Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility

Autores
Mattiazzi, Alicia Ramona; Mundiña-Weilenmann, Cecilia; Vittone, Leticia
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
Centro de Investigaciones Cardiovasculares
Materia
Ciencias Médicas
Phospholamban
Cardiac relaxation
Contractility
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/104650
Acceder
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network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractilityMattiazzi, Alicia RamonaMundiña-Weilenmann, CeciliaVittone, LeticiaCiencias MédicasPhospholambanCardiac relaxationContractilityPhospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.Centro de Investigaciones Cardiovasculares2010-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf8-17http://sedici.unlp.edu.ar/handle/10915/104650enginfo:eu-repo/semantics/altIdentifier/url/http://hdl.handle.net/11336/61840info:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/altIdentifier/hdl/11336/61840info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:22:43Zoai:sedici.unlp.edu.ar:10915/104650Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:22:44.114SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
spellingShingle Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
Mattiazzi, Alicia Ramona
Ciencias Médicas
Phospholamban
Cardiac relaxation
Contractility
title_short Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title_full Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title_fullStr Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title_full_unstemmed Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
title_sort Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
dc.creator.none.fl_str_mv Mattiazzi, Alicia Ramona
Mundiña-Weilenmann, Cecilia
Vittone, Leticia
author Mattiazzi, Alicia Ramona
author_facet Mattiazzi, Alicia Ramona
Mundiña-Weilenmann, Cecilia
Vittone, Leticia
author_role author
author2 Mundiña-Weilenmann, Cecilia
Vittone, Leticia
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Phospholamban
Cardiac relaxation
Contractility
topic Ciencias Médicas
Phospholamban
Cardiac relaxation
Contractility
dc.description.none.fl_txt_mv Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
Centro de Investigaciones Cardiovasculares
description Phospholamban (PLN) is a small sarcoplasmic reticulum (SR) protein that in the dephosphorylated state tonically inhibits the SR Ca2+-ATPase (SERCA2a). Different type of evidence to be described, points to PLN as a crucial regulator of basal cardiac Ca2+ cycling, contractility and relaxation and as a main determinant of β -adrenergic stimulatory responses in vivo. The involvement of PLN and PLN phosphorylation under pathological conditions will be also discussed.
publishDate 2010
dc.date.none.fl_str_mv 2010-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/104650
url http://sedici.unlp.edu.ar/handle/10915/104650
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://hdl.handle.net/11336/61840
info:eu-repo/semantics/altIdentifier/issn/1669-5410
info:eu-repo/semantics/altIdentifier/hdl/11336/61840
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
8-17
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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