Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds

Autores
Cittadini, María Cecilia; García Estévez, Ignacio; Escribano Bailón, M. Teresa; Rivas Gonzalo, Julián C.; Valentich, Mirta Ana; Repossi Marquez, Pablo Gaston; Soria, Elio Andres
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dietary phenolic compounds are plant metabolites with beneficial effects on the central nervous system. Thus, our aim was to identify anti-inflammatory compounds from South American plants on glia, which regulates neuro-immune response. The compounds were extracted from Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQB), and Ilex paraguariensis (IP) teas and identified by HPLC-DAD-MS. Extracts (0–200 µg/ml) were tested on human T98-G and rat C6 glioma lines. Cellular viability (by the resazurin assay), fatty acid profile (by gas chromatography) and pro-inflammatory interleukin-6 release (IL-6 by ELISA) were determined. Data were analyzed by partial least-square regression to discriminate bioactive compounds. Twenty-one compounds were determined in LG, mainly iridoids, which were linked to ω-3 and ω-6 polyunsaturated fatty acids, but not to IL-6 release. Thirty-one compounds were found in AQB, mostly hydroxybenzoic derivatives, which were positively related to IL-6 release. Twenty-three compounds were identified in IP, including caffeoylquinic derivatives and mainly chlorogenic acid. They increased the ω-7 palmitoleic fatty acid, which was related to IL-6 decrease. These results enhances phytochemical knowledge of widely available plants, and suggest the lipid-related anti-inflammatory activity of IP phenolic compounds, which give nutritional relevance to the tea.
Fil: Cittadini, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Ministerio de Salud; Argentina
Fil: García Estévez, Ignacio. Universidad de Salamanca; España
Fil: Escribano Bailón, M. Teresa. Universidad de Salamanca; España
Fil: Rivas Gonzalo, Julián C.. Universidad de Salamanca; España
Fil: Valentich, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina
Fil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina
Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina
Materia
Fatty Acids
Interleukin-6
Glioma Cells
Ilex Paraguariensis
Phenolic Compounds
Aspidosperma Quebracho-Blanco
Lantana Grisebachii
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/63908
Acceder
id CONICETDig_36abe5df3dfbe4316ec273803fd9a8a7
oai_identifier_str oai:ri.conicet.gov.ar:11336/63908
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic CompoundsCittadini, María CeciliaGarcía Estévez, IgnacioEscribano Bailón, M. TeresaRivas Gonzalo, Julián C.Valentich, Mirta AnaRepossi Marquez, Pablo GastonSoria, Elio AndresFatty AcidsInterleukin-6Glioma CellsIlex ParaguariensisPhenolic CompoundsAspidosperma Quebracho-BlancoLantana Grisebachiihttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Dietary phenolic compounds are plant metabolites with beneficial effects on the central nervous system. Thus, our aim was to identify anti-inflammatory compounds from South American plants on glia, which regulates neuro-immune response. The compounds were extracted from Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQB), and Ilex paraguariensis (IP) teas and identified by HPLC-DAD-MS. Extracts (0–200 µg/ml) were tested on human T98-G and rat C6 glioma lines. Cellular viability (by the resazurin assay), fatty acid profile (by gas chromatography) and pro-inflammatory interleukin-6 release (IL-6 by ELISA) were determined. Data were analyzed by partial least-square regression to discriminate bioactive compounds. Twenty-one compounds were determined in LG, mainly iridoids, which were linked to ω-3 and ω-6 polyunsaturated fatty acids, but not to IL-6 release. Thirty-one compounds were found in AQB, mostly hydroxybenzoic derivatives, which were positively related to IL-6 release. Twenty-three compounds were identified in IP, including caffeoylquinic derivatives and mainly chlorogenic acid. They increased the ω-7 palmitoleic fatty acid, which was related to IL-6 decrease. These results enhances phytochemical knowledge of widely available plants, and suggest the lipid-related anti-inflammatory activity of IP phenolic compounds, which give nutritional relevance to the tea.Fil: Cittadini, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Ministerio de Salud; ArgentinaFil: García Estévez, Ignacio. Universidad de Salamanca; EspañaFil: Escribano Bailón, M. Teresa. Universidad de Salamanca; EspañaFil: Rivas Gonzalo, Julián C.. Universidad de Salamanca; EspañaFil: Valentich, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; ArgentinaFil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; ArgentinaFil: Soria, Elio Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; ArgentinaLawrence Erlbaum Assoc Inc-taylor & Francis2018-02-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/63908Cittadini, María Cecilia; García Estévez, Ignacio; Escribano Bailón, M. Teresa; Rivas Gonzalo, Julián C.; Valentich, Mirta Ana; et al.; Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds; Lawrence Erlbaum Assoc Inc-taylor & Francis; Nutrition And Cancer; 70; 2; 21-2-2018; 267-2770163-5581CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/01635581.2018.1412484info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/01635581.2018.1412484info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T08:39:58Zoai:ri.conicet.gov.ar:11336/63908instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 08:39:58.502CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
title Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
spellingShingle Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
Cittadini, María Cecilia
Fatty Acids
Interleukin-6
Glioma Cells
Ilex Paraguariensis
Phenolic Compounds
Aspidosperma Quebracho-Blanco
Lantana Grisebachii
title_short Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
title_full Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
title_fullStr Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
title_full_unstemmed Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
title_sort Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds
dc.creator.none.fl_str_mv Cittadini, María Cecilia
García Estévez, Ignacio
Escribano Bailón, M. Teresa
Rivas Gonzalo, Julián C.
Valentich, Mirta Ana
Repossi Marquez, Pablo Gaston
Soria, Elio Andres
author Cittadini, María Cecilia
author_facet Cittadini, María Cecilia
García Estévez, Ignacio
Escribano Bailón, M. Teresa
Rivas Gonzalo, Julián C.
Valentich, Mirta Ana
Repossi Marquez, Pablo Gaston
Soria, Elio Andres
author_role author
author2 García Estévez, Ignacio
Escribano Bailón, M. Teresa
Rivas Gonzalo, Julián C.
Valentich, Mirta Ana
Repossi Marquez, Pablo Gaston
Soria, Elio Andres
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Fatty Acids
Interleukin-6
Glioma Cells
Ilex Paraguariensis
Phenolic Compounds
Aspidosperma Quebracho-Blanco
Lantana Grisebachii
topic Fatty Acids
Interleukin-6
Glioma Cells
Ilex Paraguariensis
Phenolic Compounds
Aspidosperma Quebracho-Blanco
Lantana Grisebachii
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Dietary phenolic compounds are plant metabolites with beneficial effects on the central nervous system. Thus, our aim was to identify anti-inflammatory compounds from South American plants on glia, which regulates neuro-immune response. The compounds were extracted from Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQB), and Ilex paraguariensis (IP) teas and identified by HPLC-DAD-MS. Extracts (0–200 µg/ml) were tested on human T98-G and rat C6 glioma lines. Cellular viability (by the resazurin assay), fatty acid profile (by gas chromatography) and pro-inflammatory interleukin-6 release (IL-6 by ELISA) were determined. Data were analyzed by partial least-square regression to discriminate bioactive compounds. Twenty-one compounds were determined in LG, mainly iridoids, which were linked to ω-3 and ω-6 polyunsaturated fatty acids, but not to IL-6 release. Thirty-one compounds were found in AQB, mostly hydroxybenzoic derivatives, which were positively related to IL-6 release. Twenty-three compounds were identified in IP, including caffeoylquinic derivatives and mainly chlorogenic acid. They increased the ω-7 palmitoleic fatty acid, which was related to IL-6 decrease. These results enhances phytochemical knowledge of widely available plants, and suggest the lipid-related anti-inflammatory activity of IP phenolic compounds, which give nutritional relevance to the tea.
Fil: Cittadini, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Ministerio de Salud; Argentina
Fil: García Estévez, Ignacio. Universidad de Salamanca; España
Fil: Escribano Bailón, M. Teresa. Universidad de Salamanca; España
Fil: Rivas Gonzalo, Julián C.. Universidad de Salamanca; España
Fil: Valentich, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina
Fil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina
Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba;Facultad de Ciencias Médicas;Cátedra de Bioquímica Molecular; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Biologia Celular; Argentina
description Dietary phenolic compounds are plant metabolites with beneficial effects on the central nervous system. Thus, our aim was to identify anti-inflammatory compounds from South American plants on glia, which regulates neuro-immune response. The compounds were extracted from Lantana grisebachii (LG), Aspidosperma quebracho-blanco (AQB), and Ilex paraguariensis (IP) teas and identified by HPLC-DAD-MS. Extracts (0–200 µg/ml) were tested on human T98-G and rat C6 glioma lines. Cellular viability (by the resazurin assay), fatty acid profile (by gas chromatography) and pro-inflammatory interleukin-6 release (IL-6 by ELISA) were determined. Data were analyzed by partial least-square regression to discriminate bioactive compounds. Twenty-one compounds were determined in LG, mainly iridoids, which were linked to ω-3 and ω-6 polyunsaturated fatty acids, but not to IL-6 release. Thirty-one compounds were found in AQB, mostly hydroxybenzoic derivatives, which were positively related to IL-6 release. Twenty-three compounds were identified in IP, including caffeoylquinic derivatives and mainly chlorogenic acid. They increased the ω-7 palmitoleic fatty acid, which was related to IL-6 decrease. These results enhances phytochemical knowledge of widely available plants, and suggest the lipid-related anti-inflammatory activity of IP phenolic compounds, which give nutritional relevance to the tea.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/63908
Cittadini, María Cecilia; García Estévez, Ignacio; Escribano Bailón, M. Teresa; Rivas Gonzalo, Julián C.; Valentich, Mirta Ana; et al.; Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds; Lawrence Erlbaum Assoc Inc-taylor & Francis; Nutrition And Cancer; 70; 2; 21-2-2018; 267-277
0163-5581
CONICET Digital
CONICET
url http://hdl.handle.net/11336/63908
identifier_str_mv Cittadini, María Cecilia; García Estévez, Ignacio; Escribano Bailón, M. Teresa; Rivas Gonzalo, Julián C.; Valentich, Mirta Ana; et al.; Modulation of Fatty Acids and Interleukin-6 in Glioma Cells by South American Tea Extracts and their Phenolic Compounds; Lawrence Erlbaum Assoc Inc-taylor & Francis; Nutrition And Cancer; 70; 2; 21-2-2018; 267-277
0163-5581
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/01635581.2018.1412484
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/01635581.2018.1412484
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lawrence Erlbaum Assoc Inc-taylor & Francis
publisher.none.fl_str_mv Lawrence Erlbaum Assoc Inc-taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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