Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology

Autores
Martinez Marignac, Veronica Lucrecia; Mondragon, Leonel; Favant, Jose Luis
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Exposure to the IR is common to certain people like professionals handling radioactive materials or to the patients undergoing radio-diagnostics and radiotherapy or as millions of people who travel by air are exposed by X-rays scanning every day. Though it is indirect cause, IR may trigger mutation in healthy cells which further induces molecular alterations. It's known that ionizing radiation generates free radicals from cytoplasmic water and ultimately induces biomolecules lesions such as DNA damage. These damages may lead to neoplasm in normal and healthy cells however IR is not by itself a recognized and indisputable carcinogen present in the environment. In order to develop some type of cancer, they have to interact within the organisms and cells with other multiple factors of high complexity from physiological to environmental components (genetics of the living being, cellular microenvironment, epigenetic factors, environmental conditions, and others, perhaps still unknown). Here we discuss and present IR effect on living cells, ways of damage determination and compounds reported as radioprotectors.
Fil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina
Fil: Mondragon, Leonel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina
Fil: Favant, Jose Luis. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
Materia
Comet assay
Effects and origin of cancer
Ionizing radiation sources
radiobiology
radioprotectors
radiomitigant agents
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98747
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biologyMartinez Marignac, Veronica LucreciaMondragon, LeonelFavant, Jose LuisComet assayEffects and origin of cancerIonizing radiation sourcesradiobiologyradioprotectorsradiomitigant agentshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Exposure to the IR is common to certain people like professionals handling radioactive materials or to the patients undergoing radio-diagnostics and radiotherapy or as millions of people who travel by air are exposed by X-rays scanning every day. Though it is indirect cause, IR may trigger mutation in healthy cells which further induces molecular alterations. It's known that ionizing radiation generates free radicals from cytoplasmic water and ultimately induces biomolecules lesions such as DNA damage. These damages may lead to neoplasm in normal and healthy cells however IR is not by itself a recognized and indisputable carcinogen present in the environment. In order to develop some type of cancer, they have to interact within the organisms and cells with other multiple factors of high complexity from physiological to environmental components (genetics of the living being, cellular microenvironment, epigenetic factors, environmental conditions, and others, perhaps still unknown). Here we discuss and present IR effect on living cells, ways of damage determination and compounds reported as radioprotectors.Fil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; ArgentinaFil: Mondragon, Leonel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; ArgentinaFil: Favant, Jose Luis. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; ArgentinaWolters Kluwer2019-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98747Martinez Marignac, Veronica Lucrecia; Mondragon, Leonel; Favant, Jose Luis; Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology; Wolters Kluwer; Clinical Cancer Investigation Journal; 8; 4; 9-2019; 129-1382278-16682278-0513CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ccij-online.org/article.asp?issn=2278-0513;year=2019;volume=8;issue=4;spage=129;epage=138;aulast=Martinezinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:15:05Zoai:ri.conicet.gov.ar:11336/98747instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:15:05.597CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology
title Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology
spellingShingle Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology
Martinez Marignac, Veronica Lucrecia
Comet assay
Effects and origin of cancer
Ionizing radiation sources
radiobiology
radioprotectors
radiomitigant agents
title_short Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology
title_full Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology
title_fullStr Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology
title_full_unstemmed Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology
title_sort Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology
dc.creator.none.fl_str_mv Martinez Marignac, Veronica Lucrecia
Mondragon, Leonel
Favant, Jose Luis
author Martinez Marignac, Veronica Lucrecia
author_facet Martinez Marignac, Veronica Lucrecia
Mondragon, Leonel
Favant, Jose Luis
author_role author
author2 Mondragon, Leonel
Favant, Jose Luis
author2_role author
author
dc.subject.none.fl_str_mv Comet assay
Effects and origin of cancer
Ionizing radiation sources
radiobiology
radioprotectors
radiomitigant agents
topic Comet assay
Effects and origin of cancer
Ionizing radiation sources
radiobiology
radioprotectors
radiomitigant agents
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Exposure to the IR is common to certain people like professionals handling radioactive materials or to the patients undergoing radio-diagnostics and radiotherapy or as millions of people who travel by air are exposed by X-rays scanning every day. Though it is indirect cause, IR may trigger mutation in healthy cells which further induces molecular alterations. It's known that ionizing radiation generates free radicals from cytoplasmic water and ultimately induces biomolecules lesions such as DNA damage. These damages may lead to neoplasm in normal and healthy cells however IR is not by itself a recognized and indisputable carcinogen present in the environment. In order to develop some type of cancer, they have to interact within the organisms and cells with other multiple factors of high complexity from physiological to environmental components (genetics of the living being, cellular microenvironment, epigenetic factors, environmental conditions, and others, perhaps still unknown). Here we discuss and present IR effect on living cells, ways of damage determination and compounds reported as radioprotectors.
Fil: Martinez Marignac, Veronica Lucrecia. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina
Fil: Mondragon, Leonel. Universidad Adventista del Plata. Facultad de Ciencias de la Salud; Argentina
Fil: Favant, Jose Luis. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina. Universidad Nacional de Entre Ríos. Facultad de Ingeniería; Argentina
description Exposure to the IR is common to certain people like professionals handling radioactive materials or to the patients undergoing radio-diagnostics and radiotherapy or as millions of people who travel by air are exposed by X-rays scanning every day. Though it is indirect cause, IR may trigger mutation in healthy cells which further induces molecular alterations. It's known that ionizing radiation generates free radicals from cytoplasmic water and ultimately induces biomolecules lesions such as DNA damage. These damages may lead to neoplasm in normal and healthy cells however IR is not by itself a recognized and indisputable carcinogen present in the environment. In order to develop some type of cancer, they have to interact within the organisms and cells with other multiple factors of high complexity from physiological to environmental components (genetics of the living being, cellular microenvironment, epigenetic factors, environmental conditions, and others, perhaps still unknown). Here we discuss and present IR effect on living cells, ways of damage determination and compounds reported as radioprotectors.
publishDate 2019
dc.date.none.fl_str_mv 2019-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98747
Martinez Marignac, Veronica Lucrecia; Mondragon, Leonel; Favant, Jose Luis; Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology; Wolters Kluwer; Clinical Cancer Investigation Journal; 8; 4; 9-2019; 129-138
2278-1668
2278-0513
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98747
identifier_str_mv Martinez Marignac, Veronica Lucrecia; Mondragon, Leonel; Favant, Jose Luis; Sources of ionizing radiation (IR) and their biological effects. An interdisciplinary view, from the physics to cell and molecular biology; Wolters Kluwer; Clinical Cancer Investigation Journal; 8; 4; 9-2019; 129-138
2278-1668
2278-0513
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ccij-online.org/article.asp?issn=2278-0513;year=2019;volume=8;issue=4;spage=129;epage=138;aulast=Martinez
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer
publisher.none.fl_str_mv Wolters Kluwer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083298741190656
score 13.22299

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