Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes
- Autores
- Mundiña, Cecilia Beatriz; Mattiazzi, Ramona Alicia
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Calcium (Ca2+) mishandling is one of the most striking abnormalities in this wide spectrum of pathologies, among which heart failure (HF) remains the leading cause of death in developed countries (Benjamin et al., 2018). A hallmark of HF in both human and animal models is impaired Ca2+ sequestration into the SR, which contributes to the decreased contractile performance in this disease (Gwathmey et al., 1987; Meyer et al., 1995; del Monte et al., 2002). Not surprisingly, this defective mechanism has been targeted with novel therapeutic strategies that are now undergoing experimental and clinical testing in animals and patients (Pfeffer et al., 2015; Hulot et al., 2016, 2017; Motloch et al., 2018). In this issue of JGP, Keceli et al. provide novel insights into the molecular mechanism from which nitroxyl (HNO), nitric oxide (NO)´s one-electron-reduced and protonated sibling, recently emerged as a promising candidate for HF treatment.
Fil: Mundiña, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina - Materia
-
NITROXYL
PHOSPHOLAMBAN
CARDIAC CONTRACTILITY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/128546
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Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytesMundiña, Cecilia BeatrizMattiazzi, Ramona AliciaNITROXYLPHOSPHOLAMBANCARDIAC CONTRACTILITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Calcium (Ca2+) mishandling is one of the most striking abnormalities in this wide spectrum of pathologies, among which heart failure (HF) remains the leading cause of death in developed countries (Benjamin et al., 2018). A hallmark of HF in both human and animal models is impaired Ca2+ sequestration into the SR, which contributes to the decreased contractile performance in this disease (Gwathmey et al., 1987; Meyer et al., 1995; del Monte et al., 2002). Not surprisingly, this defective mechanism has been targeted with novel therapeutic strategies that are now undergoing experimental and clinical testing in animals and patients (Pfeffer et al., 2015; Hulot et al., 2016, 2017; Motloch et al., 2018). In this issue of JGP, Keceli et al. provide novel insights into the molecular mechanism from which nitroxyl (HNO), nitric oxide (NO)´s one-electron-reduced and protonated sibling, recently emerged as a promising candidate for HF treatment.Fil: Mundiña, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaRockefeller University Press2019-04-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/128546Mundiña, Cecilia Beatriz; Mattiazzi, Ramona Alicia; Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes; Rockefeller University Press; Journal Of General Physiology; 151; 6; 22-4-2019; 718-7210022-1295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.jgp.org/lookup/doi/10.1085/jgp.201912342info:eu-repo/semantics/altIdentifier/doi/10.1085/jgp.201912342info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:26:58Zoai:ri.conicet.gov.ar:11336/128546instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:26:58.568CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes |
title |
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes |
spellingShingle |
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes Mundiña, Cecilia Beatriz NITROXYL PHOSPHOLAMBAN CARDIAC CONTRACTILITY |
title_short |
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes |
title_full |
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes |
title_fullStr |
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes |
title_full_unstemmed |
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes |
title_sort |
Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes |
dc.creator.none.fl_str_mv |
Mundiña, Cecilia Beatriz Mattiazzi, Ramona Alicia |
author |
Mundiña, Cecilia Beatriz |
author_facet |
Mundiña, Cecilia Beatriz Mattiazzi, Ramona Alicia |
author_role |
author |
author2 |
Mattiazzi, Ramona Alicia |
author2_role |
author |
dc.subject.none.fl_str_mv |
NITROXYL PHOSPHOLAMBAN CARDIAC CONTRACTILITY |
topic |
NITROXYL PHOSPHOLAMBAN CARDIAC CONTRACTILITY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Calcium (Ca2+) mishandling is one of the most striking abnormalities in this wide spectrum of pathologies, among which heart failure (HF) remains the leading cause of death in developed countries (Benjamin et al., 2018). A hallmark of HF in both human and animal models is impaired Ca2+ sequestration into the SR, which contributes to the decreased contractile performance in this disease (Gwathmey et al., 1987; Meyer et al., 1995; del Monte et al., 2002). Not surprisingly, this defective mechanism has been targeted with novel therapeutic strategies that are now undergoing experimental and clinical testing in animals and patients (Pfeffer et al., 2015; Hulot et al., 2016, 2017; Motloch et al., 2018). In this issue of JGP, Keceli et al. provide novel insights into the molecular mechanism from which nitroxyl (HNO), nitric oxide (NO)´s one-electron-reduced and protonated sibling, recently emerged as a promising candidate for HF treatment. Fil: Mundiña, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina |
description |
Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Calcium (Ca2+) mishandling is one of the most striking abnormalities in this wide spectrum of pathologies, among which heart failure (HF) remains the leading cause of death in developed countries (Benjamin et al., 2018). A hallmark of HF in both human and animal models is impaired Ca2+ sequestration into the SR, which contributes to the decreased contractile performance in this disease (Gwathmey et al., 1987; Meyer et al., 1995; del Monte et al., 2002). Not surprisingly, this defective mechanism has been targeted with novel therapeutic strategies that are now undergoing experimental and clinical testing in animals and patients (Pfeffer et al., 2015; Hulot et al., 2016, 2017; Motloch et al., 2018). In this issue of JGP, Keceli et al. provide novel insights into the molecular mechanism from which nitroxyl (HNO), nitric oxide (NO)´s one-electron-reduced and protonated sibling, recently emerged as a promising candidate for HF treatment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-04-22 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/128546 Mundiña, Cecilia Beatriz; Mattiazzi, Ramona Alicia; Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes; Rockefeller University Press; Journal Of General Physiology; 151; 6; 22-4-2019; 718-721 0022-1295 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/128546 |
identifier_str_mv |
Mundiña, Cecilia Beatriz; Mattiazzi, Ramona Alicia; Tracking nitroxyl-derived posttranslational modifications of phospholamban in cardiac myocytes; Rockefeller University Press; Journal Of General Physiology; 151; 6; 22-4-2019; 718-721 0022-1295 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.jgp.org/lookup/doi/10.1085/jgp.201912342 info:eu-repo/semantics/altIdentifier/doi/10.1085/jgp.201912342 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Rockefeller University Press |
publisher.none.fl_str_mv |
Rockefeller University Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.22299 |