Diagnostic value of salivary cortisol in Cushing's syndrome (CS)

Autores
Cardoso, Estela M. del Luján; Arregger, Alejandro Luis; Tumilasci, Omar Rene; Contreras, Liliana Noemí
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: The diagnosis of Cushing's syndrome (CS) remains a challenge in clinical endocrinology. The aim of this study was to determine the reproducibility and diagnostic value of late‐night salivary cortisol (SAF23) for CS and its utility along the follow‐up of treated patients. In addition, using the same radioimmunoassay reactives, the cut‐off values for saliva and serum cortisol, assessed synchronically after the overnight 1 mg dexamethasone suppression test (DST), were defined. Design: Twenty‐one patients with confirmed CS and 121 volunteers were studied. All the subjects collected 24‐h urine for cortisol (UFC). On the same day whole saliva was obtained from the subjects at 23 h for SAF23. The intraclass coefficient of correlation (ICC) of SAF23 was estimated in 47 subjects (21 CS and 26 C). At 8 h, after DST, simultaneous saliva and serum samples for cortisol (SAFdex and Fdex, respectively) were obtained in 51 subjects (17 CS and 34 C). After specific therapy, 18 patients with CS were followed with SAF23 measurements. SAF and F were expressed as nm. Results: The intraclass coefficient of correlation of SAF23 was 0·89 in CS and 0·83 in C. SAF23 > 3·8 nm showed a sensitivity and specificity of 100% and 97·5%, respectively, for diagnosing CS. SAF23 correlated positively with UFC (r = 0·685; P = 0·0001). After DST, SAFdex significantly correlated with Fdex (r = 0·61, P < 0·0001). A cut‐off value of SAFdex > 2·0 nm and Fdex > 50·0 nm detected CS with 100% sensitivity and specificity. After successful surgical therapy, 13 patients with CS had SAF23 levels < 3·8 nm (1·4 ± 0·8 nm). Conclusions: SAF23 and SAFdex seem to be good screening tools based on their noninvasive nature, remarkable reproducibility and diagnostic performances.
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tumilasci, Omar Rene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Materia
salivary cortisol
Cushing's Symdrome
1 mg dexamethasone suppresssion test
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/105165
Acceder
id CONICETDig_e0df7fb71cb64633506ee9b56cce06cf
oai_identifier_str oai:ri.conicet.gov.ar:11336/105165
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Diagnostic value of salivary cortisol in Cushing's syndrome (CS)Cardoso, Estela M. del LujánArregger, Alejandro LuisTumilasci, Omar ReneContreras, Liliana Noemísalivary cortisolCushing's Symdrome1 mg dexamethasone suppresssion testhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: The diagnosis of Cushing's syndrome (CS) remains a challenge in clinical endocrinology. The aim of this study was to determine the reproducibility and diagnostic value of late‐night salivary cortisol (SAF23) for CS and its utility along the follow‐up of treated patients. In addition, using the same radioimmunoassay reactives, the cut‐off values for saliva and serum cortisol, assessed synchronically after the overnight 1 mg dexamethasone suppression test (DST), were defined. Design: Twenty‐one patients with confirmed CS and 121 volunteers were studied. All the subjects collected 24‐h urine for cortisol (UFC). On the same day whole saliva was obtained from the subjects at 23 h for SAF23. The intraclass coefficient of correlation (ICC) of SAF23 was estimated in 47 subjects (21 CS and 26 C). At 8 h, after DST, simultaneous saliva and serum samples for cortisol (SAFdex and Fdex, respectively) were obtained in 51 subjects (17 CS and 34 C). After specific therapy, 18 patients with CS were followed with SAF23 measurements. SAF and F were expressed as nm. Results: The intraclass coefficient of correlation of SAF23 was 0·89 in CS and 0·83 in C. SAF23 > 3·8 nm showed a sensitivity and specificity of 100% and 97·5%, respectively, for diagnosing CS. SAF23 correlated positively with UFC (r = 0·685; P = 0·0001). After DST, SAFdex significantly correlated with Fdex (r = 0·61, P < 0·0001). A cut‐off value of SAFdex > 2·0 nm and Fdex > 50·0 nm detected CS with 100% sensitivity and specificity. After successful surgical therapy, 13 patients with CS had SAF23 levels < 3·8 nm (1·4 ± 0·8 nm). Conclusions: SAF23 and SAFdex seem to be good screening tools based on their noninvasive nature, remarkable reproducibility and diagnostic performances.Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tumilasci, Omar Rene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaWiley Blackwell Publishing, Inc2009-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105165Cardoso, Estela M. del Luján; Arregger, Alejandro Luis; Tumilasci, Omar Rene; Contreras, Liliana Noemí; Diagnostic value of salivary cortisol in Cushing's syndrome (CS); Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 70; 4; 4-2009; 516-5210300-0664CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2265.2008.03381.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2265.2008.03381.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:38:27Zoai:ri.conicet.gov.ar:11336/105165instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:38:27.374CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
title Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
spellingShingle Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
Cardoso, Estela M. del Luján
salivary cortisol
Cushing's Symdrome
1 mg dexamethasone suppresssion test
title_short Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
title_full Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
title_fullStr Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
title_full_unstemmed Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
title_sort Diagnostic value of salivary cortisol in Cushing's syndrome (CS)
dc.creator.none.fl_str_mv Cardoso, Estela M. del Luján
Arregger, Alejandro Luis
Tumilasci, Omar Rene
Contreras, Liliana Noemí
author Cardoso, Estela M. del Luján
author_facet Cardoso, Estela M. del Luján
Arregger, Alejandro Luis
Tumilasci, Omar Rene
Contreras, Liliana Noemí
author_role author
author2 Arregger, Alejandro Luis
Tumilasci, Omar Rene
Contreras, Liliana Noemí
author2_role author
author
author
dc.subject.none.fl_str_mv salivary cortisol
Cushing's Symdrome
1 mg dexamethasone suppresssion test
topic salivary cortisol
Cushing's Symdrome
1 mg dexamethasone suppresssion test
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: The diagnosis of Cushing's syndrome (CS) remains a challenge in clinical endocrinology. The aim of this study was to determine the reproducibility and diagnostic value of late‐night salivary cortisol (SAF23) for CS and its utility along the follow‐up of treated patients. In addition, using the same radioimmunoassay reactives, the cut‐off values for saliva and serum cortisol, assessed synchronically after the overnight 1 mg dexamethasone suppression test (DST), were defined. Design: Twenty‐one patients with confirmed CS and 121 volunteers were studied. All the subjects collected 24‐h urine for cortisol (UFC). On the same day whole saliva was obtained from the subjects at 23 h for SAF23. The intraclass coefficient of correlation (ICC) of SAF23 was estimated in 47 subjects (21 CS and 26 C). At 8 h, after DST, simultaneous saliva and serum samples for cortisol (SAFdex and Fdex, respectively) were obtained in 51 subjects (17 CS and 34 C). After specific therapy, 18 patients with CS were followed with SAF23 measurements. SAF and F were expressed as nm. Results: The intraclass coefficient of correlation of SAF23 was 0·89 in CS and 0·83 in C. SAF23 > 3·8 nm showed a sensitivity and specificity of 100% and 97·5%, respectively, for diagnosing CS. SAF23 correlated positively with UFC (r = 0·685; P = 0·0001). After DST, SAFdex significantly correlated with Fdex (r = 0·61, P < 0·0001). A cut‐off value of SAFdex > 2·0 nm and Fdex > 50·0 nm detected CS with 100% sensitivity and specificity. After successful surgical therapy, 13 patients with CS had SAF23 levels < 3·8 nm (1·4 ± 0·8 nm). Conclusions: SAF23 and SAFdex seem to be good screening tools based on their noninvasive nature, remarkable reproducibility and diagnostic performances.
Fil: Cardoso, Estela M. del Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Arregger, Alejandro Luis. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tumilasci, Omar Rene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Contreras, Liliana Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description Objective: The diagnosis of Cushing's syndrome (CS) remains a challenge in clinical endocrinology. The aim of this study was to determine the reproducibility and diagnostic value of late‐night salivary cortisol (SAF23) for CS and its utility along the follow‐up of treated patients. In addition, using the same radioimmunoassay reactives, the cut‐off values for saliva and serum cortisol, assessed synchronically after the overnight 1 mg dexamethasone suppression test (DST), were defined. Design: Twenty‐one patients with confirmed CS and 121 volunteers were studied. All the subjects collected 24‐h urine for cortisol (UFC). On the same day whole saliva was obtained from the subjects at 23 h for SAF23. The intraclass coefficient of correlation (ICC) of SAF23 was estimated in 47 subjects (21 CS and 26 C). At 8 h, after DST, simultaneous saliva and serum samples for cortisol (SAFdex and Fdex, respectively) were obtained in 51 subjects (17 CS and 34 C). After specific therapy, 18 patients with CS were followed with SAF23 measurements. SAF and F were expressed as nm. Results: The intraclass coefficient of correlation of SAF23 was 0·89 in CS and 0·83 in C. SAF23 > 3·8 nm showed a sensitivity and specificity of 100% and 97·5%, respectively, for diagnosing CS. SAF23 correlated positively with UFC (r = 0·685; P = 0·0001). After DST, SAFdex significantly correlated with Fdex (r = 0·61, P < 0·0001). A cut‐off value of SAFdex > 2·0 nm and Fdex > 50·0 nm detected CS with 100% sensitivity and specificity. After successful surgical therapy, 13 patients with CS had SAF23 levels < 3·8 nm (1·4 ± 0·8 nm). Conclusions: SAF23 and SAFdex seem to be good screening tools based on their noninvasive nature, remarkable reproducibility and diagnostic performances.
publishDate 2009
dc.date.none.fl_str_mv 2009-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/105165
Cardoso, Estela M. del Luján; Arregger, Alejandro Luis; Tumilasci, Omar Rene; Contreras, Liliana Noemí; Diagnostic value of salivary cortisol in Cushing's syndrome (CS); Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 70; 4; 4-2009; 516-521
0300-0664
CONICET Digital
CONICET
url http://hdl.handle.net/11336/105165
identifier_str_mv Cardoso, Estela M. del Luján; Arregger, Alejandro Luis; Tumilasci, Omar Rene; Contreras, Liliana Noemí; Diagnostic value of salivary cortisol in Cushing's syndrome (CS); Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 70; 4; 4-2009; 516-521
0300-0664
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2265.2008.03381.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2265.2008.03381.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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