Pituitary tumors: Cell type-specific roles for BMP-4

Autores
Labeur, Marta; Páez Pereda, Marcelo; Haedo, Mariana Raquel; Arzt, Eduardo Simon; Stalla, Günter K.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid.
Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania
Fil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; Alemania
Fil: Haedo, Mariana Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Stalla, Günter K.. Max Planck Institute of Psychiatry; Alemania
Materia
Acth
Bmp-4
Pituitary Tumors
Prolactin
Retinoic Acid
Tgf-Β
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/68915
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/68915
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pituitary tumors: Cell type-specific roles for BMP-4Labeur, MartaPáez Pereda, MarceloHaedo, Mariana RaquelArzt, Eduardo SimonStalla, Günter K.ActhBmp-4Pituitary TumorsProlactinRetinoic AcidTgf-Βhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid.Fil: Labeur, Marta. Max Planck Institute of Psychiatry; AlemaniaFil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; AlemaniaFil: Haedo, Mariana Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Stalla, Günter K.. Max Planck Institute of Psychiatry; AlemaniaElsevier Ireland2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/68915Labeur, Marta; Páez Pereda, Marcelo; Haedo, Mariana Raquel; Arzt, Eduardo Simon; Stalla, Günter K.; Pituitary tumors: Cell type-specific roles for BMP-4; Elsevier Ireland; Molecular and Cellular Endocrinology; 326; 1-2; 9-2010; 85-880303-7207CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2010.04.006info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S030372071000211Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:47Zoai:ri.conicet.gov.ar:11336/68915instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:47.544CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pituitary tumors: Cell type-specific roles for BMP-4
title Pituitary tumors: Cell type-specific roles for BMP-4
spellingShingle Pituitary tumors: Cell type-specific roles for BMP-4
Labeur, Marta
Acth
Bmp-4
Pituitary Tumors
Prolactin
Retinoic Acid
Tgf-Β
title_short Pituitary tumors: Cell type-specific roles for BMP-4
title_full Pituitary tumors: Cell type-specific roles for BMP-4
title_fullStr Pituitary tumors: Cell type-specific roles for BMP-4
title_full_unstemmed Pituitary tumors: Cell type-specific roles for BMP-4
title_sort Pituitary tumors: Cell type-specific roles for BMP-4
dc.creator.none.fl_str_mv Labeur, Marta
Páez Pereda, Marcelo
Haedo, Mariana Raquel
Arzt, Eduardo Simon
Stalla, Günter K.
author Labeur, Marta
author_facet Labeur, Marta
Páez Pereda, Marcelo
Haedo, Mariana Raquel
Arzt, Eduardo Simon
Stalla, Günter K.
author_role author
author2 Páez Pereda, Marcelo
Haedo, Mariana Raquel
Arzt, Eduardo Simon
Stalla, Günter K.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Acth
Bmp-4
Pituitary Tumors
Prolactin
Retinoic Acid
Tgf-Β
topic Acth
Bmp-4
Pituitary Tumors
Prolactin
Retinoic Acid
Tgf-Β
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid.
Fil: Labeur, Marta. Max Planck Institute of Psychiatry; Alemania
Fil: Páez Pereda, Marcelo. Max Planck Institute of Psychiatry; Alemania
Fil: Haedo, Mariana Raquel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arzt, Eduardo Simon. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Stalla, Günter K.. Max Planck Institute of Psychiatry; Alemania
description BMP-4 plays a crucial role not only in the formation of the anterior pituitary during embryo development but also in the pathogenesis of pituitary tumors in adults. In tumor cells, BMP-4 promotes prolactin secretion and lactotroph cell proliferation through a Smad-estrogen receptor crosstalk but it inhibits ACTH production and cell proliferation of corticotrophs. In addition, BMP-4 increases GH secretion in rat pituitary tumor somatolactotroph GH3 cells and FSHβ subunit gene transcription in the murine gonadotroph cell line, LβT2. Therefore, BMP-4 has a differential role on different types of pituitary tumors: it promotes pituitary prolactinoma while it inhibits corticotroph pathogenesis in Cushing's disease. The modulation of BMP-4 also plays an important role in the therapeutic mechanism of action of bromocriptine, somatostatin analogs and retinoic acid.
publishDate 2010
dc.date.none.fl_str_mv 2010-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/68915
Labeur, Marta; Páez Pereda, Marcelo; Haedo, Mariana Raquel; Arzt, Eduardo Simon; Stalla, Günter K.; Pituitary tumors: Cell type-specific roles for BMP-4; Elsevier Ireland; Molecular and Cellular Endocrinology; 326; 1-2; 9-2010; 85-88
0303-7207
CONICET Digital
CONICET
url http://hdl.handle.net/11336/68915
identifier_str_mv Labeur, Marta; Páez Pereda, Marcelo; Haedo, Mariana Raquel; Arzt, Eduardo Simon; Stalla, Günter K.; Pituitary tumors: Cell type-specific roles for BMP-4; Elsevier Ireland; Molecular and Cellular Endocrinology; 326; 1-2; 9-2010; 85-88
0303-7207
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mce.2010.04.006
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S030372071000211X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268753684856832
score 13.13397

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