Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids

Autores
Ascencio, Mariano; Florin-Christensen, Mónica; Mamoun, Choukri B.; Weir, William; Shiels, Brian; Schnittger, Leonhard
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide. In addition, diverse Babesia spp. infect humans as opportunistic hosts. Molecular phylogeny has demonstrated at least six piroplasmid lineages exemplified by B. microti, B. duncani, C. felis, T. equi, Theileria sensu stricto (T. annulata, T. parva, and T. orientalis) and Babesia sensu stricto (B. bovis, B. bigemina, and B. ovis). C1A cysteine-proteinases (C1A-Cp) are papain-like enzymes implicated in pathogenic and vital steps of the parasite life cycle such as nutrition and host cell egress. An expansion of C1A-Cp of T. annulata and T. parva with respect to B. bovis and B. ovis was previously described. In the present work, C1A-Cp paralogs were identified in available genomes of species pertaining to each piroplasmid lineage. Phylogenetic analysis revealed eight C1A-Cp groups. The profile of C1A-Cp paralogs across these groups corroborates and defines the existence of six piroplasmid lineages. C. felis, T. equi and Theileria s.s. each showed characteristic expansions into extensive families of C1A-Cp paralogs in two of the eight groups. Underlying gene duplications have occurred as independent unique evolutionary events that allow distinguishing these three piroplasmid lineages. We hypothesize that C1A-Cp paralog families may be associated with the advent of the schizont stage. Differences in the invertebrate tick host specificity and/or mode of transmission in piroplasmid lineages might also be associated with the observed C1A-Cp paralog profiles.
Instituto de Patobiología
Fil: Ascencio, Mariano E. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mamoun, Choukri B. Yale School of Medicine. Department of Internal Medicine; Estados Unidos
Fil: Weir, William. University of Glasgow. Institute of Biodiversity, Animal Health and Comparative Medicine; Reino Unido
Fil: Shiels, Brian. University of Glasgow. Institute of Biodiversity, Animal Health and Comparative Medicine; Reino Unido
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Veterinary Sciences 5 (2) : 41 (Abril 2018)
Materia
Babesia
Cisteína
Cytauxzoon
Theileria
Genómica
Filogenia
Piroplasmea
Taxonomía
Metastigmata
Enfermedades transmitidas por garrapatas
Cysteine
Genomics
Phylogeny
Taxonomy
Tickborne diseases
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/3751
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oai_identifier_str oai:localhost:20.500.12123/3751
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network_name_str INTA Digital (INTA)
spelling Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmidsAscencio, MarianoFlorin-Christensen, MónicaMamoun, Choukri B.Weir, WilliamShiels, BrianSchnittger, LeonhardBabesiaCisteínaCytauxzoonTheileriaGenómicaFilogeniaPiroplasmeaTaxonomíaMetastigmataEnfermedades transmitidas por garrapatasCysteineGenomicsPhylogenyTaxonomyTickborne diseasesPiroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide. In addition, diverse Babesia spp. infect humans as opportunistic hosts. Molecular phylogeny has demonstrated at least six piroplasmid lineages exemplified by B. microti, B. duncani, C. felis, T. equi, Theileria sensu stricto (T. annulata, T. parva, and T. orientalis) and Babesia sensu stricto (B. bovis, B. bigemina, and B. ovis). C1A cysteine-proteinases (C1A-Cp) are papain-like enzymes implicated in pathogenic and vital steps of the parasite life cycle such as nutrition and host cell egress. An expansion of C1A-Cp of T. annulata and T. parva with respect to B. bovis and B. ovis was previously described. In the present work, C1A-Cp paralogs were identified in available genomes of species pertaining to each piroplasmid lineage. Phylogenetic analysis revealed eight C1A-Cp groups. The profile of C1A-Cp paralogs across these groups corroborates and defines the existence of six piroplasmid lineages. C. felis, T. equi and Theileria s.s. each showed characteristic expansions into extensive families of C1A-Cp paralogs in two of the eight groups. Underlying gene duplications have occurred as independent unique evolutionary events that allow distinguishing these three piroplasmid lineages. We hypothesize that C1A-Cp paralog families may be associated with the advent of the schizont stage. Differences in the invertebrate tick host specificity and/or mode of transmission in piroplasmid lineages might also be associated with the observed C1A-Cp paralog profiles.Instituto de PatobiologíaFil: Ascencio, Mariano E. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mamoun, Choukri B. Yale School of Medicine. Department of Internal Medicine; Estados UnidosFil: Weir, William. University of Glasgow. Institute of Biodiversity, Animal Health and Comparative Medicine; Reino UnidoFil: Shiels, Brian. University of Glasgow. Institute of Biodiversity, Animal Health and Comparative Medicine; Reino UnidoFil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMDPI2018-10-31T18:39:33Z2018-10-31T18:39:33Z2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://www.mdpi.com/2306-7381/5/2/41http://hdl.handle.net/20.500.12123/37512306-7381https://doi.org/10.3390/vetsci5020041Veterinary Sciences 5 (2) : 41 (Abril 2018)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/PNBIO/1131034/AR./Inmunología molecular y genómica funcional aplicadas a interacciones patógeno hospedador de interés pecuario.info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-04T09:47:38Zoai:localhost:20.500.12123/3751instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:47:39.614INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
spellingShingle Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
Ascencio, Mariano
Babesia
Cisteína
Cytauxzoon
Theileria
Genómica
Filogenia
Piroplasmea
Taxonomía
Metastigmata
Enfermedades transmitidas por garrapatas
Cysteine
Genomics
Phylogeny
Taxonomy
Tickborne diseases
title_short Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title_full Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title_fullStr Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title_full_unstemmed Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
title_sort Cysteine proteinase C1A paralog profiles correspond with phylogenetic lineages of pathogenic piroplasmids
dc.creator.none.fl_str_mv Ascencio, Mariano
Florin-Christensen, Mónica
Mamoun, Choukri B.
Weir, William
Shiels, Brian
Schnittger, Leonhard
author Ascencio, Mariano
author_facet Ascencio, Mariano
Florin-Christensen, Mónica
Mamoun, Choukri B.
Weir, William
Shiels, Brian
Schnittger, Leonhard
author_role author
author2 Florin-Christensen, Mónica
Mamoun, Choukri B.
Weir, William
Shiels, Brian
Schnittger, Leonhard
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Babesia
Cisteína
Cytauxzoon
Theileria
Genómica
Filogenia
Piroplasmea
Taxonomía
Metastigmata
Enfermedades transmitidas por garrapatas
Cysteine
Genomics
Phylogeny
Taxonomy
Tickborne diseases
topic Babesia
Cisteína
Cytauxzoon
Theileria
Genómica
Filogenia
Piroplasmea
Taxonomía
Metastigmata
Enfermedades transmitidas por garrapatas
Cysteine
Genomics
Phylogeny
Taxonomy
Tickborne diseases
dc.description.none.fl_txt_mv Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide. In addition, diverse Babesia spp. infect humans as opportunistic hosts. Molecular phylogeny has demonstrated at least six piroplasmid lineages exemplified by B. microti, B. duncani, C. felis, T. equi, Theileria sensu stricto (T. annulata, T. parva, and T. orientalis) and Babesia sensu stricto (B. bovis, B. bigemina, and B. ovis). C1A cysteine-proteinases (C1A-Cp) are papain-like enzymes implicated in pathogenic and vital steps of the parasite life cycle such as nutrition and host cell egress. An expansion of C1A-Cp of T. annulata and T. parva with respect to B. bovis and B. ovis was previously described. In the present work, C1A-Cp paralogs were identified in available genomes of species pertaining to each piroplasmid lineage. Phylogenetic analysis revealed eight C1A-Cp groups. The profile of C1A-Cp paralogs across these groups corroborates and defines the existence of six piroplasmid lineages. C. felis, T. equi and Theileria s.s. each showed characteristic expansions into extensive families of C1A-Cp paralogs in two of the eight groups. Underlying gene duplications have occurred as independent unique evolutionary events that allow distinguishing these three piroplasmid lineages. We hypothesize that C1A-Cp paralog families may be associated with the advent of the schizont stage. Differences in the invertebrate tick host specificity and/or mode of transmission in piroplasmid lineages might also be associated with the observed C1A-Cp paralog profiles.
Instituto de Patobiología
Fil: Ascencio, Mariano E. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Florin-Christensen, Monica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mamoun, Choukri B. Yale School of Medicine. Department of Internal Medicine; Estados Unidos
Fil: Weir, William. University of Glasgow. Institute of Biodiversity, Animal Health and Comparative Medicine; Reino Unido
Fil: Shiels, Brian. University of Glasgow. Institute of Biodiversity, Animal Health and Comparative Medicine; Reino Unido
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Piroplasmid parasites comprising of Babesia, Theileria, and Cytauxzoon are transmitted by ticks to farm and pet animals and have a significant impact on livestock industries and animal health in tropical and subtropical regions worldwide. In addition, diverse Babesia spp. infect humans as opportunistic hosts. Molecular phylogeny has demonstrated at least six piroplasmid lineages exemplified by B. microti, B. duncani, C. felis, T. equi, Theileria sensu stricto (T. annulata, T. parva, and T. orientalis) and Babesia sensu stricto (B. bovis, B. bigemina, and B. ovis). C1A cysteine-proteinases (C1A-Cp) are papain-like enzymes implicated in pathogenic and vital steps of the parasite life cycle such as nutrition and host cell egress. An expansion of C1A-Cp of T. annulata and T. parva with respect to B. bovis and B. ovis was previously described. In the present work, C1A-Cp paralogs were identified in available genomes of species pertaining to each piroplasmid lineage. Phylogenetic analysis revealed eight C1A-Cp groups. The profile of C1A-Cp paralogs across these groups corroborates and defines the existence of six piroplasmid lineages. C. felis, T. equi and Theileria s.s. each showed characteristic expansions into extensive families of C1A-Cp paralogs in two of the eight groups. Underlying gene duplications have occurred as independent unique evolutionary events that allow distinguishing these three piroplasmid lineages. We hypothesize that C1A-Cp paralog families may be associated with the advent of the schizont stage. Differences in the invertebrate tick host specificity and/or mode of transmission in piroplasmid lineages might also be associated with the observed C1A-Cp paralog profiles.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-31T18:39:33Z
2018-10-31T18:39:33Z
2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.mdpi.com/2306-7381/5/2/41
http://hdl.handle.net/20.500.12123/3751
2306-7381
https://doi.org/10.3390/vetsci5020041
url https://www.mdpi.com/2306-7381/5/2/41
http://hdl.handle.net/20.500.12123/3751
https://doi.org/10.3390/vetsci5020041
identifier_str_mv 2306-7381
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/PNBIO/1131034/AR./Inmunología molecular y genómica funcional aplicadas a interacciones patógeno hospedador de interés pecuario.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Veterinary Sciences 5 (2) : 41 (Abril 2018)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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