Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients

Autores
Owen, Gareth I.; Pinto, Mauricio; Retamal, Ignacio N.; Fernádez, María F.; Cisternas, Betzabe; Mondaca, Sebastian; Sanchez, Cesar; Galindo, Hector; Nervi, Bruno; Ibañez, Carolina; Acevedo, Francisco; Madrid, Jorge; Peña, José; Bravo, Maria Loreto; Maturana, Maria Jose; Cordova Delgado, Miguel; Romero, Diego; de la Jara, Nathaly; Torres, Javiera; Rodriguez-Fernandez, Maria; Espinoza, Manuel; Balmaceda, Carlos; Freire, Matías; Gárate-Calderón, Valentina; Crovari, Fernando; Jimenez Fonseca, Paula; Carmona Bayonas, Alberto; Zwenger, Ariel; Armisen, Ricardo; Corvalan, Alejandro H.; Garrido, Luis Marcelo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Gastric cancer (GC) is the world’s second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to “one size fits all” therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response. The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein–Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up. The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region.
Fil: Owen, Gareth I.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile. Biomedical Research Consortium Of Chile; Chile
Fil: Pinto, Mauricio. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Retamal, Ignacio N.. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Fernádez, María F.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Cisternas, Betzabe. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Mondaca, Sebastian. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Sanchez, Cesar. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Galindo, Hector. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Nervi, Bruno. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Ibañez, Carolina. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Acevedo, Francisco. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Madrid, Jorge. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Peña, José. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Bravo, Maria Loreto. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Maturana, Maria Jose. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Cordova Delgado, Miguel. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Romero, Diego. Universidad de Chile; Chile
Fil: de la Jara, Nathaly. Universidad de Chile; Chile
Fil: Torres, Javiera. Universidad de Chile; Chile
Fil: Rodriguez-Fernandez, Maria. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Espinoza, Manuel. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Balmaceda, Carlos. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Freire, Matías. Center Of Excellence In Precision Medicine; Chile
Fil: Gárate-Calderón, Valentina. Center Of Excellence In Precision Medicine; Chile
Fil: Crovari, Fernando. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Jimenez Fonseca, Paula. Hospital Universitario Central de Asturias; España
Fil: Carmona Bayonas, Alberto. Hospital Morales Meseguer; España
Fil: Zwenger, Ariel. Hospital Provincial de Neuquén; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Armisen, Ricardo. Center Of Excellence In Precision Medicine; Chile
Fil: Corvalan, Alejandro H.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Garrido, Luis Marcelo. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Materia
cancer subtypes
chemotherapy
gastric cancer
molecular clasification
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/179767

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network_name_str CONICET Digital (CONICET)
spelling Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patientsOwen, Gareth I.Pinto, MauricioRetamal, Ignacio N.Fernádez, María F.Cisternas, BetzabeMondaca, SebastianSanchez, CesarGalindo, HectorNervi, BrunoIbañez, CarolinaAcevedo, FranciscoMadrid, JorgePeña, JoséBravo, Maria LoretoMaturana, Maria JoseCordova Delgado, MiguelRomero, Diegode la Jara, NathalyTorres, JavieraRodriguez-Fernandez, MariaEspinoza, ManuelBalmaceda, CarlosFreire, MatíasGárate-Calderón, ValentinaCrovari, FernandoJimenez Fonseca, PaulaCarmona Bayonas, AlbertoZwenger, ArielArmisen, RicardoCorvalan, Alejandro H.Garrido, Luis Marcelocancer subtypeschemotherapygastric cancermolecular clasificationhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Gastric cancer (GC) is the world’s second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to “one size fits all” therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response. The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein–Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up. The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region.Fil: Owen, Gareth I.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile. Biomedical Research Consortium Of Chile; ChileFil: Pinto, Mauricio. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Retamal, Ignacio N.. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Fernádez, María F.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Cisternas, Betzabe. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Mondaca, Sebastian. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Sanchez, Cesar. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Galindo, Hector. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Nervi, Bruno. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Ibañez, Carolina. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Acevedo, Francisco. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Madrid, Jorge. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Peña, José. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Bravo, Maria Loreto. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Maturana, Maria Jose. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Cordova Delgado, Miguel. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Romero, Diego. Universidad de Chile; ChileFil: de la Jara, Nathaly. Universidad de Chile; ChileFil: Torres, Javiera. Universidad de Chile; ChileFil: Rodriguez-Fernandez, Maria. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Espinoza, Manuel. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Balmaceda, Carlos. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Freire, Matías. Center Of Excellence In Precision Medicine; ChileFil: Gárate-Calderón, Valentina. Center Of Excellence In Precision Medicine; ChileFil: Crovari, Fernando. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; ChileFil: Jimenez Fonseca, Paula. Hospital Universitario Central de Asturias; EspañaFil: Carmona Bayonas, Alberto. Hospital Morales Meseguer; EspañaFil: Zwenger, Ariel. Hospital Provincial de Neuquén; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Armisen, Ricardo. Center Of Excellence In Precision Medicine; ChileFil: Corvalan, Alejandro H.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileFil: Garrido, Luis Marcelo. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; ChileLippincott Williams2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/179767Owen, Gareth I.; Pinto, Mauricio; Retamal, Ignacio N.; Fernádez, María F.; Cisternas, Betzabe; et al.; Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients; Lippincott Williams; Medicine; 97; 16; 4-2018; 1-81536-5964CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/MD.0000000000010419info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/md-journal/Fulltext/2018/04200/Chilean_Gastric_Cancer_Task_Force__A_study.26.aspxinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:38Zoai:ri.conicet.gov.ar:11336/179767instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:39.124CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
title Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
spellingShingle Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
Owen, Gareth I.
cancer subtypes
chemotherapy
gastric cancer
molecular clasification
title_short Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
title_full Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
title_fullStr Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
title_full_unstemmed Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
title_sort Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
dc.creator.none.fl_str_mv Owen, Gareth I.
Pinto, Mauricio
Retamal, Ignacio N.
Fernádez, María F.
Cisternas, Betzabe
Mondaca, Sebastian
Sanchez, Cesar
Galindo, Hector
Nervi, Bruno
Ibañez, Carolina
Acevedo, Francisco
Madrid, Jorge
Peña, José
Bravo, Maria Loreto
Maturana, Maria Jose
Cordova Delgado, Miguel
Romero, Diego
de la Jara, Nathaly
Torres, Javiera
Rodriguez-Fernandez, Maria
Espinoza, Manuel
Balmaceda, Carlos
Freire, Matías
Gárate-Calderón, Valentina
Crovari, Fernando
Jimenez Fonseca, Paula
Carmona Bayonas, Alberto
Zwenger, Ariel
Armisen, Ricardo
Corvalan, Alejandro H.
Garrido, Luis Marcelo
author Owen, Gareth I.
author_facet Owen, Gareth I.
Pinto, Mauricio
Retamal, Ignacio N.
Fernádez, María F.
Cisternas, Betzabe
Mondaca, Sebastian
Sanchez, Cesar
Galindo, Hector
Nervi, Bruno
Ibañez, Carolina
Acevedo, Francisco
Madrid, Jorge
Peña, José
Bravo, Maria Loreto
Maturana, Maria Jose
Cordova Delgado, Miguel
Romero, Diego
de la Jara, Nathaly
Torres, Javiera
Rodriguez-Fernandez, Maria
Espinoza, Manuel
Balmaceda, Carlos
Freire, Matías
Gárate-Calderón, Valentina
Crovari, Fernando
Jimenez Fonseca, Paula
Carmona Bayonas, Alberto
Zwenger, Ariel
Armisen, Ricardo
Corvalan, Alejandro H.
Garrido, Luis Marcelo
author_role author
author2 Pinto, Mauricio
Retamal, Ignacio N.
Fernádez, María F.
Cisternas, Betzabe
Mondaca, Sebastian
Sanchez, Cesar
Galindo, Hector
Nervi, Bruno
Ibañez, Carolina
Acevedo, Francisco
Madrid, Jorge
Peña, José
Bravo, Maria Loreto
Maturana, Maria Jose
Cordova Delgado, Miguel
Romero, Diego
de la Jara, Nathaly
Torres, Javiera
Rodriguez-Fernandez, Maria
Espinoza, Manuel
Balmaceda, Carlos
Freire, Matías
Gárate-Calderón, Valentina
Crovari, Fernando
Jimenez Fonseca, Paula
Carmona Bayonas, Alberto
Zwenger, Ariel
Armisen, Ricardo
Corvalan, Alejandro H.
Garrido, Luis Marcelo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv cancer subtypes
chemotherapy
gastric cancer
molecular clasification
topic cancer subtypes
chemotherapy
gastric cancer
molecular clasification
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Gastric cancer (GC) is the world’s second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to “one size fits all” therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response. The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein–Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up. The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region.
Fil: Owen, Gareth I.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile. Biomedical Research Consortium Of Chile; Chile
Fil: Pinto, Mauricio. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Retamal, Ignacio N.. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Fernádez, María F.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Cisternas, Betzabe. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Mondaca, Sebastian. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Sanchez, Cesar. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Galindo, Hector. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Nervi, Bruno. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Ibañez, Carolina. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Acevedo, Francisco. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Madrid, Jorge. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Peña, José. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Bravo, Maria Loreto. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Maturana, Maria Jose. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Cordova Delgado, Miguel. Biomedical Research Consortium Of Chile; Chile. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Romero, Diego. Universidad de Chile; Chile
Fil: de la Jara, Nathaly. Universidad de Chile; Chile
Fil: Torres, Javiera. Universidad de Chile; Chile
Fil: Rodriguez-Fernandez, Maria. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Espinoza, Manuel. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Balmaceda, Carlos. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Freire, Matías. Center Of Excellence In Precision Medicine; Chile
Fil: Gárate-Calderón, Valentina. Center Of Excellence In Precision Medicine; Chile
Fil: Crovari, Fernando. Pontificia Universidad Católica de Chile; Chile. Universidad Católica de Chile; Chile
Fil: Jimenez Fonseca, Paula. Hospital Universitario Central de Asturias; España
Fil: Carmona Bayonas, Alberto. Hospital Morales Meseguer; España
Fil: Zwenger, Ariel. Hospital Provincial de Neuquén; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Armisen, Ricardo. Center Of Excellence In Precision Medicine; Chile
Fil: Corvalan, Alejandro H.. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Garrido, Luis Marcelo. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
description Gastric cancer (GC) is the world’s second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to “one size fits all” therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response. The Gastric Cancer Task Force is a Chilean collaborative, noninterventional study that seeks to stratify gastric adenocarcinomas using clinical outcomes and genomic, epigenomic, and protein alterations in a cohort of 200 patients. Tumor samples from the Pathology Department and the Cancer Center at UC-Christus healthcare network, Pontificia Universidad Católica de Chile will be analyzed using a panel of 143 known cancer genes (Oncomine Comprehensive Assay) at the Center of Excellence in Precision Medicine in Santiago, Chile. In addition, promoter methylation for selected genes will be performed along with tissue microarray for clinically relevant proteins (e.g., PD-L1, Erb-2, VEGFR2, among others) and Helicobacter pylori and Epstein–Barr virus status. Obtained data will be correlated to 120 clinical parameters retrieve from medical records, including general patient information, cancer history, laboratory studies, comorbidity index, chemotherapy, targeted therapies, efficacy, and follow-up. The development of a clinically meaningful classification that encompasses comprehensive clinical and molecular parameters may improve patient treatment, predict clinical outcomes, aid patient selection/stratification for clinical trials and may offer insights into future preventive and/or therapeutic strategies in patients from Latin America region.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/179767
Owen, Gareth I.; Pinto, Mauricio; Retamal, Ignacio N.; Fernádez, María F.; Cisternas, Betzabe; et al.; Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients; Lippincott Williams; Medicine; 97; 16; 4-2018; 1-8
1536-5964
CONICET Digital
CONICET
url http://hdl.handle.net/11336/179767
identifier_str_mv Owen, Gareth I.; Pinto, Mauricio; Retamal, Ignacio N.; Fernádez, María F.; Cisternas, Betzabe; et al.; Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients; Lippincott Williams; Medicine; 97; 16; 4-2018; 1-8
1536-5964
CONICET Digital
CONICET
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language eng
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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