The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic

Autores
Ortiz Moyano, Francisco Ramiro; Raya Tonetti, María Fernanda; Tomokiyo, Mikado; Kanmani, Paulraj; Vizoso Pinto, María Guadalupe; Kim, Hojun; Quilodrán Vega, Sandra; Melnikov, Vyacheslav; Alvarez, Gladis Susana; Takahashi, Hideki; Kurata, Shoichiro; Kitazawa, Haruki; Villena, Julio Cesar
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and Streptococcus pneumoniae infections. We demonstrated that nasally administered C. pseudodiphteriticum 090104 or D. pigrum 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract.
Fil: Ortiz Moyano, Francisco Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Raya Tonetti, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Tomokiyo, Mikado. Tohoku University; Japón
Fil: Kanmani, Paulraj. Dongguk University; Corea del Sur
Fil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Kim, Hojun. Dongguk University; Corea del Sur
Fil: Quilodrán Vega, Sandra. Universidad de Concepción; Chile
Fil: Melnikov, Vyacheslav. Gabrichevsky Research Institute; Rusia
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Takahashi, Hideki. Tohoku University; Japón
Fil: Kurata, Shoichiro. Tohoku University; Japón
Fil: Kitazawa, Haruki. Tohoku University; Japón
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón
Materia
CORYNEBACTERIUM PSEUDODIPHTHERITICUM
TLR2
INNATE IMMUNITY
RESPIRATORY COMMENSAL BACTERIA
DOLOSIGRANULUM PIGRUM
TLR3
RESPIRATORY SYNCYTIAL VIRUS
STREPTOCOCCUS PNEUMONIAE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/127236
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/127236
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent CharacteristicOrtiz Moyano, Francisco RamiroRaya Tonetti, María FernandaTomokiyo, MikadoKanmani, PaulrajVizoso Pinto, María GuadalupeKim, HojunQuilodrán Vega, SandraMelnikov, VyacheslavAlvarez, Gladis SusanaTakahashi, HidekiKurata, ShoichiroKitazawa, HarukiVillena, Julio CesarCORYNEBACTERIUM PSEUDODIPHTHERITICUMTLR2INNATE IMMUNITYRESPIRATORY COMMENSAL BACTERIADOLOSIGRANULUM PIGRUMTLR3RESPIRATORY SYNCYTIAL VIRUSSTREPTOCOCCUS PNEUMONIAEhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and Streptococcus pneumoniae infections. We demonstrated that nasally administered C. pseudodiphteriticum 090104 or D. pigrum 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract.Fil: Ortiz Moyano, Francisco Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Raya Tonetti, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Tomokiyo, Mikado. Tohoku University; JapónFil: Kanmani, Paulraj. Dongguk University; Corea del SurFil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Kim, Hojun. Dongguk University; Corea del SurFil: Quilodrán Vega, Sandra. Universidad de Concepción; ChileFil: Melnikov, Vyacheslav. Gabrichevsky Research Institute; RusiaFil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Takahashi, Hideki. Tohoku University; JapónFil: Kurata, Shoichiro. Tohoku University; JapónFil: Kitazawa, Haruki. Tohoku University; JapónFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; JapónMultidisciplinary Digital Publishing Institute2020-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127236Ortiz Moyano, Francisco Ramiro; Raya Tonetti, María Fernanda; Tomokiyo, Mikado; Kanmani, Paulraj; Vizoso Pinto, María Guadalupe; et al.; The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic; Multidisciplinary Digital Publishing Institute; Microorganisms; 8; 5; 5-2020; 1-23;727-7272076-26072076-2607CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/microorganisms8050727info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/8/5/727info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:49:13Zoai:ri.conicet.gov.ar:11336/127236instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:49:14.259CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
spellingShingle The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
Ortiz Moyano, Francisco Ramiro
CORYNEBACTERIUM PSEUDODIPHTHERITICUM
TLR2
INNATE IMMUNITY
RESPIRATORY COMMENSAL BACTERIA
DOLOSIGRANULUM PIGRUM
TLR3
RESPIRATORY SYNCYTIAL VIRUS
STREPTOCOCCUS PNEUMONIAE
title_short The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title_full The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title_fullStr The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title_full_unstemmed The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
title_sort The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic
dc.creator.none.fl_str_mv Ortiz Moyano, Francisco Ramiro
Raya Tonetti, María Fernanda
Tomokiyo, Mikado
Kanmani, Paulraj
Vizoso Pinto, María Guadalupe
Kim, Hojun
Quilodrán Vega, Sandra
Melnikov, Vyacheslav
Alvarez, Gladis Susana
Takahashi, Hideki
Kurata, Shoichiro
Kitazawa, Haruki
Villena, Julio Cesar
author Ortiz Moyano, Francisco Ramiro
author_facet Ortiz Moyano, Francisco Ramiro
Raya Tonetti, María Fernanda
Tomokiyo, Mikado
Kanmani, Paulraj
Vizoso Pinto, María Guadalupe
Kim, Hojun
Quilodrán Vega, Sandra
Melnikov, Vyacheslav
Alvarez, Gladis Susana
Takahashi, Hideki
Kurata, Shoichiro
Kitazawa, Haruki
Villena, Julio Cesar
author_role author
author2 Raya Tonetti, María Fernanda
Tomokiyo, Mikado
Kanmani, Paulraj
Vizoso Pinto, María Guadalupe
Kim, Hojun
Quilodrán Vega, Sandra
Melnikov, Vyacheslav
Alvarez, Gladis Susana
Takahashi, Hideki
Kurata, Shoichiro
Kitazawa, Haruki
Villena, Julio Cesar
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CORYNEBACTERIUM PSEUDODIPHTHERITICUM
TLR2
INNATE IMMUNITY
RESPIRATORY COMMENSAL BACTERIA
DOLOSIGRANULUM PIGRUM
TLR3
RESPIRATORY SYNCYTIAL VIRUS
STREPTOCOCCUS PNEUMONIAE
topic CORYNEBACTERIUM PSEUDODIPHTHERITICUM
TLR2
INNATE IMMUNITY
RESPIRATORY COMMENSAL BACTERIA
DOLOSIGRANULUM PIGRUM
TLR3
RESPIRATORY SYNCYTIAL VIRUS
STREPTOCOCCUS PNEUMONIAE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and Streptococcus pneumoniae infections. We demonstrated that nasally administered C. pseudodiphteriticum 090104 or D. pigrum 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract.
Fil: Ortiz Moyano, Francisco Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Raya Tonetti, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Tomokiyo, Mikado. Tohoku University; Japón
Fil: Kanmani, Paulraj. Dongguk University; Corea del Sur
Fil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Kim, Hojun. Dongguk University; Corea del Sur
Fil: Quilodrán Vega, Sandra. Universidad de Concepción; Chile
Fil: Melnikov, Vyacheslav. Gabrichevsky Research Institute; Rusia
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Takahashi, Hideki. Tohoku University; Japón
Fil: Kurata, Shoichiro. Tohoku University; Japón
Fil: Kitazawa, Haruki. Tohoku University; Japón
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Tohoku University; Japón
description We investigated whether the ability of commensal respiratory bacteria to modulate the innate immune response against bacterial and viral pathogens was a shared or strain-specific characteristic. Bacterial strains belonging to the Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum species were compared by studying their influence in the Toll-like receptor (TLR)-2- and TLR3-triggered immune responses in the respiratory tract, as well as in the resistance to Respiratory Syncytial Virus (RSV) and Streptococcus pneumoniae infections. We demonstrated that nasally administered C. pseudodiphteriticum 090104 or D. pigrum 040417 were able to modulate respiratory immunity and increase the resistance against pathogens, while other strains of the same species did not influence the respiratory immune responses, demonstrating a clear strain-dependent immunomodulatory effect of respiratory commensal bacteria. We also reported here that bacterium-like particles (BLP) and cell walls derived from immunomodulatory respiratory commensal bacteria are an interesting alternative for the modulation of the respiratory immune system. Our study is a step forward in the positioning of certain strains of respiratory commensal bacteria as next-generation probiotics for the respiratory tract.
publishDate 2020
dc.date.none.fl_str_mv 2020-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127236
Ortiz Moyano, Francisco Ramiro; Raya Tonetti, María Fernanda; Tomokiyo, Mikado; Kanmani, Paulraj; Vizoso Pinto, María Guadalupe; et al.; The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic; Multidisciplinary Digital Publishing Institute; Microorganisms; 8; 5; 5-2020; 1-23;727-727
2076-2607
2076-2607
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127236
identifier_str_mv Ortiz Moyano, Francisco Ramiro; Raya Tonetti, María Fernanda; Tomokiyo, Mikado; Kanmani, Paulraj; Vizoso Pinto, María Guadalupe; et al.; The Ability of Respiratory Commensal Bacteria to Beneficially Modulate the Lung Innate Immune Response Is a Strain Dependent Characteristic; Multidisciplinary Digital Publishing Institute; Microorganisms; 8; 5; 5-2020; 1-23;727-727
2076-2607
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/microorganisms8050727
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/8/5/727
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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