009 additional cases per year per 100,000 individuals, respectively, which indicates no health concern. In addition, the percentages of the population exceeding HI values (HI > 1) for exposure to AFM1 for infants, toddlers, and other children were 45%, 49.1%, and 40.6%, respectively. Under this scenario, the most susceptible population at risk was children < 10 years old; therefore, it is necessary to establish measures to prevent contamination of AFM1 in milk and milk products.
Fil: Costamagna, D.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
Fil: Gaggiotti, M.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
Fil: Signorini Porchietto, Marcelo Lisandro. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Investigacion de la Cadena Lactea. - Instituto Nacional de Tecnologia Agropecuaria. Centro Regional Santa Fe. Estacion Experimental Agropecuaria Rafaela. Instituto de Investigacion de la Cadena Lactea.; Argentina
description A quantitative risk assessment for exposure to aflatoxin M1 (AFM1) related to the consumption of milk and traditional dairy products of Argentina was developed. The frequency and concentration of AFM1 was modelled at various stages through the milk processes, considering Argentinean practices. Concentration of AFM1 (0.046 μg/l, 95%CI = 0.002?0.264 μg/l) in raw milk was estimated. The AFM1 concentration in milk was sensitive to the carry-over rate (r = 0.80), and milk yield in the first third of lactation during the spring?summer season (r = 0.11). AFB1 levels in silage (r = 0.22), pasture during the spring?summer season (r = 0.11), concentrate (r = 0.08), and cotton seed (r = 0.05) were the factors most correlated with AFM1 concentrations. Although the results showed that MoE values for the mean and median exposure to AFM1 were < 10,000 in infants, toddlers, and other children, the additional cancer risk due to exposure to AFM1 in infants, toddlers, and other children was 0.007, 0.005, and 0.0009 additional cases per year per 100,000 individuals, respectively, which indicates no health concern. In addition, the percentages of the population exceeding HI values (HI > 1) for exposure to AFM1 for infants, toddlers, and other children were 45%, 49.1%, and 40.6%, respectively. Under this scenario, the most susceptible population at risk was children < 10 years old; therefore, it is necessary to establish measures to prevent contamination of AFM1 in milk and milk products.
publishDate 2021
dc.date.none.fl_str_mv 2021-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/184515
Costamagna, D.; Gaggiotti, M.; Signorini Porchietto, Marcelo Lisandro; Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina; Springer; Mycotoxin Research; 37; 4; 11-2021; 315-325
0178-7888
1867-1632
CONICET Digital
CONICET
url http://hdl.handle.net/11336/184515
identifier_str_mv Costamagna, D.; Gaggiotti, M.; Signorini Porchietto, Marcelo Lisandro; Quantitative risk assessment for aflatoxin M1 associated with the consumption of milk and traditional dairy products in Argentina; Springer; Mycotoxin Research; 37; 4; 11-2021; 315-325
0178-7888
1867-1632
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s12550-021-00444-w
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s12550-021-00444-w
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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