Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development

Autores
Bartos, Mariana; Gumilar, Fernanda Andrea; Bras, Cristina Liliana; Gallegos, Cristina Eugenia; Giannuzzi, Leda; Cancela, Liliana Marina; Minetti, Alejandra
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is known that exposure to high concentrations of Fluoride (F) produces deleterious health effects in human population. However, in the last years it has been concluded that low concentrations of F may have adverse health effects aswell. Transplacental passage of F and its incorporation into foetal tissues has been demonstrated. Therefore, the purpose of the presentwork was to study the effects of the exposure to lowlevels of F during pregnancy and lactation on the central nervous system functionality. Wistar rats were exposed to low F concentrations (5 and 10 mg/l) during pregnancy and lactation. Sensorimotor reflexes in the each pup were analysed and the postnatal day on which both eyes and auditory canals were opened was recorded. Locomotor activity and anxiety were subsequently analysed in 45- and 90-day-old offspring by an open field test and plus maze test, respectively. A significant delay in the development of eye opening was observed in all offspring whose mothers had been exposed to the two F concentrations tested. Exposure to 5 and 10 mg/l F was also found to significantly decrease locomotor activity only in 90-day-old male and female offspring. A low index of anxiety in the young females and in all adult offspring exposed to the two F concentrations tested was also detected. Taken together, findings from the present study show that exposure to low F concentrations during pregnancy and lactation produces dysfunction in the central nervous system mechanisms which regulate motor and sensitive development, locomotor activity and anxiety.
Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Giannuzzi, Leda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones En Criotecnología de Alimentos (i); Argentina
Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Minetti, Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Materia
Fluoride
Development Exposure
Sensory-Motor Reflexes
Locomotor Activity
Anxiety
Rat
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/7589
Acceder
id CONICETDig_72dc62f94d8d75053d4d8e1b6a40d059
oai_identifier_str oai:ri.conicet.gov.ar:11336/7589
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat DevelopmentBartos, MarianaGumilar, Fernanda AndreaBras, Cristina LilianaGallegos, Cristina EugeniaGiannuzzi, LedaCancela, Liliana MarinaMinetti, AlejandraFluorideDevelopment ExposureSensory-Motor ReflexesLocomotor ActivityAnxietyRathttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3It is known that exposure to high concentrations of Fluoride (F) produces deleterious health effects in human population. However, in the last years it has been concluded that low concentrations of F may have adverse health effects aswell. Transplacental passage of F and its incorporation into foetal tissues has been demonstrated. Therefore, the purpose of the presentwork was to study the effects of the exposure to lowlevels of F during pregnancy and lactation on the central nervous system functionality. Wistar rats were exposed to low F concentrations (5 and 10 mg/l) during pregnancy and lactation. Sensorimotor reflexes in the each pup were analysed and the postnatal day on which both eyes and auditory canals were opened was recorded. Locomotor activity and anxiety were subsequently analysed in 45- and 90-day-old offspring by an open field test and plus maze test, respectively. A significant delay in the development of eye opening was observed in all offspring whose mothers had been exposed to the two F concentrations tested. Exposure to 5 and 10 mg/l F was also found to significantly decrease locomotor activity only in 90-day-old male and female offspring. A low index of anxiety in the young females and in all adult offspring exposed to the two F concentrations tested was also detected. Taken together, findings from the present study show that exposure to low F concentrations during pregnancy and lactation produces dysfunction in the central nervous system mechanisms which regulate motor and sensitive development, locomotor activity and anxiety.Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaFil: Giannuzzi, Leda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones En Criotecnología de Alimentos (i); ArgentinaFil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Minetti, Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; ArgentinaElsevier2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7589Bartos, Mariana; Gumilar, Fernanda Andrea; Bras, Cristina Liliana; Gallegos, Cristina Eugenia; Giannuzzi, Leda; et al.; Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development; Elsevier; Physiology And Behavior; 147; 4-2015; 205-2120031-9384enghttp://hdl.handle.net/11336/185139info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0031938415002516info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physbeh.2015.04.044info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:46Zoai:ri.conicet.gov.ar:11336/7589instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:47.111CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development
title Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development
spellingShingle Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development
Bartos, Mariana
Fluoride
Development Exposure
Sensory-Motor Reflexes
Locomotor Activity
Anxiety
Rat
title_short Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development
title_full Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development
title_fullStr Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development
title_full_unstemmed Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development
title_sort Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development
dc.creator.none.fl_str_mv Bartos, Mariana
Gumilar, Fernanda Andrea
Bras, Cristina Liliana
Gallegos, Cristina Eugenia
Giannuzzi, Leda
Cancela, Liliana Marina
Minetti, Alejandra
author Bartos, Mariana
author_facet Bartos, Mariana
Gumilar, Fernanda Andrea
Bras, Cristina Liliana
Gallegos, Cristina Eugenia
Giannuzzi, Leda
Cancela, Liliana Marina
Minetti, Alejandra
author_role author
author2 Gumilar, Fernanda Andrea
Bras, Cristina Liliana
Gallegos, Cristina Eugenia
Giannuzzi, Leda
Cancela, Liliana Marina
Minetti, Alejandra
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Fluoride
Development Exposure
Sensory-Motor Reflexes
Locomotor Activity
Anxiety
Rat
topic Fluoride
Development Exposure
Sensory-Motor Reflexes
Locomotor Activity
Anxiety
Rat
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv It is known that exposure to high concentrations of Fluoride (F) produces deleterious health effects in human population. However, in the last years it has been concluded that low concentrations of F may have adverse health effects aswell. Transplacental passage of F and its incorporation into foetal tissues has been demonstrated. Therefore, the purpose of the presentwork was to study the effects of the exposure to lowlevels of F during pregnancy and lactation on the central nervous system functionality. Wistar rats were exposed to low F concentrations (5 and 10 mg/l) during pregnancy and lactation. Sensorimotor reflexes in the each pup were analysed and the postnatal day on which both eyes and auditory canals were opened was recorded. Locomotor activity and anxiety were subsequently analysed in 45- and 90-day-old offspring by an open field test and plus maze test, respectively. A significant delay in the development of eye opening was observed in all offspring whose mothers had been exposed to the two F concentrations tested. Exposure to 5 and 10 mg/l F was also found to significantly decrease locomotor activity only in 90-day-old male and female offspring. A low index of anxiety in the young females and in all adult offspring exposed to the two F concentrations tested was also detected. Taken together, findings from the present study show that exposure to low F concentrations during pregnancy and lactation produces dysfunction in the central nervous system mechanisms which regulate motor and sensitive development, locomotor activity and anxiety.
Fil: Bartos, Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Gumilar, Fernanda Andrea. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Bras, Cristina Liliana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Gallegos, Cristina Eugenia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
Fil: Giannuzzi, Leda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Centro de Investigaciones En Criotecnología de Alimentos (i); Argentina
Fil: Cancela, Liliana Marina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Minetti, Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnológico Bahia Blanca. Instituto de Ciencias Biologicas y Biomedicas del Sur; Argentina
description It is known that exposure to high concentrations of Fluoride (F) produces deleterious health effects in human population. However, in the last years it has been concluded that low concentrations of F may have adverse health effects aswell. Transplacental passage of F and its incorporation into foetal tissues has been demonstrated. Therefore, the purpose of the presentwork was to study the effects of the exposure to lowlevels of F during pregnancy and lactation on the central nervous system functionality. Wistar rats were exposed to low F concentrations (5 and 10 mg/l) during pregnancy and lactation. Sensorimotor reflexes in the each pup were analysed and the postnatal day on which both eyes and auditory canals were opened was recorded. Locomotor activity and anxiety were subsequently analysed in 45- and 90-day-old offspring by an open field test and plus maze test, respectively. A significant delay in the development of eye opening was observed in all offspring whose mothers had been exposed to the two F concentrations tested. Exposure to 5 and 10 mg/l F was also found to significantly decrease locomotor activity only in 90-day-old male and female offspring. A low index of anxiety in the young females and in all adult offspring exposed to the two F concentrations tested was also detected. Taken together, findings from the present study show that exposure to low F concentrations during pregnancy and lactation produces dysfunction in the central nervous system mechanisms which regulate motor and sensitive development, locomotor activity and anxiety.
publishDate 2015
dc.date.none.fl_str_mv 2015-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/7589
Bartos, Mariana; Gumilar, Fernanda Andrea; Bras, Cristina Liliana; Gallegos, Cristina Eugenia; Giannuzzi, Leda; et al.; Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development; Elsevier; Physiology And Behavior; 147; 4-2015; 205-212
0031-9384
url http://hdl.handle.net/11336/7589
identifier_str_mv Bartos, Mariana; Gumilar, Fernanda Andrea; Bras, Cristina Liliana; Gallegos, Cristina Eugenia; Giannuzzi, Leda; et al.; Neurobehavioural Effects of Exposure to Fluoride in the Earliest Stages of Rat Development; Elsevier; Physiology And Behavior; 147; 4-2015; 205-212
0031-9384
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://hdl.handle.net/11336/185139
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0031938415002516
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physbeh.2015.04.044
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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