Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology
- Autores
- Martinez Marignac, Veronica Lucrecia; Mondragon, Leonel; Favant, Jose Luis
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Exposure to the IR is common to certain people like professionals handling radioactive materials or to the patients undergoing radio-diagnostics and radiotherapy or as millions of people who travel by air are exposed by X-rays scanning every day. Though it is indirect cause, IR may trigger mutation in healthy cells which further induces molecular alterations. It's known that ionizing radiation generates free radicals from cytoplasmic water and ultimately induces biomolecules lesions such as DNA damage. These damages may lead to neoplasm in normal and healthy cells however IR is not by itself a recognized and indisputable carcinogen present in the environment. In order to develop some type of cancer, they have to interact within the organisms and cells with other multiple factors of high complexity from physiological to environmental components (genetics of the living being, cellular microenvironment, epigenetic factors, environmental conditions, and others, perhaps still unknown). Here we discuss and present IR effect on living cells, ways of damage determination and compounds reported as radioprotectors.
Fil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina
Fil: Mondragon, Leonel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina
Fil: Favant, Jose Luis. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina - Materia
-
Comet assay
Effects and origin of cancer
Ionizing radiation sources
radiobiology
radioprotectors
radiomitigant agents - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/98747
Ver los metadatos del registro completo
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Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biologyMartinez Marignac, Veronica LucreciaMondragon, LeonelFavant, Jose LuisComet assayEffects and origin of cancerIonizing radiation sourcesradiobiologyradioprotectorsradiomitigant agentshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Exposure to the IR is common to certain people like professionals handling radioactive materials or to the patients undergoing radio-diagnostics and radiotherapy or as millions of people who travel by air are exposed by X-rays scanning every day. Though it is indirect cause, IR may trigger mutation in healthy cells which further induces molecular alterations. It's known that ionizing radiation generates free radicals from cytoplasmic water and ultimately induces biomolecules lesions such as DNA damage. These damages may lead to neoplasm in normal and healthy cells however IR is not by itself a recognized and indisputable carcinogen present in the environment. In order to develop some type of cancer, they have to interact within the organisms and cells with other multiple factors of high complexity from physiological to environmental components (genetics of the living being, cellular microenvironment, epigenetic factors, environmental conditions, and others, perhaps still unknown). Here we discuss and present IR effect on living cells, ways of damage determination and compounds reported as radioprotectors.Fil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; ArgentinaFil: Mondragon, Leonel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; ArgentinaFil: Favant, Jose Luis. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaWolters Kluwer2019-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98747Martinez Marignac, Veronica Lucrecia; Mondragon, Leonel; Favant, Jose Luis; Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology; Wolters Kluwer; Clinical Cancer Investigation Journal; 8; 4; 9-2019; 129-1382278-16682278-0513CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ccij-online.org/article.asp?issn=2278-0513;year=2019;volume=8;issue=4;spage=129;epage=138;aulast=Martinezinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:52Zoai:ri.conicet.gov.ar:11336/98747instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:53.196CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology |
title |
Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology |
spellingShingle |
Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology Martinez Marignac, Veronica Lucrecia Comet assay Effects and origin of cancer Ionizing radiation sources radiobiology radioprotectors radiomitigant agents |
title_short |
Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology |
title_full |
Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology |
title_fullStr |
Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology |
title_full_unstemmed |
Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology |
title_sort |
Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology |
dc.creator.none.fl_str_mv |
Martinez Marignac, Veronica Lucrecia Mondragon, Leonel Favant, Jose Luis |
author |
Martinez Marignac, Veronica Lucrecia |
author_facet |
Martinez Marignac, Veronica Lucrecia Mondragon, Leonel Favant, Jose Luis |
author_role |
author |
author2 |
Mondragon, Leonel Favant, Jose Luis |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Comet assay Effects and origin of cancer Ionizing radiation sources radiobiology radioprotectors radiomitigant agents |
topic |
Comet assay Effects and origin of cancer Ionizing radiation sources radiobiology radioprotectors radiomitigant agents |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Exposure to the IR is common to certain people like professionals handling radioactive materials or to the patients undergoing radio-diagnostics and radiotherapy or as millions of people who travel by air are exposed by X-rays scanning every day. Though it is indirect cause, IR may trigger mutation in healthy cells which further induces molecular alterations. It's known that ionizing radiation generates free radicals from cytoplasmic water and ultimately induces biomolecules lesions such as DNA damage. These damages may lead to neoplasm in normal and healthy cells however IR is not by itself a recognized and indisputable carcinogen present in the environment. In order to develop some type of cancer, they have to interact within the organisms and cells with other multiple factors of high complexity from physiological to environmental components (genetics of the living being, cellular microenvironment, epigenetic factors, environmental conditions, and others, perhaps still unknown). Here we discuss and present IR effect on living cells, ways of damage determination and compounds reported as radioprotectors. Fil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina Fil: Mondragon, Leonel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina Fil: Favant, Jose Luis. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina |
description |
Exposure to the IR is common to certain people like professionals handling radioactive materials or to the patients undergoing radio-diagnostics and radiotherapy or as millions of people who travel by air are exposed by X-rays scanning every day. Though it is indirect cause, IR may trigger mutation in healthy cells which further induces molecular alterations. It's known that ionizing radiation generates free radicals from cytoplasmic water and ultimately induces biomolecules lesions such as DNA damage. These damages may lead to neoplasm in normal and healthy cells however IR is not by itself a recognized and indisputable carcinogen present in the environment. In order to develop some type of cancer, they have to interact within the organisms and cells with other multiple factors of high complexity from physiological to environmental components (genetics of the living being, cellular microenvironment, epigenetic factors, environmental conditions, and others, perhaps still unknown). Here we discuss and present IR effect on living cells, ways of damage determination and compounds reported as radioprotectors. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/98747 Martinez Marignac, Veronica Lucrecia; Mondragon, Leonel; Favant, Jose Luis; Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology; Wolters Kluwer; Clinical Cancer Investigation Journal; 8; 4; 9-2019; 129-138 2278-1668 2278-0513 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/98747 |
identifier_str_mv |
Martinez Marignac, Veronica Lucrecia; Mondragon, Leonel; Favant, Jose Luis; Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology; Wolters Kluwer; Clinical Cancer Investigation Journal; 8; 4; 9-2019; 129-138 2278-1668 2278-0513 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.ccij-online.org/article.asp?issn=2278-0513;year=2019;volume=8;issue=4;spage=129;epage=138;aulast=Martinez |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wolters Kluwer |
publisher.none.fl_str_mv |
Wolters Kluwer |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614135368646656 |
score |
13.070432 |