Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus

Autores
Cardoso, Estela M. del Luján; Persi, Gabriel; Gonzalez, Natalia; Tumilasci, Omar Rene; Arregger, Alejandro Luis; Burgos, Myriam; Rodriguez, Viviana; Molina, Ana M.; Contreras, Liliana Noemí
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: Adrenal insufficiency has been reported among critically ill HIV-infected patients. This is the first study that attempts to detect subclinical hypoadrenal states in non-critical HIV patients through salivary steroids in response to intramuscular low-dose ACTH injection. Patients and methods: We studied 21 ambulatory adult HIV-infected patients without specific clinical signs or symptoms of adrenal insufficiency. Normal salivary flow-rate and salivary -amylase activity confirmed adequate salivary gland function. Salivary cortisol (SAF) and salivary aldosterone (SAL) were obtained at baseline and 30min after the injection of 25g of ACTH in the deltoid muscle (LDTs). Assessment of salivary steroids after stimulation with 250g of intramuscular ACTH (HDTs) was performed on those who hyporesponded to LDTs. Basal blood samples were drawn for steroids, renin and ACTH measurements. Results: At baseline SAF and SAL correlated significantly (p = 0.0001) with basal serum cortisol and aldosterone (r = 0.70 and 0.91, respectively). Plasma ACTH and renin concentrations were within the normal range in all patients. Eight of the twenty-one HIV+ patients were LDTs hyporesponders in either SAF (n:1) or SAL (n:7). LDTs repeated in six cases after a year reconfirmed the impairment of aldosterone secretion. LDTs hyporesponders had normal steroid responses to HDTs. Conclusions: LDTs is a simple, safe, well-accepted and non-invasive approach to assess adrenal function in HIV-infected ambulatory patients. It revealed subnormal cortisol (5%) and aldosterone responses (33%) when HDTs results were normal.
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Persi, Gabriel. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Gonzalez, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Tumilasci, Omar Rene. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Burgos, Myriam. Hospital Tornú; Argentina
Fil: Rodriguez, Viviana. Hospital Tornú; Argentina
Fil: Molina, Ana M.. Hospital Tornú; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
adrenal insufficiency
HIV
salivary steroids
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/109255
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/109255
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virusCardoso, Estela M. del LujánPersi, GabrielGonzalez, NataliaTumilasci, Omar ReneArregger, Alejandro LuisBurgos, MyriamRodriguez, VivianaMolina, Ana M.Contreras, Liliana Noemíadrenal insufficiencyHIVsalivary steroidshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: Adrenal insufficiency has been reported among critically ill HIV-infected patients. This is the first study that attempts to detect subclinical hypoadrenal states in non-critical HIV patients through salivary steroids in response to intramuscular low-dose ACTH injection. Patients and methods: We studied 21 ambulatory adult HIV-infected patients without specific clinical signs or symptoms of adrenal insufficiency. Normal salivary flow-rate and salivary -amylase activity confirmed adequate salivary gland function. Salivary cortisol (SAF) and salivary aldosterone (SAL) were obtained at baseline and 30min after the injection of 25g of ACTH in the deltoid muscle (LDTs). Assessment of salivary steroids after stimulation with 250g of intramuscular ACTH (HDTs) was performed on those who hyporesponded to LDTs. Basal blood samples were drawn for steroids, renin and ACTH measurements. Results: At baseline SAF and SAL correlated significantly (p = 0.0001) with basal serum cortisol and aldosterone (r = 0.70 and 0.91, respectively). Plasma ACTH and renin concentrations were within the normal range in all patients. Eight of the twenty-one HIV+ patients were LDTs hyporesponders in either SAF (n:1) or SAL (n:7). LDTs repeated in six cases after a year reconfirmed the impairment of aldosterone secretion. LDTs hyporesponders had normal steroid responses to HDTs. Conclusions: LDTs is a simple, safe, well-accepted and non-invasive approach to assess adrenal function in HIV-infected ambulatory patients. It revealed subnormal cortisol (5%) and aldosterone responses (33%) when HDTs results were normal.Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Persi, Gabriel. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Gonzalez, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Tumilasci, Omar Rene. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Burgos, Myriam. Hospital Tornú; ArgentinaFil: Rodriguez, Viviana. Hospital Tornú; ArgentinaFil: Molina, Ana M.. Hospital Tornú; ArgentinaFil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaElsevier Science Inc2007-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/109255Cardoso, Estela M. del Luján; Persi, Gabriel; Gonzalez, Natalia; Tumilasci, Omar Rene; Arregger, Alejandro Luis; et al.; Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus; Elsevier Science Inc; Steroids; 72; 4; 4-2007; 328-3340039-128XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/17257634/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.steroids.2006.12.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:50Zoai:ri.conicet.gov.ar:11336/109255instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:50.554CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus
title Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus
spellingShingle Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus
Cardoso, Estela M. del Luján
adrenal insufficiency
HIV
salivary steroids
title_short Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus
title_full Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus
title_fullStr Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus
title_full_unstemmed Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus
title_sort Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus
dc.creator.none.fl_str_mv Cardoso, Estela M. del Luján
Persi, Gabriel
Gonzalez, Natalia
Tumilasci, Omar Rene
Arregger, Alejandro Luis
Burgos, Myriam
Rodriguez, Viviana
Molina, Ana M.
Contreras, Liliana Noemí
author Cardoso, Estela M. del Luján
author_facet Cardoso, Estela M. del Luján
Persi, Gabriel
Gonzalez, Natalia
Tumilasci, Omar Rene
Arregger, Alejandro Luis
Burgos, Myriam
Rodriguez, Viviana
Molina, Ana M.
Contreras, Liliana Noemí
author_role author
author2 Persi, Gabriel
Gonzalez, Natalia
Tumilasci, Omar Rene
Arregger, Alejandro Luis
Burgos, Myriam
Rodriguez, Viviana
Molina, Ana M.
Contreras, Liliana Noemí
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv adrenal insufficiency
HIV
salivary steroids
topic adrenal insufficiency
HIV
salivary steroids
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: Adrenal insufficiency has been reported among critically ill HIV-infected patients. This is the first study that attempts to detect subclinical hypoadrenal states in non-critical HIV patients through salivary steroids in response to intramuscular low-dose ACTH injection. Patients and methods: We studied 21 ambulatory adult HIV-infected patients without specific clinical signs or symptoms of adrenal insufficiency. Normal salivary flow-rate and salivary -amylase activity confirmed adequate salivary gland function. Salivary cortisol (SAF) and salivary aldosterone (SAL) were obtained at baseline and 30min after the injection of 25g of ACTH in the deltoid muscle (LDTs). Assessment of salivary steroids after stimulation with 250g of intramuscular ACTH (HDTs) was performed on those who hyporesponded to LDTs. Basal blood samples were drawn for steroids, renin and ACTH measurements. Results: At baseline SAF and SAL correlated significantly (p = 0.0001) with basal serum cortisol and aldosterone (r = 0.70 and 0.91, respectively). Plasma ACTH and renin concentrations were within the normal range in all patients. Eight of the twenty-one HIV+ patients were LDTs hyporesponders in either SAF (n:1) or SAL (n:7). LDTs repeated in six cases after a year reconfirmed the impairment of aldosterone secretion. LDTs hyporesponders had normal steroid responses to HDTs. Conclusions: LDTs is a simple, safe, well-accepted and non-invasive approach to assess adrenal function in HIV-infected ambulatory patients. It revealed subnormal cortisol (5%) and aldosterone responses (33%) when HDTs results were normal.
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Persi, Gabriel. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Gonzalez, Natalia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Tumilasci, Omar Rene. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Burgos, Myriam. Hospital Tornú; Argentina
Fil: Rodriguez, Viviana. Hospital Tornú; Argentina
Fil: Molina, Ana M.. Hospital Tornú; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Objective: Adrenal insufficiency has been reported among critically ill HIV-infected patients. This is the first study that attempts to detect subclinical hypoadrenal states in non-critical HIV patients through salivary steroids in response to intramuscular low-dose ACTH injection. Patients and methods: We studied 21 ambulatory adult HIV-infected patients without specific clinical signs or symptoms of adrenal insufficiency. Normal salivary flow-rate and salivary -amylase activity confirmed adequate salivary gland function. Salivary cortisol (SAF) and salivary aldosterone (SAL) were obtained at baseline and 30min after the injection of 25g of ACTH in the deltoid muscle (LDTs). Assessment of salivary steroids after stimulation with 250g of intramuscular ACTH (HDTs) was performed on those who hyporesponded to LDTs. Basal blood samples were drawn for steroids, renin and ACTH measurements. Results: At baseline SAF and SAL correlated significantly (p = 0.0001) with basal serum cortisol and aldosterone (r = 0.70 and 0.91, respectively). Plasma ACTH and renin concentrations were within the normal range in all patients. Eight of the twenty-one HIV+ patients were LDTs hyporesponders in either SAF (n:1) or SAL (n:7). LDTs repeated in six cases after a year reconfirmed the impairment of aldosterone secretion. LDTs hyporesponders had normal steroid responses to HDTs. Conclusions: LDTs is a simple, safe, well-accepted and non-invasive approach to assess adrenal function in HIV-infected ambulatory patients. It revealed subnormal cortisol (5%) and aldosterone responses (33%) when HDTs results were normal.
publishDate 2007
dc.date.none.fl_str_mv 2007-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/109255
Cardoso, Estela M. del Luján; Persi, Gabriel; Gonzalez, Natalia; Tumilasci, Omar Rene; Arregger, Alejandro Luis; et al.; Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus; Elsevier Science Inc; Steroids; 72; 4; 4-2007; 328-334
0039-128X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/109255
identifier_str_mv Cardoso, Estela M. del Luján; Persi, Gabriel; Gonzalez, Natalia; Tumilasci, Omar Rene; Arregger, Alejandro Luis; et al.; Assessment of adrenal function by measurement of salivary steroids in response to corticotrophin in patients infected with human immunodeficiency virus; Elsevier Science Inc; Steroids; 72; 4; 4-2007; 328-334
0039-128X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/17257634/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.steroids.2006.12.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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