Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation

Autores
Gumilar, Fernanda Andrea; Lencinas, Ileana; Bras, Cristina Liliana; Giannuzzi, Leda; Minetti, Alejandra
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Abstract Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the effects of iAs on the development and function of the central nervous system (CNS) have received less attention and only a few studies have focused on neurobehavioral effects. Thus, in order to characterize developmental and behavioral alterations induced by iAs exposure, pregnant Wistar rats were exposed to 0.05 and 0.10 mg/L iAs through drinking water during gestation and lactation. Sensory-motor reflexes in each pup were analyzed and the postnatal day when righting reflex, cliff aversion and negative geotaxis were observed was recorded. Functional Observational Battery (FOB) and locomotor activity in an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. Both FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Lencinas, Ileana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Giannuzzi, Leda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigaciones en Criotecnología de Alimentos (i); Argentina
Fil: Minetti, Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Materia
ARSENIC
DEVELOPMENT EXPOSURE
SENSORY-MOTOR REFLEXES
FUNCTIONAL OBSERVATIONAL BATTERY
LOCOMOTOR ACTIVITY
RAT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7590
Acceder
id CONICETDig_355117ad2044645c49a0d900261e7106
oai_identifier_str oai:ri.conicet.gov.ar:11336/7590
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactationGumilar, Fernanda AndreaLencinas, IleanaBras, Cristina LilianaGiannuzzi, LedaMinetti, AlejandraARSENICDEVELOPMENT EXPOSURESENSORY-MOTOR REFLEXESFUNCTIONAL OBSERVATIONAL BATTERYLOCOMOTOR ACTIVITYRAThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Abstract Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the effects of iAs on the development and function of the central nervous system (CNS) have received less attention and only a few studies have focused on neurobehavioral effects. Thus, in order to characterize developmental and behavioral alterations induced by iAs exposure, pregnant Wistar rats were exposed to 0.05 and 0.10 mg/L iAs through drinking water during gestation and lactation. Sensory-motor reflexes in each pup were analyzed and the postnatal day when righting reflex, cliff aversion and negative geotaxis were observed was recorded. Functional Observational Battery (FOB) and locomotor activity in an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. Both FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Lencinas, Ileana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Giannuzzi, Leda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigaciones en Criotecnología de Alimentos (i); ArgentinaFil: Minetti, Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaElsevier2015-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7590Gumilar, Fernanda Andrea; Lencinas, Ileana; Bras, Cristina Liliana; Giannuzzi, Leda; Minetti, Alejandra; Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation; Elsevier; Neurotoxicology And Teratology.; 49; 2-2015; 1-90892-0362enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0892036215000136info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ntt.2015.02.005info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:23:05Zoai:ri.conicet.gov.ar:11336/7590instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:05.775CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
spellingShingle Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
Gumilar, Fernanda Andrea
ARSENIC
DEVELOPMENT EXPOSURE
SENSORY-MOTOR REFLEXES
FUNCTIONAL OBSERVATIONAL BATTERY
LOCOMOTOR ACTIVITY
RAT
title_short Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title_full Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title_fullStr Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title_full_unstemmed Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
title_sort Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation
dc.creator.none.fl_str_mv Gumilar, Fernanda Andrea
Lencinas, Ileana
Bras, Cristina Liliana
Giannuzzi, Leda
Minetti, Alejandra
author Gumilar, Fernanda Andrea
author_facet Gumilar, Fernanda Andrea
Lencinas, Ileana
Bras, Cristina Liliana
Giannuzzi, Leda
Minetti, Alejandra
author_role author
author2 Lencinas, Ileana
Bras, Cristina Liliana
Giannuzzi, Leda
Minetti, Alejandra
author2_role author
author
author
author
dc.subject.none.fl_str_mv ARSENIC
DEVELOPMENT EXPOSURE
SENSORY-MOTOR REFLEXES
FUNCTIONAL OBSERVATIONAL BATTERY
LOCOMOTOR ACTIVITY
RAT
topic ARSENIC
DEVELOPMENT EXPOSURE
SENSORY-MOTOR REFLEXES
FUNCTIONAL OBSERVATIONAL BATTERY
LOCOMOTOR ACTIVITY
RAT
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Abstract Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the effects of iAs on the development and function of the central nervous system (CNS) have received less attention and only a few studies have focused on neurobehavioral effects. Thus, in order to characterize developmental and behavioral alterations induced by iAs exposure, pregnant Wistar rats were exposed to 0.05 and 0.10 mg/L iAs through drinking water during gestation and lactation. Sensory-motor reflexes in each pup were analyzed and the postnatal day when righting reflex, cliff aversion and negative geotaxis were observed was recorded. Functional Observational Battery (FOB) and locomotor activity in an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. Both FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Lencinas, Ileana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Giannuzzi, Leda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico La Plata. Centro de Investigaciones en Criotecnología de Alimentos (i); Argentina
Fil: Minetti, Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
description Abstract Arsenic (As) is one of the most toxic naturally occurring contaminants in the environment. The major source of human exposure to inorganic As (iAs) is through contaminated drinking water. Although both genotoxicity and carcinogenicity derived from this metalloid have been thoroughly studied, the effects of iAs on the development and function of the central nervous system (CNS) have received less attention and only a few studies have focused on neurobehavioral effects. Thus, in order to characterize developmental and behavioral alterations induced by iAs exposure, pregnant Wistar rats were exposed to 0.05 and 0.10 mg/L iAs through drinking water during gestation and lactation. Sensory-motor reflexes in each pup were analyzed and the postnatal day when righting reflex, cliff aversion and negative geotaxis were observed was recorded. Functional Observational Battery (FOB) and locomotor activity in an open field were assessed in 90-day-old offspring. Results show that rats exposed to low iAs concentrations through drinking water during early development evidence a delay in the development of sensory-motor reflexes. Both FOB procedure and open-field tests showed a decrease in locomotor activity in adult rats. This study reveals that exposure to the above-mentioned iAs concentrations produces dysfunction in the CNS mechanisms whose role is to regulate motor and sensory development and locomotor activity.
publishDate 2015
dc.date.none.fl_str_mv 2015-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7590
Gumilar, Fernanda Andrea; Lencinas, Ileana; Bras, Cristina Liliana; Giannuzzi, Leda; Minetti, Alejandra; Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation; Elsevier; Neurotoxicology And Teratology.; 49; 2-2015; 1-9
0892-0362
url http://hdl.handle.net/11336/7590
identifier_str_mv Gumilar, Fernanda Andrea; Lencinas, Ileana; Bras, Cristina Liliana; Giannuzzi, Leda; Minetti, Alejandra; Locomotor activity and sensory-motor developmental alterations in rat offspring exposed to Arsenic prenatally and via lactation; Elsevier; Neurotoxicology And Teratology.; 49; 2-2015; 1-9
0892-0362
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0892036215000136
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ntt.2015.02.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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