Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli

Autores
Paez, Paulina Laura; Bazán, Claudia Marcela; Bongiovanni, Maria Eugenia; Toneatto, Judith; Albesa, Inés; Becerra, María Cecilia; Argüello, Gerardo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections. The main aim of this work was to establish the potential of the synthetic alfa-diimine chromium(III) and Ruthenium(II) complexes (where the alfa-diimine ligands are bpy = 2,2-bipyridine; phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2´,3´-c]-phenazine) like [Cr(phen)3]3+, [Cr(phen)2(dppz)]3+, [Ru(phen)3]2+ and [Ru(bpy)3]2+ as antibacterial agents by generating oxidative stress. The [Cr(phen)3]3+ and [Cr(phen)2(dppz)]3+ complexes showed activity against Gram positive and Gram negative bacteria with minimum inhibitory concentrations (MICs) ranging from 0.125 µg/mL to 1 µg/mL, while [Ru(phen)3]2+ and [Ru(bpy)3]2+ does not exhibit antimicrobial activity against the two bacterial genera studied at the concentration range used. When ciprofloxacin was combined with [Cr(phen)3]3+ for the inhibition of Staphylococcus aureus and Escherichia coli, an important synergistic effect was observed, FIC 0.066 for S. aureus and FIC 0.064 for E. coli. The work described here shows that chromium(III) complexes are bactericidal for S. aureus and E. coli. Our results indicate that alfa-diimine chromium(III) complexes may be interesting to open new paths for metallodrug chemotherapy against different bacterial genera since some of these complexes have been found to exhibit remarkable antibacterial activities.
Fil: Paez, Paulina Laura. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Bazán, Claudia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones En Fisico- Química de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Investigaciones En Fisico- Química de Córdoba; Argentina
Fil: Bongiovanni, Maria Eugenia. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones En Fisico- Química de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Investigaciones En Fisico- Química de Córdoba; Argentina
Fil: Albesa, Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Argüello, Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones En Fisico- Química de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Investigaciones En Fisico- Química de Córdoba; Argentina
Materia
OXIDATIVE STRESS
ANTIMICROBIAL ACTIVITY
ITS NUCLEAR ITS
RUTHENIUM (II) COMPLEXES
ESCHERICHIA COLI
STAPHYLOCOCCUS AUREUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16368
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/16368
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coliPaez, Paulina LauraBazán, Claudia MarcelaBongiovanni, Maria EugeniaToneatto, JudithAlbesa, InésBecerra, María CeciliaArgüello, GerardoOXIDATIVE STRESSANTIMICROBIAL ACTIVITYITS NUCLEAR ITSRUTHENIUM (II) COMPLEXESESCHERICHIA COLISTAPHYLOCOCCUS AUREUShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections. The main aim of this work was to establish the potential of the synthetic alfa-diimine chromium(III) and Ruthenium(II) complexes (where the alfa-diimine ligands are bpy = 2,2-bipyridine; phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2´,3´-c]-phenazine) like [Cr(phen)3]3+, [Cr(phen)2(dppz)]3+, [Ru(phen)3]2+ and [Ru(bpy)3]2+ as antibacterial agents by generating oxidative stress. The [Cr(phen)3]3+ and [Cr(phen)2(dppz)]3+ complexes showed activity against Gram positive and Gram negative bacteria with minimum inhibitory concentrations (MICs) ranging from 0.125 µg/mL to 1 µg/mL, while [Ru(phen)3]2+ and [Ru(bpy)3]2+ does not exhibit antimicrobial activity against the two bacterial genera studied at the concentration range used. When ciprofloxacin was combined with [Cr(phen)3]3+ for the inhibition of Staphylococcus aureus and Escherichia coli, an important synergistic effect was observed, FIC 0.066 for S. aureus and FIC 0.064 for E. coli. The work described here shows that chromium(III) complexes are bactericidal for S. aureus and E. coli. Our results indicate that alfa-diimine chromium(III) complexes may be interesting to open new paths for metallodrug chemotherapy against different bacterial genera since some of these complexes have been found to exhibit remarkable antibacterial activities.Fil: Paez, Paulina Laura. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; ArgentinaFil: Bazán, Claudia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones En Fisico- Química de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Investigaciones En Fisico- Química de Córdoba; ArgentinaFil: Bongiovanni, Maria Eugenia. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; ArgentinaFil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones En Fisico- Química de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Investigaciones En Fisico- Química de Córdoba; ArgentinaFil: Albesa, Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Argüello, Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones En Fisico- Química de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Investigaciones En Fisico- Química de Córdoba; ArgentinaHindawi Publishing Corporation2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16368Paez, Paulina Laura; Bazán, Claudia Marcela; Bongiovanni, Maria Eugenia; Toneatto, Judith; Albesa, Inés; et al.; Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli; Hindawi Publishing Corporation; BioMed Research International; 2013; 8-2013; 1-72314-61332314-6141enginfo:eu-repo/semantics/altIdentifier/url/http://www.hindawi.com/journals/bmri/2013/906912/info:eu-repo/semantics/altIdentifier/doi/10.1155/2013/906912info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:37Zoai:ri.conicet.gov.ar:11336/16368instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:38.287CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli
title Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli
spellingShingle Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli
Paez, Paulina Laura
OXIDATIVE STRESS
ANTIMICROBIAL ACTIVITY
ITS NUCLEAR ITS
RUTHENIUM (II) COMPLEXES
ESCHERICHIA COLI
STAPHYLOCOCCUS AUREUS
title_short Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli
title_full Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli
title_fullStr Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli
title_full_unstemmed Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli
title_sort Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli
dc.creator.none.fl_str_mv Paez, Paulina Laura
Bazán, Claudia Marcela
Bongiovanni, Maria Eugenia
Toneatto, Judith
Albesa, Inés
Becerra, María Cecilia
Argüello, Gerardo
author Paez, Paulina Laura
author_facet Paez, Paulina Laura
Bazán, Claudia Marcela
Bongiovanni, Maria Eugenia
Toneatto, Judith
Albesa, Inés
Becerra, María Cecilia
Argüello, Gerardo
author_role author
author2 Bazán, Claudia Marcela
Bongiovanni, Maria Eugenia
Toneatto, Judith
Albesa, Inés
Becerra, María Cecilia
Argüello, Gerardo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv OXIDATIVE STRESS
ANTIMICROBIAL ACTIVITY
ITS NUCLEAR ITS
RUTHENIUM (II) COMPLEXES
ESCHERICHIA COLI
STAPHYLOCOCCUS AUREUS
topic OXIDATIVE STRESS
ANTIMICROBIAL ACTIVITY
ITS NUCLEAR ITS
RUTHENIUM (II) COMPLEXES
ESCHERICHIA COLI
STAPHYLOCOCCUS AUREUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections. The main aim of this work was to establish the potential of the synthetic alfa-diimine chromium(III) and Ruthenium(II) complexes (where the alfa-diimine ligands are bpy = 2,2-bipyridine; phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2´,3´-c]-phenazine) like [Cr(phen)3]3+, [Cr(phen)2(dppz)]3+, [Ru(phen)3]2+ and [Ru(bpy)3]2+ as antibacterial agents by generating oxidative stress. The [Cr(phen)3]3+ and [Cr(phen)2(dppz)]3+ complexes showed activity against Gram positive and Gram negative bacteria with minimum inhibitory concentrations (MICs) ranging from 0.125 µg/mL to 1 µg/mL, while [Ru(phen)3]2+ and [Ru(bpy)3]2+ does not exhibit antimicrobial activity against the two bacterial genera studied at the concentration range used. When ciprofloxacin was combined with [Cr(phen)3]3+ for the inhibition of Staphylococcus aureus and Escherichia coli, an important synergistic effect was observed, FIC 0.066 for S. aureus and FIC 0.064 for E. coli. The work described here shows that chromium(III) complexes are bactericidal for S. aureus and E. coli. Our results indicate that alfa-diimine chromium(III) complexes may be interesting to open new paths for metallodrug chemotherapy against different bacterial genera since some of these complexes have been found to exhibit remarkable antibacterial activities.
Fil: Paez, Paulina Laura. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Bazán, Claudia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones En Fisico- Química de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Investigaciones En Fisico- Química de Córdoba; Argentina
Fil: Bongiovanni, Maria Eugenia. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
Fil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones En Fisico- Química de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Investigaciones En Fisico- Química de Córdoba; Argentina
Fil: Albesa, Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Becerra, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Fil: Argüello, Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones En Fisico- Química de Córdoba. Universidad Nacional de Córdoba. Facultad de Cs.químicas. Instituto de Investigaciones En Fisico- Química de Córdoba; Argentina
description The prevalence of antibiotic resistance has resulted in the need for new approaches to be developed to combat previously easily treatable infections. The main aim of this work was to establish the potential of the synthetic alfa-diimine chromium(III) and Ruthenium(II) complexes (where the alfa-diimine ligands are bpy = 2,2-bipyridine; phen = 1,10-phenanthroline and dppz = dipyrido[3,2-a:2´,3´-c]-phenazine) like [Cr(phen)3]3+, [Cr(phen)2(dppz)]3+, [Ru(phen)3]2+ and [Ru(bpy)3]2+ as antibacterial agents by generating oxidative stress. The [Cr(phen)3]3+ and [Cr(phen)2(dppz)]3+ complexes showed activity against Gram positive and Gram negative bacteria with minimum inhibitory concentrations (MICs) ranging from 0.125 µg/mL to 1 µg/mL, while [Ru(phen)3]2+ and [Ru(bpy)3]2+ does not exhibit antimicrobial activity against the two bacterial genera studied at the concentration range used. When ciprofloxacin was combined with [Cr(phen)3]3+ for the inhibition of Staphylococcus aureus and Escherichia coli, an important synergistic effect was observed, FIC 0.066 for S. aureus and FIC 0.064 for E. coli. The work described here shows that chromium(III) complexes are bactericidal for S. aureus and E. coli. Our results indicate that alfa-diimine chromium(III) complexes may be interesting to open new paths for metallodrug chemotherapy against different bacterial genera since some of these complexes have been found to exhibit remarkable antibacterial activities.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16368
Paez, Paulina Laura; Bazán, Claudia Marcela; Bongiovanni, Maria Eugenia; Toneatto, Judith; Albesa, Inés; et al.; Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli; Hindawi Publishing Corporation; BioMed Research International; 2013; 8-2013; 1-7
2314-6133
2314-6141
url http://hdl.handle.net/11336/16368
identifier_str_mv Paez, Paulina Laura; Bazán, Claudia Marcela; Bongiovanni, Maria Eugenia; Toneatto, Judith; Albesa, Inés; et al.; Oxidative Stress and Antimicrobial Activity of Chromium(III) and Ruthenium(II) Complexes on Staphylococcus aureus and Escherichia coli; Hindawi Publishing Corporation; BioMed Research International; 2013; 8-2013; 1-7
2314-6133
2314-6141
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1155/2013/906912
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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