Seeking for Regulatory Mechanisms of Phospholamban Expression

Autores
Mundiña, Cecilia Beatriz
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this issue of Circulation Research, Ren et al13 introduced a novel transcription factor involved in the regulation of PLN expression, ZBTB20. ZBTB20 is a member of the broad complex, Tramtrack, and bric-a-brac and POZ (poxvirus and zinc finger) family of transcriptional repressors. ZBTB20 is involved in the regulation of various biological processes in different tissues, such as cellular proliferation and differentiation, glucose and lipid metabolism, inflammation, tissue repair, and oncogenesis.Due to its versatility, global knockout mice lacking ZBTB20 exhibit mortality within the first month of age.14 Up to day 16 postpartum, besides hypotension, the transgenic mice display defects in cardiac development and contractility, suggesting a potential cardiac role of ZBTB20. In the current study, Ren et al13 go a step further in exploring the importance of this transcription factor in cardiac function by generating a mouse model with cardiomyocyte-specific ablation of ZBTB20. These mice exhibited normal heart development but showed an increase in basal contractility and SERCa2a activity, attributed to a reduction in PLN expression. The results identify ZBTB20 as a novel transcription factor implicated in the regulation of PLN expression. Unfortunately, it was somewhat disappointing to find that the promoter region of the PLN gene lacks ZBTB20 binding sites. Therefore, additional investigation will be required to understand the mechanism by which ZBTB20 controls PLN expression.
Fil: Mundiña, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
Materia
PHOSPHOLAMBAN EXPRESSION
ZBTB20 TRANSCRIPTION FACTOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/257290
Acceder
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spelling Seeking for Regulatory Mechanisms of Phospholamban ExpressionMundiña, Cecilia BeatrizPHOSPHOLAMBAN EXPRESSIONZBTB20 TRANSCRIPTION FACTORhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3In this issue of Circulation Research, Ren et al13 introduced a novel transcription factor involved in the regulation of PLN expression, ZBTB20. ZBTB20 is a member of the broad complex, Tramtrack, and bric-a-brac and POZ (poxvirus and zinc finger) family of transcriptional repressors. ZBTB20 is involved in the regulation of various biological processes in different tissues, such as cellular proliferation and differentiation, glucose and lipid metabolism, inflammation, tissue repair, and oncogenesis.Due to its versatility, global knockout mice lacking ZBTB20 exhibit mortality within the first month of age.14 Up to day 16 postpartum, besides hypotension, the transgenic mice display defects in cardiac development and contractility, suggesting a potential cardiac role of ZBTB20. In the current study, Ren et al13 go a step further in exploring the importance of this transcription factor in cardiac function by generating a mouse model with cardiomyocyte-specific ablation of ZBTB20. These mice exhibited normal heart development but showed an increase in basal contractility and SERCa2a activity, attributed to a reduction in PLN expression. The results identify ZBTB20 as a novel transcription factor implicated in the regulation of PLN expression. Unfortunately, it was somewhat disappointing to find that the promoter region of the PLN gene lacks ZBTB20 binding sites. Therefore, additional investigation will be required to understand the mechanism by which ZBTB20 controls PLN expression.Fil: Mundiña, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaLippincott Williams2024-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/257290Mundiña, Cecilia Beatriz; Seeking for Regulatory Mechanisms of Phospholamban Expression; Lippincott Williams; Circulation Research; 134; 3; 2-2024; 266-2680009-7330CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.324109info:eu-repo/semantics/altIdentifier/doi/10.1161/CIRCRESAHA.124.324109info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:45Zoai:ri.conicet.gov.ar:11336/257290instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:46.192CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Seeking for Regulatory Mechanisms of Phospholamban Expression
title Seeking for Regulatory Mechanisms of Phospholamban Expression
spellingShingle Seeking for Regulatory Mechanisms of Phospholamban Expression
Mundiña, Cecilia Beatriz
PHOSPHOLAMBAN EXPRESSION
ZBTB20 TRANSCRIPTION FACTOR
title_short Seeking for Regulatory Mechanisms of Phospholamban Expression
title_full Seeking for Regulatory Mechanisms of Phospholamban Expression
title_fullStr Seeking for Regulatory Mechanisms of Phospholamban Expression
title_full_unstemmed Seeking for Regulatory Mechanisms of Phospholamban Expression
title_sort Seeking for Regulatory Mechanisms of Phospholamban Expression
dc.creator.none.fl_str_mv Mundiña, Cecilia Beatriz
author Mundiña, Cecilia Beatriz
author_facet Mundiña, Cecilia Beatriz
author_role author
dc.subject.none.fl_str_mv PHOSPHOLAMBAN EXPRESSION
ZBTB20 TRANSCRIPTION FACTOR
topic PHOSPHOLAMBAN EXPRESSION
ZBTB20 TRANSCRIPTION FACTOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In this issue of Circulation Research, Ren et al13 introduced a novel transcription factor involved in the regulation of PLN expression, ZBTB20. ZBTB20 is a member of the broad complex, Tramtrack, and bric-a-brac and POZ (poxvirus and zinc finger) family of transcriptional repressors. ZBTB20 is involved in the regulation of various biological processes in different tissues, such as cellular proliferation and differentiation, glucose and lipid metabolism, inflammation, tissue repair, and oncogenesis.Due to its versatility, global knockout mice lacking ZBTB20 exhibit mortality within the first month of age.14 Up to day 16 postpartum, besides hypotension, the transgenic mice display defects in cardiac development and contractility, suggesting a potential cardiac role of ZBTB20. In the current study, Ren et al13 go a step further in exploring the importance of this transcription factor in cardiac function by generating a mouse model with cardiomyocyte-specific ablation of ZBTB20. These mice exhibited normal heart development but showed an increase in basal contractility and SERCa2a activity, attributed to a reduction in PLN expression. The results identify ZBTB20 as a novel transcription factor implicated in the regulation of PLN expression. Unfortunately, it was somewhat disappointing to find that the promoter region of the PLN gene lacks ZBTB20 binding sites. Therefore, additional investigation will be required to understand the mechanism by which ZBTB20 controls PLN expression.
Fil: Mundiña, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; Argentina
description In this issue of Circulation Research, Ren et al13 introduced a novel transcription factor involved in the regulation of PLN expression, ZBTB20. ZBTB20 is a member of the broad complex, Tramtrack, and bric-a-brac and POZ (poxvirus and zinc finger) family of transcriptional repressors. ZBTB20 is involved in the regulation of various biological processes in different tissues, such as cellular proliferation and differentiation, glucose and lipid metabolism, inflammation, tissue repair, and oncogenesis.Due to its versatility, global knockout mice lacking ZBTB20 exhibit mortality within the first month of age.14 Up to day 16 postpartum, besides hypotension, the transgenic mice display defects in cardiac development and contractility, suggesting a potential cardiac role of ZBTB20. In the current study, Ren et al13 go a step further in exploring the importance of this transcription factor in cardiac function by generating a mouse model with cardiomyocyte-specific ablation of ZBTB20. These mice exhibited normal heart development but showed an increase in basal contractility and SERCa2a activity, attributed to a reduction in PLN expression. The results identify ZBTB20 as a novel transcription factor implicated in the regulation of PLN expression. Unfortunately, it was somewhat disappointing to find that the promoter region of the PLN gene lacks ZBTB20 binding sites. Therefore, additional investigation will be required to understand the mechanism by which ZBTB20 controls PLN expression.
publishDate 2024
dc.date.none.fl_str_mv 2024-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/257290
Mundiña, Cecilia Beatriz; Seeking for Regulatory Mechanisms of Phospholamban Expression; Lippincott Williams; Circulation Research; 134; 3; 2-2024; 266-268
0009-7330
CONICET Digital
CONICET
url http://hdl.handle.net/11336/257290
identifier_str_mv Mundiña, Cecilia Beatriz; Seeking for Regulatory Mechanisms of Phospholamban Expression; Lippincott Williams; Circulation Research; 134; 3; 2-2024; 266-268
0009-7330
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.324109
info:eu-repo/semantics/altIdentifier/doi/10.1161/CIRCRESAHA.124.324109
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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