Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.

Autores
Dietrich, Valeria; Szpilbarg, Natalia; Damiano, Alicia Ermelinda
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although the etiology of preeclampsia is unknown, accumulated evidence suggests that the expression of a variety of syncytiotrophoblast transporters is reduced or abnormal. Here, we have examined the expression of NHE-3 in preeclamptic placentas. We found that NHE-3 expression significantly decreased and its labeling was almost undetectable in the cytosol of syncytiotrophoblast cells. Even though the inductor mechanisms of NHE-3 decrease are not clear yet, we speculated that alterations in TNF-α and aldosterone levels observed in preeclampsia might be downregulating NHE-3 expression. Further studies are needed to define whether these alterations play a direct role either in the pathogenesis or in the adaptative response of preeclampsia.
Fil: Dietrich, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina;
Fil: Szpilbarg, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina;
Fil: Damiano, Alicia Ermelinda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina;
Materia
Preeclampsia
Nhe-3
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1915
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.Dietrich, ValeriaSzpilbarg, NataliaDamiano, Alicia ErmelindaPreeclampsiaNhe-3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Although the etiology of preeclampsia is unknown, accumulated evidence suggests that the expression of a variety of syncytiotrophoblast transporters is reduced or abnormal. Here, we have examined the expression of NHE-3 in preeclamptic placentas. We found that NHE-3 expression significantly decreased and its labeling was almost undetectable in the cytosol of syncytiotrophoblast cells. Even though the inductor mechanisms of NHE-3 decrease are not clear yet, we speculated that alterations in TNF-α and aldosterone levels observed in preeclampsia might be downregulating NHE-3 expression. Further studies are needed to define whether these alterations play a direct role either in the pathogenesis or in the adaptative response of preeclampsia.Fil: Dietrich, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina;Fil: Szpilbarg, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina;Fil: Damiano, Alicia Ermelinda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina;Elsevier2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1915Dietrich, Valeria; Szpilbarg, Natalia; Damiano, Alicia Ermelinda; Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.; Elsevier; Placenta; 34; 9; 9-2013; 828-8300143-4004enginfo:eu-repo/semantics/reference es info:eu-repo/semantics/reference/pmid/23810111info:eu-repo/semantics/altIdentifier/doi/doi:10.1016/j.placenta.2013.06.005info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/23810111info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:39:27Zoai:ri.conicet.gov.ar:11336/1915instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:39:27.329CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.
title Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.
spellingShingle Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.
Dietrich, Valeria
Preeclampsia
Nhe-3
title_short Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.
title_full Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.
title_fullStr Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.
title_full_unstemmed Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.
title_sort Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.
dc.creator.none.fl_str_mv Dietrich, Valeria
Szpilbarg, Natalia
Damiano, Alicia Ermelinda
author Dietrich, Valeria
author_facet Dietrich, Valeria
Szpilbarg, Natalia
Damiano, Alicia Ermelinda
author_role author
author2 Szpilbarg, Natalia
Damiano, Alicia Ermelinda
author2_role author
author
dc.subject.none.fl_str_mv Preeclampsia
Nhe-3
topic Preeclampsia
Nhe-3
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Although the etiology of preeclampsia is unknown, accumulated evidence suggests that the expression of a variety of syncytiotrophoblast transporters is reduced or abnormal. Here, we have examined the expression of NHE-3 in preeclamptic placentas. We found that NHE-3 expression significantly decreased and its labeling was almost undetectable in the cytosol of syncytiotrophoblast cells. Even though the inductor mechanisms of NHE-3 decrease are not clear yet, we speculated that alterations in TNF-α and aldosterone levels observed in preeclampsia might be downregulating NHE-3 expression. Further studies are needed to define whether these alterations play a direct role either in the pathogenesis or in the adaptative response of preeclampsia.
Fil: Dietrich, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina;
Fil: Szpilbarg, Natalia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina;
Fil: Damiano, Alicia Ermelinda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Biología Celular y Molecular; Argentina;
description Although the etiology of preeclampsia is unknown, accumulated evidence suggests that the expression of a variety of syncytiotrophoblast transporters is reduced or abnormal. Here, we have examined the expression of NHE-3 in preeclamptic placentas. We found that NHE-3 expression significantly decreased and its labeling was almost undetectable in the cytosol of syncytiotrophoblast cells. Even though the inductor mechanisms of NHE-3 decrease are not clear yet, we speculated that alterations in TNF-α and aldosterone levels observed in preeclampsia might be downregulating NHE-3 expression. Further studies are needed to define whether these alterations play a direct role either in the pathogenesis or in the adaptative response of preeclampsia.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1915
Dietrich, Valeria; Szpilbarg, Natalia; Damiano, Alicia Ermelinda; Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.; Elsevier; Placenta; 34; 9; 9-2013; 828-830
0143-4004
url http://hdl.handle.net/11336/1915
identifier_str_mv Dietrich, Valeria; Szpilbarg, Natalia; Damiano, Alicia Ermelinda; Reduced expression of Na (+)/H(+) exchanger isoform 3 (NHE-3) in preeclamptic placentas.; Elsevier; Placenta; 34; 9; 9-2013; 828-830
0143-4004
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/reference es info:eu-repo/semantics/reference/pmid/23810111
info:eu-repo/semantics/altIdentifier/doi/doi:10.1016/j.placenta.2013.06.005
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/23810111
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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