Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort

Autores
Larcade, Ramon; DeShea, Lise; Lang, Gillian A.; Caballero, Mauricio Tomás; Ferretti, Adrian; Beasley, William H.; Tipple, Trent E.; Vain, Néstor Eduardo; Prudent, Luis; Lang, Mark L.; Polack, Fernando Pedro; Ofman, Gaston
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: COVID-19 disproportionally affects pregnant women and their newborn, yet little is known about the variables that modulate the maternal-fetal immune response to infection.Methods: We prospectively studied socioeconomic, biologic and clinical factors affecting humoral immunity in 87 unvaccinated pregnant women admitted to hospital in the Buenos Aires metropolitan area for symptoms consistent with COVID-19 disease.Results: The number of days between symptom onset and childbirth predicted maternal and newborn virus Spike protein Receptor Binding Domain (RBD)-specific IgG. These findings suggest newborns may benefit less when mothers deliver soon after COVID-19 infection. Similarly, a longer time between symptom onset and birth predicted higher in utero transfer of maternal IgG and its concentration in cord blood. Older gestational ages at birth were associated with lower maternal IgG: cord blood IgG ratios. Eighty seven percent of women with confirmed SARS-CoV-2 infection developed RBD-specific IgA responses in breast milk within 96 h of childbirth. IgA was not significantly associated with time from infection but correlated with maternal serum IgG and placental transfer.Conclusions: These results demonstrate the combined role of biologic, clinical and socioeconomic variables associated with maternal SARS-CoV-2 RBD-specific antibodies and supports early vaccination strategies for COVID-19 in socioeconomically vulnerable pregnant women.
Fil: Larcade, Ramon. No especifíca;
Fil: DeShea, Lise. Oklahoma State University; Estados Unidos
Fil: Lang, Gillian A.. Oklahoma State University; Estados Unidos
Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferretti, Adrian. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Beasley, William H.. Oklahoma State University; Estados Unidos
Fil: Tipple, Trent E.. Oklahoma State University; Estados Unidos
Fil: Vain, Néstor Eduardo. No especifíca;
Fil: Prudent, Luis. No especifíca;
Fil: Lang, Mark L.. Oklahoma State University; Estados Unidos
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Ofman, Gaston. Fundación para la Investigación en Infectología Infantil; Argentina
Materia
SARS COV2
COVID-19
PREGNANCY
ANTIBODIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/152100
Acceder
id CONICETDig_fa1049e096b65720e3af85728f9d8a46
oai_identifier_str oai:ri.conicet.gov.ar:11336/152100
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohortLarcade, RamonDeShea, LiseLang, Gillian A.Caballero, Mauricio TomásFerretti, AdrianBeasley, William H.Tipple, Trent E.Vain, Néstor EduardoPrudent, LuisLang, Mark L.Polack, Fernando PedroOfman, GastonSARS COV2COVID-19PREGNANCYANTIBODIEShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: COVID-19 disproportionally affects pregnant women and their newborn, yet little is known about the variables that modulate the maternal-fetal immune response to infection.Methods: We prospectively studied socioeconomic, biologic and clinical factors affecting humoral immunity in 87 unvaccinated pregnant women admitted to hospital in the Buenos Aires metropolitan area for symptoms consistent with COVID-19 disease.Results: The number of days between symptom onset and childbirth predicted maternal and newborn virus Spike protein Receptor Binding Domain (RBD)-specific IgG. These findings suggest newborns may benefit less when mothers deliver soon after COVID-19 infection. Similarly, a longer time between symptom onset and birth predicted higher in utero transfer of maternal IgG and its concentration in cord blood. Older gestational ages at birth were associated with lower maternal IgG: cord blood IgG ratios. Eighty seven percent of women with confirmed SARS-CoV-2 infection developed RBD-specific IgA responses in breast milk within 96 h of childbirth. IgA was not significantly associated with time from infection but correlated with maternal serum IgG and placental transfer.Conclusions: These results demonstrate the combined role of biologic, clinical and socioeconomic variables associated with maternal SARS-CoV-2 RBD-specific antibodies and supports early vaccination strategies for COVID-19 in socioeconomically vulnerable pregnant women.Fil: Larcade, Ramon. No especifíca;Fil: DeShea, Lise. Oklahoma State University; Estados UnidosFil: Lang, Gillian A.. Oklahoma State University; Estados UnidosFil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferretti, Adrian. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Beasley, William H.. Oklahoma State University; Estados UnidosFil: Tipple, Trent E.. Oklahoma State University; Estados UnidosFil: Vain, Néstor Eduardo. No especifíca;Fil: Prudent, Luis. No especifíca;Fil: Lang, Mark L.. Oklahoma State University; Estados UnidosFil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Ofman, Gaston. Fundación para la Investigación en Infectología Infantil; ArgentinaUniversity of Chicago Press2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152100Larcade, Ramon; DeShea, Lise; Lang, Gillian A.; Caballero, Mauricio Tomás; Ferretti, Adrian; et al.; Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort; University of Chicago Press; Journal Of Infectious Diseases; 12-2021; 1-290022-1899CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiab591/6448432info:eu-repo/semantics/altIdentifier/doi/10.1093/infdis/jiab591info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:53:02Zoai:ri.conicet.gov.ar:11336/152100instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:53:02.791CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
title Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
spellingShingle Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
Larcade, Ramon
SARS COV2
COVID-19
PREGNANCY
ANTIBODIES
title_short Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
title_full Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
title_fullStr Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
title_full_unstemmed Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
title_sort Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort
dc.creator.none.fl_str_mv Larcade, Ramon
DeShea, Lise
Lang, Gillian A.
Caballero, Mauricio Tomás
Ferretti, Adrian
Beasley, William H.
Tipple, Trent E.
Vain, Néstor Eduardo
Prudent, Luis
Lang, Mark L.
Polack, Fernando Pedro
Ofman, Gaston
author Larcade, Ramon
author_facet Larcade, Ramon
DeShea, Lise
Lang, Gillian A.
Caballero, Mauricio Tomás
Ferretti, Adrian
Beasley, William H.
Tipple, Trent E.
Vain, Néstor Eduardo
Prudent, Luis
Lang, Mark L.
Polack, Fernando Pedro
Ofman, Gaston
author_role author
author2 DeShea, Lise
Lang, Gillian A.
Caballero, Mauricio Tomás
Ferretti, Adrian
Beasley, William H.
Tipple, Trent E.
Vain, Néstor Eduardo
Prudent, Luis
Lang, Mark L.
Polack, Fernando Pedro
Ofman, Gaston
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS COV2
COVID-19
PREGNANCY
ANTIBODIES
topic SARS COV2
COVID-19
PREGNANCY
ANTIBODIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: COVID-19 disproportionally affects pregnant women and their newborn, yet little is known about the variables that modulate the maternal-fetal immune response to infection.Methods: We prospectively studied socioeconomic, biologic and clinical factors affecting humoral immunity in 87 unvaccinated pregnant women admitted to hospital in the Buenos Aires metropolitan area for symptoms consistent with COVID-19 disease.Results: The number of days between symptom onset and childbirth predicted maternal and newborn virus Spike protein Receptor Binding Domain (RBD)-specific IgG. These findings suggest newborns may benefit less when mothers deliver soon after COVID-19 infection. Similarly, a longer time between symptom onset and birth predicted higher in utero transfer of maternal IgG and its concentration in cord blood. Older gestational ages at birth were associated with lower maternal IgG: cord blood IgG ratios. Eighty seven percent of women with confirmed SARS-CoV-2 infection developed RBD-specific IgA responses in breast milk within 96 h of childbirth. IgA was not significantly associated with time from infection but correlated with maternal serum IgG and placental transfer.Conclusions: These results demonstrate the combined role of biologic, clinical and socioeconomic variables associated with maternal SARS-CoV-2 RBD-specific antibodies and supports early vaccination strategies for COVID-19 in socioeconomically vulnerable pregnant women.
Fil: Larcade, Ramon. No especifíca;
Fil: DeShea, Lise. Oklahoma State University; Estados Unidos
Fil: Lang, Gillian A.. Oklahoma State University; Estados Unidos
Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferretti, Adrian. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Beasley, William H.. Oklahoma State University; Estados Unidos
Fil: Tipple, Trent E.. Oklahoma State University; Estados Unidos
Fil: Vain, Néstor Eduardo. No especifíca;
Fil: Prudent, Luis. No especifíca;
Fil: Lang, Mark L.. Oklahoma State University; Estados Unidos
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Ofman, Gaston. Fundación para la Investigación en Infectología Infantil; Argentina
description Background: COVID-19 disproportionally affects pregnant women and their newborn, yet little is known about the variables that modulate the maternal-fetal immune response to infection.Methods: We prospectively studied socioeconomic, biologic and clinical factors affecting humoral immunity in 87 unvaccinated pregnant women admitted to hospital in the Buenos Aires metropolitan area for symptoms consistent with COVID-19 disease.Results: The number of days between symptom onset and childbirth predicted maternal and newborn virus Spike protein Receptor Binding Domain (RBD)-specific IgG. These findings suggest newborns may benefit less when mothers deliver soon after COVID-19 infection. Similarly, a longer time between symptom onset and birth predicted higher in utero transfer of maternal IgG and its concentration in cord blood. Older gestational ages at birth were associated with lower maternal IgG: cord blood IgG ratios. Eighty seven percent of women with confirmed SARS-CoV-2 infection developed RBD-specific IgA responses in breast milk within 96 h of childbirth. IgA was not significantly associated with time from infection but correlated with maternal serum IgG and placental transfer.Conclusions: These results demonstrate the combined role of biologic, clinical and socioeconomic variables associated with maternal SARS-CoV-2 RBD-specific antibodies and supports early vaccination strategies for COVID-19 in socioeconomically vulnerable pregnant women.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/152100
Larcade, Ramon; DeShea, Lise; Lang, Gillian A.; Caballero, Mauricio Tomás; Ferretti, Adrian; et al.; Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort; University of Chicago Press; Journal Of Infectious Diseases; 12-2021; 1-29
0022-1899
CONICET Digital
CONICET
url http://hdl.handle.net/11336/152100
identifier_str_mv Larcade, Ramon; DeShea, Lise; Lang, Gillian A.; Caballero, Mauricio Tomás; Ferretti, Adrian; et al.; Maternal-fetal immunologic response to SARS-CoV-2 infection in a symptomatic vulnerable population: A prospective cohort; University of Chicago Press; Journal Of Infectious Diseases; 12-2021; 1-29
0022-1899
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiab591/6448432
info:eu-repo/semantics/altIdentifier/doi/10.1093/infdis/jiab591
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv University of Chicago Press
publisher.none.fl_str_mv University of Chicago Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613624408047616
score 13.070432

Publicaciones similares