A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles

Autores
Caraballo, Diego Alfredo; Lema, Cristina; Novaro, Laura; Gury Dohmen, Federico; Russo, Susana; Beltrán, Fernando J.; Palacios, Gustavo; Cisterna, Daniel Marcelo
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The rabies virus (RABV) is characterized by a history dominated by host shifts within and among bats and carnivores. One of the main outcomes of long-term RABV maintenance in dogs was the establishment of variants in a wide variety of mesocarnivores. In this study, we present the most comprehensive phylogenetic and phylogeographic analysis, contributing to a better understanding of the origins, diversification, and the role of different host species in the evolution and diffusion of a dog-related variant endemic of South America. A total of 237 complete Nucleoprotein gene sequences were studied, corresponding to wild and domestic species, performing selection analyses, ancestral states reconstructions, and recombination analyses. This variant originated in Brazil and disseminated through Argentina and Paraguay, where a previously unknown lineage was found. A single host shift was identified in the phylogeny, from dog to the crab-eating fox (Cerdocyon thous) in the Northeast of Brazil. Although this process occurred in a background of purifying selection, there is evidence of adaptive evolution-or selection of sub-consensus sequences-in internal branches after the host shift. The interaction of domestic and wild cycles persisted after host switching, as revealed by spillover and putative recombination events.
Fil: Caraballo, Diego Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
Fil: Lema, Cristina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Novaro, Laura. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Gury Dohmen, Federico. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina
Fil: Russo, Susana. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Beltrán, Fernando J.. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina
Fil: Palacios, Gustavo. Icahn School of Medicine at Mount Sinai; Estados Unidos
Fil: Cisterna, Daniel Marcelo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Materia
DOG-RELATED
HOST SHIFT
NUCLEOPROTEIN
PHYLOGENY
RABIES
RECOMBINATION
SELECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/182003
Acceder
id CONICETDig_3545ab48d115ff1c20d74bca6ede2ccc
oai_identifier_str oai:ri.conicet.gov.ar:11336/182003
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cyclesCaraballo, Diego AlfredoLema, CristinaNovaro, LauraGury Dohmen, FedericoRusso, SusanaBeltrán, Fernando J.Palacios, GustavoCisterna, Daniel MarceloDOG-RELATEDHOST SHIFTNUCLEOPROTEINPHYLOGENYRABIESRECOMBINATIONSELECTIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The rabies virus (RABV) is characterized by a history dominated by host shifts within and among bats and carnivores. One of the main outcomes of long-term RABV maintenance in dogs was the establishment of variants in a wide variety of mesocarnivores. In this study, we present the most comprehensive phylogenetic and phylogeographic analysis, contributing to a better understanding of the origins, diversification, and the role of different host species in the evolution and diffusion of a dog-related variant endemic of South America. A total of 237 complete Nucleoprotein gene sequences were studied, corresponding to wild and domestic species, performing selection analyses, ancestral states reconstructions, and recombination analyses. This variant originated in Brazil and disseminated through Argentina and Paraguay, where a previously unknown lineage was found. A single host shift was identified in the phylogeny, from dog to the crab-eating fox (Cerdocyon thous) in the Northeast of Brazil. Although this process occurred in a background of purifying selection, there is evidence of adaptive evolution-or selection of sub-consensus sequences-in internal branches after the host shift. The interaction of domestic and wild cycles persisted after host switching, as revealed by spillover and putative recombination events.Fil: Caraballo, Diego Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Lema, Cristina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; ArgentinaFil: Novaro, Laura. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Gury Dohmen, Federico. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; ArgentinaFil: Russo, Susana. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Beltrán, Fernando J.. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; ArgentinaFil: Palacios, Gustavo. Icahn School of Medicine at Mount Sinai; Estados UnidosFil: Cisterna, Daniel Marcelo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; ArgentinaMDPI2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182003Caraballo, Diego Alfredo; Lema, Cristina; Novaro, Laura; Gury Dohmen, Federico; Russo, Susana; et al.; A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles; MDPI; Viruses; 13; 12; 12-2021; 1-211999-4915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/v13122484info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:21:16Zoai:ri.conicet.gov.ar:11336/182003instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:21:16.68CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles
title A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles
spellingShingle A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles
Caraballo, Diego Alfredo
DOG-RELATED
HOST SHIFT
NUCLEOPROTEIN
PHYLOGENY
RABIES
RECOMBINATION
SELECTION
title_short A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles
title_full A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles
title_fullStr A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles
title_full_unstemmed A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles
title_sort A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles
dc.creator.none.fl_str_mv Caraballo, Diego Alfredo
Lema, Cristina
Novaro, Laura
Gury Dohmen, Federico
Russo, Susana
Beltrán, Fernando J.
Palacios, Gustavo
Cisterna, Daniel Marcelo
author Caraballo, Diego Alfredo
author_facet Caraballo, Diego Alfredo
Lema, Cristina
Novaro, Laura
Gury Dohmen, Federico
Russo, Susana
Beltrán, Fernando J.
Palacios, Gustavo
Cisterna, Daniel Marcelo
author_role author
author2 Lema, Cristina
Novaro, Laura
Gury Dohmen, Federico
Russo, Susana
Beltrán, Fernando J.
Palacios, Gustavo
Cisterna, Daniel Marcelo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DOG-RELATED
HOST SHIFT
NUCLEOPROTEIN
PHYLOGENY
RABIES
RECOMBINATION
SELECTION
topic DOG-RELATED
HOST SHIFT
NUCLEOPROTEIN
PHYLOGENY
RABIES
RECOMBINATION
SELECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The rabies virus (RABV) is characterized by a history dominated by host shifts within and among bats and carnivores. One of the main outcomes of long-term RABV maintenance in dogs was the establishment of variants in a wide variety of mesocarnivores. In this study, we present the most comprehensive phylogenetic and phylogeographic analysis, contributing to a better understanding of the origins, diversification, and the role of different host species in the evolution and diffusion of a dog-related variant endemic of South America. A total of 237 complete Nucleoprotein gene sequences were studied, corresponding to wild and domestic species, performing selection analyses, ancestral states reconstructions, and recombination analyses. This variant originated in Brazil and disseminated through Argentina and Paraguay, where a previously unknown lineage was found. A single host shift was identified in the phylogeny, from dog to the crab-eating fox (Cerdocyon thous) in the Northeast of Brazil. Although this process occurred in a background of purifying selection, there is evidence of adaptive evolution-or selection of sub-consensus sequences-in internal branches after the host shift. The interaction of domestic and wild cycles persisted after host switching, as revealed by spillover and putative recombination events.
Fil: Caraballo, Diego Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
Fil: Lema, Cristina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Novaro, Laura. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Gury Dohmen, Federico. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina
Fil: Russo, Susana. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Beltrán, Fernando J.. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina
Fil: Palacios, Gustavo. Icahn School of Medicine at Mount Sinai; Estados Unidos
Fil: Cisterna, Daniel Marcelo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
description The rabies virus (RABV) is characterized by a history dominated by host shifts within and among bats and carnivores. One of the main outcomes of long-term RABV maintenance in dogs was the establishment of variants in a wide variety of mesocarnivores. In this study, we present the most comprehensive phylogenetic and phylogeographic analysis, contributing to a better understanding of the origins, diversification, and the role of different host species in the evolution and diffusion of a dog-related variant endemic of South America. A total of 237 complete Nucleoprotein gene sequences were studied, corresponding to wild and domestic species, performing selection analyses, ancestral states reconstructions, and recombination analyses. This variant originated in Brazil and disseminated through Argentina and Paraguay, where a previously unknown lineage was found. A single host shift was identified in the phylogeny, from dog to the crab-eating fox (Cerdocyon thous) in the Northeast of Brazil. Although this process occurred in a background of purifying selection, there is evidence of adaptive evolution-or selection of sub-consensus sequences-in internal branches after the host shift. The interaction of domestic and wild cycles persisted after host switching, as revealed by spillover and putative recombination events.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/182003
Caraballo, Diego Alfredo; Lema, Cristina; Novaro, Laura; Gury Dohmen, Federico; Russo, Susana; et al.; A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles; MDPI; Viruses; 13; 12; 12-2021; 1-21
1999-4915
CONICET Digital
CONICET
url http://hdl.handle.net/11336/182003
identifier_str_mv Caraballo, Diego Alfredo; Lema, Cristina; Novaro, Laura; Gury Dohmen, Federico; Russo, Susana; et al.; A novel terrestrial rabies virus lineage occurring in south america: Origin, diversification, and evidence of contact between wild and domestic cycles; MDPI; Viruses; 13; 12; 12-2021; 1-21
1999-4915
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/v13122484
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614200760991744
score 13.070432

Publicaciones similares