Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
- Autores
- Owen, Gareth I.; Pinto, Mauricio; Retamal, Ignacio N.; Fernádez, María F.; Cisternas, Betzabe; Mondaca, Sebastian; Sanchez, Cesar; Galindo, Hector; Nervi, Bruno; Ibañez, Carolina; Acevedo, Francisco; Madrid, Jorge; Peña, José; Bravo, Maria Loreto; Maturana, Maria Jose; Cordova Delgado, Miguel; Romero, Diego; de la Jara, Nathaly; Torres, Javiera; Rodriguez-Fernandez, Maria; Espinoza, Manuel; Balmaceda, Carlos; Freire, Matías; Gárate-Calderón, Valentina; Crovari, Fernando; Jimenez Fonseca, Paula; Carmona Bayonas, Alberto; Zwenger, Ariel; Armisen, Ricardo; Corvalan, Alejandro H.; Garrido, Luis Marcelo
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Gastric cancer (GC) is the world’s second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to “one size fits all” therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response. The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein–Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up. The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region.
Fil: Owen, Gareth I.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile. Biomedical Research Consortium Of Chile; Chile
Fil: Pinto, Mauricio. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Retamal, Ignacio N.. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Fernádez, María F.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Cisternas, Betzabe. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Mondaca, Sebastian. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Sanchez, Cesar. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Galindo, Hector. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Nervi, Bruno. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Ibañez, Carolina. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Acevedo, Francisco. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Madrid, Jorge. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Peña, José. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Bravo, Maria Loreto. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Maturana, Maria Jose. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Cordova Delgado, Miguel. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Romero, Diego. Universidad de Chile; Chile
Fil: de la Jara, Nathaly. Universidad de Chile; Chile
Fil: Torres, Javiera. Universidad de Chile; Chile
Fil: Rodriguez-Fernandez, Maria. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Espinoza, Manuel. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Balmaceda, Carlos. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Freire, Matías. Center Of Excellence In Precision Medicine; Chile
Fil: Gárate-Calderón, Valentina. Center Of Excellence In Precision Medicine; Chile
Fil: Crovari, Fernando. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Jimenez Fonseca, Paula. Hospital Universitario Central de Asturias; España
Fil: Carmona Bayonas, Alberto. Hospital Morales Meseguer; España
Fil: Zwenger, Ariel. Hospital Provincial de Neuquén; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Armisen, Ricardo. Center Of Excellence In Precision Medicine; Chile
Fil: Corvalan, Alejandro H.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Garrido, Luis Marcelo. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile - Materia
-
cancer subtypes
chemotherapy
gastric cancer
molecular clasification - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/179767
Ver los metadatos del registro completo
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Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patientsOwen, Gareth I.Pinto, MauricioRetamal, Ignacio N.Fernádez, María F.Cisternas, BetzabeMondaca, SebastianSanchez, CesarGalindo, HectorNervi, BrunoIbañez, CarolinaAcevedo, FranciscoMadrid, JorgePeña, JoséBravo, Maria LoretoMaturana, Maria JoseCordova Delgado, MiguelRomero, Diegode la Jara, NathalyTorres, JavieraRodriguez-Fernandez, MariaEspinoza, ManuelBalmaceda, CarlosFreire, MatíasGárate-Calderón, ValentinaCrovari, FernandoJimenez Fonseca, PaulaCarmona Bayonas, AlbertoZwenger, ArielArmisen, RicardoCorvalan, Alejandro H.Garrido, Luis Marcelocancer subtypeschemotherapygastric cancermolecular clasificationhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Gastric cancer (GC) is the world’s second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to “one size fits all” therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response. The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein–Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up. The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region.Fil: Owen, Gareth I.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile. Biomedical Research Consortium Of Chile; ChileFil: Pinto, Mauricio. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Retamal, Ignacio N.. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Fernádez, María F.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Cisternas, Betzabe. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Mondaca, Sebastian. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Sanchez, Cesar. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Galindo, Hector. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Nervi, Bruno. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Ibañez, Carolina. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Acevedo, Francisco. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Madrid, Jorge. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Peña, José. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Bravo, Maria Loreto. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Maturana, Maria Jose. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Cordova Delgado, Miguel. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Romero, Diego. Universidad de Chile; ChileFil: de la Jara, Nathaly. Universidad de Chile; ChileFil: Torres, Javiera. Universidad de Chile; ChileFil: Rodriguez-Fernandez, Maria. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Espinoza, Manuel. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Balmaceda, Carlos. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Freire, Matías. Center Of Excellence In Precision Medicine; ChileFil: Gárate-Calderón, Valentina. Center Of Excellence In Precision Medicine; ChileFil: Crovari, Fernando. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Jimenez Fonseca, Paula. Hospital Universitario Central de Asturias; EspañaFil: Carmona Bayonas, Alberto. Hospital Morales Meseguer; EspañaFil: Zwenger, Ariel. Hospital Provincial de Neuquén; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Armisen, Ricardo. Center Of Excellence In Precision Medicine; ChileFil: Corvalan, Alejandro H.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Garrido, Luis Marcelo. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileLippincott Williams2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/179767Owen, Gareth I.; Pinto, Mauricio; Retamal, Ignacio N.; Fernádez, María F.; Cisternas, Betzabe; et al.; Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients; Lippincott Williams; Medicine; 97; 16; 4-2018; 1-81536-5964CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/MD.0000000000010419info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/md-journal/Fulltext/2018/04200/Chilean_Gastric_Cancer_Task_Force__A_study.26.aspxinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:46:48Zoai:ri.conicet.gov.ar:11336/179767instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:46:48.581CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients |
| title |
Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients |
| spellingShingle |
Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients Owen, Gareth I. cancer subtypes chemotherapy gastric cancer molecular clasification |
| title_short |
Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients |
| title_full |
Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients |
| title_fullStr |
Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients |
| title_full_unstemmed |
Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients |
| title_sort |
Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients |
| dc.creator.none.fl_str_mv |
Owen, Gareth I. Pinto, Mauricio Retamal, Ignacio N. Fernádez, María F. Cisternas, Betzabe Mondaca, Sebastian Sanchez, Cesar Galindo, Hector Nervi, Bruno Ibañez, Carolina Acevedo, Francisco Madrid, Jorge Peña, José Bravo, Maria Loreto Maturana, Maria Jose Cordova Delgado, Miguel Romero, Diego de la Jara, Nathaly Torres, Javiera Rodriguez-Fernandez, Maria Espinoza, Manuel Balmaceda, Carlos Freire, Matías Gárate-Calderón, Valentina Crovari, Fernando Jimenez Fonseca, Paula Carmona Bayonas, Alberto Zwenger, Ariel Armisen, Ricardo Corvalan, Alejandro H. Garrido, Luis Marcelo |
| author |
Owen, Gareth I. |
| author_facet |
Owen, Gareth I. Pinto, Mauricio Retamal, Ignacio N. Fernádez, María F. Cisternas, Betzabe Mondaca, Sebastian Sanchez, Cesar Galindo, Hector Nervi, Bruno Ibañez, Carolina Acevedo, Francisco Madrid, Jorge Peña, José Bravo, Maria Loreto Maturana, Maria Jose Cordova Delgado, Miguel Romero, Diego de la Jara, Nathaly Torres, Javiera Rodriguez-Fernandez, Maria Espinoza, Manuel Balmaceda, Carlos Freire, Matías Gárate-Calderón, Valentina Crovari, Fernando Jimenez Fonseca, Paula Carmona Bayonas, Alberto Zwenger, Ariel Armisen, Ricardo Corvalan, Alejandro H. Garrido, Luis Marcelo |
| author_role |
author |
| author2 |
Pinto, Mauricio Retamal, Ignacio N. Fernádez, María F. Cisternas, Betzabe Mondaca, Sebastian Sanchez, Cesar Galindo, Hector Nervi, Bruno Ibañez, Carolina Acevedo, Francisco Madrid, Jorge Peña, José Bravo, Maria Loreto Maturana, Maria Jose Cordova Delgado, Miguel Romero, Diego de la Jara, Nathaly Torres, Javiera Rodriguez-Fernandez, Maria Espinoza, Manuel Balmaceda, Carlos Freire, Matías Gárate-Calderón, Valentina Crovari, Fernando Jimenez Fonseca, Paula Carmona Bayonas, Alberto Zwenger, Ariel Armisen, Ricardo Corvalan, Alejandro H. Garrido, Luis Marcelo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
cancer subtypes chemotherapy gastric cancer molecular clasification |
| topic |
cancer subtypes chemotherapy gastric cancer molecular clasification |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Gastric cancer (GC) is the world’s second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to “one size fits all” therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response. The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein–Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up. The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region. Fil: Owen, Gareth I.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile. Biomedical Research Consortium Of Chile; Chile Fil: Pinto, Mauricio. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Retamal, Ignacio N.. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Fernádez, María F.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile Fil: Cisternas, Betzabe. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile Fil: Mondaca, Sebastian. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Sanchez, Cesar. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Galindo, Hector. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Nervi, Bruno. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile Fil: Ibañez, Carolina. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile Fil: Acevedo, Francisco. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Madrid, Jorge. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Peña, José. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Bravo, Maria Loreto. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile Fil: Maturana, Maria Jose. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile Fil: Cordova Delgado, Miguel. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile Fil: Romero, Diego. Universidad de Chile; Chile Fil: de la Jara, Nathaly. Universidad de Chile; Chile Fil: Torres, Javiera. Universidad de Chile; Chile Fil: Rodriguez-Fernandez, Maria. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile Fil: Espinoza, Manuel. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Balmaceda, Carlos. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Freire, Matías. Center Of Excellence In Precision Medicine; Chile Fil: Gárate-Calderón, Valentina. Center Of Excellence In Precision Medicine; Chile Fil: Crovari, Fernando. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile Fil: Jimenez Fonseca, Paula. Hospital Universitario Central de Asturias; España Fil: Carmona Bayonas, Alberto. Hospital Morales Meseguer; España Fil: Zwenger, Ariel. Hospital Provincial de Neuquén; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Armisen, Ricardo. Center Of Excellence In Precision Medicine; Chile Fil: Corvalan, Alejandro H.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile Fil: Garrido, Luis Marcelo. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile |
| description |
Gastric cancer (GC) is the world’s second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to “one size fits all” therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response. The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein–Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up. The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-04 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/179767 Owen, Gareth I.; Pinto, Mauricio; Retamal, Ignacio N.; Fernádez, María F.; Cisternas, Betzabe; et al.; Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients; Lippincott Williams; Medicine; 97; 16; 4-2018; 1-8 1536-5964 CONICET Digital CONICET |
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http://hdl.handle.net/11336/179767 |
| identifier_str_mv |
Owen, Gareth I.; Pinto, Mauricio; Retamal, Ignacio N.; Fernádez, María F.; Cisternas, Betzabe; et al.; Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients; Lippincott Williams; Medicine; 97; 16; 4-2018; 1-8 1536-5964 CONICET Digital CONICET |
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eng |
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eng |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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