Degrade to survive : the intricate world of piroplasmid proteases

Autores
Florin-Christensen, Mónica; Sojka, Daniel; Ganzinelli, Sabrina Belen; Snebergerová, Pavla; Suarez, Carlos Esteban; Schnittger, Leonhard
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.
Instituto de Patobiología
Fil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Florin-Christensen, Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sojka, Daniel. Academy of Sciences of the Czech Republic. Institute of Parasitology; República Checa
Fil: Ganzinelli Sabrina Belen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Ganzinelli Sabrina Belen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Snebergerová, Pavla. Academy of Sciences of the Czech Republic. Institute of Parasitology; República Checa
Fil: Snebergerová, Pavla. University of South Bohemia. Faculty of Science; República Checa
Fil: Suarez, Carlos Esteban. United States Department of Agricultural-Agricultural Research Service. Animal Disease Research Unit; Estados Unidos
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Schnittger, Leonhard. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fuente
Trends in Parasitology 39 (7) : 532-546 (July 2023)
Materia
Babesia
Theileria
Peptidases
Vaccines
Peptidasas
Vacuna
Piroplasmids
Degradome
Piroplásmidos
Degradoma
Nivel de accesibilidad
acceso restringido
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/15219
Acceder
id INTADig_444c60dda24798b41d4d0d88670c6dd4
oai_identifier_str oai:localhost:20.500.12123/15219
network_acronym_str INTADig
repository_id_str l
network_name_str INTA Digital (INTA)
spelling Degrade to survive : the intricate world of piroplasmid proteasesFlorin-Christensen, MónicaSojka, DanielGanzinelli, Sabrina BelenSnebergerová, PavlaSuarez, Carlos EstebanSchnittger, LeonhardBabesiaTheileriaPeptidasesVaccinesPeptidasasVacunaPiroplasmidsDegradomePiroplásmidosDegradomaPiroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.Instituto de PatobiologíaFil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Florin-Christensen, Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sojka, Daniel. Academy of Sciences of the Czech Republic. Institute of Parasitology; República ChecaFil: Ganzinelli Sabrina Belen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Ganzinelli Sabrina Belen. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Snebergerová, Pavla. Academy of Sciences of the Czech Republic. Institute of Parasitology; República ChecaFil: Snebergerová, Pavla. University of South Bohemia. Faculty of Science; República ChecaFil: Suarez, Carlos Esteban. United States Department of Agricultural-Agricultural Research Service. Animal Disease Research Unit; Estados UnidosFil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; ArgentinaFil: Schnittger, Leonhard. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2023-09-15T10:19:06Z2023-09-15T10:19:06Z2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/15219https://www.sciencedirect.com/science/article/pii/S14714922230011861471-5007https://doi.org/10.1016/j.pt.2023.04.010Trends in Parasitology 39 (7) : 532-546 (July 2023)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2019-PD-E5-I102-001, Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud públicainfo:eu-repograntAgreement/INTA/2019-PD-E5-I105-001, Patógenos animales: su interacción con el hospedador y el medio ambiente. Impacto en productividad, ecosistemas, sanidad animal y salud pública en el marco ?Una Salud?info:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y lainfo:eu-repo/semantics/restrictedAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-09-11T10:24:43Zoai:localhost:20.500.12123/15219instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-11 10:24:43.461INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv Degrade to survive : the intricate world of piroplasmid proteases
title Degrade to survive : the intricate world of piroplasmid proteases
spellingShingle Degrade to survive : the intricate world of piroplasmid proteases
Florin-Christensen, Mónica
Babesia
Theileria
Peptidases
Vaccines
Peptidasas
Vacuna
Piroplasmids
Degradome
Piroplásmidos
Degradoma
title_short Degrade to survive : the intricate world of piroplasmid proteases
title_full Degrade to survive : the intricate world of piroplasmid proteases
title_fullStr Degrade to survive : the intricate world of piroplasmid proteases
title_full_unstemmed Degrade to survive : the intricate world of piroplasmid proteases
title_sort Degrade to survive : the intricate world of piroplasmid proteases
dc.creator.none.fl_str_mv Florin-Christensen, Mónica
Sojka, Daniel
Ganzinelli, Sabrina Belen
Snebergerová, Pavla
Suarez, Carlos Esteban
Schnittger, Leonhard
author Florin-Christensen, Mónica
author_facet Florin-Christensen, Mónica
Sojka, Daniel
Ganzinelli, Sabrina Belen
Snebergerová, Pavla
Suarez, Carlos Esteban
Schnittger, Leonhard
author_role author
author2 Sojka, Daniel
Ganzinelli, Sabrina Belen
Snebergerová, Pavla
Suarez, Carlos Esteban
Schnittger, Leonhard
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Babesia
Theileria
Peptidases
Vaccines
Peptidasas
Vacuna
Piroplasmids
Degradome
Piroplásmidos
Degradoma
topic Babesia
Theileria
Peptidases
Vaccines
Peptidasas
Vacuna
Piroplasmids
Degradome
Piroplásmidos
Degradoma
dc.description.none.fl_txt_mv Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.
Instituto de Patobiología
Fil: Florin-Christensen, Mónica. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Florin-Christensen, Mónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sojka, Daniel. Academy of Sciences of the Czech Republic. Institute of Parasitology; República Checa
Fil: Ganzinelli Sabrina Belen. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Ganzinelli Sabrina Belen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Snebergerová, Pavla. Academy of Sciences of the Czech Republic. Institute of Parasitology; República Checa
Fil: Snebergerová, Pavla. University of South Bohemia. Faculty of Science; República Checa
Fil: Suarez, Carlos Esteban. United States Department of Agricultural-Agricultural Research Service. Animal Disease Research Unit; Estados Unidos
Fil: Schnittger, Leonhard. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Patobiología Veterinaria; Argentina
Fil: Schnittger, Leonhard. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Piroplasmids of the genera Babesia, Theileria, and Cytauxzoon are tick-transmitted parasites with a high impact on animals and humans. They have complex life cycles in their definitive arthropod and intermediate vertebrate hosts involving numerous processes, including invasion of, and egress from, host cells, parasite growth, transformation, and migration. Like other parasitic protozoa, piroplasmids are equipped with different types of protease to fulfill many of such essential processes. Blockade of some key proteases, using inhibitors or antibodies, hinders piroplasmid growth, highlighting their potential usefulness in drug therapies and vaccine development. A better understanding of the functional significance of these enzymes will contribute to the development of improved control measures for the devastating animal and human diseases caused by these pathogens.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-15T10:19:06Z
2023-09-15T10:19:06Z
2023-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/15219
https://www.sciencedirect.com/science/article/pii/S1471492223001186
1471-5007
https://doi.org/10.1016/j.pt.2023.04.010
url http://hdl.handle.net/20.500.12123/15219
https://www.sciencedirect.com/science/article/pii/S1471492223001186
https://doi.org/10.1016/j.pt.2023.04.010
identifier_str_mv 1471-5007
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2019-PD-E5-I102-001, Desarrollo de vacunas y tecnologías para mejorar las estrategias profilácticas y terapéuticas de las enfermedades que afectan la producción animal y la salud pública
info:eu-repograntAgreement/INTA/2019-PD-E5-I105-001, Patógenos animales: su interacción con el hospedador y el medio ambiente. Impacto en productividad, ecosistemas, sanidad animal y salud pública en el marco ?Una Salud?
info:eu-repograntAgreement/INTA/2019-PE-E5-I109-001, Convocatoria: Estudios para el control de enfermedades subtropicales y/o transmitidas por vectores (Tristeza Bovina, Garrapatas, Miasis, Tripanosomiasis, Lengua Azul y la
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv restrictedAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Trends in Parasitology 39 (7) : 532-546 (July 2023)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
_version_ 1842975519721652224
score 12.993085

Publicaciones similares