Antigenic and molecular characterization of rabies virus in Argentina

Autores
Cisterna, Daniel; Bonaventura, Romina; López de Caillou, Susana; Pozo, Oscar; Andreau, Maria Lidia; Dalla Fontana, María L.; Echegoyen, Cristina; de Mattos, Carlos; de Mattos, Cecilia; Russo, Susana; Novaro, Laura; Elberger, Diana; Freire, María Cecilia
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Fil: Cisterna, Daniel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.
Fil: Bonaventura, Romina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.
Fil: Caillou, Susana. División de zoonosis; Tucuman, Argentina.
Fil: Pozo, Oscar. Ministerio de Salud. División de Zoonosis Urbana; Argentina.
Fil: Andreau, Maria Lidia. Laboratorio Regional de Diagnóstico de Rabia; Chaco, Argentina.
Fil: Dalla Fontana, María L. Laboratorio de Zoonosis; Santa Fe, Argentina.
Fil: Echegoyen, Cristina. Dirección Nacional de Epidemiología; Argentina.
Fil: de Mattos, Carlos. Centers for Desease Control and Prevention. Rabies Section; Estados Unidos.
Fil: de Mattos, Cecilia. Centers for Desease Control and Prevention. Rabies Section; Estados Unidos.
Fil: Russo, Susana. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios y Control Técnico; Argentina.
Fil: Novaro, Laura. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios y Control Técnico; Argentina.
Fil: Elberger, Diana. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios y Control Técnico; Argentina.
Fil: Freire, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.
The nucleoprotein genes of 54 human, domestic and wild animals rabies isolates obtained in Argentina between 1995 and 2002 were characterized using monoclonal antibodies and partial gene sequence analysis. The antigenic and genetic diversities of rabies virus in samples from bat and bat-related cases were studied, leading to the identification of five distinct genetic variants. Rabies viruses isolated from vampire bat related cases were very similar to each other, showing 98.9% overall similarity. Specific antigenic variants (AgV) were detected associated with different insectivorous bats species, in samples from Tadarida brasiliensis and Eumops patagonicus bats. In contrast, isolates from Myotis sp. and Histiotus sp. bats could not be matched to any antigenic type. Additionally, bat rabies cases were also detected in southern provinces previously considered rabies-free. Finally, two independent antigenic and genetic variants co-circulating in northern Argentina were found in isolates obtained from dogs and dog-related cases, suggesting two independent cycles of virus transmission. This is the first national coordinated study of antigenic as well as molecular epidemiology of rabies in Argentina. The information presented here will improve our knowledge about rabies epidemiology and therefore, will assist preventing fatal human cases.
Materia
Virus de la Rabia
Nucleoproteínas
Epidemiología Molecular
Quirópteros
Antivirales
Nivel de accesibilidad
acceso abierto
Condiciones de uso
none
Repositorio
Sistema de Gestión del Conocimiento ANLIS MALBRÁN
Institución
Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
OAI Identificador
oai:sgc.anlis.gob.ar:123456789/1916
Acceder
id SGCANLIS_2979898f057a48d17202145e9ff6c79b
oai_identifier_str oai:sgc.anlis.gob.ar:123456789/1916
network_acronym_str SGCANLIS
repository_id_str a
network_name_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
spelling Antigenic and molecular characterization of rabies virus in ArgentinaCisterna, DanielBonaventura, RominaLópez de Caillou, SusanaPozo, OscarAndreau, Maria LidiaDalla Fontana, María L.Echegoyen, Cristinade Mattos, Carlosde Mattos, CeciliaRusso, SusanaNovaro, LauraElberger, DianaFreire, María CeciliaVirus de la RabiaNucleoproteínasEpidemiología MolecularQuirópterosAntiviralesFil: Cisterna, Daniel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.Fil: Bonaventura, Romina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.Fil: Caillou, Susana. División de zoonosis; Tucuman, Argentina.Fil: Pozo, Oscar. Ministerio de Salud. División de Zoonosis Urbana; Argentina.Fil: Andreau, Maria Lidia. Laboratorio Regional de Diagnóstico de Rabia; Chaco, Argentina.Fil: Dalla Fontana, María L. Laboratorio de Zoonosis; Santa Fe, Argentina.Fil: Echegoyen, Cristina. Dirección Nacional de Epidemiología; Argentina.Fil: de Mattos, Carlos. Centers for Desease Control and Prevention. Rabies Section; Estados Unidos.Fil: de Mattos, Cecilia. Centers for Desease Control and Prevention. Rabies Section; Estados Unidos.Fil: Russo, Susana. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios y Control Técnico; Argentina.Fil: Novaro, Laura. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios y Control Técnico; Argentina.Fil: Elberger, Diana. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios y Control Técnico; Argentina.Fil: Freire, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.The nucleoprotein genes of 54 human, domestic and wild animals rabies isolates obtained in Argentina between 1995 and 2002 were characterized using monoclonal antibodies and partial gene sequence analysis. The antigenic and genetic diversities of rabies virus in samples from bat and bat-related cases were studied, leading to the identification of five distinct genetic variants. Rabies viruses isolated from vampire bat related cases were very similar to each other, showing 98.9% overall similarity. Specific antigenic variants (AgV) were detected associated with different insectivorous bats species, in samples from Tadarida brasiliensis and Eumops patagonicus bats. In contrast, isolates from Myotis sp. and Histiotus sp. bats could not be matched to any antigenic type. Additionally, bat rabies cases were also detected in southern provinces previously considered rabies-free. Finally, two independent antigenic and genetic variants co-circulating in northern Argentina were found in isolates obtained from dogs and dog-related cases, suggesting two independent cycles of virus transmission. This is the first national coordinated study of antigenic as well as molecular epidemiology of rabies in Argentina. The information presented here will improve our knowledge about rabies epidemiology and therefore, will assist preventing fatal human cases.2005-05info:ar-repo/semantics/articuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdf0168-1702http://sgc.anlis.gob.ar/handle/123456789/191610.1016/j.virusres.2004.10.013Virus researchnoneinfo:eu-repo/semantics/openAccessengreponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁNinstname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"instacron:ANLIS2025-10-16T10:11:44Zoai:sgc.anlis.gob.ar:123456789/1916Institucionalhttp://sgc.anlis.gob.ar/Organismo científico-tecnológicoNo correspondehttp://sgc.anlis.gob.ar/oai/biblioteca@anlis.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-10-16 10:11:45.281Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"false
dc.title.none.fl_str_mv Antigenic and molecular characterization of rabies virus in Argentina
title Antigenic and molecular characterization of rabies virus in Argentina
spellingShingle Antigenic and molecular characterization of rabies virus in Argentina
Cisterna, Daniel
Virus de la Rabia
Nucleoproteínas
Epidemiología Molecular
Quirópteros
Antivirales
title_short Antigenic and molecular characterization of rabies virus in Argentina
title_full Antigenic and molecular characterization of rabies virus in Argentina
title_fullStr Antigenic and molecular characterization of rabies virus in Argentina
title_full_unstemmed Antigenic and molecular characterization of rabies virus in Argentina
title_sort Antigenic and molecular characterization of rabies virus in Argentina
dc.creator.none.fl_str_mv Cisterna, Daniel
Bonaventura, Romina
López de Caillou, Susana
Pozo, Oscar
Andreau, Maria Lidia
Dalla Fontana, María L.
Echegoyen, Cristina
de Mattos, Carlos
de Mattos, Cecilia
Russo, Susana
Novaro, Laura
Elberger, Diana
Freire, María Cecilia
author Cisterna, Daniel
author_facet Cisterna, Daniel
Bonaventura, Romina
López de Caillou, Susana
Pozo, Oscar
Andreau, Maria Lidia
Dalla Fontana, María L.
Echegoyen, Cristina
de Mattos, Carlos
de Mattos, Cecilia
Russo, Susana
Novaro, Laura
Elberger, Diana
Freire, María Cecilia
author_role author
author2 Bonaventura, Romina
López de Caillou, Susana
Pozo, Oscar
Andreau, Maria Lidia
Dalla Fontana, María L.
Echegoyen, Cristina
de Mattos, Carlos
de Mattos, Cecilia
Russo, Susana
Novaro, Laura
Elberger, Diana
Freire, María Cecilia
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Virus de la Rabia
Nucleoproteínas
Epidemiología Molecular
Quirópteros
Antivirales
topic Virus de la Rabia
Nucleoproteínas
Epidemiología Molecular
Quirópteros
Antivirales
dc.description.none.fl_txt_mv Fil: Cisterna, Daniel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.
Fil: Bonaventura, Romina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.
Fil: Caillou, Susana. División de zoonosis; Tucuman, Argentina.
Fil: Pozo, Oscar. Ministerio de Salud. División de Zoonosis Urbana; Argentina.
Fil: Andreau, Maria Lidia. Laboratorio Regional de Diagnóstico de Rabia; Chaco, Argentina.
Fil: Dalla Fontana, María L. Laboratorio de Zoonosis; Santa Fe, Argentina.
Fil: Echegoyen, Cristina. Dirección Nacional de Epidemiología; Argentina.
Fil: de Mattos, Carlos. Centers for Desease Control and Prevention. Rabies Section; Estados Unidos.
Fil: de Mattos, Cecilia. Centers for Desease Control and Prevention. Rabies Section; Estados Unidos.
Fil: Russo, Susana. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios y Control Técnico; Argentina.
Fil: Novaro, Laura. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios y Control Técnico; Argentina.
Fil: Elberger, Diana. Servicio Nacional de Sanidad y Calidad Agroalimentaria. Dirección de Laboratorios y Control Técnico; Argentina.
Fil: Freire, María Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.
The nucleoprotein genes of 54 human, domestic and wild animals rabies isolates obtained in Argentina between 1995 and 2002 were characterized using monoclonal antibodies and partial gene sequence analysis. The antigenic and genetic diversities of rabies virus in samples from bat and bat-related cases were studied, leading to the identification of five distinct genetic variants. Rabies viruses isolated from vampire bat related cases were very similar to each other, showing 98.9% overall similarity. Specific antigenic variants (AgV) were detected associated with different insectivorous bats species, in samples from Tadarida brasiliensis and Eumops patagonicus bats. In contrast, isolates from Myotis sp. and Histiotus sp. bats could not be matched to any antigenic type. Additionally, bat rabies cases were also detected in southern provinces previously considered rabies-free. Finally, two independent antigenic and genetic variants co-circulating in northern Argentina were found in isolates obtained from dogs and dog-related cases, suggesting two independent cycles of virus transmission. This is the first national coordinated study of antigenic as well as molecular epidemiology of rabies in Argentina. The information presented here will improve our knowledge about rabies epidemiology and therefore, will assist preventing fatal human cases.
description Fil: Cisterna, Daniel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Neurovirus; Argentina.
publishDate 2005
dc.date.none.fl_str_mv 2005-05
dc.type.none.fl_str_mv info:ar-repo/semantics/articulo
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv 0168-1702
http://sgc.anlis.gob.ar/handle/123456789/1916
10.1016/j.virusres.2004.10.013
identifier_str_mv 0168-1702
10.1016/j.virusres.2004.10.013
url http://sgc.anlis.gob.ar/handle/123456789/1916
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Virus research
dc.rights.none.fl_str_mv none
info:eu-repo/semantics/openAccess
rights_invalid_str_mv none
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname:Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron:ANLIS
reponame_str Sistema de Gestión del Conocimiento ANLIS MALBRÁN
collection Sistema de Gestión del Conocimiento ANLIS MALBRÁN
instname_str Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
instacron_str ANLIS
institution ANLIS
repository.name.fl_str_mv Sistema de Gestión del Conocimiento ANLIS MALBRÁN - Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"
repository.mail.fl_str_mv biblioteca@anlis.gov.ar
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score 12.712165

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