Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates

Autores
Macchione, Ana Fabiola; Segovia, Marisol Magalí; Molina, Juan Carlos; Abate, Paula
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Early ethanol exposure disrupts neonatal respiratory patterns and it has been suggested as risk factor associated with the Sudden Infant Death Syndrome. Ambient hypoxia acts as an environmental stressor eliciting breathing adaptations that may be altered by the EtOH exposure. However, the specific effects induce by chronic, acute or the combination of them EtOH intoxication are not clearly understood. In an animal model equivalent to the 3rd human gestational trimester, breathing frequencies and apneas were recorded against an intermittent hypoxic experience as a function of EtOH pre-exposure and/or acute EtOH intoxication. Pups pre-exposed to 0.0 or 2.0g/kg of EtOH (DPs 3-5-7, ig) were evaluated at DP9 in sobriety-0.0g/kg- or under the state of EtOH intoxication-2.0g/kg-. Breathing rates and apneas were recorded through whole body plexismography during 35 minutes [5 min of initial normoxia, followed by 3 episodes of hypoxia (O2 8%) of 5 min, separated by periods of recovery-normoxia of the same duration].First acute EtOH intoxication diminished the hypoxic ventilatory response (HVR) during the test (p=0.034) relative to it expressed in pups never intoxicated. The prior experience with the drug significantly modified the HVR patterns, as follow: in sobriety, EtOH pre-exposed pups exhibited a depressed HVR relative to vehicle pre-exposed pups. On the contrary, under the state of intoxication, EtOH pre-exposed pups elicited an exacerbated HVR when were defied by hypoxia respect to vehicle pre-exposed pups. With regard to apneas, an increase in the number of apneas was triggered by both, the first acute EtOH intoxication or by the history with the drug in sober pups (p= 0.017). In summary, specific HVR alterations and apneic episodes occurrence were observed in neonates depending on the type of EtOH exposure received (acute or chronic). These results emphasize the complexity of the disruptive EtOH effects upon breathing at this early and critical stage of development.
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Segovia, Marisol Magalí. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunió Anual de La Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas
Buenos Aires
Argentina
Sociedad Argentina de Inmunología
Sociedad Argentina de Investigación Clínica
Asociación Argentina de Farmacología Experimental
Sociedad Argentina de Nanomedicinas
Materia
ETANOL
RESPIRACIÓN
NEONATOS
HIPOXIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/159636
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/159636
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonatesMacchione, Ana FabiolaSegovia, Marisol MagalíMolina, Juan CarlosAbate, PaulaETANOLRESPIRACIÓNNEONATOSHIPOXIAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Early ethanol exposure disrupts neonatal respiratory patterns and it has been suggested as risk factor associated with the Sudden Infant Death Syndrome. Ambient hypoxia acts as an environmental stressor eliciting breathing adaptations that may be altered by the EtOH exposure. However, the specific effects induce by chronic, acute or the combination of them EtOH intoxication are not clearly understood. In an animal model equivalent to the 3rd human gestational trimester, breathing frequencies and apneas were recorded against an intermittent hypoxic experience as a function of EtOH pre-exposure and/or acute EtOH intoxication. Pups pre-exposed to 0.0 or 2.0g/kg of EtOH (DPs 3-5-7, ig) were evaluated at DP9 in sobriety-0.0g/kg- or under the state of EtOH intoxication-2.0g/kg-. Breathing rates and apneas were recorded through whole body plexismography during 35 minutes [5 min of initial normoxia, followed by 3 episodes of hypoxia (O2 8%) of 5 min, separated by periods of recovery-normoxia of the same duration].First acute EtOH intoxication diminished the hypoxic ventilatory response (HVR) during the test (p=0.034) relative to it expressed in pups never intoxicated. The prior experience with the drug significantly modified the HVR patterns, as follow: in sobriety, EtOH pre-exposed pups exhibited a depressed HVR relative to vehicle pre-exposed pups. On the contrary, under the state of intoxication, EtOH pre-exposed pups elicited an exacerbated HVR when were defied by hypoxia respect to vehicle pre-exposed pups. With regard to apneas, an increase in the number of apneas was triggered by both, the first acute EtOH intoxication or by the history with the drug in sober pups (p= 0.017). In summary, specific HVR alterations and apneic episodes occurrence were observed in neonates depending on the type of EtOH exposure received (acute or chronic). These results emphasize the complexity of the disruptive EtOH effects upon breathing at this early and critical stage of development.Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Segovia, Marisol Magalí. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaFil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Abate, Paula. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaLXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunió Anual de La Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de NanomedicinasBuenos AiresArgentinaSociedad Argentina de InmunologíaSociedad Argentina de Investigación ClínicaAsociación Argentina de Farmacología ExperimentalSociedad Argentina de NanomedicinasFundación Revista Medicina2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/159636Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunió Anual de La Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas; Buenos Aires; Argentina; 2021; 87-871669-9106CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.saic.org.ar/revista-medicinaNacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:16:47Zoai:ri.conicet.gov.ar:11336/159636instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:16:47.714CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates
title Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates
spellingShingle Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates
Macchione, Ana Fabiola
ETANOL
RESPIRACIÓN
NEONATOS
HIPOXIA
title_short Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates
title_full Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates
title_fullStr Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates
title_full_unstemmed Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates
title_sort Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates
dc.creator.none.fl_str_mv Macchione, Ana Fabiola
Segovia, Marisol Magalí
Molina, Juan Carlos
Abate, Paula
author Macchione, Ana Fabiola
author_facet Macchione, Ana Fabiola
Segovia, Marisol Magalí
Molina, Juan Carlos
Abate, Paula
author_role author
author2 Segovia, Marisol Magalí
Molina, Juan Carlos
Abate, Paula
author2_role author
author
author
dc.subject.none.fl_str_mv ETANOL
RESPIRACIÓN
NEONATOS
HIPOXIA
topic ETANOL
RESPIRACIÓN
NEONATOS
HIPOXIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Early ethanol exposure disrupts neonatal respiratory patterns and it has been suggested as risk factor associated with the Sudden Infant Death Syndrome. Ambient hypoxia acts as an environmental stressor eliciting breathing adaptations that may be altered by the EtOH exposure. However, the specific effects induce by chronic, acute or the combination of them EtOH intoxication are not clearly understood. In an animal model equivalent to the 3rd human gestational trimester, breathing frequencies and apneas were recorded against an intermittent hypoxic experience as a function of EtOH pre-exposure and/or acute EtOH intoxication. Pups pre-exposed to 0.0 or 2.0g/kg of EtOH (DPs 3-5-7, ig) were evaluated at DP9 in sobriety-0.0g/kg- or under the state of EtOH intoxication-2.0g/kg-. Breathing rates and apneas were recorded through whole body plexismography during 35 minutes [5 min of initial normoxia, followed by 3 episodes of hypoxia (O2 8%) of 5 min, separated by periods of recovery-normoxia of the same duration].First acute EtOH intoxication diminished the hypoxic ventilatory response (HVR) during the test (p=0.034) relative to it expressed in pups never intoxicated. The prior experience with the drug significantly modified the HVR patterns, as follow: in sobriety, EtOH pre-exposed pups exhibited a depressed HVR relative to vehicle pre-exposed pups. On the contrary, under the state of intoxication, EtOH pre-exposed pups elicited an exacerbated HVR when were defied by hypoxia respect to vehicle pre-exposed pups. With regard to apneas, an increase in the number of apneas was triggered by both, the first acute EtOH intoxication or by the history with the drug in sober pups (p= 0.017). In summary, specific HVR alterations and apneic episodes occurrence were observed in neonates depending on the type of EtOH exposure received (acute or chronic). These results emphasize the complexity of the disruptive EtOH effects upon breathing at this early and critical stage of development.
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Segovia, Marisol Magalí. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Fil: Molina, Juan Carlos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Abate, Paula. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunió Anual de La Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas
Buenos Aires
Argentina
Sociedad Argentina de Inmunología
Sociedad Argentina de Investigación Clínica
Asociación Argentina de Farmacología Experimental
Sociedad Argentina de Nanomedicinas
description Early ethanol exposure disrupts neonatal respiratory patterns and it has been suggested as risk factor associated with the Sudden Infant Death Syndrome. Ambient hypoxia acts as an environmental stressor eliciting breathing adaptations that may be altered by the EtOH exposure. However, the specific effects induce by chronic, acute or the combination of them EtOH intoxication are not clearly understood. In an animal model equivalent to the 3rd human gestational trimester, breathing frequencies and apneas were recorded against an intermittent hypoxic experience as a function of EtOH pre-exposure and/or acute EtOH intoxication. Pups pre-exposed to 0.0 or 2.0g/kg of EtOH (DPs 3-5-7, ig) were evaluated at DP9 in sobriety-0.0g/kg- or under the state of EtOH intoxication-2.0g/kg-. Breathing rates and apneas were recorded through whole body plexismography during 35 minutes [5 min of initial normoxia, followed by 3 episodes of hypoxia (O2 8%) of 5 min, separated by periods of recovery-normoxia of the same duration].First acute EtOH intoxication diminished the hypoxic ventilatory response (HVR) during the test (p=0.034) relative to it expressed in pups never intoxicated. The prior experience with the drug significantly modified the HVR patterns, as follow: in sobriety, EtOH pre-exposed pups exhibited a depressed HVR relative to vehicle pre-exposed pups. On the contrary, under the state of intoxication, EtOH pre-exposed pups elicited an exacerbated HVR when were defied by hypoxia respect to vehicle pre-exposed pups. With regard to apneas, an increase in the number of apneas was triggered by both, the first acute EtOH intoxication or by the history with the drug in sober pups (p= 0.017). In summary, specific HVR alterations and apneic episodes occurrence were observed in neonates depending on the type of EtOH exposure received (acute or chronic). These results emphasize the complexity of the disruptive EtOH effects upon breathing at this early and critical stage of development.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/159636
Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunió Anual de La Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas; Buenos Aires; Argentina; 2021; 87-87
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/159636
identifier_str_mv Differential effects of the ethanol acute or chronic exposure on the early hypoxic ventilatory response (hvr) in rat neonates; LXVI Reunión Anual de la Sociedad Argentina de Investigación Clínica; LXIX Reunión Anual de la Sociedad Argentina de Inmunología; LIII Reunió Anual de La Asociación Argentina de Farmacología Experimental y XI Reunión Anual de la Asociación Argentina de Nanomedicinas; Buenos Aires; Argentina; 2021; 87-87
1669-9106
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.saic.org.ar/revista-medicina
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Nacional
dc.publisher.none.fl_str_mv Fundación Revista Medicina
publisher.none.fl_str_mv Fundación Revista Medicina
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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