Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids

Autores
Ascencio, Mariano; Jacobsen, Monica Ofelia; Mamoun, Choukri B.; Weir, William; Shiels, Brian; Schnittger, Leonhard
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide. In addition, diverse Babesia spp. infect humans as opportunistic hosts. Molecular phylogeny has demonstrated at least six piroplasmid lineages exemplified by B. microti, B. duncani, C. felis, T. equi, Theileria sensu stricto (T. annulata, T. parva, and T. orientalis) and Babesia sensu stricto (B. bovis, B. bigemina, and B. ovis). C1A cysteine-proteinases (C1A-Cp) are papain-like enzymes implicated in pathogenic and vital steps of the parasite life cycle such as nutrition and host cell egress. An expansion of C1A-Cp of T. annulata and T. parva with respect to B. bovis and B. ovis was previously described. In the present work, C1A-Cp paralogs were identified in available genomes of species pertaining to each piroplasmid lineage. Phylogenetic analysis revealed eight C1A-Cp groups. The profile of C1A-Cp paralogs across these groups corroborates and defines the existence of six piroplasmid lineages. C. felis, T. equi and Theileria s.s. each showed characteristic expansions into extensive families of C1A-Cp paralogs in two of the eight groups. Underlying gene duplications have occurred as independent unique evolutionary events that allow distinguishing these three piroplasmid lineages. We hypothesize that C1A-Cp paralog families may be associated with the advent of the schizont stage. Differences in the invertebrate tick host specificity and/or mode of transmission in piroplasmid lineages might also be associated with the observed C1A-Cp paralog profiles.
Fil: Ascencio, Mariano. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Jacobsen, Monica Ofelia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mamoun, Choukri B.. University of Yale; Estados Unidos
Fil: Weir, William. University of Glasgow; Reino Unido
Fil: Shiels, Brian. University of Glasgow; Reino Unido
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
BABESIA
C1A CYSTEINE-PROTEINASES
COMPARATIVE GENOMICS
CYSTEINE PROTEINASES
CYTAUXZOON
EVOLUTIONARY GENOMICS
MOLECULAR PHYLOGENY
PIROPLASMIDS
TAXONOMY
THEILERIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/176645
Acceder
id CONICETDig_32ba0e65aa5563c0a10164ba4b41a806
oai_identifier_str oai:ri.conicet.gov.ar:11336/176645
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmidsAscencio, MarianoJacobsen, Monica OfeliaMamoun, Choukri B.Weir, WilliamShiels, BrianSchnittger, LeonhardBABESIAC1A CYSTEINE-PROTEINASESCOMPARATIVE GENOMICSCYSTEINE PROTEINASESCYTAUXZOONEVOLUTIONARY GENOMICSMOLECULAR PHYLOGENYPIROPLASMIDSTAXONOMYTHEILERIAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide. In addition, diverse Babesia spp. infect humans as opportunistic hosts. Molecular phylogeny has demonstrated at least six piroplasmid lineages exemplified by B. microti, B. duncani, C. felis, T. equi, Theileria sensu stricto (T. annulata, T. parva, and T. orientalis) and Babesia sensu stricto (B. bovis, B. bigemina, and B. ovis). C1A cysteine-proteinases (C1A-Cp) are papain-like enzymes implicated in pathogenic and vital steps of the parasite life cycle such as nutrition and host cell egress. An expansion of C1A-Cp of T. annulata and T. parva with respect to B. bovis and B. ovis was previously described. In the present work, C1A-Cp paralogs were identified in available genomes of species pertaining to each piroplasmid lineage. Phylogenetic analysis revealed eight C1A-Cp groups. The profile of C1A-Cp paralogs across these groups corroborates and defines the existence of six piroplasmid lineages. C. felis, T. equi and Theileria s.s. each showed characteristic expansions into extensive families of C1A-Cp paralogs in two of the eight groups. Underlying gene duplications have occurred as independent unique evolutionary events that allow distinguishing these three piroplasmid lineages. We hypothesize that C1A-Cp paralog families may be associated with the advent of the schizont stage. Differences in the invertebrate tick host specificity and/or mode of transmission in piroplasmid lineages might also be associated with the observed C1A-Cp paralog profiles.Fil: Ascencio, Mariano. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Jacobsen, Monica Ofelia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mamoun, Choukri B.. University of Yale; Estados UnidosFil: Weir, William. University of Glasgow; Reino UnidoFil: Shiels, Brian. University of Glasgow; Reino UnidoFil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMDPI2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/176645Ascencio, Mariano; Jacobsen, Monica Ofelia; Mamoun, Choukri B.; Weir, William; Shiels, Brian; et al.; Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids; MDPI; Veterinary Sciences; 5; 2; 6-2018; 1-122306-7381CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/2306-7381/5/2/41info:eu-repo/semantics/altIdentifier/doi/10.3390/vetsci5020041info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:06:58Zoai:ri.conicet.gov.ar:11336/176645instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:06:58.335CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
spellingShingle Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
Ascencio, Mariano
BABESIA
C1A CYSTEINE-PROTEINASES
COMPARATIVE GENOMICS
CYSTEINE PROTEINASES
CYTAUXZOON
EVOLUTIONARY GENOMICS
MOLECULAR PHYLOGENY
PIROPLASMIDS
TAXONOMY
THEILERIA
title_short Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title_full Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title_fullStr Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title_full_unstemmed Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title_sort Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
dc.creator.none.fl_str_mv Ascencio, Mariano
Jacobsen, Monica Ofelia
Mamoun, Choukri B.
Weir, William
Shiels, Brian
Schnittger, Leonhard
author Ascencio, Mariano
author_facet Ascencio, Mariano
Jacobsen, Monica Ofelia
Mamoun, Choukri B.
Weir, William
Shiels, Brian
Schnittger, Leonhard
author_role author
author2 Jacobsen, Monica Ofelia
Mamoun, Choukri B.
Weir, William
Shiels, Brian
Schnittger, Leonhard
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv BABESIA
C1A CYSTEINE-PROTEINASES
COMPARATIVE GENOMICS
CYSTEINE PROTEINASES
CYTAUXZOON
EVOLUTIONARY GENOMICS
MOLECULAR PHYLOGENY
PIROPLASMIDS
TAXONOMY
THEILERIA
topic BABESIA
C1A CYSTEINE-PROTEINASES
COMPARATIVE GENOMICS
CYSTEINE PROTEINASES
CYTAUXZOON
EVOLUTIONARY GENOMICS
MOLECULAR PHYLOGENY
PIROPLASMIDS
TAXONOMY
THEILERIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide. In addition, diverse Babesia spp. infect humans as opportunistic hosts. Molecular phylogeny has demonstrated at least six piroplasmid lineages exemplified by B. microti, B. duncani, C. felis, T. equi, Theileria sensu stricto (T. annulata, T. parva, and T. orientalis) and Babesia sensu stricto (B. bovis, B. bigemina, and B. ovis). C1A cysteine-proteinases (C1A-Cp) are papain-like enzymes implicated in pathogenic and vital steps of the parasite life cycle such as nutrition and host cell egress. An expansion of C1A-Cp of T. annulata and T. parva with respect to B. bovis and B. ovis was previously described. In the present work, C1A-Cp paralogs were identified in available genomes of species pertaining to each piroplasmid lineage. Phylogenetic analysis revealed eight C1A-Cp groups. The profile of C1A-Cp paralogs across these groups corroborates and defines the existence of six piroplasmid lineages. C. felis, T. equi and Theileria s.s. each showed characteristic expansions into extensive families of C1A-Cp paralogs in two of the eight groups. Underlying gene duplications have occurred as independent unique evolutionary events that allow distinguishing these three piroplasmid lineages. We hypothesize that C1A-Cp paralog families may be associated with the advent of the schizont stage. Differences in the invertebrate tick host specificity and/or mode of transmission in piroplasmid lineages might also be associated with the observed C1A-Cp paralog profiles.
Fil: Ascencio, Mariano. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Jacobsen, Monica Ofelia. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mamoun, Choukri B.. University of Yale; Estados Unidos
Fil: Weir, William. University of Glasgow; Reino Unido
Fil: Shiels, Brian. University of Glasgow; Reino Unido
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide. In addition, diverse Babesia spp. infect humans as opportunistic hosts. Molecular phylogeny has demonstrated at least six piroplasmid lineages exemplified by B. microti, B. duncani, C. felis, T. equi, Theileria sensu stricto (T. annulata, T. parva, and T. orientalis) and Babesia sensu stricto (B. bovis, B. bigemina, and B. ovis). C1A cysteine-proteinases (C1A-Cp) are papain-like enzymes implicated in pathogenic and vital steps of the parasite life cycle such as nutrition and host cell egress. An expansion of C1A-Cp of T. annulata and T. parva with respect to B. bovis and B. ovis was previously described. In the present work, C1A-Cp paralogs were identified in available genomes of species pertaining to each piroplasmid lineage. Phylogenetic analysis revealed eight C1A-Cp groups. The profile of C1A-Cp paralogs across these groups corroborates and defines the existence of six piroplasmid lineages. C. felis, T. equi and Theileria s.s. each showed characteristic expansions into extensive families of C1A-Cp paralogs in two of the eight groups. Underlying gene duplications have occurred as independent unique evolutionary events that allow distinguishing these three piroplasmid lineages. We hypothesize that C1A-Cp paralog families may be associated with the advent of the schizont stage. Differences in the invertebrate tick host specificity and/or mode of transmission in piroplasmid lineages might also be associated with the observed C1A-Cp paralog profiles.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/176645
Ascencio, Mariano; Jacobsen, Monica Ofelia; Mamoun, Choukri B.; Weir, William; Shiels, Brian; et al.; Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids; MDPI; Veterinary Sciences; 5; 2; 6-2018; 1-12
2306-7381
CONICET Digital
CONICET
url http://hdl.handle.net/11336/176645
identifier_str_mv Ascencio, Mariano; Jacobsen, Monica Ofelia; Mamoun, Choukri B.; Weir, William; Shiels, Brian; et al.; Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids; MDPI; Veterinary Sciences; 5; 2; 6-2018; 1-12
2306-7381
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.mdpi.com/2306-7381/5/2/41
info:eu-repo/semantics/altIdentifier/doi/10.3390/vetsci5020041
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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