The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus
- Autores
- Barrutieta Arberas, I.; Ortuzar, N.; Vaquero Rodríguez, A.; Picó-Gallardo, M.; Bengoetxea, H.; Guevara, M. A.; Gargiulo, Pascual Angel; Lafuente, J. V.
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Major depressive disorder (MDD) is a complex illness that is arising as a growing public health concern. Although several brain areas are related to this type of disorders, at the cellular level, the parvalbumin-positive cells of the hippocampus interplay a very relevant role. They control pyramidal cell bursts, neuronal networks, basic microcircuit functions, and other complex neuronal tasks involved in mood disorders. In resistant depressions, the efficacy of current antidepressant treatments drops dramatically, so the new rapid-acting antidepressants (RAADs) are being postulated as novel treatments. Ketamine at subanesthetic doses and its derivative metabolites have been proposed as RAADs due to their rapid and sustained action by blocking N-methyl-d-aspartate (NMDA) receptors, which in turn lead to the release of brain-derived neurotrophic factor (BDNF). This mechanism produces a rapid plasticity activation mediated by neurotransmitter homeostasis, synapse recovery, and increased dendritic spines and therefore, it is a promising therapeutic approach to improve cognitive symptoms in MDD.
Fil: Barrutieta Arberas, I.. Universidad del País Vasco; España
Fil: Ortuzar, N.. Universidad del País Vasco; España
Fil: Vaquero Rodríguez, A.. Universidad del País Vasco; España
Fil: Picó-Gallardo, M.. Universidad del País Vasco; España
Fil: Bengoetxea, H.. Universidad del País Vasco; España
Fil: Guevara, M. A.. Universidad Nacional de Cuyo; Argentina
Fil: Gargiulo, Pascual Angel. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina
Fil: Lafuente, J. V.. Universidad del País Vasco; España - Materia
-
BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)
HIPPOCAMPUS (HC)
INTERNEURONS (INS)
KETAMINE
MAJOR DEPRESSIVE DISORDER (MDD)
N-METHYL-D-ASPARTATE RECEPTORS (NMDARS) - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/222316
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
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The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampusBarrutieta Arberas, I.Ortuzar, N.Vaquero Rodríguez, A.Picó-Gallardo, M.Bengoetxea, H.Guevara, M. A.Gargiulo, Pascual AngelLafuente, J. V.BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)HIPPOCAMPUS (HC)INTERNEURONS (INS)KETAMINEMAJOR DEPRESSIVE DISORDER (MDD)N-METHYL-D-ASPARTATE RECEPTORS (NMDARS)https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Major depressive disorder (MDD) is a complex illness that is arising as a growing public health concern. Although several brain areas are related to this type of disorders, at the cellular level, the parvalbumin-positive cells of the hippocampus interplay a very relevant role. They control pyramidal cell bursts, neuronal networks, basic microcircuit functions, and other complex neuronal tasks involved in mood disorders. In resistant depressions, the efficacy of current antidepressant treatments drops dramatically, so the new rapid-acting antidepressants (RAADs) are being postulated as novel treatments. Ketamine at subanesthetic doses and its derivative metabolites have been proposed as RAADs due to their rapid and sustained action by blocking N-methyl-d-aspartate (NMDA) receptors, which in turn lead to the release of brain-derived neurotrophic factor (BDNF). This mechanism produces a rapid plasticity activation mediated by neurotransmitter homeostasis, synapse recovery, and increased dendritic spines and therefore, it is a promising therapeutic approach to improve cognitive symptoms in MDD.Fil: Barrutieta Arberas, I.. Universidad del País Vasco; EspañaFil: Ortuzar, N.. Universidad del País Vasco; EspañaFil: Vaquero Rodríguez, A.. Universidad del País Vasco; EspañaFil: Picó-Gallardo, M.. Universidad del País Vasco; EspañaFil: Bengoetxea, H.. Universidad del País Vasco; EspañaFil: Guevara, M. A.. Universidad Nacional de Cuyo; ArgentinaFil: Gargiulo, Pascual Angel. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; ArgentinaFil: Lafuente, J. V.. Universidad del País Vasco; EspañaSoc Experimental Biology Medicine2023-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/222316Barrutieta Arberas, I.; Ortuzar, N.; Vaquero Rodríguez, A.; Picó-Gallardo, M.; Bengoetxea, H.; et al.; The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus; Soc Experimental Biology Medicine; Experimental Biology And Medicine; 248; 7; 5-2023; 588-5951535-3702CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/15353702231170007info:eu-repo/semantics/altIdentifier/doi/10.1177/15353702231170007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:51:00Zoai:ri.conicet.gov.ar:11336/222316instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:51:01.247CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus |
title |
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus |
spellingShingle |
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus Barrutieta Arberas, I. BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) HIPPOCAMPUS (HC) INTERNEURONS (INS) KETAMINE MAJOR DEPRESSIVE DISORDER (MDD) N-METHYL-D-ASPARTATE RECEPTORS (NMDARS) |
title_short |
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus |
title_full |
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus |
title_fullStr |
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus |
title_full_unstemmed |
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus |
title_sort |
The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus |
dc.creator.none.fl_str_mv |
Barrutieta Arberas, I. Ortuzar, N. Vaquero Rodríguez, A. Picó-Gallardo, M. Bengoetxea, H. Guevara, M. A. Gargiulo, Pascual Angel Lafuente, J. V. |
author |
Barrutieta Arberas, I. |
author_facet |
Barrutieta Arberas, I. Ortuzar, N. Vaquero Rodríguez, A. Picó-Gallardo, M. Bengoetxea, H. Guevara, M. A. Gargiulo, Pascual Angel Lafuente, J. V. |
author_role |
author |
author2 |
Ortuzar, N. Vaquero Rodríguez, A. Picó-Gallardo, M. Bengoetxea, H. Guevara, M. A. Gargiulo, Pascual Angel Lafuente, J. V. |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) HIPPOCAMPUS (HC) INTERNEURONS (INS) KETAMINE MAJOR DEPRESSIVE DISORDER (MDD) N-METHYL-D-ASPARTATE RECEPTORS (NMDARS) |
topic |
BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) HIPPOCAMPUS (HC) INTERNEURONS (INS) KETAMINE MAJOR DEPRESSIVE DISORDER (MDD) N-METHYL-D-ASPARTATE RECEPTORS (NMDARS) |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Major depressive disorder (MDD) is a complex illness that is arising as a growing public health concern. Although several brain areas are related to this type of disorders, at the cellular level, the parvalbumin-positive cells of the hippocampus interplay a very relevant role. They control pyramidal cell bursts, neuronal networks, basic microcircuit functions, and other complex neuronal tasks involved in mood disorders. In resistant depressions, the efficacy of current antidepressant treatments drops dramatically, so the new rapid-acting antidepressants (RAADs) are being postulated as novel treatments. Ketamine at subanesthetic doses and its derivative metabolites have been proposed as RAADs due to their rapid and sustained action by blocking N-methyl-d-aspartate (NMDA) receptors, which in turn lead to the release of brain-derived neurotrophic factor (BDNF). This mechanism produces a rapid plasticity activation mediated by neurotransmitter homeostasis, synapse recovery, and increased dendritic spines and therefore, it is a promising therapeutic approach to improve cognitive symptoms in MDD. Fil: Barrutieta Arberas, I.. Universidad del País Vasco; España Fil: Ortuzar, N.. Universidad del País Vasco; España Fil: Vaquero Rodríguez, A.. Universidad del País Vasco; España Fil: Picó-Gallardo, M.. Universidad del País Vasco; España Fil: Bengoetxea, H.. Universidad del País Vasco; España Fil: Guevara, M. A.. Universidad Nacional de Cuyo; Argentina Fil: Gargiulo, Pascual Angel. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina Fil: Lafuente, J. V.. Universidad del País Vasco; España |
description |
Major depressive disorder (MDD) is a complex illness that is arising as a growing public health concern. Although several brain areas are related to this type of disorders, at the cellular level, the parvalbumin-positive cells of the hippocampus interplay a very relevant role. They control pyramidal cell bursts, neuronal networks, basic microcircuit functions, and other complex neuronal tasks involved in mood disorders. In resistant depressions, the efficacy of current antidepressant treatments drops dramatically, so the new rapid-acting antidepressants (RAADs) are being postulated as novel treatments. Ketamine at subanesthetic doses and its derivative metabolites have been proposed as RAADs due to their rapid and sustained action by blocking N-methyl-d-aspartate (NMDA) receptors, which in turn lead to the release of brain-derived neurotrophic factor (BDNF). This mechanism produces a rapid plasticity activation mediated by neurotransmitter homeostasis, synapse recovery, and increased dendritic spines and therefore, it is a promising therapeutic approach to improve cognitive symptoms in MDD. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/222316 Barrutieta Arberas, I.; Ortuzar, N.; Vaquero Rodríguez, A.; Picó-Gallardo, M.; Bengoetxea, H.; et al.; The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus; Soc Experimental Biology Medicine; Experimental Biology And Medicine; 248; 7; 5-2023; 588-595 1535-3702 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/222316 |
identifier_str_mv |
Barrutieta Arberas, I.; Ortuzar, N.; Vaquero Rodríguez, A.; Picó-Gallardo, M.; Bengoetxea, H.; et al.; The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus; Soc Experimental Biology Medicine; Experimental Biology And Medicine; 248; 7; 5-2023; 588-595 1535-3702 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/10.1177/15353702231170007 info:eu-repo/semantics/altIdentifier/doi/10.1177/15353702231170007 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Soc Experimental Biology Medicine |
publisher.none.fl_str_mv |
Soc Experimental Biology Medicine |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |