Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility

Autores
Mattiazzi, Ramona Alicia; Mundiña, Cecilia Beatriz; Vittone, Leticia Beatriz
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; Argentina
Fil: Mundiña, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; Argentina
Fil: Vittone, Leticia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; Argentina
Materia
PHOSPHOLAMBAN
CARDIAC RELAXATION
CONTRACTILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/61840
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractilityMattiazzi, Ramona AliciaMundiña, Cecilia BeatrizVittone, Leticia BeatrizPHOSPHOLAMBANCARDIAC RELAXATIONCONTRACTILITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; ArgentinaFil: Mundiña, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; ArgentinaFil: Vittone, Leticia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; ArgentinaSAFIS2010-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/mswordapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/61840Mattiazzi, Ramona Alicia; Mundiña, Cecilia Beatriz; Vittone, Leticia Beatriz; Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility; SAFIS; Physiological Mini-Reviews; 5; 3; 11-2010; 8-171669-54021669-5410CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/50info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:37Zoai:ri.conicet.gov.ar:11336/61840instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:37.63CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
spellingShingle Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
Mattiazzi, Ramona Alicia
PHOSPHOLAMBAN
CARDIAC RELAXATION
CONTRACTILITY
title_short Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title_full Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title_fullStr Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title_full_unstemmed Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title_sort Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
dc.creator.none.fl_str_mv Mattiazzi, Ramona Alicia
Mundiña, Cecilia Beatriz
Vittone, Leticia Beatriz
author Mattiazzi, Ramona Alicia
author_facet Mattiazzi, Ramona Alicia
Mundiña, Cecilia Beatriz
Vittone, Leticia Beatriz
author_role author
author2 Mundiña, Cecilia Beatriz
Vittone, Leticia Beatriz
author2_role author
author
dc.subject.none.fl_str_mv PHOSPHOLAMBAN
CARDIAC RELAXATION
CONTRACTILITY
topic PHOSPHOLAMBAN
CARDIAC RELAXATION
CONTRACTILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
Fil: Mattiazzi, Ramona Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; Argentina
Fil: Mundiña, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; Argentina
Fil: Vittone, Leticia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares ; Argentina
description Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
publishDate 2010
dc.date.none.fl_str_mv 2010-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/61840
Mattiazzi, Ramona Alicia; Mundiña, Cecilia Beatriz; Vittone, Leticia Beatriz; Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility; SAFIS; Physiological Mini-Reviews; 5; 3; 11-2010; 8-17
1669-5402
1669-5410
CONICET Digital
CONICET
url http://hdl.handle.net/11336/61840
identifier_str_mv Mattiazzi, Ramona Alicia; Mundiña, Cecilia Beatriz; Vittone, Leticia Beatriz; Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility; SAFIS; Physiological Mini-Reviews; 5; 3; 11-2010; 8-17
1669-5402
1669-5410
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/archive/id/50
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/msword
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAFIS
publisher.none.fl_str_mv SAFIS
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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