Clinical Characteristics of Melancholic and Nonmelancholic Depressions

Autores
Valerio, Marina Paula; Lomastro, María Julieta; Igoa, Ana; Martino, Diego Javier
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study aimed to compare clinical-demographic features of melancholic and nonmelancholic depressions. We included 141 depressed inpatients classified as melancholic and nonmelancholic by the Sydney Melancholia Prototype Index (SMPI) and Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria. Results were controlled for confounders, including severity measures. Melancholic patients by both diagnostic systems were more severely depressed and presented more psychotic symptoms, neurological soft signs, and psychomotor disturbances. Melancholic patients classified by the SMPI were also older at illness onset and had fewer suicide attempts. After controlling for confounders, although all differences remained significant for SMPI diagnosis, the DSM-5 diagnosis of melancholia was only associated with further impaired motor sequencing. The results obtained with the SMPI support the hypothesis that melancholia has clinical features qualitatively different from those of nonmelancholic depressions. Contrarily, the DSM-5 specifier seems to reflect the severity of depressive episodes rather than core clinical features of melancholia.
Fil: Valerio, Marina Paula. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
Fil: Lomastro, María Julieta. Psychiatric Emergencies Hospital Torcuato de Alvear; Argentina
Fil: Igoa, Ana. Psychiatric Emergencies Hospital Torcuato de Alvear; Argentina
Fil: Martino, Diego Javier. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
Materia
BIPOLAR DISORDER
MAJOR DEPRESSIVE DISORDER
MAJOR DEPRESSIVE EPISODE
MELANCHOLIA
NEUROLOGICAL SOFT SIGNS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/218557
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Clinical Characteristics of Melancholic and Nonmelancholic DepressionsValerio, Marina PaulaLomastro, María JulietaIgoa, AnaMartino, Diego JavierBIPOLAR DISORDERMAJOR DEPRESSIVE DISORDERMAJOR DEPRESSIVE EPISODEMELANCHOLIANEUROLOGICAL SOFT SIGNShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3This study aimed to compare clinical-demographic features of melancholic and nonmelancholic depressions. We included 141 depressed inpatients classified as melancholic and nonmelancholic by the Sydney Melancholia Prototype Index (SMPI) and Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria. Results were controlled for confounders, including severity measures. Melancholic patients by both diagnostic systems were more severely depressed and presented more psychotic symptoms, neurological soft signs, and psychomotor disturbances. Melancholic patients classified by the SMPI were also older at illness onset and had fewer suicide attempts. After controlling for confounders, although all differences remained significant for SMPI diagnosis, the DSM-5 diagnosis of melancholia was only associated with further impaired motor sequencing. The results obtained with the SMPI support the hypothesis that melancholia has clinical features qualitatively different from those of nonmelancholic depressions. Contrarily, the DSM-5 specifier seems to reflect the severity of depressive episodes rather than core clinical features of melancholia.Fil: Valerio, Marina Paula. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; ArgentinaFil: Lomastro, María Julieta. Psychiatric Emergencies Hospital Torcuato de Alvear; ArgentinaFil: Igoa, Ana. Psychiatric Emergencies Hospital Torcuato de Alvear; ArgentinaFil: Martino, Diego Javier. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; ArgentinaLippincott Williams2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/218557Valerio, Marina Paula; Lomastro, María Julieta; Igoa, Ana; Martino, Diego Javier; Clinical Characteristics of Melancholic and Nonmelancholic Depressions; Lippincott Williams; Journal Of Nervous And Mental Disease; 211; 3; 3-2023; 248-2520022-3018CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/NMD.0000000000001616info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/jonmd/abstract/2023/03000/clinical_characteristics_of_melancholic_and.13.aspxinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:56Zoai:ri.conicet.gov.ar:11336/218557instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:56.428CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical Characteristics of Melancholic and Nonmelancholic Depressions
title Clinical Characteristics of Melancholic and Nonmelancholic Depressions
spellingShingle Clinical Characteristics of Melancholic and Nonmelancholic Depressions
Valerio, Marina Paula
BIPOLAR DISORDER
MAJOR DEPRESSIVE DISORDER
MAJOR DEPRESSIVE EPISODE
MELANCHOLIA
NEUROLOGICAL SOFT SIGNS
title_short Clinical Characteristics of Melancholic and Nonmelancholic Depressions
title_full Clinical Characteristics of Melancholic and Nonmelancholic Depressions
title_fullStr Clinical Characteristics of Melancholic and Nonmelancholic Depressions
title_full_unstemmed Clinical Characteristics of Melancholic and Nonmelancholic Depressions
title_sort Clinical Characteristics of Melancholic and Nonmelancholic Depressions
dc.creator.none.fl_str_mv Valerio, Marina Paula
Lomastro, María Julieta
Igoa, Ana
Martino, Diego Javier
author Valerio, Marina Paula
author_facet Valerio, Marina Paula
Lomastro, María Julieta
Igoa, Ana
Martino, Diego Javier
author_role author
author2 Lomastro, María Julieta
Igoa, Ana
Martino, Diego Javier
author2_role author
author
author
dc.subject.none.fl_str_mv BIPOLAR DISORDER
MAJOR DEPRESSIVE DISORDER
MAJOR DEPRESSIVE EPISODE
MELANCHOLIA
NEUROLOGICAL SOFT SIGNS
topic BIPOLAR DISORDER
MAJOR DEPRESSIVE DISORDER
MAJOR DEPRESSIVE EPISODE
MELANCHOLIA
NEUROLOGICAL SOFT SIGNS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This study aimed to compare clinical-demographic features of melancholic and nonmelancholic depressions. We included 141 depressed inpatients classified as melancholic and nonmelancholic by the Sydney Melancholia Prototype Index (SMPI) and Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria. Results were controlled for confounders, including severity measures. Melancholic patients by both diagnostic systems were more severely depressed and presented more psychotic symptoms, neurological soft signs, and psychomotor disturbances. Melancholic patients classified by the SMPI were also older at illness onset and had fewer suicide attempts. After controlling for confounders, although all differences remained significant for SMPI diagnosis, the DSM-5 diagnosis of melancholia was only associated with further impaired motor sequencing. The results obtained with the SMPI support the hypothesis that melancholia has clinical features qualitatively different from those of nonmelancholic depressions. Contrarily, the DSM-5 specifier seems to reflect the severity of depressive episodes rather than core clinical features of melancholia.
Fil: Valerio, Marina Paula. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
Fil: Lomastro, María Julieta. Psychiatric Emergencies Hospital Torcuato de Alvear; Argentina
Fil: Igoa, Ana. Psychiatric Emergencies Hospital Torcuato de Alvear; Argentina
Fil: Martino, Diego Javier. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencias Cognitivas y Traslacional; Argentina
description This study aimed to compare clinical-demographic features of melancholic and nonmelancholic depressions. We included 141 depressed inpatients classified as melancholic and nonmelancholic by the Sydney Melancholia Prototype Index (SMPI) and Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria. Results were controlled for confounders, including severity measures. Melancholic patients by both diagnostic systems were more severely depressed and presented more psychotic symptoms, neurological soft signs, and psychomotor disturbances. Melancholic patients classified by the SMPI were also older at illness onset and had fewer suicide attempts. After controlling for confounders, although all differences remained significant for SMPI diagnosis, the DSM-5 diagnosis of melancholia was only associated with further impaired motor sequencing. The results obtained with the SMPI support the hypothesis that melancholia has clinical features qualitatively different from those of nonmelancholic depressions. Contrarily, the DSM-5 specifier seems to reflect the severity of depressive episodes rather than core clinical features of melancholia.
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/218557
Valerio, Marina Paula; Lomastro, María Julieta; Igoa, Ana; Martino, Diego Javier; Clinical Characteristics of Melancholic and Nonmelancholic Depressions; Lippincott Williams; Journal Of Nervous And Mental Disease; 211; 3; 3-2023; 248-252
0022-3018
CONICET Digital
CONICET
url http://hdl.handle.net/11336/218557
identifier_str_mv Valerio, Marina Paula; Lomastro, María Julieta; Igoa, Ana; Martino, Diego Javier; Clinical Characteristics of Melancholic and Nonmelancholic Depressions; Lippincott Williams; Journal Of Nervous And Mental Disease; 211; 3; 3-2023; 248-252
0022-3018
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1097/NMD.0000000000001616
info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/jonmd/abstract/2023/03000/clinical_characteristics_of_melancholic_and.13.aspx
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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