An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina

Autores
Gonzalez Pereyra, Maria Laura; Carvalho, Eulogio C. Q.; Tissera, Jorge; Keller, Kelly Moura; Magnoli, Carina Elizabeth; Rosa, Carlos A. R.; Dalcero, Ana Maria; Cavaglieri, Lilia Reneé
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chinchillas are known to be very sensitive to aflatoxins and often a large number of animals die if an outbreak occurs. An acute aflatoxicosis outbreak in a chinchilla farm in Argentina is described in this study. A commercial feed suspected of causing the death of 200 animals was sampled. Nine livers from 9 dead chinchillas were analyzed for their macroscopic and microscopic characteristics through necropsy and histopathologic analysis. Aflatoxins B1, B2, G1 and G2 were determined in feed by thin layer chromatography. Gross macroscopic inspection of livers revealed general enlargement, pale-yellowish coloration, hypertrophy, blunt boards and decreased consistence. Size and color were remarkably different from a healthy organ. Histopathologic analyses of hepatic parenchyma showed severe and diffuse alterations by cytoplasmic vacuolation in hepatocytes. Sudan III staining confirmed the lipidic nature of the content present in the vacuoles. The feed was positive for AFB1 in quantities that exceeded the recommended levels. Histopathology confirmed that lesions were typical alterations associated with aflatoxins intake. Monitoring feed for mycotoxins is crucial to prevent outbreaks, to improve management practices and to diminish exposure risk of animals and humans to these harmful toxins.
Fil: Gonzalez Pereyra, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; Argentina
Fil: Carvalho, Eulogio C. Q.. Universidade Federal Fluminense; Brasil
Fil: Tissera, Jorge. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Keller, Kelly Moura. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Magnoli, Carina Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; Argentina
Fil: Rosa, Carlos A. R.. Conselho Nacional de Desenvolvimiento Científico e Tecnológico; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Dalcero, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; Argentina
Fil: Cavaglieri, Lilia Reneé. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; Argentina
Materia
Acute aflatoxicosis
Outbreak
Chinchillas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/241834
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in ArgentinaGonzalez Pereyra, Maria LauraCarvalho, Eulogio C. Q.Tissera, JorgeKeller, Kelly MouraMagnoli, Carina ElizabethRosa, Carlos A. R.Dalcero, Ana MariaCavaglieri, Lilia ReneéAcute aflatoxicosisOutbreakChinchillashttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Chinchillas are known to be very sensitive to aflatoxins and often a large number of animals die if an outbreak occurs. An acute aflatoxicosis outbreak in a chinchilla farm in Argentina is described in this study. A commercial feed suspected of causing the death of 200 animals was sampled. Nine livers from 9 dead chinchillas were analyzed for their macroscopic and microscopic characteristics through necropsy and histopathologic analysis. Aflatoxins B1, B2, G1 and G2 were determined in feed by thin layer chromatography. Gross macroscopic inspection of livers revealed general enlargement, pale-yellowish coloration, hypertrophy, blunt boards and decreased consistence. Size and color were remarkably different from a healthy organ. Histopathologic analyses of hepatic parenchyma showed severe and diffuse alterations by cytoplasmic vacuolation in hepatocytes. Sudan III staining confirmed the lipidic nature of the content present in the vacuoles. The feed was positive for AFB1 in quantities that exceeded the recommended levels. Histopathology confirmed that lesions were typical alterations associated with aflatoxins intake. Monitoring feed for mycotoxins is crucial to prevent outbreaks, to improve management practices and to diminish exposure risk of animals and humans to these harmful toxins.Fil: Gonzalez Pereyra, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; ArgentinaFil: Carvalho, Eulogio C. Q.. Universidade Federal Fluminense; BrasilFil: Tissera, Jorge. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Keller, Kelly Moura. Universidade Federal Rural do Rio de Janeiro; BrasilFil: Magnoli, Carina Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; ArgentinaFil: Rosa, Carlos A. R.. Conselho Nacional de Desenvolvimiento Científico e Tecnológico; Brasil. Universidade Federal Rural do Rio de Janeiro; BrasilFil: Dalcero, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; ArgentinaFil: Cavaglieri, Lilia Reneé. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; ArgentinaAmerican Association of Veterinary Laboratory Diagnosticians2008-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/241834Gonzalez Pereyra, Maria Laura; Carvalho, Eulogio C. Q.; Tissera, Jorge; Keller, Kelly Moura; Magnoli, Carina Elizabeth; et al.; An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina; American Association of Veterinary Laboratory Diagnosticians; Journal of Veterinary Diagnostic Investigation; 20; 6; 11-2008; 853-8561040-6387CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/104063870802000629info:eu-repo/semantics/altIdentifier/doi/10.1177/104063870802000629info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:25Zoai:ri.conicet.gov.ar:11336/241834instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:26.262CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina
title An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina
spellingShingle An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina
Gonzalez Pereyra, Maria Laura
Acute aflatoxicosis
Outbreak
Chinchillas
title_short An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina
title_full An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina
title_fullStr An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina
title_full_unstemmed An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina
title_sort An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina
dc.creator.none.fl_str_mv Gonzalez Pereyra, Maria Laura
Carvalho, Eulogio C. Q.
Tissera, Jorge
Keller, Kelly Moura
Magnoli, Carina Elizabeth
Rosa, Carlos A. R.
Dalcero, Ana Maria
Cavaglieri, Lilia Reneé
author Gonzalez Pereyra, Maria Laura
author_facet Gonzalez Pereyra, Maria Laura
Carvalho, Eulogio C. Q.
Tissera, Jorge
Keller, Kelly Moura
Magnoli, Carina Elizabeth
Rosa, Carlos A. R.
Dalcero, Ana Maria
Cavaglieri, Lilia Reneé
author_role author
author2 Carvalho, Eulogio C. Q.
Tissera, Jorge
Keller, Kelly Moura
Magnoli, Carina Elizabeth
Rosa, Carlos A. R.
Dalcero, Ana Maria
Cavaglieri, Lilia Reneé
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Acute aflatoxicosis
Outbreak
Chinchillas
topic Acute aflatoxicosis
Outbreak
Chinchillas
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chinchillas are known to be very sensitive to aflatoxins and often a large number of animals die if an outbreak occurs. An acute aflatoxicosis outbreak in a chinchilla farm in Argentina is described in this study. A commercial feed suspected of causing the death of 200 animals was sampled. Nine livers from 9 dead chinchillas were analyzed for their macroscopic and microscopic characteristics through necropsy and histopathologic analysis. Aflatoxins B1, B2, G1 and G2 were determined in feed by thin layer chromatography. Gross macroscopic inspection of livers revealed general enlargement, pale-yellowish coloration, hypertrophy, blunt boards and decreased consistence. Size and color were remarkably different from a healthy organ. Histopathologic analyses of hepatic parenchyma showed severe and diffuse alterations by cytoplasmic vacuolation in hepatocytes. Sudan III staining confirmed the lipidic nature of the content present in the vacuoles. The feed was positive for AFB1 in quantities that exceeded the recommended levels. Histopathology confirmed that lesions were typical alterations associated with aflatoxins intake. Monitoring feed for mycotoxins is crucial to prevent outbreaks, to improve management practices and to diminish exposure risk of animals and humans to these harmful toxins.
Fil: Gonzalez Pereyra, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; Argentina
Fil: Carvalho, Eulogio C. Q.. Universidade Federal Fluminense; Brasil
Fil: Tissera, Jorge. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Keller, Kelly Moura. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Magnoli, Carina Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; Argentina
Fil: Rosa, Carlos A. R.. Conselho Nacional de Desenvolvimiento Científico e Tecnológico; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Dalcero, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; Argentina
Fil: Cavaglieri, Lilia Reneé. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto; Argentina
description Chinchillas are known to be very sensitive to aflatoxins and often a large number of animals die if an outbreak occurs. An acute aflatoxicosis outbreak in a chinchilla farm in Argentina is described in this study. A commercial feed suspected of causing the death of 200 animals was sampled. Nine livers from 9 dead chinchillas were analyzed for their macroscopic and microscopic characteristics through necropsy and histopathologic analysis. Aflatoxins B1, B2, G1 and G2 were determined in feed by thin layer chromatography. Gross macroscopic inspection of livers revealed general enlargement, pale-yellowish coloration, hypertrophy, blunt boards and decreased consistence. Size and color were remarkably different from a healthy organ. Histopathologic analyses of hepatic parenchyma showed severe and diffuse alterations by cytoplasmic vacuolation in hepatocytes. Sudan III staining confirmed the lipidic nature of the content present in the vacuoles. The feed was positive for AFB1 in quantities that exceeded the recommended levels. Histopathology confirmed that lesions were typical alterations associated with aflatoxins intake. Monitoring feed for mycotoxins is crucial to prevent outbreaks, to improve management practices and to diminish exposure risk of animals and humans to these harmful toxins.
publishDate 2008
dc.date.none.fl_str_mv 2008-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/241834
Gonzalez Pereyra, Maria Laura; Carvalho, Eulogio C. Q.; Tissera, Jorge; Keller, Kelly Moura; Magnoli, Carina Elizabeth; et al.; An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina; American Association of Veterinary Laboratory Diagnosticians; Journal of Veterinary Diagnostic Investigation; 20; 6; 11-2008; 853-856
1040-6387
CONICET Digital
CONICET
url http://hdl.handle.net/11336/241834
identifier_str_mv Gonzalez Pereyra, Maria Laura; Carvalho, Eulogio C. Q.; Tissera, Jorge; Keller, Kelly Moura; Magnoli, Carina Elizabeth; et al.; An Outbreak of Acute Aflatoxicosis on a Chinchilla (Chinchilla Lanigera) Farm in Argentina; American Association of Veterinary Laboratory Diagnosticians; Journal of Veterinary Diagnostic Investigation; 20; 6; 11-2008; 853-856
1040-6387
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/10.1177/104063870802000629
info:eu-repo/semantics/altIdentifier/doi/10.1177/104063870802000629
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association of Veterinary Laboratory Diagnosticians
publisher.none.fl_str_mv American Association of Veterinary Laboratory Diagnosticians
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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