Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment

Autores
Miranda, Agustín Ramiro; Cittadini, María Cecilia; Albrecht, Claudia; Soria, Elio Andres
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polyphenols provide by diet may act as antioxidant in the Central Nervous Systemand exert a protective effect on metabolic diseases. The aim of this study was toestablish tea extract effects on oxidative status and murine overweight in accordancewith polyphenolic availability in different encephalic regions. Methods: Balb/cmice (female, n>3) with overweight received for 15 days 100 mg/Kg/d of extractfrom Lantana grisebachii, Aspidosperma quebracho-blanco, or Ilex paraguariensisextracts and control group (received water without extract). Body weight gain wasrecorded regularly. Polyphenols, hydroperoxides (HP), lipid peroxides (LP), andsuperoxide anion (SO) were measured in brain (telencephalon and diencephalon),midbrain, brainstem and cerebellum. Results were compared by ANOVA followedby the Tukey test (P<0.05). Results: A. quebracho-blanco-based treatment decreasedweight gain and increased polyphenols in brainstem (p<0.02), although it concomitantly increased SO and LP in this region (p=0.0029 and p=0.0280, respectively).L. grisebachii-based treatment reduced oxidative markers differentially ineach region (p<0.05). I. paraguariensis-based treatment oxidized midbrain and cerebellum,although it was antioxidant in the brainstem (p<0.05). All treatments were antioxidant in telencephalon (p=0.0029). Conclusions: The A. quebracho-blanco extract was active on overweight and increased polyphenols in brainstem, with safe functional derivatives being required to avoid oxidative stress. Other extracts affected oxidative status in a region-dependent manner.
Fil: Miranda, Agustín Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Ministerio de Salud de la Nación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Cittadini, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Ministerio de Salud de la Nación; Argentina
Fil: Albrecht, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Ministerio de Salud de la Nación; Argentina
Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
CENTRAL NERVOUS SYSTEM
ASPIDOSPERMA QUEBRACHO BLANCO
ILEX PARAGUARIENSIS
LANTANA GRISEBACHII
OBESITY
INFUSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/63972
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/63972
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatmentMiranda, Agustín RamiroCittadini, María CeciliaAlbrecht, ClaudiaSoria, Elio AndresCENTRAL NERVOUS SYSTEMASPIDOSPERMA QUEBRACHO BLANCOILEX PARAGUARIENSISLANTANA GRISEBACHIIOBESITYINFUSIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Polyphenols provide by diet may act as antioxidant in the Central Nervous Systemand exert a protective effect on metabolic diseases. The aim of this study was toestablish tea extract effects on oxidative status and murine overweight in accordancewith polyphenolic availability in different encephalic regions. Methods: Balb/cmice (female, n>3) with overweight received for 15 days 100 mg/Kg/d of extractfrom Lantana grisebachii, Aspidosperma quebracho-blanco, or Ilex paraguariensisextracts and control group (received water without extract). Body weight gain wasrecorded regularly. Polyphenols, hydroperoxides (HP), lipid peroxides (LP), andsuperoxide anion (SO) were measured in brain (telencephalon and diencephalon),midbrain, brainstem and cerebellum. Results were compared by ANOVA followedby the Tukey test (P<0.05). Results: A. quebracho-blanco-based treatment decreasedweight gain and increased polyphenols in brainstem (p<0.02), although it concomitantly increased SO and LP in this region (p=0.0029 and p=0.0280, respectively).L. grisebachii-based treatment reduced oxidative markers differentially ineach region (p<0.05). I. paraguariensis-based treatment oxidized midbrain and cerebellum,although it was antioxidant in the brainstem (p<0.05). All treatments were antioxidant in telencephalon (p=0.0029). Conclusions: The A. quebracho-blanco extract was active on overweight and increased polyphenols in brainstem, with safe functional derivatives being required to avoid oxidative stress. Other extracts affected oxidative status in a region-dependent manner.Fil: Miranda, Agustín Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Ministerio de Salud de la Nación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Cittadini, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Ministerio de Salud de la Nación; ArgentinaFil: Albrecht, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Ministerio de Salud de la Nación; ArgentinaFil: Soria, Elio Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaUniversidad Nacional de Córdoba2017-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/63972Miranda, Agustín Ramiro; Cittadini, María Cecilia; Albrecht, Claudia; Soria, Elio Andres; Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment; Universidad Nacional de Córdoba; Revista Facultad de Ciencias Medicas; 74; 3; 8-2017; 197-2000014-6722CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://revistas.unc.edu.ar/index.php/med/article/view/14815info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-26T09:07:59Zoai:ri.conicet.gov.ar:11336/63972instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-26 09:08:00.089CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
spellingShingle Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
Miranda, Agustín Ramiro
CENTRAL NERVOUS SYSTEM
ASPIDOSPERMA QUEBRACHO BLANCO
ILEX PARAGUARIENSIS
LANTANA GRISEBACHII
OBESITY
INFUSION
title_short Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title_full Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title_fullStr Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title_full_unstemmed Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
title_sort Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment
dc.creator.none.fl_str_mv Miranda, Agustín Ramiro
Cittadini, María Cecilia
Albrecht, Claudia
Soria, Elio Andres
author Miranda, Agustín Ramiro
author_facet Miranda, Agustín Ramiro
Cittadini, María Cecilia
Albrecht, Claudia
Soria, Elio Andres
author_role author
author2 Cittadini, María Cecilia
Albrecht, Claudia
Soria, Elio Andres
author2_role author
author
author
dc.subject.none.fl_str_mv CENTRAL NERVOUS SYSTEM
ASPIDOSPERMA QUEBRACHO BLANCO
ILEX PARAGUARIENSIS
LANTANA GRISEBACHII
OBESITY
INFUSION
topic CENTRAL NERVOUS SYSTEM
ASPIDOSPERMA QUEBRACHO BLANCO
ILEX PARAGUARIENSIS
LANTANA GRISEBACHII
OBESITY
INFUSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Polyphenols provide by diet may act as antioxidant in the Central Nervous Systemand exert a protective effect on metabolic diseases. The aim of this study was toestablish tea extract effects on oxidative status and murine overweight in accordancewith polyphenolic availability in different encephalic regions. Methods: Balb/cmice (female, n>3) with overweight received for 15 days 100 mg/Kg/d of extractfrom Lantana grisebachii, Aspidosperma quebracho-blanco, or Ilex paraguariensisextracts and control group (received water without extract). Body weight gain wasrecorded regularly. Polyphenols, hydroperoxides (HP), lipid peroxides (LP), andsuperoxide anion (SO) were measured in brain (telencephalon and diencephalon),midbrain, brainstem and cerebellum. Results were compared by ANOVA followedby the Tukey test (P<0.05). Results: A. quebracho-blanco-based treatment decreasedweight gain and increased polyphenols in brainstem (p<0.02), although it concomitantly increased SO and LP in this region (p=0.0029 and p=0.0280, respectively).L. grisebachii-based treatment reduced oxidative markers differentially ineach region (p<0.05). I. paraguariensis-based treatment oxidized midbrain and cerebellum,although it was antioxidant in the brainstem (p<0.05). All treatments were antioxidant in telencephalon (p=0.0029). Conclusions: The A. quebracho-blanco extract was active on overweight and increased polyphenols in brainstem, with safe functional derivatives being required to avoid oxidative stress. Other extracts affected oxidative status in a region-dependent manner.
Fil: Miranda, Agustín Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Ministerio de Salud de la Nación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Cittadini, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Ministerio de Salud de la Nación; Argentina
Fil: Albrecht, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Ministerio de Salud de la Nación; Argentina
Fil: Soria, Elio Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description Polyphenols provide by diet may act as antioxidant in the Central Nervous Systemand exert a protective effect on metabolic diseases. The aim of this study was toestablish tea extract effects on oxidative status and murine overweight in accordancewith polyphenolic availability in different encephalic regions. Methods: Balb/cmice (female, n>3) with overweight received for 15 days 100 mg/Kg/d of extractfrom Lantana grisebachii, Aspidosperma quebracho-blanco, or Ilex paraguariensisextracts and control group (received water without extract). Body weight gain wasrecorded regularly. Polyphenols, hydroperoxides (HP), lipid peroxides (LP), andsuperoxide anion (SO) were measured in brain (telencephalon and diencephalon),midbrain, brainstem and cerebellum. Results were compared by ANOVA followedby the Tukey test (P<0.05). Results: A. quebracho-blanco-based treatment decreasedweight gain and increased polyphenols in brainstem (p<0.02), although it concomitantly increased SO and LP in this region (p=0.0029 and p=0.0280, respectively).L. grisebachii-based treatment reduced oxidative markers differentially ineach region (p<0.05). I. paraguariensis-based treatment oxidized midbrain and cerebellum,although it was antioxidant in the brainstem (p<0.05). All treatments were antioxidant in telencephalon (p=0.0029). Conclusions: The A. quebracho-blanco extract was active on overweight and increased polyphenols in brainstem, with safe functional derivatives being required to avoid oxidative stress. Other extracts affected oxidative status in a region-dependent manner.
publishDate 2017
dc.date.none.fl_str_mv 2017-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/63972
Miranda, Agustín Ramiro; Cittadini, María Cecilia; Albrecht, Claudia; Soria, Elio Andres; Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment; Universidad Nacional de Córdoba; Revista Facultad de Ciencias Medicas; 74; 3; 8-2017; 197-200
0014-6722
CONICET Digital
CONICET
url http://hdl.handle.net/11336/63972
identifier_str_mv Miranda, Agustín Ramiro; Cittadini, María Cecilia; Albrecht, Claudia; Soria, Elio Andres; Regional oxidative stress in encephalon of female mice with polyphenolic exposure from tea extracts in oral overweight plant-based treatment; Universidad Nacional de Córdoba; Revista Facultad de Ciencias Medicas; 74; 3; 8-2017; 197-200
0014-6722
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://revistas.unc.edu.ar/index.php/med/article/view/14815
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional de Córdoba
publisher.none.fl_str_mv Universidad Nacional de Córdoba
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.011256

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