Assessment of Corticoadrenal Reserve Through Salivary Steroids

Autores
Cardoso, Estela M. del Luján; Persi, Gabriel; Arregger, Alejandro Luis; Contreras, Liliana Noemí
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Recent reports have reinforced the usefulness of salivary cortisol (SAF) in the evaluation of cortisol dynamics and the diagnosis of Cushing syndrome. However few data are available on the usefulness of SAF and salivary aldosterone (SAL) in response to corticotrophin (ACTH) stimulus. The aim of the authors ‘ study was to standardize the response of SAF and SAL to the intramuscular injection of 250 mg of synthetic human ACTH in 21 healthy patients. Salivary samples were obtained in baseline conditions and during 30,60,90,120 minutes after ACTH administration. The results showed that all healthy  volunteers achieved SAF and SAL concentrations of at least 40.0 nmol/L and 100.0 pmol/L , respectively , after the stimulus. The clinical usefulness of this test was confirmed when patients with known adrenal dysfunction were studied. In three patients with primary adrenal insufficiency, blunted SAF and SAL responses were obtained. Six patients with secondary adrenal insufficiency demonstrated subnormal or blunted SAF and normal SAL responses after ACTH stimulation. Corticoadrenal reserve can be easily , noninvasively, and accurately investigated through the simultaneous measurement of salivary cortisol and aldosterone in response to corticotrophin. Salivary aldosterone was helpful in the differential diagnosis of adrenocortical hypofunction.
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Persi, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
salivary cortisol
salivary aldosterone
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/101406
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/101406
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Assessment of Corticoadrenal Reserve Through Salivary SteroidsCardoso, Estela M. del LujánPersi, GabrielArregger, Alejandro LuisContreras, Liliana Noemísalivary cortisolsalivary aldosteronehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Recent reports have reinforced the usefulness of salivary cortisol (SAF) in the evaluation of cortisol dynamics and the diagnosis of Cushing syndrome. However few data are available on the usefulness of SAF and salivary aldosterone (SAL) in response to corticotrophin (ACTH) stimulus. The aim of the authors ‘ study was to standardize the response of SAF and SAL to the intramuscular injection of 250 mg of synthetic human ACTH in 21 healthy patients. Salivary samples were obtained in baseline conditions and during 30,60,90,120 minutes after ACTH administration. The results showed that all healthy  volunteers achieved SAF and SAL concentrations of at least 40.0 nmol/L and 100.0 pmol/L , respectively , after the stimulus. The clinical usefulness of this test was confirmed when patients with known adrenal dysfunction were studied. In three patients with primary adrenal insufficiency, blunted SAF and SAL responses were obtained. Six patients with secondary adrenal insufficiency demonstrated subnormal or blunted SAF and normal SAL responses after ACTH stimulation. Corticoadrenal reserve can be easily , noninvasively, and accurately investigated through the simultaneous measurement of salivary cortisol and aldosterone in response to corticotrophin. Salivary aldosterone was helpful in the differential diagnosis of adrenocortical hypofunction.Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Persi, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaLippincott Williams2002-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdftext/richtexttext/richtextapplication/pdfhttp://hdl.handle.net/11336/101406Cardoso, Estela M. del Luján; Persi, Gabriel; Arregger, Alejandro Luis; Contreras, Liliana Noemí; Assessment of Corticoadrenal Reserve Through Salivary Steroids; Lippincott Williams; Endocrinologist; 12; 1; 12-2002; 38-441051-2144CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/theendocrinologist/Abstract/2002/01000/Assessment_of_Corticoadrenal_Reserve_Through.9.aspxinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:19Zoai:ri.conicet.gov.ar:11336/101406instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:20.147CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Assessment of Corticoadrenal Reserve Through Salivary Steroids
title Assessment of Corticoadrenal Reserve Through Salivary Steroids
spellingShingle Assessment of Corticoadrenal Reserve Through Salivary Steroids
Cardoso, Estela M. del Luján
salivary cortisol
salivary aldosterone
title_short Assessment of Corticoadrenal Reserve Through Salivary Steroids
title_full Assessment of Corticoadrenal Reserve Through Salivary Steroids
title_fullStr Assessment of Corticoadrenal Reserve Through Salivary Steroids
title_full_unstemmed Assessment of Corticoadrenal Reserve Through Salivary Steroids
title_sort Assessment of Corticoadrenal Reserve Through Salivary Steroids
dc.creator.none.fl_str_mv Cardoso, Estela M. del Luján
Persi, Gabriel
Arregger, Alejandro Luis
Contreras, Liliana Noemí
author Cardoso, Estela M. del Luján
author_facet Cardoso, Estela M. del Luján
Persi, Gabriel
Arregger, Alejandro Luis
Contreras, Liliana Noemí
author_role author
author2 Persi, Gabriel
Arregger, Alejandro Luis
Contreras, Liliana Noemí
author2_role author
author
author
dc.subject.none.fl_str_mv salivary cortisol
salivary aldosterone
topic salivary cortisol
salivary aldosterone
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Recent reports have reinforced the usefulness of salivary cortisol (SAF) in the evaluation of cortisol dynamics and the diagnosis of Cushing syndrome. However few data are available on the usefulness of SAF and salivary aldosterone (SAL) in response to corticotrophin (ACTH) stimulus. The aim of the authors ‘ study was to standardize the response of SAF and SAL to the intramuscular injection of 250 mg of synthetic human ACTH in 21 healthy patients. Salivary samples were obtained in baseline conditions and during 30,60,90,120 minutes after ACTH administration. The results showed that all healthy  volunteers achieved SAF and SAL concentrations of at least 40.0 nmol/L and 100.0 pmol/L , respectively , after the stimulus. The clinical usefulness of this test was confirmed when patients with known adrenal dysfunction were studied. In three patients with primary adrenal insufficiency, blunted SAF and SAL responses were obtained. Six patients with secondary adrenal insufficiency demonstrated subnormal or blunted SAF and normal SAL responses after ACTH stimulation. Corticoadrenal reserve can be easily , noninvasively, and accurately investigated through the simultaneous measurement of salivary cortisol and aldosterone in response to corticotrophin. Salivary aldosterone was helpful in the differential diagnosis of adrenocortical hypofunction.
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Persi, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Arregger, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Recent reports have reinforced the usefulness of salivary cortisol (SAF) in the evaluation of cortisol dynamics and the diagnosis of Cushing syndrome. However few data are available on the usefulness of SAF and salivary aldosterone (SAL) in response to corticotrophin (ACTH) stimulus. The aim of the authors ‘ study was to standardize the response of SAF and SAL to the intramuscular injection of 250 mg of synthetic human ACTH in 21 healthy patients. Salivary samples were obtained in baseline conditions and during 30,60,90,120 minutes after ACTH administration. The results showed that all healthy  volunteers achieved SAF and SAL concentrations of at least 40.0 nmol/L and 100.0 pmol/L , respectively , after the stimulus. The clinical usefulness of this test was confirmed when patients with known adrenal dysfunction were studied. In three patients with primary adrenal insufficiency, blunted SAF and SAL responses were obtained. Six patients with secondary adrenal insufficiency demonstrated subnormal or blunted SAF and normal SAL responses after ACTH stimulation. Corticoadrenal reserve can be easily , noninvasively, and accurately investigated through the simultaneous measurement of salivary cortisol and aldosterone in response to corticotrophin. Salivary aldosterone was helpful in the differential diagnosis of adrenocortical hypofunction.
publishDate 2002
dc.date.none.fl_str_mv 2002-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/101406
Cardoso, Estela M. del Luján; Persi, Gabriel; Arregger, Alejandro Luis; Contreras, Liliana Noemí; Assessment of Corticoadrenal Reserve Through Salivary Steroids; Lippincott Williams; Endocrinologist; 12; 1; 12-2002; 38-44
1051-2144
CONICET Digital
CONICET
url http://hdl.handle.net/11336/101406
identifier_str_mv Cardoso, Estela M. del Luján; Persi, Gabriel; Arregger, Alejandro Luis; Contreras, Liliana Noemí; Assessment of Corticoadrenal Reserve Through Salivary Steroids; Lippincott Williams; Endocrinologist; 12; 1; 12-2002; 38-44
1051-2144
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/theendocrinologist/Abstract/2002/01000/Assessment_of_Corticoadrenal_Reserve_Through.9.aspx
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
text/richtext
text/richtext
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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