Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?

Autores
Caraballo, Diego Alfredo; Vico, María Lorena; Piccirilli, María Guadalupe; Hirmas Riade, Stella Maris; Russo, Susana; Martínez, Gustavo; Beltrán, Fernando J.; Cisterna, Daniel Marcelo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The rabies virus (RABV) is the exclusive lyssavirus affecting both wild and domestic mammalian hosts in the Americas, including humans. Additionally, the Americas stand out as the sole region where bat rabies occurs. While carnivore rabies is being increasingly managed across the region, bats are emerging as significant reservoirs of RABV infection for humans and domestic animals. Knowledge of the bat species maintaining rabies and comprehending cross-species transmission (CST) and host shift processes are pivotal for directing surveillance as well as ecological research involving wildlife reservoir hosts. Prior research indicates that bat RABV CST is influenced by host genetic similarity and geographic overlap, reflecting host adaptation. In this study, we compiled and analyzed a comprehensive nucleoprotein gene dataset representing bat-borne RABV diversity in Argentina and the broader Americas using Bayesian phylogenetics. We examined the association between host genus and geography, finding both factors shaping the global phylogenetic structure. Utilizing a phylogeographic approach, we inferred CST and identified key bat hosts driving transmission. Consistent with CST determinants, we observed monophyletic/paraphyletic clustering of most bat genera in the RABV phylogeny, with stronger CST evidence between host genera of the same family. We further discuss Myotis as a potential ancestral spreader of much of RABV diversity.
Fil: Caraballo, Diego Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
Fil: Vico, María Lorena. No especifíca;
Fil: Piccirilli, María Guadalupe. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Hirmas Riade, Stella Maris. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Russo, Susana. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Martínez, Gustavo. No especifíca;
Fil: Beltrán, Fernando J.. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina
Fil: Cisterna, Daniel Marcelo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Materia
BATS
RABIES
PHYLOGENY
CROSS-SPECIES TRANSMISSION
HOST SHIFT
SPILLOVER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/265269
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/265269
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?Caraballo, Diego AlfredoVico, María LorenaPiccirilli, María GuadalupeHirmas Riade, Stella MarisRusso, SusanaMartínez, GustavoBeltrán, Fernando J.Cisterna, Daniel MarceloBATSRABIESPHYLOGENYCROSS-SPECIES TRANSMISSIONHOST SHIFTSPILLOVERhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The rabies virus (RABV) is the exclusive lyssavirus affecting both wild and domestic mammalian hosts in the Americas, including humans. Additionally, the Americas stand out as the sole region where bat rabies occurs. While carnivore rabies is being increasingly managed across the region, bats are emerging as significant reservoirs of RABV infection for humans and domestic animals. Knowledge of the bat species maintaining rabies and comprehending cross-species transmission (CST) and host shift processes are pivotal for directing surveillance as well as ecological research involving wildlife reservoir hosts. Prior research indicates that bat RABV CST is influenced by host genetic similarity and geographic overlap, reflecting host adaptation. In this study, we compiled and analyzed a comprehensive nucleoprotein gene dataset representing bat-borne RABV diversity in Argentina and the broader Americas using Bayesian phylogenetics. We examined the association between host genus and geography, finding both factors shaping the global phylogenetic structure. Utilizing a phylogeographic approach, we inferred CST and identified key bat hosts driving transmission. Consistent with CST determinants, we observed monophyletic/paraphyletic clustering of most bat genera in the RABV phylogeny, with stronger CST evidence between host genera of the same family. We further discuss Myotis as a potential ancestral spreader of much of RABV diversity.Fil: Caraballo, Diego Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Vico, María Lorena. No especifíca;Fil: Piccirilli, María Guadalupe. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; ArgentinaFil: Hirmas Riade, Stella Maris. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; ArgentinaFil: Russo, Susana. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; ArgentinaFil: Martínez, Gustavo. No especifíca;Fil: Beltrán, Fernando J.. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; ArgentinaFil: Cisterna, Daniel Marcelo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; ArgentinaMDPI2024-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265269Caraballo, Diego Alfredo; Vico, María Lorena; Piccirilli, María Guadalupe; Hirmas Riade, Stella Maris; Russo, Susana; et al.; Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?; MDPI; Viruses; 16; 8; 8-2024; 1-151999-4915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/16/8/1302info:eu-repo/semantics/altIdentifier/doi/10.3390/v16081302info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:57:06Zoai:ri.conicet.gov.ar:11336/265269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:57:06.42CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?
title Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?
spellingShingle Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?
Caraballo, Diego Alfredo
BATS
RABIES
PHYLOGENY
CROSS-SPECIES TRANSMISSION
HOST SHIFT
SPILLOVER
title_short Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?
title_full Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?
title_fullStr Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?
title_full_unstemmed Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?
title_sort Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?
dc.creator.none.fl_str_mv Caraballo, Diego Alfredo
Vico, María Lorena
Piccirilli, María Guadalupe
Hirmas Riade, Stella Maris
Russo, Susana
Martínez, Gustavo
Beltrán, Fernando J.
Cisterna, Daniel Marcelo
author Caraballo, Diego Alfredo
author_facet Caraballo, Diego Alfredo
Vico, María Lorena
Piccirilli, María Guadalupe
Hirmas Riade, Stella Maris
Russo, Susana
Martínez, Gustavo
Beltrán, Fernando J.
Cisterna, Daniel Marcelo
author_role author
author2 Vico, María Lorena
Piccirilli, María Guadalupe
Hirmas Riade, Stella Maris
Russo, Susana
Martínez, Gustavo
Beltrán, Fernando J.
Cisterna, Daniel Marcelo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BATS
RABIES
PHYLOGENY
CROSS-SPECIES TRANSMISSION
HOST SHIFT
SPILLOVER
topic BATS
RABIES
PHYLOGENY
CROSS-SPECIES TRANSMISSION
HOST SHIFT
SPILLOVER
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The rabies virus (RABV) is the exclusive lyssavirus affecting both wild and domestic mammalian hosts in the Americas, including humans. Additionally, the Americas stand out as the sole region where bat rabies occurs. While carnivore rabies is being increasingly managed across the region, bats are emerging as significant reservoirs of RABV infection for humans and domestic animals. Knowledge of the bat species maintaining rabies and comprehending cross-species transmission (CST) and host shift processes are pivotal for directing surveillance as well as ecological research involving wildlife reservoir hosts. Prior research indicates that bat RABV CST is influenced by host genetic similarity and geographic overlap, reflecting host adaptation. In this study, we compiled and analyzed a comprehensive nucleoprotein gene dataset representing bat-borne RABV diversity in Argentina and the broader Americas using Bayesian phylogenetics. We examined the association between host genus and geography, finding both factors shaping the global phylogenetic structure. Utilizing a phylogeographic approach, we inferred CST and identified key bat hosts driving transmission. Consistent with CST determinants, we observed monophyletic/paraphyletic clustering of most bat genera in the RABV phylogeny, with stronger CST evidence between host genera of the same family. We further discuss Myotis as a potential ancestral spreader of much of RABV diversity.
Fil: Caraballo, Diego Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
Fil: Vico, María Lorena. No especifíca;
Fil: Piccirilli, María Guadalupe. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Hirmas Riade, Stella Maris. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Russo, Susana. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina
Fil: Martínez, Gustavo. No especifíca;
Fil: Beltrán, Fernando J.. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; Argentina
Fil: Cisterna, Daniel Marcelo. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
description The rabies virus (RABV) is the exclusive lyssavirus affecting both wild and domestic mammalian hosts in the Americas, including humans. Additionally, the Americas stand out as the sole region where bat rabies occurs. While carnivore rabies is being increasingly managed across the region, bats are emerging as significant reservoirs of RABV infection for humans and domestic animals. Knowledge of the bat species maintaining rabies and comprehending cross-species transmission (CST) and host shift processes are pivotal for directing surveillance as well as ecological research involving wildlife reservoir hosts. Prior research indicates that bat RABV CST is influenced by host genetic similarity and geographic overlap, reflecting host adaptation. In this study, we compiled and analyzed a comprehensive nucleoprotein gene dataset representing bat-borne RABV diversity in Argentina and the broader Americas using Bayesian phylogenetics. We examined the association between host genus and geography, finding both factors shaping the global phylogenetic structure. Utilizing a phylogeographic approach, we inferred CST and identified key bat hosts driving transmission. Consistent with CST determinants, we observed monophyletic/paraphyletic clustering of most bat genera in the RABV phylogeny, with stronger CST evidence between host genera of the same family. We further discuss Myotis as a potential ancestral spreader of much of RABV diversity.
publishDate 2024
dc.date.none.fl_str_mv 2024-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/265269
Caraballo, Diego Alfredo; Vico, María Lorena; Piccirilli, María Guadalupe; Hirmas Riade, Stella Maris; Russo, Susana; et al.; Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?; MDPI; Viruses; 16; 8; 8-2024; 1-15
1999-4915
CONICET Digital
CONICET
url http://hdl.handle.net/11336/265269
identifier_str_mv Caraballo, Diego Alfredo; Vico, María Lorena; Piccirilli, María Guadalupe; Hirmas Riade, Stella Maris; Russo, Susana; et al.; Bat Rabies in the Americas: Is Myotis the Main Ancestral Spreader?; MDPI; Viruses; 16; 8; 8-2024; 1-15
1999-4915
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/16/8/1302
info:eu-repo/semantics/altIdentifier/doi/10.3390/v16081302
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.928904

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