Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission
- Autores
- Mendizabal, Manuel; Piñero, Federico; Ridruejo, Ezequiel; Anders, Margarita; Silveyra, María Dolores; Torre, Aldo; Montes, Pedro; Urzúa, Alvaro; Pages, Josefina; Toro, Luis G.; Díaz, Javier; Gonzalez Ballerga, Esteban; Miranda Zazueta, Godolfino; Peralta, Mirta; Gutiérrez, Isabel; Michelato, Douglas; Venturelli, Maria Grazia; Varón, Adriana; Vera Pozo, Emilia; Tagle, Martín; García, Matías; Tassara, Alfredo; Brutti, Julia; Ruiz García, Sandro; Bustios, Carla; Escajadillo, Nataly; Macias, Yuridia; Higuera de la Tijera, Fátima; Gómez, Andrés J.; Dominguez, Alejandra; Castillo Barradas, Mauricio; Contreras, Fernando; Scarpin, Aldana; Schinoni, Maria Isabel; Toledo, Claudio; Girala, Marcos; Mainardi, Victoria; Sanchez, Abel; Bessone, Fernando; Rubinstein, Fernando Adrian; Silva, Marcelo Oscar
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction & objectives: The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the prognostic value of abnormal liver tests on admission of hospitalized patients with COVID-19. Materials & methods: We performed a prospective cohort study including 1611 hospitalized patients with confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 2020 in 38 different Hospitals from 11 Latin American countries. We registered clinical and laboratory parameters, including liver function tests, on admission and during hospitalization. All patients were followed until discharge or death. We fit multivariable logistic regression models, further post-estimation effect through margins and inverse probability weighting. Results: Overall, 57.8% of the patients were male with a mean age of 52.3 years, 8.5% had chronic liver disease and 3.4% had cirrhosis. Abnormal liver tests on admission were present on 45.2% (CI 42.7–47.7) of the cohort (n = 726). Overall, 15.1% (CI 13.4–16.9) of patients died (n = 244). Patients with abnormal liver tests on admission presented higher mortality 18.7% (CI 15.9–21.7), compared to those with normal liver biochemistries 12.2% (CI 10.1–14.6); P < .0001). After excluding patients with history of chronic liver disease, abnormal liver tests on admission were independently associated with death [OR 1.5 (CI 1.1–2.0); P = 0.01], and severe COVID-19 (2.6 [2.0–3.3], P < .0001), both adjusted by age, gender, diabetes, pneumonia and body mass index >30. Conclusions: The presence of abnormal liver tests on admission is independently associated with mortality and severe COVID-19 in hospitalized patients with COVID-19 infection and may be used as surrogate marker of inflammation.
Fil: Mendizabal, Manuel. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Piñero, Federico. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Anders, Margarita. Hospital Aleman; Argentina
Fil: Silveyra, María Dolores. Sanatorio Anchorena; Argentina
Fil: Torre, Aldo. Centro Médico ABC; México
Fil: Montes, Pedro. Hospital Nacional Daniel A. Carrión; Perú
Fil: Urzúa, Alvaro. Hospital Clínico de la Universidad de Chile; Chile
Fil: Pages, Josefina. Universidad Austral. Hospital Universitario Austral; Argentina
Fil: Toro, Luis G.. Hospitales de San Vicente Fundación de Medellín y Rionegro; Colombia
Fil: Díaz, Javier. Hospital Nacional Edgardo Rebagliati Martins; Perú
Fil: Gonzalez Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Miranda Zazueta, Godolfino. Instituto Nacional de Ciencias Médicas y Nutrición; México
Fil: Peralta, Mirta. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Gutiérrez, Isabel. Centro Médico ABC; México
Fil: Michelato, Douglas. Hospital Especializado en Enfermedades Infecciosas Instituto Couto Maia; Brasil
Fil: Venturelli, Maria Grazia. Hospital Nacional Guillermo Almenara Irigoyen; Perú
Fil: Varón, Adriana. Fundación Cardio-Infantil; Colombia
Fil: Vera Pozo, Emilia. Hospital Regional Dr. Teodoro Maldonado Carbo; Ecuador
Fil: Tagle, Martín. Clínica Anglo-Americana; Perú
Fil: García, Matías. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Tassara, Alfredo. Hospital Aleman; Argentina
Fil: Brutti, Julia. Sanatorio Anchorena; Argentina
Fil: Ruiz García, Sandro. Hospital de Víctor Lazarte Echegaray; Perú
Fil: Bustios, Carla. Clínica Delgado; Perú
Fil: Escajadillo, Nataly. Hospital Nacional Almanzor Aguinaga Asenjo; Perú
Fil: Macias, Yuridia. No especifíca;
Fil: Higuera de la Tijera, Fátima. Hospital General de México “Dr. Eduardo Liceaga"; México
Fil: Gómez, Andrés J.. Hospital Universitario Fundación Santa Fé de Bogotá; Colombia
Fil: Dominguez, Alejandra. Hospital Padre Hurtado; Chile
Fil: Castillo Barradas, Mauricio. Hospital de Especialidades del Centro Médico Nacional La Raza; México
Fil: Contreras, Fernando. No especifíca;
Fil: Scarpin, Aldana. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
Fil: Schinoni, Maria Isabel. Hospital Alianza; Brasil
Fil: Toledo, Claudio. Universidad Austral de Chile; Chile
Fil: Girala, Marcos. Universidad Nacional de Asunción; Paraguay
Fil: Mainardi, Victoria. Hospital Central De las Fuerzas Armadas; Uruguay
Fil: Sanchez, Abel. Hospital Roosevelt; Guatemala
Fil: Bessone, Fernando. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Rubinstein, Fernando Adrian. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Silva, Marcelo Oscar. Universidad Austral. Hospital Universitario Austral; Argentina - Materia
-
CORONAVIRUS
DEATH
HEPATITIS
PANDEMIC
SARS-COV-2
COVID-19 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/135658
Ver los metadatos del registro completo
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Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admissionMendizabal, ManuelPiñero, FedericoRidruejo, EzequielAnders, MargaritaSilveyra, María DoloresTorre, AldoMontes, PedroUrzúa, AlvaroPages, JosefinaToro, Luis G.Díaz, JavierGonzalez Ballerga, EstebanMiranda Zazueta, GodolfinoPeralta, MirtaGutiérrez, IsabelMichelato, DouglasVenturelli, Maria GraziaVarón, AdrianaVera Pozo, EmiliaTagle, MartínGarcía, MatíasTassara, AlfredoBrutti, JuliaRuiz García, SandroBustios, CarlaEscajadillo, NatalyMacias, YuridiaHiguera de la Tijera, FátimaGómez, Andrés J.Dominguez, AlejandraCastillo Barradas, MauricioContreras, FernandoScarpin, AldanaSchinoni, Maria IsabelToledo, ClaudioGirala, MarcosMainardi, VictoriaSanchez, AbelBessone, FernandoRubinstein, Fernando AdrianSilva, Marcelo OscarCORONAVIRUSDEATHHEPATITISPANDEMICSARS-COV-2COVID-19https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction & objectives: The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the prognostic value of abnormal liver tests on admission of hospitalized patients with COVID-19. Materials & methods: We performed a prospective cohort study including 1611 hospitalized patients with confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 2020 in 38 different Hospitals from 11 Latin American countries. We registered clinical and laboratory parameters, including liver function tests, on admission and during hospitalization. All patients were followed until discharge or death. We fit multivariable logistic regression models, further post-estimation effect through margins and inverse probability weighting. Results: Overall, 57.8% of the patients were male with a mean age of 52.3 years, 8.5% had chronic liver disease and 3.4% had cirrhosis. Abnormal liver tests on admission were present on 45.2% (CI 42.7–47.7) of the cohort (n = 726). Overall, 15.1% (CI 13.4–16.9) of patients died (n = 244). Patients with abnormal liver tests on admission presented higher mortality 18.7% (CI 15.9–21.7), compared to those with normal liver biochemistries 12.2% (CI 10.1–14.6); P < .0001). After excluding patients with history of chronic liver disease, abnormal liver tests on admission were independently associated with death [OR 1.5 (CI 1.1–2.0); P = 0.01], and severe COVID-19 (2.6 [2.0–3.3], P < .0001), both adjusted by age, gender, diabetes, pneumonia and body mass index >30. Conclusions: The presence of abnormal liver tests on admission is independently associated with mortality and severe COVID-19 in hospitalized patients with COVID-19 infection and may be used as surrogate marker of inflammation.Fil: Mendizabal, Manuel. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Piñero, Federico. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Anders, Margarita. Hospital Aleman; ArgentinaFil: Silveyra, María Dolores. Sanatorio Anchorena; ArgentinaFil: Torre, Aldo. Centro Médico ABC; MéxicoFil: Montes, Pedro. Hospital Nacional Daniel A. Carrión; PerúFil: Urzúa, Alvaro. Hospital Clínico de la Universidad de Chile; ChileFil: Pages, Josefina. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Toro, Luis G.. Hospitales de San Vicente Fundación de Medellín y Rionegro; ColombiaFil: Díaz, Javier. Hospital Nacional Edgardo Rebagliati Martins; PerúFil: Gonzalez Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Miranda Zazueta, Godolfino. Instituto Nacional de Ciencias Médicas y Nutrición; MéxicoFil: Peralta, Mirta. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Gutiérrez, Isabel. Centro Médico ABC; MéxicoFil: Michelato, Douglas. Hospital Especializado en Enfermedades Infecciosas Instituto Couto Maia; BrasilFil: Venturelli, Maria Grazia. Hospital Nacional Guillermo Almenara Irigoyen; PerúFil: Varón, Adriana. Fundación Cardio-Infantil; ColombiaFil: Vera Pozo, Emilia. Hospital Regional Dr. Teodoro Maldonado Carbo; EcuadorFil: Tagle, Martín. Clínica Anglo-Americana; PerúFil: García, Matías. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Tassara, Alfredo. Hospital Aleman; ArgentinaFil: Brutti, Julia. Sanatorio Anchorena; ArgentinaFil: Ruiz García, Sandro. Hospital de Víctor Lazarte Echegaray; PerúFil: Bustios, Carla. Clínica Delgado; PerúFil: Escajadillo, Nataly. Hospital Nacional Almanzor Aguinaga Asenjo; PerúFil: Macias, Yuridia. No especifíca;Fil: Higuera de la Tijera, Fátima. Hospital General de México “Dr. Eduardo Liceaga"; MéxicoFil: Gómez, Andrés J.. Hospital Universitario Fundación Santa Fé de Bogotá; ColombiaFil: Dominguez, Alejandra. Hospital Padre Hurtado; ChileFil: Castillo Barradas, Mauricio. Hospital de Especialidades del Centro Médico Nacional La Raza; MéxicoFil: Contreras, Fernando. No especifíca;Fil: Scarpin, Aldana. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Schinoni, Maria Isabel. Hospital Alianza; BrasilFil: Toledo, Claudio. Universidad Austral de Chile; ChileFil: Girala, Marcos. Universidad Nacional de Asunción; ParaguayFil: Mainardi, Victoria. Hospital Central De las Fuerzas Armadas; UruguayFil: Sanchez, Abel. Hospital Roosevelt; GuatemalaFil: Bessone, Fernando. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Rubinstein, Fernando Adrian. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Silva, Marcelo Oscar. Universidad Austral. Hospital Universitario Austral; ArgentinaMexican Association of Hepatology2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/135658Mendizabal, Manuel; Piñero, Federico; Ridruejo, Ezequiel; Anders, Margarita; Silveyra, María Dolores; et al.; Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission; Mexican Association of Hepatology; Annals of Hepatology; 21; 3-2021; 1-81665-2681CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1665268120302234?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.aohep.2020.100298info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:18:04Zoai:ri.conicet.gov.ar:11336/135658instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:18:04.776CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission |
| title |
Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission |
| spellingShingle |
Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission Mendizabal, Manuel CORONAVIRUS DEATH HEPATITIS PANDEMIC SARS-COV-2 COVID-19 |
| title_short |
Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission |
| title_full |
Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission |
| title_fullStr |
Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission |
| title_full_unstemmed |
Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission |
| title_sort |
Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission |
| dc.creator.none.fl_str_mv |
Mendizabal, Manuel Piñero, Federico Ridruejo, Ezequiel Anders, Margarita Silveyra, María Dolores Torre, Aldo Montes, Pedro Urzúa, Alvaro Pages, Josefina Toro, Luis G. Díaz, Javier Gonzalez Ballerga, Esteban Miranda Zazueta, Godolfino Peralta, Mirta Gutiérrez, Isabel Michelato, Douglas Venturelli, Maria Grazia Varón, Adriana Vera Pozo, Emilia Tagle, Martín García, Matías Tassara, Alfredo Brutti, Julia Ruiz García, Sandro Bustios, Carla Escajadillo, Nataly Macias, Yuridia Higuera de la Tijera, Fátima Gómez, Andrés J. Dominguez, Alejandra Castillo Barradas, Mauricio Contreras, Fernando Scarpin, Aldana Schinoni, Maria Isabel Toledo, Claudio Girala, Marcos Mainardi, Victoria Sanchez, Abel Bessone, Fernando Rubinstein, Fernando Adrian Silva, Marcelo Oscar |
| author |
Mendizabal, Manuel |
| author_facet |
Mendizabal, Manuel Piñero, Federico Ridruejo, Ezequiel Anders, Margarita Silveyra, María Dolores Torre, Aldo Montes, Pedro Urzúa, Alvaro Pages, Josefina Toro, Luis G. Díaz, Javier Gonzalez Ballerga, Esteban Miranda Zazueta, Godolfino Peralta, Mirta Gutiérrez, Isabel Michelato, Douglas Venturelli, Maria Grazia Varón, Adriana Vera Pozo, Emilia Tagle, Martín García, Matías Tassara, Alfredo Brutti, Julia Ruiz García, Sandro Bustios, Carla Escajadillo, Nataly Macias, Yuridia Higuera de la Tijera, Fátima Gómez, Andrés J. Dominguez, Alejandra Castillo Barradas, Mauricio Contreras, Fernando Scarpin, Aldana Schinoni, Maria Isabel Toledo, Claudio Girala, Marcos Mainardi, Victoria Sanchez, Abel Bessone, Fernando Rubinstein, Fernando Adrian Silva, Marcelo Oscar |
| author_role |
author |
| author2 |
Piñero, Federico Ridruejo, Ezequiel Anders, Margarita Silveyra, María Dolores Torre, Aldo Montes, Pedro Urzúa, Alvaro Pages, Josefina Toro, Luis G. Díaz, Javier Gonzalez Ballerga, Esteban Miranda Zazueta, Godolfino Peralta, Mirta Gutiérrez, Isabel Michelato, Douglas Venturelli, Maria Grazia Varón, Adriana Vera Pozo, Emilia Tagle, Martín García, Matías Tassara, Alfredo Brutti, Julia Ruiz García, Sandro Bustios, Carla Escajadillo, Nataly Macias, Yuridia Higuera de la Tijera, Fátima Gómez, Andrés J. Dominguez, Alejandra Castillo Barradas, Mauricio Contreras, Fernando Scarpin, Aldana Schinoni, Maria Isabel Toledo, Claudio Girala, Marcos Mainardi, Victoria Sanchez, Abel Bessone, Fernando Rubinstein, Fernando Adrian Silva, Marcelo Oscar |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
CORONAVIRUS DEATH HEPATITIS PANDEMIC SARS-COV-2 COVID-19 |
| topic |
CORONAVIRUS DEATH HEPATITIS PANDEMIC SARS-COV-2 COVID-19 |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Introduction & objectives: The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the prognostic value of abnormal liver tests on admission of hospitalized patients with COVID-19. Materials & methods: We performed a prospective cohort study including 1611 hospitalized patients with confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 2020 in 38 different Hospitals from 11 Latin American countries. We registered clinical and laboratory parameters, including liver function tests, on admission and during hospitalization. All patients were followed until discharge or death. We fit multivariable logistic regression models, further post-estimation effect through margins and inverse probability weighting. Results: Overall, 57.8% of the patients were male with a mean age of 52.3 years, 8.5% had chronic liver disease and 3.4% had cirrhosis. Abnormal liver tests on admission were present on 45.2% (CI 42.7–47.7) of the cohort (n = 726). Overall, 15.1% (CI 13.4–16.9) of patients died (n = 244). Patients with abnormal liver tests on admission presented higher mortality 18.7% (CI 15.9–21.7), compared to those with normal liver biochemistries 12.2% (CI 10.1–14.6); P < .0001). After excluding patients with history of chronic liver disease, abnormal liver tests on admission were independently associated with death [OR 1.5 (CI 1.1–2.0); P = 0.01], and severe COVID-19 (2.6 [2.0–3.3], P < .0001), both adjusted by age, gender, diabetes, pneumonia and body mass index >30. Conclusions: The presence of abnormal liver tests on admission is independently associated with mortality and severe COVID-19 in hospitalized patients with COVID-19 infection and may be used as surrogate marker of inflammation. Fil: Mendizabal, Manuel. Universidad Austral. Hospital Universitario Austral; Argentina Fil: Piñero, Federico. Universidad Austral. Hospital Universitario Austral; Argentina Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina Fil: Anders, Margarita. Hospital Aleman; Argentina Fil: Silveyra, María Dolores. Sanatorio Anchorena; Argentina Fil: Torre, Aldo. Centro Médico ABC; México Fil: Montes, Pedro. Hospital Nacional Daniel A. Carrión; Perú Fil: Urzúa, Alvaro. Hospital Clínico de la Universidad de Chile; Chile Fil: Pages, Josefina. Universidad Austral. Hospital Universitario Austral; Argentina Fil: Toro, Luis G.. Hospitales de San Vicente Fundación de Medellín y Rionegro; Colombia Fil: Díaz, Javier. Hospital Nacional Edgardo Rebagliati Martins; Perú Fil: Gonzalez Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina Fil: Miranda Zazueta, Godolfino. Instituto Nacional de Ciencias Médicas y Nutrición; México Fil: Peralta, Mirta. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina Fil: Gutiérrez, Isabel. Centro Médico ABC; México Fil: Michelato, Douglas. Hospital Especializado en Enfermedades Infecciosas Instituto Couto Maia; Brasil Fil: Venturelli, Maria Grazia. Hospital Nacional Guillermo Almenara Irigoyen; Perú Fil: Varón, Adriana. Fundación Cardio-Infantil; Colombia Fil: Vera Pozo, Emilia. Hospital Regional Dr. Teodoro Maldonado Carbo; Ecuador Fil: Tagle, Martín. Clínica Anglo-Americana; Perú Fil: García, Matías. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina Fil: Tassara, Alfredo. Hospital Aleman; Argentina Fil: Brutti, Julia. Sanatorio Anchorena; Argentina Fil: Ruiz García, Sandro. Hospital de Víctor Lazarte Echegaray; Perú Fil: Bustios, Carla. Clínica Delgado; Perú Fil: Escajadillo, Nataly. Hospital Nacional Almanzor Aguinaga Asenjo; Perú Fil: Macias, Yuridia. No especifíca; Fil: Higuera de la Tijera, Fátima. Hospital General de México “Dr. Eduardo Liceaga"; México Fil: Gómez, Andrés J.. Hospital Universitario Fundación Santa Fé de Bogotá; Colombia Fil: Dominguez, Alejandra. Hospital Padre Hurtado; Chile Fil: Castillo Barradas, Mauricio. Hospital de Especialidades del Centro Médico Nacional La Raza; México Fil: Contreras, Fernando. No especifíca; Fil: Scarpin, Aldana. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina Fil: Schinoni, Maria Isabel. Hospital Alianza; Brasil Fil: Toledo, Claudio. Universidad Austral de Chile; Chile Fil: Girala, Marcos. Universidad Nacional de Asunción; Paraguay Fil: Mainardi, Victoria. Hospital Central De las Fuerzas Armadas; Uruguay Fil: Sanchez, Abel. Hospital Roosevelt; Guatemala Fil: Bessone, Fernando. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina Fil: Rubinstein, Fernando Adrian. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Silva, Marcelo Oscar. Universidad Austral. Hospital Universitario Austral; Argentina |
| description |
Introduction & objectives: The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the prognostic value of abnormal liver tests on admission of hospitalized patients with COVID-19. Materials & methods: We performed a prospective cohort study including 1611 hospitalized patients with confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 2020 in 38 different Hospitals from 11 Latin American countries. We registered clinical and laboratory parameters, including liver function tests, on admission and during hospitalization. All patients were followed until discharge or death. We fit multivariable logistic regression models, further post-estimation effect through margins and inverse probability weighting. Results: Overall, 57.8% of the patients were male with a mean age of 52.3 years, 8.5% had chronic liver disease and 3.4% had cirrhosis. Abnormal liver tests on admission were present on 45.2% (CI 42.7–47.7) of the cohort (n = 726). Overall, 15.1% (CI 13.4–16.9) of patients died (n = 244). Patients with abnormal liver tests on admission presented higher mortality 18.7% (CI 15.9–21.7), compared to those with normal liver biochemistries 12.2% (CI 10.1–14.6); P < .0001). After excluding patients with history of chronic liver disease, abnormal liver tests on admission were independently associated with death [OR 1.5 (CI 1.1–2.0); P = 0.01], and severe COVID-19 (2.6 [2.0–3.3], P < .0001), both adjusted by age, gender, diabetes, pneumonia and body mass index >30. Conclusions: The presence of abnormal liver tests on admission is independently associated with mortality and severe COVID-19 in hospitalized patients with COVID-19 infection and may be used as surrogate marker of inflammation. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-03 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/135658 Mendizabal, Manuel; Piñero, Federico; Ridruejo, Ezequiel; Anders, Margarita; Silveyra, María Dolores; et al.; Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission; Mexican Association of Hepatology; Annals of Hepatology; 21; 3-2021; 1-8 1665-2681 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/135658 |
| identifier_str_mv |
Mendizabal, Manuel; Piñero, Federico; Ridruejo, Ezequiel; Anders, Margarita; Silveyra, María Dolores; et al.; Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission; Mexican Association of Hepatology; Annals of Hepatology; 21; 3-2021; 1-8 1665-2681 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1665268120302234?via%3Dihub info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aohep.2020.100298 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Mexican Association of Hepatology |
| publisher.none.fl_str_mv |
Mexican Association of Hepatology |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1846083329455030272 |
| score |
13.22299 |