Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice

Autores
Bras, Cristina Liliana; Dominguez, Sergio Ariel; Codón, Stella Maris; Minetti, Silvia Alejandra; Ferrero, Adriana Alicia
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aim of the study: Several extracts of Schinus molle var. areira L. plant proved to be useful for the treatment of different pathologies and for the control of insect pest. Due to these potential uses, it is necessary to study their safety. In this work, we evaluated the effects of subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira in mice. Materials and methods: The plant extract was added to the diet at 1. g/kg. body weight/day for 90 days. At the end of the exposure, behavioral and functional parameters in a functional observational battery and motor activity in an open field were assessed. Finally, several biochemical and histopathological studies were realized. Results: The exposure to extract from leaves produced an increase in the number of rearings in the open field and of urine pools in the functional observational battery. On the other hand, the exposure to extract from fruits produced an increase in the neutrophil count and a decrease in the lymphocyte count and in the total cholesterol levels. None of the exposures affected the different organs evaluated. Conclusions: Our results suggest that subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira should be potentially useful in the treatment of lipid pathologies and safe to use.
Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Zoología de Invertebrados II; Argentina
Fil: Dominguez, Sergio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Codón, Stella Maris. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Minetti, Silvia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Ferrero, Adriana Alicia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Zoología de Invertebrados II; Argentina
Materia
Biochemical Study
Functional Observational Battery
Histopathological Study
Motor Activity
Schinus Molle Var. Areira
Subchronic Exposure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/68737
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/68737
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in miceBras, Cristina LilianaDominguez, Sergio ArielCodón, Stella MarisMinetti, Silvia AlejandraFerrero, Adriana AliciaBiochemical StudyFunctional Observational BatteryHistopathological StudyMotor ActivitySchinus Molle Var. AreiraSubchronic Exposurehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Aim of the study: Several extracts of Schinus molle var. areira L. plant proved to be useful for the treatment of different pathologies and for the control of insect pest. Due to these potential uses, it is necessary to study their safety. In this work, we evaluated the effects of subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira in mice. Materials and methods: The plant extract was added to the diet at 1. g/kg. body weight/day for 90 days. At the end of the exposure, behavioral and functional parameters in a functional observational battery and motor activity in an open field were assessed. Finally, several biochemical and histopathological studies were realized. Results: The exposure to extract from leaves produced an increase in the number of rearings in the open field and of urine pools in the functional observational battery. On the other hand, the exposure to extract from fruits produced an increase in the neutrophil count and a decrease in the lymphocyte count and in the total cholesterol levels. None of the exposures affected the different organs evaluated. Conclusions: Our results suggest that subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira should be potentially useful in the treatment of lipid pathologies and safe to use.Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Zoología de Invertebrados II; ArgentinaFil: Dominguez, Sergio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Codón, Stella Maris. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Minetti, Silvia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Ferrero, Adriana Alicia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Zoología de Invertebrados II; ArgentinaElsevier Ireland2010-10-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/68737Bras, Cristina Liliana; Dominguez, Sergio Ariel; Codón, Stella Maris; Minetti, Silvia Alejandra; Ferrero, Adriana Alicia; Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice; Elsevier Ireland; Journal of Ethnopharmacology; 132; 1; 28-10-2010; 321-3270378-8741CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378874110005829info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jep.2010.08.035info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:13Zoai:ri.conicet.gov.ar:11336/68737instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:13.308CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice
title Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice
spellingShingle Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice
Bras, Cristina Liliana
Biochemical Study
Functional Observational Battery
Histopathological Study
Motor Activity
Schinus Molle Var. Areira
Subchronic Exposure
title_short Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice
title_full Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice
title_fullStr Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice
title_full_unstemmed Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice
title_sort Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice
dc.creator.none.fl_str_mv Bras, Cristina Liliana
Dominguez, Sergio Ariel
Codón, Stella Maris
Minetti, Silvia Alejandra
Ferrero, Adriana Alicia
author Bras, Cristina Liliana
author_facet Bras, Cristina Liliana
Dominguez, Sergio Ariel
Codón, Stella Maris
Minetti, Silvia Alejandra
Ferrero, Adriana Alicia
author_role author
author2 Dominguez, Sergio Ariel
Codón, Stella Maris
Minetti, Silvia Alejandra
Ferrero, Adriana Alicia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Biochemical Study
Functional Observational Battery
Histopathological Study
Motor Activity
Schinus Molle Var. Areira
Subchronic Exposure
topic Biochemical Study
Functional Observational Battery
Histopathological Study
Motor Activity
Schinus Molle Var. Areira
Subchronic Exposure
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Aim of the study: Several extracts of Schinus molle var. areira L. plant proved to be useful for the treatment of different pathologies and for the control of insect pest. Due to these potential uses, it is necessary to study their safety. In this work, we evaluated the effects of subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira in mice. Materials and methods: The plant extract was added to the diet at 1. g/kg. body weight/day for 90 days. At the end of the exposure, behavioral and functional parameters in a functional observational battery and motor activity in an open field were assessed. Finally, several biochemical and histopathological studies were realized. Results: The exposure to extract from leaves produced an increase in the number of rearings in the open field and of urine pools in the functional observational battery. On the other hand, the exposure to extract from fruits produced an increase in the neutrophil count and a decrease in the lymphocyte count and in the total cholesterol levels. None of the exposures affected the different organs evaluated. Conclusions: Our results suggest that subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira should be potentially useful in the treatment of lipid pathologies and safe to use.
Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Zoología de Invertebrados II; Argentina
Fil: Dominguez, Sergio Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Codón, Stella Maris. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Minetti, Silvia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
Fil: Ferrero, Adriana Alicia. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Laboratorio de Zoología de Invertebrados II; Argentina
description Aim of the study: Several extracts of Schinus molle var. areira L. plant proved to be useful for the treatment of different pathologies and for the control of insect pest. Due to these potential uses, it is necessary to study their safety. In this work, we evaluated the effects of subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira in mice. Materials and methods: The plant extract was added to the diet at 1. g/kg. body weight/day for 90 days. At the end of the exposure, behavioral and functional parameters in a functional observational battery and motor activity in an open field were assessed. Finally, several biochemical and histopathological studies were realized. Results: The exposure to extract from leaves produced an increase in the number of rearings in the open field and of urine pools in the functional observational battery. On the other hand, the exposure to extract from fruits produced an increase in the neutrophil count and a decrease in the lymphocyte count and in the total cholesterol levels. None of the exposures affected the different organs evaluated. Conclusions: Our results suggest that subchronic exposure to ethanolic extracts from leaves and fruits of Schinus molle var. areira should be potentially useful in the treatment of lipid pathologies and safe to use.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-28
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/68737
Bras, Cristina Liliana; Dominguez, Sergio Ariel; Codón, Stella Maris; Minetti, Silvia Alejandra; Ferrero, Adriana Alicia; Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice; Elsevier Ireland; Journal of Ethnopharmacology; 132; 1; 28-10-2010; 321-327
0378-8741
CONICET Digital
CONICET
url http://hdl.handle.net/11336/68737
identifier_str_mv Bras, Cristina Liliana; Dominguez, Sergio Ariel; Codón, Stella Maris; Minetti, Silvia Alejandra; Ferrero, Adriana Alicia; Consequences of subchronic exposure to ethanolic extract from fruits and leaves of Schinus molle var. areira L. in mice; Elsevier Ireland; Journal of Ethnopharmacology; 132; 1; 28-10-2010; 321-327
0378-8741
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378874110005829
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jep.2010.08.035
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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